ライフサイエンスコーパス: target molecule

1 ich can recognize and specifically bind to a target molecule.

2 folded conformation around the small neutral target molecule.

3 ynthesis of the acyclic dienyl moiety of the target molecule.

4 od that, in principle, can be applied to any target molecule.

5 to match the vibrational fingerprint of the target molecule.

6 source with the electronic absorption of the target molecule.

7 be selectively created and integrated in the target molecule.

8 proving the stereospecific formation of the target molecule.

9 nalized with DNA probes complementary to the target molecule.

10 protein in the free-energy landscape of the target molecule.

11 It is a polymerization method around the target molecule.

12 d domino reaction and ultimately yielded the target molecule.

13 d finally globally deprotected to afford the target molecule.

14 ions of the aptamer chain in presence of the target molecule.

15 hemical signal was used for the detection of target molecule.

16 formational changes upon binding the desired target molecule.

17 sitions and orientations with respect to the target molecule.

18 e probes are available to bind with the same target molecule.

19 le inequivalent C-H bonds are present in the target molecule.

20 cess that corresponds to the amount of bound target molecule.

21 e-specific oxidoreductase an attractive drug target molecule.

22 ow the engineered protein interacts with the target molecule.

23 folded/unfolded) upon specific binding to a target molecule.

24 ines the degree of effort required to make a target molecule.

25 ucturally simple and seemingly unconstrained target molecule.

26 which the majority contain only zero or one target molecule.

27 s interrupted and not easily accessible to a target molecule.

28 ntrol can be achieved for sensing of the new target molecule.

29 and capable of rebinding selectively to this target molecule.

30 ial defect in the linear deubiquitination of target molecules.

31 for the synthesis of a variety of bioactive target molecules.

32 e unreliable for samples containing very few target molecules.

33 eporter for the presence of nonelectroactive target molecules.

34 d/or binding affinity of oligonucleotides to target molecules.

35 re to afford nitriles, an important class of target molecules.

36 and can be generated against a wide array of target molecules.

37 o-recognition elements for a wide variety of target molecules.

38 the highest imprinting effectiveness for the target molecules.

39 pler broadening due to spatial motion of the target molecules.

40 with respect to specificity and affinity for target molecules.

41 ommodities, moving away from simple fuels as target molecules.

42 to levels of low femtomolar concentration of target molecules.

43 that can be used in the synthesis of complex target molecules.

44 with the removal of the carbamoyl moiety in target molecules.

45 magnetic field and stabilized by multivalent target molecules.

46 f-detection specifications for low-abundance target molecules.

47 es independent of their affinities for their target molecules.

48 w they are characterized in terms of sensing target molecules.

49 selectively tailored surface chemistries for target molecules.

50 carriers for transportation of retinoids to target molecules.

51 covery of nucleic acid aptamers for multiple target molecules.

52 nity and specificity towards a wide range of target molecules.

53 easy sample preparation with minimal loss of target molecules.

54 ification of extremely low concentrations of target molecules.

55 and photodynamic therapies, and delivery of target molecules.

56 n the synthesis of pharmaceutically relevant target molecules.

57 ids, and terpenes in the carbon framework of target molecules.

58 mer probe for the amplified detection of the target molecules.

59 and how etomidate affects its GABAA receptor target molecules.

60 n when magnetic nanoparticles (MNPs) bind to target molecules.

61 s hydrated form, bicarbonate (HCO3(-)), into target molecules.

62 g their affinity and specificity towards the target molecules.

63 in proportion to the chemical nature of the target molecules.

64 man fingerprint spectrum with trace level of target molecules.

65 g events between purified bacteria- and host-target molecules.

66 ementarity of base-pairing between probe and target molecules.

67 n our diversity oriented approach toward the target molecules.

68 (MIPs) for the specific recognition of NMP22 target molecules.

69 caused reduction in atherothrombosis-related target molecules.

70 very of both activities within one precisely targeted molecule.

71 o determine the binding affinities of ASGP-R-targeted molecules.

72 nergy profiles of eight systems for the four targeted molecules.

73 for the first time as late-stage gametocyte-targeting molecules.

74 type alone or T cells coexpressing these two targeting molecules.

75 nd highlights the significance of HIF-1alpha-targeting molecules.

76 he genome that are inaccessible to other DNA-targeting molecules.

77 cytic C-type lectin receptors are attractive targeting molecules.

