ライフサイエンスコーパス: target

1 d expression of PML, a STAT3 transcriptional target.

2 K20me1) methyltransferase, as a druggable NB target.

3 veral candidates capable of engaging a given target.

4 ioactive small molecules and their molecular targets.

5 1 diabetes do not meet recommended glycemic targets.

6 ential diagnostic biomarkers and therapeutic targets.

7 molecular pathophysiology and potential drug targets.

8 assays) are not suitable for small molecule targets.

9 reveals novel potential protein kinase drug targets.

10 g for antibiotics with interesting and novel targets.

11 regulation of canonical PU.1 transcriptional targets.

12 d increased somatic hypermutation in AID off-targets.

13 ating phosphorylation of critical downstream targets.

14 ttranscriptional regulation of messenger RNA targets.

15 ysis that detects expression of 1129 protein targets.

16 ors as a potent vector for the cochlear cell targets.

17 Pregnant CGM users spent more time in target (68% vs 61%; p=0.0034) and less time hyperglycaem

18 Overall, 25 targets, 73 suspects, and 5 TPs were detected.

19 gs establish that EVs secreted by AFSC could target a specific signaling pathway within the glomerulu

20 For compounds with in vivo target activity data (e.g. animal toxicity testing resul

21 Targeting ADCC-Abs to internal proteins may be a potenti

22 Although the introduction of novel targeted agents has improved patient outcomes in several

23 l as sortilin-independent sorting mechanisms target aggregated Golgi membrane proteins for lysosomal

24 Mechanistically, UBE2O specifically targets AMPKalpha2 for ubiquitination and degradation, a

25 We designed an approach to target an extracellular matrix protein, the fibronectin

26 ing number of cardiovascular risk factors at target and major adverse cardiovascular outcomes among p

27 tivity between an individual's rTMS cortical target and the subgenual cingulate predicts antidepressa

28 ane protein functions, or involved with drug targeting and delivery.

29 izing these nanostructures with moieties for targeting and fluorescence, characterizing their biophys

30 cA is necessary and sufficient to direct the targeting and translocation of RodZ to the bacterial pla

31 es reduced expression of key transcriptional targets and lengthens the period of circadian molecular

32 definition of E dimers as the key antigenic target, and deep understanding of neutralizing mechanism

33 ave helped them to efficiently discriminate, target, and obtain edible fruits and/or leaves from a gr

34 SEFL mutations eliminated off-target antibody-dependent monocyte phagocytosis of cynom

35 Using a conditional targeting approach, we ablated the major CLP gene Irf6 o

36 e results underscore that, even if the Paris targets are realized, there could still be a significant

37 In vitro reconstitution and in vivo targeting assays show that SecA is necessary and suffici

38 Target Audience and The target audience for this guideli

39 Target Audience and The target audience for this guideline includes all clinicia

40 hermore, this approach was able to produce a targeted autosome loss in aneuploid mouse embryonic stem

41 Finally, macrophage infiltration and target:background ratio were higher in the carotid plaqu

42 ng role of BCL6 and provide the rationale of targeting BCL6 as a potential therapeutic approach.

43 CPSs are important vaccine targets because they are easily accessible and recogniza

44 Targeted bisulfite sequencing was performed with a subse

45 et sequences at an average ratio of 29.2% by targeting both DNA strands simultaneously with an over 9

46 patients experience disease progression with targeted BRAF inhibitors, we hypothesized therapeutic re

47 expression programs and is an emerging drug target, but its oncogenic role is unclear.

48 egulated by endosomal recycling and vacuolar targeting, but the role of vacuole-related proteins in B

49 rom a 35S promoter::GU-US reporter transgene targeted by CRISPR/Cas9.

50 ix bundle structure that can be specifically targeted by fusion-inhibitory peptides.

