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1 roach has identified the AID/RAD51 axis as a target for a potentially clinically translatable pharmac
2 HIV reservoir that should be therapeutically targeted for a functional HIV-1 cure.
3 or activation may be a promising therapeutic target for acute MI.
4 ntify this enzyme as a potential therapeutic target for acute myeloid leukaemia.
5 phagy and establishes ErbB2 as a therapeutic target for AD.
6 estigating other pathways may reveal optimal targets for addressing metabolic dysfunction in ALS.
7             We selected 12 diverse molecular targets for Affimer selection to exemplify their use in
8 and LTs, which might represent a therapeutic target for airway inflammation and remodeling.
9   Thus, Dyrk1A might be an ideal therapeutic target for Alzheimer's disease, especially for Down synd
10 tion of let-7 expression could provide a new target for an anti-inflammatory approach in diabetic vas
11                        Generally the protein target for anesthetics is assumed to be neuronal membran
12  point to its potential as a new therapeutic target for angiogenesis-related diseases.
13 nd immune cells, leading to more susceptible targets for anti-PD-L1 immunotherapy.
14           Bacterial enzymes are an important target for antibacterial compounds.
15 e breast cancers (TNBCs), may be a potential target for antibody-drug conjugates.
16 mers, they represent particularly attractive targets for antibody therapy.
17                     As such, it represents a target for anticancer or antidiabetic drug development.
18 he nucleus and cytosol and is an established target for anticancer therapeutics.
19 ritically important enzyme that is an active target for anticancer therapeutics.
20 esis that Fe-S cluster synthesis is a viable target for antimicrobial development.
21 motors play diverse roles in mitosis and are targets for antimitotic drugs.
22  interface on VP24 that may serve as a novel target for antiviral therapeutic intervention.
23 suggests that the SLII domain is a potential target for antiviral therapy.
24 tuted allenes chiral, making them attractive targets for asymmetric synthesis.
25 ocyte activity may provide novel therapeutic targets for attenuating this inflammation and thereby pr
26 in type 1 domain-containing 7A (THSD7A) is a target for autoimmunity in patients with membranous neph
27 industrial levels is considered a reasonable target for avoiding the most devastating impacts of anth
28 tudy and validate 14alpha-demethylase as the target for azoles in Acanthamoeba.
29 only identifies RXRalpha as a direct protein target for berberine but also dissects their binding mod
30 n biodiversity to be measured over time, the targets for biodiversity conservation to be defined and
31 n over time, this paper provides a potential target for blocking the progression of CVD.
32 D4 is once again in the spotlight as a novel target for both addiction and Parkinson's disease (PD),
33                              The appropriate target for BP in patients with CKD and hypertension rema
34 s the identification of FYN as a therapeutic target for breast tumors with heterozygous or homozygous
35 n in smokers, representing novel therapeutic targets for breast cancer patients who smoke.
36 mor cells and have been considered potential targets for cancer therapy.
37  promise as novel biomarkers and therapeutic targets for cancer.
38 s identify Nur77 as a critical intracellular target for celastrol and unravel a mechanism of Nur77-de
39 er implicating it as a potential therapeutic target for CF.
40  the Nrf2 pathway as a promising therapeutic target for CKD.
41 tifies these cells as attractive therapeutic targets for CKD in humans.
42  path-based approach instead of single point target for climate policy design.
43 munity and inflammatory disease, and a novel target for clinical applications.
44  RNA levels, implicating FoxM1 as a critical target for cyclin B1 inhibition during MVM infection.IMP
45 e low-density lipoprotein (LDL) receptor was targeted for degradation via inducible degrader of the L
46 llopregnanolone may be potential therapeutic targets for depression and anxiety in traditionally trea
47 te that these loops could serve as excellent targets for designing anti-CVA6 vaccines.Coxsackievirus
48 ated inflammation, TcpB might be a candidate target for developing drugs against LPS-induced septicem
49 rgy generation, it may represent a potential target for developing new antifungals.