78 gments with a detection limit down to 20 DNA target molecules (1.5aM range), making it suitable for a

79 Target molecules 12 and derivatives 14, 17, 18, and 20 t

80 etection from 1microL(-1) to 10(5)microL(-1) target molecules (20 to 2 million targets), making it su

81 the stem P1 and inhibited recognition of the target molecule 7-methylamino-7-deazaguanine (preQ 1 ).

82 t installation of nitrogen atoms en route to target molecules (89 references).

83 d concurrently generated, in addition to the target molecule, a series of diastereomers reflective of

84 With conservative estimates of relative target molecule abundance, it is revealed that filopodia

85 ing a solid-state host matrix containing the target molecule, allowing the observation of phosphoresc

86 ters all electronic structure changes of the target molecule along the entire reaction pathway.

87 ty (4.4% RSD) for complementary nucleic acid target molecules, along with reusability.

88 s (DC), but almost all available systems use target molecules also expressed on other cells and thus

89 Such targeting molecules also have been used to deliver nanop

90 nate from various precursor ions for a given target molecule and may be acquired at varying energies

91 horesis (ITP) to preconcentrate and co-focus target molecules and beads into a single ITP zone.

92 Target molecules and binding epitopes must be accessible

93 lecular interaction for seven macromolecular target molecules and four small-molecule ligands.

94 pment as it interferes with the detection of target molecules and may give rise to false positive sig

95 Beneficial microbes that target molecules and pathways, such as oxidative stress,

96 er act as biological switches in response to target molecules and provide a signal amplification mech

97 le loading of vesicles with small numbers of target molecules and thus raise a significant measuremen

98 he difference of diffusion rates between the targeted molecule and the aptamer/target complex, and th

99 of principle, we chose a dendritic cell (DC)-targeting molecule and specific model antigens to genera

100 report the development of novel microcystin-targeting molecules and their application in microcystin

101 isms of attack vary with the malignancy, the target molecule, and the antibody design, offering oppor

102 nanogate, which could selectively respond to target molecules, and control enzymatic reaction for ele

103 dicated that our sensor binds selectively to target molecules, and the non-specific binding where ads

104 One of them can be neutralized by SR-BI-targeting molecules, and it is critical only for wild-ty

105 gE aptamer/cDNA G1 pair with a suitable anti-target molecule aptamer and cDNA.

106 Herein, interaction between DNA probes and target molecule are also investigated and result reveale

107 monoterpene fragments used to construct the target molecules are also reported.

108 Current approaches for incorporating target molecules are based on multistep postfunctionaliz

109 damage in HD neurons, and these mitochondria-targeted molecules are potential therapeutic molecules f

110 sculature has opened the possibility of PSMA-targeted molecules as generalizable cancer imaging and t

111 se results, thus, support the use of amyloid-targeting molecules as potential supplements for microbi

112 termine both temporal and spatial changes in target molecules, as well as the activity of enzymes.

113 bserving the real-time binding events of the target molecule at nanomolar concentration levels and co

114 including the (a) selection against various target molecules; (b) modulation of protein function in

115 s via desorption of the aptamer strands when target molecules bind with the aptamer.

116 luate the interaction between aggregates and target molecules but also offers new insight for underst

117 derivatization reactions widens the scope of targeted molecules but also clearly points out mineral m

118 only increased the surface area for sensing target molecules, but also constituted an optical sensin

119 enable to the preparation of the carbocyclic target molecule by suitable postrearrangement transforma

120 They bind to target molecules by folding into 3D structures that can

121 tunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step i

122 re polymerized in the presence of a specific target molecule called the 'template' and capable of reb

123 owever, the presence of a nitrogen atom in a target molecule can complicate its chemical synthesis be

124 Although spatially precise excitation of target molecules can be achieved using two-photon laser-

125 ids autofluorescence and photobleaching, and target molecules can be detected specifically and sensit

126 These targeted molecules can be expressed on or drive the cell

127 cross-linker, radical initiator, along with target molecule (cephalexin) in a porogenic material.

128 changes to a hairpin structure, bringing the target molecules close to the surface and triggering ele

129 ies are presented: (i) the first consists in targeting molecules containing a pair of well-defined an

130 the mechanisms driving bacterial sepsis, the target molecules controlling vascular leakage are still

131 The extent of methylation of a target molecule could also be coarsely quantified using

132 he remaining single-stranded portion of each target molecule could subsequently hybridize to compleme

133 pproach improves contrast because each SPARC-targeting molecule delivers a large number of nanopartic

134 trix and the subsequent incorporation of the target molecule depend on the surface quality.