51 Envs) on the surfaces of HIV-1 particles are targeted by host antibodies.

52 matosensory cortex subregions are distinctly targeted by local versus distal acupuncture electrostimu

53 Fibronectin (Fn), a ubiquitous host molecule targeted by many pathogens, promotes vascular interactio

54 We proved that it was directly targeted by miR-124-3p with a luciferase reporter assay.

55 malaria infection, Plasmodium parasites are targeted by the autophagy machinery of the host cell, an

56 STATEMENT Neurons communicate with multiple targets by forming axonal branches.

57 formed between the line joining pursuer and target (called the range vector) and an external referen

58 ivo and compared its effects to non-caveolar target CD31/PECAM-1.

59 us viral fusion proteins (F) insert into the target cell membrane, and form a transient intermediate

60 ed tenofovir by metabolism more rapidly than target cells convert to pharmacologically active drug.

61 of the CRISPR-Cas9 genome-editing system to target cells in human body.

62 stion, while protecting the integrity of the target cells.

63 i might have evolved multiple effectors that target chloroplasts or nuclei.

64 ing mechanism and an explanation for RAG off-target cleavage observed in humans.

65 installation, indicating that no sources of target compounds were introduced or, that source introdu

66 sts new possibilities for discovering BACE-1-targeted compounds with more complex mechanisms of actio

67 The slope of a SWCNT electrode in a target concentration range (10(2) 10(6)cells/mL) was 4.5

68 ; nontargeted conditions (10.4-8.4 days) and targeted conditions (3.6-2.8 days).

69 Additional trials of medications aimed at targeting cytokine overactivity that act directly on bra

70 For example, we demonstrate targeted deletions in up to six genes by expressing 12 g

71 Finally, we showed that ABCD4 lysosomal targeting depends on co-expression of, and interaction w

72 Mechanistically, microRNA-146a reduced its target DLST-the E2 subcomponent of the alpha-ketoglutara

73 lones are broad-spectrum antibacterials that target DNA gyrase by stabilizing DNA-cleavage complexes,

74 The target DNA partly hybridizes with capture probe on the g

75 ld sensing chip and the unpaired fragment of target DNA works as a trigger to initiate the nonlinear

76 ructures through specific hybridization with target DNA.

77 One system (type I-F) targets DNA.

78 ectopic DNMT1 expression increases, whereas targeted DNMT1 depletion abrogates KIT signaling cascade

79 1 is mediated by its conserved mitochondrial targeting domain (MTD), which, in unstressed conditions,

80 d novel therapeutic approaches are needed to target dormant tumors.

81 ent strategies for these diseases have often targeted downstream pathways to ameliorate consequences

82 ating the challenge in treating cancers with targeted drugs, which by selecting for drug resistance c

83 ses with 11 actin regulators and three actin-targeting drugs suggest that PMS contains short actin fi

84 t 51% of patients exercised below prescribed target during supervised HIIT and 80% above target in MC

85 to improve drug specificity by reducing off-target effects.

86 showed miRNA-193a-5p level, and its related targets expression, similar to that observed in healthy

87 mic data indicates epigenetic control of Sp1 targets' expression in a cell/tissue specific manner.

88 s problem is to use two-photon microscopy to target fluorescently labeled neurons.

89 within 12% and 10% of achieving the 90-90-90 target for "on ART" and for "viral suppression," respect

90 or activation may be a promising therapeutic target for acute MI.

91 tion of let-7 expression could provide a new target for an anti-inflammatory approach in diabetic vas

92 point to its potential as a new therapeutic target for angiogenesis-related diseases.

93 suggests that the SLII domain is a potential target for antiviral therapy.

94 st that Gab2 might be a powerful therapeutic target for HCC.

95 st-F) or prefusion (pre-F) conformation is a target for neutralizing antibodies and therefore an attr

96 study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high-risk gro

97 Our findings suggest a potential target for the control of vessel restenosis.

98 This system represents a potential target for the treatment of metabolic diseases and has b

99 id interactions and offers a new therapeutic target for the treatment of opioid use disorder.

100 ract this effect, representing an attractive target for therapeutic intervention.

101 highlighting its potential as a therapeutic target for treating autoimmune diseases.

