1 roach has identified the AID/RAD51 axis as a
target for a potentially clinically translatable pharmac
2 HIV reservoir that should be therapeutically
targeted for a functional HIV-1 cure.
3 or activation may be a promising therapeutic
target for acute MI.
4 ntify this enzyme as a potential therapeutic
target for acute myeloid leukaemia.
5 phagy and establishes ErbB2 as a therapeutic
target for AD.
6 estigating other pathways may reveal optimal
targets for addressing metabolic dysfunction in ALS.
7 We selected 12 diverse molecular
targets for Affimer selection to exemplify their use in
8 and LTs, which might represent a therapeutic
target for airway inflammation and remodeling.
9 Thus, Dyrk1A might be an ideal therapeutic
target for Alzheimer's disease, especially for Down synd
10 tion of let-7 expression could provide a new
target for an anti-inflammatory approach in diabetic vas
11 Generally the protein
target for anesthetics is assumed to be neuronal membran
12 point to its potential as a new therapeutic
target for angiogenesis-related diseases.
13 nd immune cells, leading to more susceptible
targets for anti-PD-L1 immunotherapy.
14 Bacterial enzymes are an important
target for antibacterial compounds.
15 e breast cancers (TNBCs), may be a potential
target for antibody-drug conjugates.
16 mers, they represent particularly attractive
targets for antibody therapy.
17 As such, it represents a
target for anticancer or antidiabetic drug development.
18 he nucleus and cytosol and is an established
target for anticancer therapeutics.
19 ritically important enzyme that is an active
target for anticancer therapeutics.
20 esis that Fe-S cluster synthesis is a viable
target for antimicrobial development.
21 motors play diverse roles in mitosis and are
targets for antimitotic drugs.
22 interface on VP24 that may serve as a novel
target for antiviral therapeutic intervention.
23 suggests that the SLII domain is a potential
target for antiviral therapy.
24 tuted allenes chiral, making them attractive
targets for asymmetric synthesis.
25 ocyte activity may provide novel therapeutic
targets for attenuating this inflammation and thereby pr
26 in type 1 domain-containing 7A (THSD7A) is a
target for autoimmunity in patients with membranous neph
27 industrial levels is considered a reasonable
target for avoiding the most devastating impacts of anth
28 tudy and validate 14alpha-demethylase as the
target for azoles in Acanthamoeba.
29 only identifies RXRalpha as a direct protein
target for berberine but also dissects their binding mod
30 n biodiversity to be measured over time, the
targets for biodiversity conservation to be defined and
31 n over time, this paper provides a potential
target for blocking the progression of CVD.
32 D4 is once again in the spotlight as a novel
target for both addiction and Parkinson's disease (PD),
33 The appropriate
target for BP in patients with CKD and hypertension rema
34 s the identification of FYN as a therapeutic
target for breast tumors with heterozygous or homozygous
35 n in smokers, representing novel therapeutic
targets for breast cancer patients who smoke.
36 mor cells and have been considered potential
targets for cancer therapy.
37 promise as novel biomarkers and therapeutic
targets for cancer.
38 s identify Nur77 as a critical intracellular
target for celastrol and unravel a mechanism of Nur77-de
39 er implicating it as a potential therapeutic
target for CF.
40 the Nrf2 pathway as a promising therapeutic
target for CKD.
41 tifies these cells as attractive therapeutic
targets for CKD in humans.
42 path-based approach instead of single point
target for climate policy design.
43 munity and inflammatory disease, and a novel
target for clinical applications.
44 RNA levels, implicating FoxM1 as a critical
target for cyclin B1 inhibition during MVM infection.IMP
45 e low-density lipoprotein (LDL) receptor was
targeted for degradation via inducible degrader of the L
46 llopregnanolone may be potential therapeutic
targets for depression and anxiety in traditionally trea
47 te that these loops could serve as excellent
targets for designing anti-CVA6 vaccines.Coxsackievirus
48 ated inflammation, TcpB might be a candidate
target for developing drugs against LPS-induced septicem
49 rgy generation, it may represent a potential
target for developing new antifungals.