50                We identify several potential targets for developing novel control measures aimed at r
51 d to the endolysosomal calcium as a critical target for development of anti-Ebola drugs.
52 s to serve as novel biomarkers and molecular targets for developmental therapeutics in aggressive PCa
53 ence, T-channels may be a promising new drug target for different cognitive deficits.
54 t different temperatures may be specifically targeted for different applications, such as for emulsif
55 ulfurated species as well as the therapeutic targets for diseases in which these molecules are involv
56 g that DGKalpha is an attractive therapeutic target for DN.
57 NP, VP35, and VP24, represents an attractive target for drug development; however, the molecular dete
58 rase is overexpressed, making it a potential target for drug discovery.
59 eration of a tumorigenic environment and are targets for drug and vaccine-based control measures.
60                Thus, MMPs present attractive targets for drug design and have been a focus for inhibi
61 s and therefore are proposed to be potential targets for drug development.
62 hosphodiesterases are proving to be fruitful targets for drug discovery.
63 cilitate the identification of new potential targets for drug discovery.
64 bind to mutated EGFR can help identify novel targets for drug discovery.
65 hysiological hallmarks that represent common targets for drug discovery.
66 ies of these loci may aid in identifying new targets for drugs that may modify atrial conduction or t
67 dence and provide much-needed information on targets for effective interventions.
68  (CRE) are high-priority bacterial pathogens targeted for efforts to decrease transmissions and infec
69              The estrogen receptor (ER) is a target for endocrine therapy in breast cancer patients.
70  receptor that is a physiologically relevant target for endogenous opioid neurotransmitters and analg
71 ty, is expressed in B cells, which are known targets for environmental pollutants.
72 allowed us to confirm the relevance of these targets for EOC and further provided important insights
73 ents with EoE and is a potential therapeutic target for EoE and related eosinophilic and allergic dis
74 one (MK) biosynthesis pathway is a potential target for evaluating antimicrobials in gram-positive ba
75 ted to dominant individuals are specifically targeted for forcible eviction from the group, often suf
76  of honey varies more than 100-fold, it is a target for fraud.
77 racticed and represent a potential immediate target for further improvements.
78 ucorum and indicate this gene as a promising target for future hemipterans pest control.
79 sic stroke, we propose that it is a sensible target for future research into rehabilitative treatment
80  during pregnancy and represents a potential target for future therapy.
81  the heart failure (HF) epidemic and provide targets for future health policy interventions in Medica
82 itability of spatial ability makes it a good target for gene-hunting research; (ii) some genes will b
83                             SLA class I is a target for genome editing in xenotransplantation.
84       A major barrier to achieving ambitious targets for global control of HIV and hepatitis C virus
85                The identification of protein targets for haptenation by AX has been approached by mas
86 st that Gab2 might be a powerful therapeutic target for HCC.
87 ation, thus offering a potential therapeutic target for HCC.
88 umorigenesis and offer promising therapeutic targets for HCC and other cancers.
89 hat Foxp1 might be an attractive therapeutic target for HD.
90 PCRs) and is a potential pharmacotherapeutic target for heart failure, hypertension, and other cardio
91 that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy.
92 makes the His biosynthetic route a promising target for herbicides, antifungal agents, and antibiotic
93 lator of the Hh pathway and a potential drug target for Hh-driven cancers.
94 sure possible is not necessarily the optimal target for high-risk patients, although it is not possib
95 gesting that SP110b may serve as a potential target for host-directed therapy aimed at manipulating h
96 iated interaction represents a potential new target for host-oriented inhibitors of EBOV egress.
97 ests that these pathways are potential novel targets for host directed therapy in CNS TB.
98 These findings identify TRPA1 as a molecular target for HQ and provide insights into the mechanism of
99 r tissues and identify potential therapeutic targets for hypertension.
100 s thus a potential biomarker and therapeutic target for IBD, and has particular relevance for anti-TN
101                   Cell death is an important target for imaging the early response of tumors to treat
102 1) constitutes an attractive pharmacological target for immunosuppression, fibroproliferative disorde
103 ss marker" of the normal cell and a possible target for immunotherapeutic approaches in tumors.