102 ing pathway offers an innovative therapeutic target for treating hypoxic-ischemic human diseases and

103 The apelinergic system is a promising target for treatment of disease, but this remains to be

104 holic steatohepatitis (NASH) and a promising target for treatment of the condition.

105 ndosomes, where it prevents PD-L1 from being targeted for lysosome-mediated degradation.

106 f malaria suggests that interventions may be targeted for maximum impact.

107 patients and what modifiable factors can be targeted for preventive intervention.

108 These patients should be preferentially targeted for secondary prophylaxis and/or regular medica

109 llopregnanolone may be potential therapeutic targets for depression and anxiety in traditionally trea

110 bind to mutated EGFR can help identify novel targets for drug discovery.

111 allowed us to confirm the relevance of these targets for EOC and further provided important insights

112 ces and services could be key to identifying targets for interventions to reverse this trend.

113 inase and NF-kappaB as potential therapeutic targets for prevention of squamous cell carcinoma in pat

114 Developing novel targets for SE therapy and diagnosis is important and ne

115 eric DNA sequences, but are also interesting targets for supramolecular chemistry and nanotechnology.

116 ys, which may identify potential therapeutic targets for the disease.

117 these processes may be potential therapeutic targets for the prevention and treatment of diabetes.

118 STS and 17beta-HSD1 are attractive targets for the treatment of estrogen-dependent diseases

119 A major factor in the variation of SUMO-target function is the balance between the conjugated/de

120 all RNAs generate sharply defined domains of target gene expression through an intrinsic and direct t

121 Further, regulator target gene lists frequently are not curated or have per

122 amily disrupted the interaction of PU.1 with target gene promoters and led to downregulation of canon

123 The SMYD2 transcriptional target gene Ptpn13 also linked SMYD2 to other PKD-associ

124 bosome Affinity Purification (TRAP) and CREB-target gene repositories.

125 MMB target genes are overexpressed in several different canc

126 provides positional information to activate target genes at different positions along the anterior-p

127 selectively reduced CSLC only were found to target genes for cholesterol and unsaturated fatty acid

128 By contrast, activation of the Eomes target genes Foxa2 and Lhx1 is associated with higher or

129 repress the transactivation of the AR/AR-V7 target genes in ligand dependent and independent manners

130 Target genes of a cis-regulatory motif were identified f

131 phenotype; furthermore, H3K27me3 coverage at target genes was strongly reduced in eol1 clf double mut

132 ranscriptional activator that induces myriad target genes, those p53-inducible genes most critical fo

133 ynthesis, concomitant with downregulation of target genes.

134 to a myriad of genomic sites and switch the targeted genes on or off with precision.

135 hromatin-associated RNAs (caRNAs) with their target genomic sequences by proximity ligation, forming

136 isease that is essential to plan the optimal target groups, timing, and cost of national influenza va

137 A combined approach targeting HDAC1/HDAC2 and MYC may present a novel and mo

138 ify current developments in structure-guided target identification and fragment-based lead discovery

139 such data can add substantial confidence to target identification and validation analyses.

140 gher probability of being categorized as the target identity.

141 F1 and the potential therapeutic application targeting IF1 remain obscure.

142 Small-animal SPECT/CT-based MMP-targeted imaging of the lungs is feasible and reflects p

143 This interaction may represent a therapeutic target in cancers that express ephrinB1.

144 CH signaling axis as a candidate therapeutic target in glioma patients.

145 target during supervised HIIT and 80% above target in MCT.

146 -guided prostate biopsy was performed in 134 targets in 106 men who (a) had not previously undergone

147 ind cruise search for nonregenerating sparse targets in a 2D space with steps drawn from a Levy distr

148 ycation, oxidation and glycoxidation protein targets in diverse heated milks.

149 rugs directed against KIT and other relevant targets in neoplastic mast cells and will hopefully rece

150 e a rapid and cost-effective means to detect targets in situ; however, existing LFA formats (predomin

151 an infect T cells, a previously unrecognized target, in vitro.