50 We identify several potential
targets for developing novel control measures aimed at r
51 d to the endolysosomal calcium as a critical
target for development of anti-Ebola drugs.
52 s to serve as novel biomarkers and molecular
targets for developmental therapeutics in aggressive PCa
53 ence, T-channels may be a promising new drug
target for different cognitive deficits.
54 t different temperatures may be specifically
targeted for different applications, such as for emulsif
55 ulfurated species as well as the therapeutic
targets for diseases in which these molecules are involv
56 g that DGKalpha is an attractive therapeutic
target for DN.
57 NP, VP35, and VP24, represents an attractive
target for drug development; however, the molecular dete
58 rase is overexpressed, making it a potential
target for drug discovery.
59 eration of a tumorigenic environment and are
targets for drug and vaccine-based control measures.
60 Thus, MMPs present attractive
targets for drug design and have been a focus for inhibi
61 s and therefore are proposed to be potential
targets for drug development.
62 hosphodiesterases are proving to be fruitful
targets for drug discovery.
63 cilitate the identification of new potential
targets for drug discovery.
64 bind to mutated EGFR can help identify novel
targets for drug discovery.
65 hysiological hallmarks that represent common
targets for drug discovery.
66 ies of these loci may aid in identifying new
targets for drugs that may modify atrial conduction or t
67 dence and provide much-needed information on
targets for effective interventions.
68 (CRE) are high-priority bacterial pathogens
targeted for efforts to decrease transmissions and infec
69 The estrogen receptor (ER) is a
target for endocrine therapy in breast cancer patients.
70 receptor that is a physiologically relevant
target for endogenous opioid neurotransmitters and analg
71 ty, is expressed in B cells, which are known
targets for environmental pollutants.
72 allowed us to confirm the relevance of these
targets for EOC and further provided important insights
73 ents with EoE and is a potential therapeutic
target for EoE and related eosinophilic and allergic dis
74 one (MK) biosynthesis pathway is a potential
target for evaluating antimicrobials in gram-positive ba
75 ted to dominant individuals are specifically
targeted for forcible eviction from the group, often suf
76 of honey varies more than 100-fold, it is a
target for fraud.
77 racticed and represent a potential immediate
target for further improvements.
78 ucorum and indicate this gene as a promising
target for future hemipterans pest control.
79 sic stroke, we propose that it is a sensible
target for future research into rehabilitative treatment
80 during pregnancy and represents a potential
target for future therapy.
81 the heart failure (HF) epidemic and provide
targets for future health policy interventions in Medica
82 itability of spatial ability makes it a good
target for gene-hunting research; (ii) some genes will b
83 SLA class I is a
target for genome editing in xenotransplantation.
84 A major barrier to achieving ambitious
targets for global control of HIV and hepatitis C virus
85 The identification of protein
targets for haptenation by AX has been approached by mas
86 st that Gab2 might be a powerful therapeutic
target for HCC.
87 ation, thus offering a potential therapeutic
target for HCC.
88 umorigenesis and offer promising therapeutic
targets for HCC and other cancers.
89 hat Foxp1 might be an attractive therapeutic
target for HD.
90 PCRs) and is a potential pharmacotherapeutic
target for heart failure, hypertension, and other cardio
91 that intestinal HIF-2alpha could be a viable
target for hepatic steatosis therapy.
92 makes the His biosynthetic route a promising
target for herbicides, antifungal agents, and antibiotic
93 lator of the Hh pathway and a potential drug
target for Hh-driven cancers.
94 sure possible is not necessarily the optimal
target for high-risk patients, although it is not possib
95 gesting that SP110b may serve as a potential
target for host-directed therapy aimed at manipulating h
96 iated interaction represents a potential new
target for host-oriented inhibitors of EBOV egress.
97 ests that these pathways are potential novel
targets for host directed therapy in CNS TB.
98 These findings identify TRPA1 as a molecular
target for HQ and provide insights into the mechanism of
99 r tissues and identify potential therapeutic
targets for hypertension.
100 s thus a potential biomarker and therapeutic
target for IBD, and has particular relevance for anti-TN
101 Cell death is an important
target for imaging the early response of tumors to treat
102 1) constitutes an attractive pharmacological
target for immunosuppression, fibroproliferative disorde
103 ss marker" of the normal cell and a possible
target for immunotherapeutic approaches in tumors.