104 of a hypermutant state that may constitute a target for immunotherapeutic interventions.
105   SLAMF7 is under intense investigation as a target for immunotherapy in multiple myeloma.
106 al quality of cereal grains has been a major target for improvement using breeding and biotechnology
107                 A potential biotechnological target for improving the production of biofuels is the m
108 nsplantation and represents a novel clinical target for improving transplant outcomes.
109  (SDGs) in 2015, which established ambitious targets for improving child survival by 2030, optimal in
110 er day, making cyst production an attractive target for infection control.
111 athogen transporter may serve as therapeutic targets for infectious diseases.
112 findings identify claudin-3 as a therapeutic target for inhibiting overactivation of Wnt-signaling to
113   Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their role in mediating ge
114     Our study identifies Vps34 as a new drug target for insulin resistance in Type-2 diabetes, in whi
115 ted with incident HF in blacks and represent targets for intensified HF prevention.
116 nts in HIV pathogenesis and highlights novel targets for interrupting the virus life cycle in substan
117  to the mosquito vector and has emerged as a target for intervention in eradication efforts.
118 kenpox and herpes zoster and providing a new target for intervention of neuropathy induced by VZV.
119 onditions of reduced glucose and may provide targets for intervention in neurodegenerative disorders.
120 de for RHD in Uganda to identify appropriate targets for intervention.
121 rofile of early ischemia induced changes and targets for intervention.
122 ces and services could be key to identifying targets for interventions to reverse this trend.
123 The GR is widely recognized as a therapeutic target for its ability to counter proinflammatory signal
124 that CDK20 is a novel, promising therapeutic target for lung cancer.
125 ndosomes, where it prevents PD-L1 from being targeted for lysosome-mediated degradation.
126 p complex represents a promising therapeutic target for many important T3SS-containing pathogens.
127     Clay mineral-bearing locations have been targeted for martian exploration as potentially habitabl
128 f malaria suggests that interventions may be targeted for maximum impact.
129 D and suggest that mGluR5 may be a promising target for mechanism-based treatments aimed at mitigatin
130 ogical processes, and cell types that can be targeted for mechanistic study and therapeutic targeting
131 iduals during positive processing, informing targets for mechanistic intervention.
132 true cell factories, making them interesting targets for metabolic engineering.
133  and suggest PLD2 as a potential therapeutic target for metastatic breast cancer.
134  screening to identify ICAM-1 as a potential target for metastatic melanoma (MM).
135 inhibition, suggesting these proteins as new targets for metformin.
136 ing regulation, and reveals a potential drug target for modulating Hh signaling activity.
137 therefore be considered as a key therapeutic target for modulating the chronic inflammatory response
138  membrane-proximal domains could provide new targets for modulation of Tie receptor activity.
139 um-iodide symporter (hNIS) is an established target for molecular imaging and radionuclide therapy.
140 ne receptor 4 (CXCR4) represents a promising target for molecular imaging of different CXCR4-positive
141 strate that SRPK2 is a potential therapeutic target for mTORC1-driven metabolic disorders.
142 poxia-induced DWMI and may represent a novel target for much needed therapies.
143 KChIP1, KChIP2, and DPP10 are potential drug targets for neuropathic pain because they form a channel
144 ne A2A receptor is an attractive therapeutic target for neuropsychiatric disorders.
145                    DLPFC may be an important target for neurostimulation therapies in addition to the
146 st-F) or prefusion (pre-F) conformation is a target for neutralizing antibodies and therefore an attr
147 t demonstration that the RBS is an important target for neutralizing antibodies, it is not clear how
148 viral nonstructural 5A protein (NS5A) is the target for new antiviral drugs.
149      SOCE may therefore serve as a potential target for new bronchodilators to reduce airway hyper-re
150 uses of mortality, it may provide a valuable target for new research on strategies to improve health.