152 been evolved to recognize a diverse array of targets, including a short peptide.

153 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin

154 Targeted inhibition of Rho-associated kinase (ROCK)2 dow

155 re, we use optical tissue clearing and a TAM-targeting injectable fluorescent nanoparticle (NP) to ex

156 A dual enrichment strategy targets intact protein kinases via capture on immobilize

157 esenting a new potential glomerulus-specific targeted intervention.

158 ve acceptability of FP, and to strategically target interventions toward adolescents and rural poor w

159 for maximizing information dissemination and targeted interventions in regulatory networks, to the de

160 A particularly promising target is the bacterial two-component system.

161 To investigate the clinical application of targeting JAK for ALK- ALCL, we treated ALK- cell lines

162 low-cycling, persistent state in response to targeted kinase inhibitors.

163 m, 5%, was applied topically to a designated target lesion once per day for 4 consecutive days on day

164 tumors showed up-regulation of beta-catenin targets like glutamine synthetase (GS), leukocyte cell-d

165 To explain why klotho preferentially targets lipid rafts we show that clustering of gangliosi

166 It has been challenging to target maladaptive generalized memories without affectin

167 aminoglycan (GAG)-bound CXCL10, resulting in target-mediated clearance, which was corroborated using

168 FtsY, interacts with and is regulated at the target membrane remain unclear.

169 Via targeted metabolomics assays, whereby carotenoids and as

170 Targeted metabolomics methods have already identified ne

171 Drugs targeting metabotropic glutamate receptor 5 (mGluR5) hav

172 Patients meeting target mismatch criteria were analyzed as a subgroup to

173 ensitization of TRPA1 nociceptors stimulates targeted modification of the receptor.

174 Targeted modifications to CP2 based on crystallographic

175 for the first time as late-stage gametocyte-targeting molecules.

176 split fragments that could tandemly bind to target mRNA.

177 translated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT

178 ly appropriate times during the life course, target multiple risks, and build on existing delivery pl

179 pears to work universally, the efficiency of targeted mutagenesis and the adverse generation of off-t

180 ional relevance of these amino acids using a targeted mutagenesis strategy.

181 a novel and molecularly defined strategy to target mutant p53 in pancreatic cancer.

182 utagenesis and the adverse generation of off-target mutations vary greatly between different organism

183 udies assessing the therapeutic potential of targeting Nck in aggressive cancers.

184 We demonstrate that targeted next-generation DNA sequencing reactions and in

185 e disorders when an abnormal immune response targets normal biological components.

186 Common to all target nuclei investigated here is the maintenance of pr

187 processing was useful in helping to identify target odors over background.

188 Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria.

189 ition, stress kinase activation, mechanistic target of rapamycin (mTOR) activation, loss of glutamate

190 flammatory cells by activating the mammalian target of rapamycin (mTOR) pathway.

191 propionic acid (AMPA) receptor and mammalian target of rapamycin (mTOR) signaling, respectively.

192 lower levels of phosphorylation of mammalian target of rapamycin (phospho-mTOR).

193 Mechanistic target of rapamycin inhibition by either nutrient starva

194 d protein kinase B, phosphorylated mammalian target of rapamycin, phosphorylated eukaryotic translati

195 ons why germ plasm might be neither a direct target of selection nor causally linked to accelerated a

196 It is believed to be the cellular target of several antimycobacterial compounds; however,

197 atography experiments identified the primary target of the compounds as the T3SS needle pore protein

198 y have clinical significance, as therapeutic targeting of a signaling pathway such as NG2/CSPG4 may h

199 y complex molecules by small interfering RNA targeting of class II transactivator can reduce the capa

200 s genes, including Sox17, shifts the genomic targeting of Fli1 to favour nearby Sox consensus sites a

201 allelic regulatory activity, and CRISPR/Cas9 targeting of human chondrocytes demonstrates that the re

202 step in the care cascade enables appropriate targeting of interventions and resources.