104 of a hypermutant state that may constitute a
target for immunotherapeutic interventions.
105 SLAMF7 is under intense investigation as a
target for immunotherapy in multiple myeloma.
106 al quality of cereal grains has been a major
target for improvement using breeding and biotechnology
107 A potential biotechnological
target for improving the production of biofuels is the m
108 nsplantation and represents a novel clinical
target for improving transplant outcomes.
109 (SDGs) in 2015, which established ambitious
targets for improving child survival by 2030, optimal in
110 er day, making cyst production an attractive
target for infection control.
111 athogen transporter may serve as therapeutic
targets for infectious diseases.
112 findings identify claudin-3 as a therapeutic
target for inhibiting overactivation of Wnt-signaling to
113 Trimethyllysine (Kme3) reader proteins are
targets for inhibition due to their role in mediating ge
114 Our study identifies Vps34 as a new drug
target for insulin resistance in Type-2 diabetes, in whi
115 ted with incident HF in blacks and represent
targets for intensified HF prevention.
116 nts in HIV pathogenesis and highlights novel
targets for interrupting the virus life cycle in substan
117 to the mosquito vector and has emerged as a
target for intervention in eradication efforts.
118 kenpox and herpes zoster and providing a new
target for intervention of neuropathy induced by VZV.
119 onditions of reduced glucose and may provide
targets for intervention in neurodegenerative disorders.
120 de for RHD in Uganda to identify appropriate
targets for intervention.
121 rofile of early ischemia induced changes and
targets for intervention.
122 ces and services could be key to identifying
targets for interventions to reverse this trend.
123 The GR is widely recognized as a therapeutic
target for its ability to counter proinflammatory signal
124 that CDK20 is a novel, promising therapeutic
target for lung cancer.
125 ndosomes, where it prevents PD-L1 from being
targeted for lysosome-mediated degradation.
126 p complex represents a promising therapeutic
target for many important T3SS-containing pathogens.
127 Clay mineral-bearing locations have been
targeted for martian exploration as potentially habitabl
128 f malaria suggests that interventions may be
targeted for maximum impact.
129 D and suggest that mGluR5 may be a promising
target for mechanism-based treatments aimed at mitigatin
130 ogical processes, and cell types that can be
targeted for mechanistic study and therapeutic targeting
131 iduals during positive processing, informing
targets for mechanistic intervention.
132 true cell factories, making them interesting
targets for metabolic engineering.
133 and suggest PLD2 as a potential therapeutic
target for metastatic breast cancer.
134 screening to identify ICAM-1 as a potential
target for metastatic melanoma (MM).
135 inhibition, suggesting these proteins as new
targets for metformin.
136 ing regulation, and reveals a potential drug
target for modulating Hh signaling activity.
137 therefore be considered as a key therapeutic
target for modulating the chronic inflammatory response
138 membrane-proximal domains could provide new
targets for modulation of Tie receptor activity.
139 um-iodide symporter (hNIS) is an established
target for molecular imaging and radionuclide therapy.
140 ne receptor 4 (CXCR4) represents a promising
target for molecular imaging of different CXCR4-positive
141 strate that SRPK2 is a potential therapeutic
target for mTORC1-driven metabolic disorders.
142 poxia-induced DWMI and may represent a novel
target for much needed therapies.
143 KChIP1, KChIP2, and DPP10 are potential drug
targets for neuropathic pain because they form a channel
144 ne A2A receptor is an attractive therapeutic
target for neuropsychiatric disorders.
145 DLPFC may be an important
target for neurostimulation therapies in addition to the
146 st-F) or prefusion (pre-F) conformation is a
target for neutralizing antibodies and therefore an attr
147 t demonstration that the RBS is an important
target for neutralizing antibodies, it is not clear how
148 viral nonstructural 5A protein (NS5A) is the
target for new antiviral drugs.
149 SOCE may therefore serve as a potential
target for new bronchodilators to reduce airway hyper-re
150 uses of mortality, it may provide a valuable
target for new research on strategies to improve health.