151  SEDS proteins have exceptional potential as targets for new antibacterial therapeutic agents.
152 have identified factor XII (FXII) and FXI as targets for new anticoagulants that may be even safer th
153  mechanisms of SOCE may therefore form novel targets for new bronchodilators.
154 sing current therapeutics and by identifying targets for new groups.
155 t CRL4 (DCAF1) E3 ligase, which represents a target for novel anti-human immunodeficiency virus (HIV)
156 la virus disease pathology and as a possible target for novel countermeasures.
157  repair, making G2-M checkpoint inhibition a target for novel therapeutic development.
158 the human population, HLA-E is an attractive target for novel vaccine and immunotherapeutic modalitie
159                        To identify potential targets for novel control approaches, we have identified
160 within 12% and 10% of achieving the 90-90-90 target for "on ART" and for "viral suppression," respect
161 ic limiting steps, which could be fruitfully targeted for optimized PE consumption by R. ruber.
162  as both a serum biomarker and a therapeutic target for ovarian cancer.
163 disease progression and identify therapeutic targets for patients.
164 suggest that NOX4 is a potential therapeutic target for PDAC.
165 re an urgent need to discover more effective targets for PEL management.
166 naling pathway may serve as novel actionable targets for PEL management.
167 ied by SASS in different individuals provide targets for personalized (psycho)therapy.
168 ay drive malignant development and offer new targets for personalized therapy.
169  from patients with CHS and could be a novel target for pharmaceutical intervention.
170  role of interleukin-1 (IL-1) signaling as a target for pharmacological intervention.
171 stream pathway of mTOR, as a new therapeutic target for PKD.
172                          These motions are a target for possible new therapies; however, the control
173 but the extracellular N-terminus, which is a target for post-translational modifications, typically i
174 ins use microRNAs (miRNAs) to identify mRNAs targeted for post-transcriptional repression.
175  making this process a potential therapeutic target for posttraumatic stress disorder (PTSD), a menta
176 d neovascularization, and thus, may serve as targets for potential therapeutic interventions.
177  study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high-risk gro
178 e-associated infections, and thus a clinical target for preventing poststroke infection, has also bee
179  platelet miR-223 is a potential therapeutic target for prevention of arterial thrombosis.
180 that alpha9-containing nAChRs are a critical target for prevention of chronic cancer chemotherapy-ind
181 inase and NF-kappaB as potential therapeutic targets for prevention of squamous cell carcinoma in pat
182  patients and what modifiable factors can be targeted for preventive intervention.
183 cally grounded development into a marker and target for prognosis, detection, and treatment of invasi
184  inhibition of NRG3 signaling as a potential target for psychiatric treatment development.
185 (4)K (phosphatidylinositol-4-OH kinase) is a target for pyrazolopyridines and that KDU731 warrants fu
186 tosensory connectivity could be an important target for recovery of hand function in children with US
187               Beverages are one of the first targets for reducing added sugar consumption, and hence
188 iomarker of injury for outcome prediction or target for rehabilitation intervention.
189 substrates of mood disorders is an important target for research.
190 significance of KDM3A as a novel therapeutic target for resistant ovarian cancer.
191 es who exercise regularly, including glucose targets for safe and effective exercise, and nutritional
192 LR/37/67 kDa, could be potential therapeutic targets for schwannomas and other Merlin-deficient tumou
193 ter SCI, and may provide a novel therapeutic target for SCI.
194 sis and highlight ASXL3 as a novel candidate target for SCLC therapy.
195 ggest a new means of its attenuation and new targets for screening of antiviral drugs.
196                             Developing novel targets for SE therapy and diagnosis is important and ne
197      These patients should be preferentially targeted for secondary prophylaxis and/or regular medica
198 ng region of the 5J7 quaternary epitope is a target for serotype-specific neutralizing antibodies aft
199 inker-binding site on the SBD is a potential target for small molecule modulators of the Hsp70 allost
200         Bacterial cell wall synthesis is the target for some of our most powerful antibiotics and has
201                   The disease is a potential target for stem cell therapy but success is likely to be
202 on beliefs and habit strength are modifiable targets for strategies to improve adherence in psoriasis
203 ate astroglial calcium pathways as potential targets for stroke therapy.