203 Therefore, the targeting of PSMA has become increasingly important over

204 mmunization activities (SIAs) continued, the targeting of settlements at high risk for polio transmis

205 in vitro and in vivo Notably, pharmacologic targeting of SPHK1 or YAP/TAZ was sufficient to inhibit

206 uppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX.

207 Mitochondrial targeting of Vms1 is mediated by its conserved mitochond

208 suppressed the phosphorylation of downstream targets of AXL signaling such as AKT and P70S6K.

209 of addressing hemodynamic and neurohormonal targets of HF therapy.

210 iosynthetic enzymes are among the downstream targets of mTORC1-SRPK2 signaling.

211 -A1, which in turn are revealed as potential targets of SlCBL10.

212 d endoscopic features are becoming important targets of therapy.

213 , the first new central nervous system (CNS)-targeted oligonucleotide-based drug (nusinersen/Spinraza

214 ulators of V-ATPase either are restricted to targeting one membranous subunit of V-ATPase or have poo

215 atient with infection or colonisation with a target organism was discharged were terminally disinfect

216 alamus is needed to establish the utility of targeting oxytocin signalling in obesity.

217 Targeting PARP-associated DNA repair may represent a nov

218 Targeted patch-clamp recording is a powerful method for

219 pose that DHMA acts as a molecular beacon to target pathogens to their preferred sites of infection i

220 d predict response to radiation and identify target pathways that may be exploited for neoadjuvant th

221 s guideline includes all clinicians, and the target patient population includes adults with joint inf

222 s of plasticity that are appropriate for the target performance environments.

223 All children underwent singleton WES with targeted phenotype-driven analysis.

224 ent were randomly assigned (1:1) to vascular-targeted photodynamic therapy (4 mg/kg padeliporfin intr

225 generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage

226 ies protect against RSV and why specifically targeting prefusion F could have great clinical potentia

227 ting truncal events is more efficacious than targeting private events in reducing the tumor burden.

228 rs to be both an anticipatory effect (future targeted procedures reducing readmission before payments

229 r infrared video goggles with built-in laser target projection and liquid crystal display shutters fo

230 ponses that are critical for regeneration by targeting proregenerative P2Y2 nucleotide receptor (P2Y2

231 direct and regulate vaspin interaction with target proteases or other proteins and may play an impor

232 ike protein Pup to lysine side chains of the target protein via an isopeptide bond.

233 d high rates (88-100%) of mutagenesis in the target protein-encoding sites of MSTN.

234 Targeted protein degradation through ubiquitination is a

235 ular signaling pathways and sulfhydration of target proteins.

236 dentification of ZPR1 and HoxA5 as potential targets provides a paradigm for developing strategies to

237 this assumption result in underestimation of target quantity, when using Poisson modeling, especially

238 ence control confers potential for molecular targeting, recognition and biocatalysis, as well as mole

239 larly involves unmasking of a cytosolic Art1-target region coupled to activation of Art1 via TORC1.

240 nce scaffold, representing a mean 98% of the target region.

241 ealing novel RNA functions and their genomic target regions.

242 ether, these results suggest that germ plasm targeting represents a fitness strategy adopted by some

243 n for proximal sites, and this suggests that target sequence and chromatin state modulate cleavage an

244 R error correcting capabilities, and capture target sequences at an average ratio of 29.2% by targeti

245 whole-genome sequencing, RNA-seq, ChIP-seq, targeted sequencing and single-cell whole-genome sequenc

246 that HSP22E and HSP22F are major chloroplast-targeted sHsps that have emerged from a recent gene dupl

247 lar NP could be a promising nanoplatform for targeted siRNA delivery to EFGR-overexpressing cancer ce

248 Effective target sites fall within two domains, which are conserve

249 d translocation frequency to IGH and AID off-target sites in human chronic lymphocytic leukaemia and

250 miR-18a directly targeted Smad4, Hif1a, and Rora, all key transcription f

251 atible with the ecological requirements of a target species.