151 SEDS proteins have exceptional potential as
targets for new antibacterial therapeutic agents.
152 have identified factor XII (FXII) and FXI as
targets for new anticoagulants that may be even safer th
153 mechanisms of SOCE may therefore form novel
targets for new bronchodilators.
154 sing current therapeutics and by identifying
targets for new groups.
155 t CRL4 (DCAF1) E3 ligase, which represents a
target for novel anti-human immunodeficiency virus (HIV)
156 la virus disease pathology and as a possible
target for novel countermeasures.
157 repair, making G2-M checkpoint inhibition a
target for novel therapeutic development.
158 the human population, HLA-E is an attractive
target for novel vaccine and immunotherapeutic modalitie
159 To identify potential
targets for novel control approaches, we have identified
160 within 12% and 10% of achieving the 90-90-90
target for "
on ART" and for "viral suppression," respect
161 ic limiting steps, which could be fruitfully
targeted for optimized PE consumption by R. ruber.
162 as both a serum biomarker and a therapeutic
target for ovarian cancer.
163 disease progression and identify therapeutic
targets for patients.
164 suggest that NOX4 is a potential therapeutic
target for PDAC.
165 re an urgent need to discover more effective
targets for PEL management.
166 naling pathway may serve as novel actionable
targets for PEL management.
167 ied by SASS in different individuals provide
targets for personalized (psycho)therapy.
168 ay drive malignant development and offer new
targets for personalized therapy.
169 from patients with CHS and could be a novel
target for pharmaceutical intervention.
170 role of interleukin-1 (IL-1) signaling as a
target for pharmacological intervention.
171 stream pathway of mTOR, as a new therapeutic
target for PKD.
172 These motions are a
target for possible new therapies; however, the control
173 but the extracellular N-terminus, which is a
target for post-translational modifications, typically i
174 ins use microRNAs (miRNAs) to identify mRNAs
targeted for post-transcriptional repression.
175 making this process a potential therapeutic
target for posttraumatic stress disorder (PTSD), a menta
176 d neovascularization, and thus, may serve as
targets for potential therapeutic interventions.
177 study, we evaluated HuR as a small-molecule
target for preventing colorectal cancer in high-risk gro
178 e-associated infections, and thus a clinical
target for preventing poststroke infection, has also bee
179 platelet miR-223 is a potential therapeutic
target for prevention of arterial thrombosis.
180 that alpha9-containing nAChRs are a critical
target for prevention of chronic cancer chemotherapy-ind
181 inase and NF-kappaB as potential therapeutic
targets for prevention of squamous cell carcinoma in pat
182 patients and what modifiable factors can be
targeted for preventive intervention.
183 cally grounded development into a marker and
target for prognosis, detection, and treatment of invasi
184 inhibition of NRG3 signaling as a potential
target for psychiatric treatment development.
185 (4)K (phosphatidylinositol-4-OH kinase) is a
target for pyrazolopyridines and that KDU731 warrants fu
186 tosensory connectivity could be an important
target for recovery of hand function in children with US
187 Beverages are one of the first
targets for reducing added sugar consumption, and hence
188 iomarker of injury for outcome prediction or
target for rehabilitation intervention.
189 substrates of mood disorders is an important
target for research.
190 significance of KDM3A as a novel therapeutic
target for resistant ovarian cancer.
191 es who exercise regularly, including glucose
targets for safe and effective exercise, and nutritional
192 LR/37/67 kDa, could be potential therapeutic
targets for schwannomas and other Merlin-deficient tumou
193 ter SCI, and may provide a novel therapeutic
target for SCI.
194 sis and highlight ASXL3 as a novel candidate
target for SCLC therapy.
195 ggest a new means of its attenuation and new
targets for screening of antiviral drugs.
196 Developing novel
targets for SE therapy and diagnosis is important and ne
197 These patients should be preferentially
targeted for secondary prophylaxis and/or regular medica
198 ng region of the 5J7 quaternary epitope is a
target for serotype-specific neutralizing antibodies aft
199 inker-binding site on the SBD is a potential
target for small molecule modulators of the Hsp70 allost
200 Bacterial cell wall synthesis is the
target for some of our most powerful antibiotics and has
201 The disease is a potential
target for stem cell therapy but success is likely to be
202 on beliefs and habit strength are modifiable
targets for strategies to improve adherence in psoriasis
203 ate astroglial calcium pathways as potential
targets for stroke therapy.