135 ehavioral studies that demonstrate how multi-targeted molecule design can address the pathology of ne

136 summarizes the evolution of natalizumab from target molecule discovery through regulatory approval, v

137 Detection of the target molecules distinguished host infection status in

138 When using our approach, the target molecules do not need to be captured by two captu

139 mplate and demonstrate high affinity for the target molecule (e.g., melamine and trypsin in our publi

140 Interactions of bacteria with target molecules (e.g. antibiotics) or other microorgani

141 ind simultaneously to different sites on the target molecule, enabling highly sensitive and specific

142 One candidate targeting molecule enriched in the vLGN and IGL during r

143 es in aqueous solution for these hydrophobic target molecules, exceeding the values of known syntheti

144 Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-

145 nd to represent, in an autologous setting, a target molecule for anti-tumor T cells.

146 in HUVECs and that CXCR7 may be a potential target molecule for endothelial regeneration and repair

147 function of Noxa, this could be a potential target molecule for future treatment approaches for H. p

148 nine-rich C kinase substrate) as a potential target molecule for kidney cancer.

149 The roster of current candidate target molecules for endothelial nanomedicine includes p

150 d to procure the first milligrams of diverse target molecules for in vitro evaluation.

151 , FoxO1 and p27(Kip1) may serve as promising target molecules for promoting timely oligodendrogenesis

152 -derived CICs and to identify CIC-associated target molecules for T cell immunotherapy.

153 on of CD137 and PD1, thereby displaying more target molecules for the corresponding mAbs.

154 n in tubers and SEGAs and provides potential target molecules for therapeutic development in TSC.

155 source for the discovery of new nucleic acid targeting molecules for more than half a century.

156 families, and demonstrate that its presence targets molecules for TLR detection, while its absence e

157 act by specifically binding and sequestering target molecules found on bacterial cells.

158 n the strengths of SERS for the detection of target molecules from complex mixtures and the clinical

159 cartridge allows for selective enrichment of target molecules from larger sample volumes and removal

160 Air sampling based on diffusion of target molecules from the atmospheric gas phase to passi

161 is nanocomposite enable simple separation of targeted molecules from a complex matrix while the silve

162 ide the chemical identity of the capture and targeted molecules from their vibrational Raman fingerpr

163 2-alkylpyrrolidines (an important family of target molecules) from N-Boc-pyrrolidine, a commercially

164 c acids that can selectively bind to various target molecules, have been widely used for constructing

165 The inherent properties of the target molecule help to define which of these mechanisms

166 racellular domain (NICD) and upregulation of target molecules Hey1 and Hes1.

167 ef that was necessary for the degradation of targeted molecules HLA-A2, CD4, and CD8.

168 ndrance and the fastest rate when binding to target molecules immobilized on surface.

169 trolled endocytosis of a specifically tagged target molecule in different types of living human cells

170 ithin a few minutes for determination of the target molecule in low sample volume at disposable cost-

171 essary to control the surface density of the target molecule in order to ensure that only one molecul

172 limit of detection is 1 pM for short 27 base target molecules in a 15-min assay.

173 ely monodisperse in size and can encapsulate target molecules in a robust, well-defined manner.

174 roach can be easily adopted to monitor other target molecules in a simple, low-cost, sensitive and se

175 It has been applied both to identify target molecules in cell types that are important for co

176 in which effector concentrations are read by target molecules in cells.

177 olution, dried, and then rehydrated by ssDNA target molecules in droplets for hybridization and detec

178 A novel strategy to sense target molecules in human blood serum is achieved by imm

179 s requiring strong spatial interrelations of target molecules in key pathologic activation processes

180 lization as well as for the concentration of target molecules in microsystems.

181 ey regulator, orchestrating a major group of target molecules in the oncogenic hierarchy.

182 Upregulation of Wnt/beta-catenin target molecules in the optic cup and stalk may underlie

183 By targeting molecules in pfGCs with several mutant mouse m

184 sought to identify differentially expressed targeting molecules in these LGN subnuclei.

185 edes the study of specific human VWF (huVWF) targeting molecules in thrombosis.