204 eric DNA sequences, but are also interesting targets for supramolecular chemistry and nanotechnology.
205 t that these interneurons represent the main targets for supraspinal and sensory afferent signals adj
206 lds the promise of identifying non-intuitive targets for tackling both acquired and intrinsic resista
207  in OPA1 an attractive potential therapeutic target for TBI.
208 f TCL and represents a potential therapeutic target for TCL.
209             Our findings suggest a potential target for the control of vessel restenosis.
210 ranscription initiation and provides a novel target for the development of antiviral therapy.
211 t these cells may represent a novel cellular target for the development of fast-acting antidepressant
212 pports the view that SRSF10 may be used as a target for the development of new anti-viral agents.
213 etics, and infection, and a critical current target for the development of new therapeutic and prophy
214 acids in the mycobacterial cell wall, is the target for the frontline anti-TB drug isoniazid.
215 ish the Them2/PC-TP complex as an attractive target for the management of hepatic steatosis and insul
216  IL-17-IL-17R axis may provide an attractive target for the management of SAg-mediated illnesses.
217 gulates lipoapoptosis and may be an amenable target for the prevention of CKD progression.
218 erefore, deletion of this gene can provide a target for the rational development of vaccines.
219 ent study showed that CRBN, a direct protein target for the teratogenic and antitumor activities of i
220 asion and therefore represents an attractive target for the therapy of RA.
221 dritic spine density, suggesting a potential target for the treatment of addiction in chronic users.
222 notion that SPHK1 is a bona fide therapeutic target for the treatment of AML.
223 ying this histone demethylase as a potential target for the treatment of anxiety and depression.
224 ion in wound repair and identify a potential target for the treatment of chronic inflammation in diab
225 arnered attention as a promising therapeutic target for the treatment of CKD.
226 ese results suggest that REV-ERB is a potent target for the treatment of DMD.
227       Thus, SPHK2 might be an attractive new target for the treatment of fibrosis in chronic kidney d
228 factor for heart failure and is considered a target for the treatment of heart failure.
229           This system represents a potential target for the treatment of metabolic diseases and has b
230 ests that Nav1.7 may provide a potential new target for the treatment of neuropathic pain, including
231  suggest that Tet2 may present a therapeutic target for the treatment of non-hematologic malignancies
232 id interactions and offers a new therapeutic target for the treatment of opioid use disorder.
233 glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson's disease (PD).
234 ptor, a G-protein-coupled receptor that is a target for the treatment of Parkinson's disease.
235  glutamatergic signaling represents a viable target for the treatment of substance use disorders.
236 and capsid assembly may represent attractive targets for the development of antiviral agents against
237 ys, which may identify potential therapeutic targets for the disease.
238 s where most mediators were not known direct targets for the drug.
239                                              Targets for the identified miRNAs were predicted using f
240 these processes may be potential therapeutic targets for the prevention and treatment of diabetes.
241 g inflammasome activation may serve as novel targets for the prevention and treatment of HF in T2DM.
242 lsolin signaling pathway, providing new drug targets for the treatment of demyelination diseases.
243           STS and 17beta-HSD1 are attractive targets for the treatment of estrogen-dependent diseases
244 nd this could serve as novel pharmacological targets for the treatment of mood disorders.
245 -cell compensation are potentially important targets for the treatment of T2D.
246     Here, we present an overview of NET as a target for theranostics; review its current role in some
247 d in platelet aggregation and is a validated target for therapeutic approaches and diagnostic imaging
248               Full and effective use of this target for therapeutic benefit requires a complete under
249 on of ACT-PLA activity thus emerges as novel target for therapeutic control of the disease.
250 hat an NP-mediated translation strategy is a target for therapeutic intervention against this viral d
251 ract this effect, representing an attractive target for therapeutic intervention.