252 results suggest that designing compounds to target specific receptor states, rather than specific re

253 ignals to diverse targets without distorting target-specific contrast preferences and spatial recepti

254 of genomes challenges the identification of target-specific oligonucleotides, which limits genetics

255 ferent barrel columns in the BC, albeit with target-specific precision.

256 NSC-370284 and UC-514321 both directly target STAT3/5, transcriptional activators of TET1, and

257 Viral components target subcellular organelles to access host machineries

258 nces show the same response as the hazardous target substances.

259 et surprisingly, mRNA levels of key ISR gene targets such as Atf5 and Trib3 failed to increase.

260 lation of BIC/microRNA 155 (miR-155) and its target, suppressor of cytokine signaling 1 (SOCS-1).

261 acetyl-L-cysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DN

262 nguished by conventional Src inhibitors that target the kinase domain.

263 y is required to test effects of agents that target the NO pathway in reducing arterial stiffness in

264 variant (UbV) library to develop inhibitors targeting the DUBs USP7 and USP10, which are involved in

265 ific PCR and real-time PCR with EvaGreen dye targeting the ITS region of Carthamus tinctorius L.

266 variant that escapes neutralization by MAbs targeting the neutralizing epitope (NE) antigenic site.

267 onsequences of protein dysfunction; however, targeting the source of that dysfunction, the affected p

268 Injection of Cas9-guide RNA-lipid complexes targeting the Tmc1(Bth) allele into the cochlea of neona

269 study suggests that a combinatorial regimen targeting the vasculature, GSCs, and GECs, using drugs a

270 d a size-controlled, dual tumor-mitochondria-targeted theranostic nanoplatform (Porphyrin-PEG Nanocom

271 predict whether cancers respond to specific targeted therapies are performed increasingly often.

272 Targeted therapy for neuropsychiatric disorders requires

273 4.4% received prior potent androgen receptor-targeted therapy.

274 Interventions that target these events will interrupt tuberculosis transmis

275 tream of proallergic events and suggest that targeting this molecule could be a novel approach to tre

276 ly, these data provide proof of concept that targeting thrombin or fibrin(ogen) may limit pathologies

277 ic negative regulator of TLR4 signaling that targets TIRAP.

278 es of space-filling neurons to innervate all target tissues in Drosophila.

279 est the potential of using a single receptor target to develop RNA aptamers with dual activity for ef

280 icates a potential host-directed therapeutic target to limit the damaging inflammation associated wit

281 epigenetic activator of ERalpha that can be targeted to block ERalpha gene expression is a critical

282 a pattern of acquisition of DNA methylation targeted to candidate enhancers active in liver cells, e

283 S-palmitoylation of JAM-C can be potentially targeted to control cancer metastasis.

284 interrupt tuberculosis transmission must be targeted to high-risk groups and settings.

285 Others are targeted to the inner chloroplast envelope membrane by u

286 ona fide Ser/Thr protein phosphatase that is targeted to the mitochondrial intermembrane space (IMS)

287 Akt may help in the development of potential targets to control the pathophysiological processes of c

288 cting molecules that could serve as new drug targets to treat APOL1-associated renal diseases.

289 g a tetracycline inducible short hairpin RNA targeting TRAF3IP2.

290 ans, were confirmed by RT-qPCR Corresponding target transcripts, predicted in silico and validated by

291 We show that targeting truncal events is more efficacious than target

292 ovements in potency directly correlated with target tubulin binding affinity, and the reduction in di

293 Immune checkpoint therapies target tumor antigen-specific T cells, but less is known

294 ngside complementary biological reagents for target validation in drug discovery.

295 To determine direct targets, we performed a chromatin immunoprecipitation ag

296 As expected, SRSF3 and SRSF7 targets were detected in all fractions, with intron, sno

297 sults suggest that PIP4Kgamma is a druggable target whose inhibition enhances productive autophagy an

298 Potentially, targets will be consumed at 1 M per day per reactor, de

299 We enhanced the dCas9-MS2 anchor for genome targeting with Fkbp/Frb dimerizing fusion proteins to al

300 ute precise object motion signals to diverse targets without distorting target-specific contrast pref