186 physiological process of fibrogenesis; these target molecules include collagen types I, III, and IV,

187 significant changes in potential downstream target molecules including Cd36, Ppargamma, Glut2 protei

188 Illustrative examples are provided for some target molecules, including terminal alkynes, strained r

189 lusively by lysozyme and not other cell wall-targeting molecules, including the peptidoglycan deacety

190 Addition of target molecule induces a change in the charge distribut

191 h moieties include atomic ions, low affinity target molecules, inorganic anions, biometabolites, path

192 electronic pre-resonance conditions to image target molecules inside living cells with very high vibr

193 ed biosensors to transduce the presence of a target molecule into a dose-dependent fluorescence signa

194 Target molecules involved in C1 binding and mechanisms o

195 s to the construction of fluorine-containing target molecules is important for a variety of scientifi

196 The number of target molecules is inferred from the position of the re

197 The synthetic route to the targeted molecule is simple, concise, and high yielding

198 Additionally, none of the TNF-alpha-targeting molecules is expected to interfere with the im

199 the capture and transport of other important target molecules, leading toward diverse biomedical and

200 elective detection of a low molecular weight target molecule (less than 200 Da) by aptamer-based sens

201 setup was used for the detection of the five target molecules (less than 3 h for 96 samples).

202 -radiative modes in the matrix surrounding a target molecule may also have broader applications in li

203 of binding to distinct epitopes on the same target molecule may enable fine-tuning of intracellular

204 These findings indicate that mitochondria-targeted molecules may be an effective therapeutic appro

205 These findings suggest that mitochondria-targeted molecules MitoQ and SS31 are protective against

206 e the protective effects of the mitochondria-targeted molecules MitoQ and SS31 in striatal neurons th

207 cooperative complex only in the presence of target molecules, moving a methylene blue (MB)-conjugate

208 ERbeta is the target molecule of DPN because DPN treatment fails to de

209 presence in cellulosic materials makes it a target molecule of the pulp and paper industry's bleachi

210 appropriate validation, ultimately identify target molecules of diagnostic, prognostic, or therapeut

211 re-programmed sequential release of multiple target molecules of opposite solubility (hydrophobic and

212 Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptid

213 amed vasculature because they possess intact targeting molecules of integrin beta2.

214 mechanism of adhesion by covalent bonding to target molecules on host cells that mimics that used by

215 n reaction is triggered after the capture of target molecules on the immunodevice surface.

216 AgAb action paralleled the abundance of the targeted molecules on lymphoma cells as well as their HL

217 However, the effects of Abeta-targeting molecules on other cellular processes, includi

218 lin (apoCaM) often appears inert, modulating target molecules only upon conversion to its Ca(2+)-boun

219 desulfurase IscS and transferring it to the target molecule or additional sulfur carrier proteins.

220 functionality that is required in the final target molecule or facilitating subsequent chemical tran

221 ion, is crucial for molecular recognition of target molecules or cells.

222 Rad10 recognizes these structurally distinct target molecules or how it is incorporated into the prot

223 tics requires molecular amplification of the target molecules or molecular signal amplification after

224 An aptamer can specifically bind to its target molecule, or hybridize with its complementary str

225 Potential novel therapies targeting molecules other than VEGF and using new drug-d

226 The quantitative analysis of target molecules over a large concentration range has be

227 The dimensions of the target molecule play a key role in the efficiency of the

228 al tool where obtaining single crystals of a target molecule presents a significant challenge and it

229 n and for the apoptotic effect of the hRpn13-targeting molecule RA190.

230 he excellent efficiency of the MIP sites for target molecule recognition.

231 reated neurons, suggesting that mitochondria-targeted molecules reduce fission activity.

232 set of receptors that have adapted to detect target molecules relating to numerous cellular pathways.

233 iting increased in vitro resistance to SR-BI-targeting molecules remain responsive to anti-SR-BI mAb

234 at dsDNA react differently than ssDNA to the targeted molecules, requiring more energy to move the mo

235 dual binders, by bringing together different target molecules, restricting their conformational flexi

236 gene, capable of orchestrating a variety of target molecules, resulting in the activation of several

237 A proteomic screen for target molecules revealed that CRM1 inhibitors in neuron

238 ylboron compounds are an important family of target molecules, serving as useful intermediates, as we

239 stem has the merits of wide applicability to target molecules, small sample volume, and a low detecti

240 e same mAb for an almost unlimited number of target molecule specificities, reducing manufacturing co

241 ptasensors capable of specifically sensing a target molecule such as ATP, HIV, ochratoxin, potassium

242 is designed to detect a potpourri of complex target molecules such as cell surface antigens, allergen

243 alcium noise properties on calcium-regulated target molecules such as the ubiquitous IP(3)R.

244 In the presence of target molecules, such as ochratoxin A (OTA), adenosine

245 selectivity to CRP when compared with other target molecules, such as urea or creatinine, while main

246 , thereby greatly expanding the diversity of target molecules that are readily accessible.