252 e separated from toxicity, providing a novel target for therapeutic intervention.
253 , and provides a potential underlying neural target for therapeutic interventions, and for identifyin
254 ing the spread to epithelia as an attractive target for therapeutic strategies.
255 ing that this subcellular structure could be targeted for therapeutic purposes.
256 rhythmias, and how these mechanisms might be targeted for therapeutic purposes.
257 VRKs and establishing their potential use as targets for therapeutic intervention has been limited by
258 ptotoxicity and neurodegeneration and to new targets for therapeutic intervention.
259 adequate, prompting the need to identify new targets for therapeutic intervention.
260 viral transformation-driven synthetic lethal targets for therapeutic intervention.
261            Our results suggest several novel targets for therapeutic intervention.
262 pathic and familial cases, and suggest novel targets for therapeutic intervention.
263 vide insight into pathogenesis and potential targets for therapeutic intervention.
264 ing and identifies a repertoire of potential targets for therapeutic manipulation.
265 hese three isoforms thus represent potential targets for therapeutic RNA interference (RNAi) in both
266 tein in cancer, represents a pharmacological target for therapy and a Molecular Beacon (MB) specific
267  T-bet-expressing B cells may be a potential target for therapy for autoimmune diseases.
268 y indicates that miR-96 might be a potential target for therapy of pediatric SE.
269 ant p53 GOF in tumorigenesis, which could be targeted for therapy in tumors containing mutant p53.
270 ctional and molecular phenotype which can be targeted for therapy.
271 ntributory to neurodegeneration to be useful targets for therapy of senile dementias.-Goetzl, E.
272                    Based on plausible output targets for these cells, we propose a complete circuit f
273 r, making the discovery of novel therapeutic targets for this disease imperative.
274 , and therefore we present novel therapeutic targets for this disease.
275 /Notch1 signaling is a potential therapeutic target for TNBC.
276                    Bitter taste receptors as targets for tocolytics in preterm labor therapy.
277 d highlight RHAMM as a candidate therapeutic target for treating advanced prostate cancer.
278  highlighting its potential as a therapeutic target for treating autoimmune diseases.
279 creasing attention as a possible therapeutic target for treating disorders that stem from traumatic m
280 s, indicating that JNK1 may be a therapeutic target for treating fungal infection.
281 ing pathway offers an innovative therapeutic target for treating hypoxic-ischemic human diseases and
282 ression and could be a potential therapeutic target for treating UM in the clinic.
283 ism of PKA and IkappaB pathway, which may be targeted for treating S. aureus infection.
284 expression in the IC and subiculum, could be targets for treating amygdala-related disorders.
285 s among the most promising immunotherapeutic targets for treating cancer, autoimmunity, and infectiou
286 ogical matrix collagens and may be promising targets for treating fibrogenesis.
287 t has recently emerged as a highly promising target for treatment of a number of autoimmune diseases.
288        The apelinergic system is a promising target for treatment of disease, but this remains to be
289 has been identified as a potential molecular target for treatment of neurodegeneration.
290 tion and insulin resistance and as potential target for treatment of T2DM.
291 holic steatohepatitis (NASH) and a promising target for treatment of the condition.
292 The impairment of HR by HPV oncogenes may be targeted for treatment of HPV(+) malignancies.
293                  Thus, PPIP5Ks are potential targets for tumor therapy.
294 tem that identifies and evaluates new cancer targets for tumor-targeting nanomedicine.
295  demonstrated by the identification of novel targets for two clinically used tyrosine kinase inhibito
296 peptide 1 (GLP-1) receptor (GLP-1R) is a key target for type 2 diabetes (T2D) treatment.
297 unctionally conserved epitope is a potential target for vaccines against P. falciparum.
298 tter observations make obestatin a promising target for vascular prevention in obesity and diabetes.
299 al role in fat metabolism and is a validated target for weight loss.
300  of CD14+ monocytes as an important cellular target for ZIKV infection during the viremic phase.

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