204 eric DNA sequences, but are also interesting
targets for supramolecular chemistry and nanotechnology.
205 t that these interneurons represent the main
targets for supraspinal and sensory afferent signals adj
206 lds the promise of identifying non-intuitive
targets for tackling both acquired and intrinsic resista
207 in OPA1 an attractive potential therapeutic
target for TBI.
208 f TCL and represents a potential therapeutic
target for TCL.
209 Our findings suggest a potential
target for the control of vessel restenosis.
210 ranscription initiation and provides a novel
target for the development of antiviral therapy.
211 t these cells may represent a novel cellular
target for the development of fast-acting antidepressant
212 pports the view that SRSF10 may be used as a
target for the development of new anti-viral agents.
213 etics, and infection, and a critical current
target for the development of new therapeutic and prophy
214 acids in the mycobacterial cell wall, is the
target for the frontline anti-TB drug isoniazid.
215 ish the Them2/PC-TP complex as an attractive
target for the management of hepatic steatosis and insul
216 IL-17-IL-17R axis may provide an attractive
target for the management of SAg-mediated illnesses.
217 gulates lipoapoptosis and may be an amenable
target for the prevention of CKD progression.
218 erefore, deletion of this gene can provide a
target for the rational development of vaccines.
219 ent study showed that CRBN, a direct protein
target for the teratogenic and antitumor activities of i
220 asion and therefore represents an attractive
target for the therapy of RA.
221 dritic spine density, suggesting a potential
target for the treatment of addiction in chronic users.
222 notion that SPHK1 is a bona fide therapeutic
target for the treatment of AML.
223 ying this histone demethylase as a potential
target for the treatment of anxiety and depression.
224 ion in wound repair and identify a potential
target for the treatment of chronic inflammation in diab
225 arnered attention as a promising therapeutic
target for the treatment of CKD.
226 ese results suggest that REV-ERB is a potent
target for the treatment of DMD.
227 Thus, SPHK2 might be an attractive new
target for the treatment of fibrosis in chronic kidney d
228 factor for heart failure and is considered a
target for the treatment of heart failure.
229 This system represents a potential
target for the treatment of metabolic diseases and has b
230 ests that Nav1.7 may provide a potential new
target for the treatment of neuropathic pain, including
231 suggest that Tet2 may present a therapeutic
target for the treatment of non-hematologic malignancies
232 id interactions and offers a new therapeutic
target for the treatment of opioid use disorder.
233 glutamate receptor 4 (mGluR4) is an emerging
target for the treatment of Parkinson's disease (PD).
234 ptor, a G-protein-coupled receptor that is a
target for the treatment of Parkinson's disease.
235 glutamatergic signaling represents a viable
target for the treatment of substance use disorders.
236 and capsid assembly may represent attractive
targets for the development of antiviral agents against
237 ys, which may identify potential therapeutic
targets for the disease.
238 s where most mediators were not known direct
targets for the drug.
239 Targets for the identified miRNAs were predicted using f
240 these processes may be potential therapeutic
targets for the prevention and treatment of diabetes.
241 g inflammasome activation may serve as novel
targets for the prevention and treatment of HF in T2DM.
242 lsolin signaling pathway, providing new drug
targets for the treatment of demyelination diseases.
243 STS and 17beta-HSD1 are attractive
targets for the treatment of estrogen-dependent diseases
244 nd this could serve as novel pharmacological
targets for the treatment of mood disorders.
245 -cell compensation are potentially important
targets for the treatment of T2D.
246 Here, we present an overview of NET as a
target for theranostics; review its current role in some
247 d in platelet aggregation and is a validated
target for therapeutic approaches and diagnostic imaging
248 Full and effective use of this
target for therapeutic benefit requires a complete under
249 on of ACT-PLA activity thus emerges as novel
target for therapeutic control of the disease.