247 ect proteins based on affinity separation of target molecules that can potentially be used for probin

248 hway offers further prospects for mining new target molecules that could regulate plant development.

249 namely to alpha-tocopheryl succinate, an SDH-targeting molecule that induced RIP1/PARP1-mediated necr

250 significantly limited the number of amyloid-targeting molecules that have been studied to date.

251 Targeting molecules that promote T-cell survival may the

252 f a NIP shows no binding properties toward a target molecule, the corresponding imprinted polymer (MI

253 , if a NIP shows binding properties toward a target molecule, the corresponding MIP will show a signi

254 Using glucose as the target molecule, the screening of UV excitation due to p

255 By labeling a small fraction (<0.2%) of target molecules, the "tracer" DNA tracks the available

256 Proteins can bind target molecules through either induced fit or conformat

257 mixer to shorten the time of transport of a target molecule to a probe.

258 A origami nanoassembly, wherein binding of a target molecule to any of these probes leads to mechanoc

259 Qki5 is, thus, an interesting target molecule to combat doxorubicin-induced cardiotoxi

260 ders that recognize specific epitopes on the target molecule to exert a desired modulation of biologi

261 signaling in the hippocampus and a possible target molecule to limit brain damage during hemorrhagic

262 ny medical and chemical applications require target molecules to be delivered in a controlled manner

263 e of fluorochrome labelled probes allows the target molecules to be detected by measuring the fluores

264 t complexes, in which we covalently link the target molecules to carrier proteins, and then crystalli

265 heir binding specificity and affinity to the target molecules to interfere with designated molecular

266 nce is limited by the diffusive transport of target molecules to the surface.

267 ing of one (multivalent) or two (monovalent) target molecules to these elements opens the stem, enhan

268 actions between different DNA sequences with targeted molecules to rank the nucleobase sensing perfor

269 GCs or a novel generation of nonsteroidal GR-targeting molecules, to meet the increasing clinical nee

270 The binding of two affinity ligands to the target molecule triggers assembly of the DNA motifs and

271 bserver effects in which the dynamics of the target molecule under study are significantly perturbed,

272 lecular recognition of one enantiomer of the target molecule using a DNA aptamer, and the ability of

273 ar mobility facilitates extensive studies of target molecules using a variety of mass spectrometric m

274 posites can be used to simultaneously purify target molecules using external magnetic field and produ

275 have a high affinity and specificity to the target molecules, using the developed competitive assay

276 gation of an approach toward the challenging target molecules via a key guanylation step employing di

277 showed that the diastereomeric purity of the target molecule was >91 %, the highest obtained to date.

278 tive binding ability of RNA aptamer with its target molecule was determined by change in capacitance

279 Solvent extraction of the target molecule was optimised and followed by subsequent

280 Specific staining and immobilization of the target molecules was achieved via a double hybridization

281 624 pM, corresponding to approximately 10(5) target molecules, was achieved using nine distinct appro

282 ped liposomes for heterogeneous detection of target molecules were designed and synthesized.

283 approaches to the unusual amino acids in the target molecules were developed on the basis of a Negish

284 17 cell differentiation and IL-17 downstream target molecules were greatly down-regulated in CIA mous

285 Therefore, target molecules were indirectly labeled by pre-hybridiz

286 zed, and finally, combinatorial libraries of target molecules were synthesized.

287 ates from association of completely atomized target molecules, whereas in the late plasma, the increa

288 ature of the capture sequence to release the target molecule, which is then electrophoresed to a reco

289 e the magnetization of specific protons on a target molecule, which is then transferred to water prot

290 ical environment, while allowing coupling to target molecules, which can be biological in nature (e.g

291 ion of TGF-beta synthesis by those TNF-alpha-targeting molecules, which are able to trigger mTNF-alph

292 pecificities of envelope proteins to desired target molecules while maintaining fusion activity, it i

293 bling selective chemical imaging of specific target molecules, while simultaneously providing topogra

294 sitates the simultaneous binding of a single target molecule with two affinity ligands each conjugate

295 promise for the detection of a wide range of target molecules with close to a single molecule level o

296 Meanwhile, target molecules with different affinities can be adsorb

297 are 'synthetic antibodies' that can bind to target molecules with high affinity and specificity.

298 emistry reported offers a route to synthetic target molecules with spherical shape, well-defined surf

299 g diffusivity of an unknown concentration of target molecules with that of a reference solution.

300 of nanoparticles delivered to cells by each targeting molecule would lead to higher signal-to-noise