250 hat an NP-mediated translation strategy is a
target for therapeutic intervention against this viral d
251 ract this effect, representing an attractive
target for therapeutic intervention.
252 e separated from toxicity, providing a novel
target for therapeutic intervention.
253 , and provides a potential underlying neural
target for therapeutic interventions, and for identifyin
254 ing the spread to epithelia as an attractive
target for therapeutic strategies.
255 ing that this subcellular structure could be
targeted for therapeutic purposes.
256 rhythmias, and how these mechanisms might be
targeted for therapeutic purposes.
257 VRKs and establishing their potential use as
targets for therapeutic intervention has been limited by
258 ptotoxicity and neurodegeneration and to new
targets for therapeutic intervention.
259 adequate, prompting the need to identify new
targets for therapeutic intervention.
260 viral transformation-driven synthetic lethal
targets for therapeutic intervention.
261 Our results suggest several novel
targets for therapeutic intervention.
262 pathic and familial cases, and suggest novel
targets for therapeutic intervention.
263 vide insight into pathogenesis and potential
targets for therapeutic intervention.
264 ing and identifies a repertoire of potential
targets for therapeutic manipulation.
265 hese three isoforms thus represent potential
targets for therapeutic RNA interference (RNAi) in both
266 tein in cancer, represents a pharmacological
target for therapy and a Molecular Beacon (MB) specific
267 T-bet-expressing B cells may be a potential
target for therapy for autoimmune diseases.
268 y indicates that miR-96 might be a potential
target for therapy of pediatric SE.
269 ant p53 GOF in tumorigenesis, which could be
targeted for therapy in tumors containing mutant p53.
270 ctional and molecular phenotype which can be
targeted for therapy.
271 ntributory to neurodegeneration to be useful
targets for therapy of senile dementias.-Goetzl, E.
272 Based on plausible output
targets for these cells, we propose a complete circuit f
273 r, making the discovery of novel therapeutic
targets for this disease imperative.
274 , and therefore we present novel therapeutic
targets for this disease.
275 /Notch1 signaling is a potential therapeutic
target for TNBC.
276 Bitter taste receptors as
targets for tocolytics in preterm labor therapy.
277 d highlight RHAMM as a candidate therapeutic
target for treating advanced prostate cancer.
278 highlighting its potential as a therapeutic
target for treating autoimmune diseases.
279 creasing attention as a possible therapeutic
target for treating disorders that stem from traumatic m
280 s, indicating that JNK1 may be a therapeutic
target for treating fungal infection.
281 ing pathway offers an innovative therapeutic
target for treating hypoxic-ischemic human diseases and
282 ression and could be a potential therapeutic
target for treating UM in the clinic.
283 ism of PKA and IkappaB pathway, which may be
targeted for treating S. aureus infection.
284 expression in the IC and subiculum, could be
targets for treating amygdala-related disorders.
285 s among the most promising immunotherapeutic
targets for treating cancer, autoimmunity, and infectiou
286 ogical matrix collagens and may be promising
targets for treating fibrogenesis.
287 t has recently emerged as a highly promising
target for treatment of a number of autoimmune diseases.
288 The apelinergic system is a promising
target for treatment of disease, but this remains to be
289 has been identified as a potential molecular
target for treatment of neurodegeneration.
290 tion and insulin resistance and as potential
target for treatment of T2DM.
291 holic steatohepatitis (NASH) and a promising
target for treatment of the condition.
292 The impairment of HR by HPV oncogenes may be
targeted for treatment of HPV(+) malignancies.
293 Thus, PPIP5Ks are potential
targets for tumor therapy.
294 tem that identifies and evaluates new cancer
targets for tumor-targeting nanomedicine.
295 demonstrated by the identification of novel
targets for two clinically used tyrosine kinase inhibito
296 peptide 1 (GLP-1) receptor (GLP-1R) is a key
target for type 2 diabetes (T2D) treatment.
297 unctionally conserved epitope is a potential
target for vaccines against P. falciparum.
298 tter observations make obestatin a promising
target for vascular prevention in obesity and diabetes.
299 al role in fat metabolism and is a validated
target for weight loss.
300 of CD14+ monocytes as an important cellular
target for ZIKV infection during the viremic phase.