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1 of the 15 patients (80%) were adjusted to a target of 0 pd hyperphoria and 10 degrees incyclotropia
2 d to a low-fat dietary pattern intervention (target of 20% of energy from fat), and 60% were randomly
3 a pre-breakfast self-measured plasma glucose target of 4.0-5.5 mmol/L [72-99 mg/dL]) for 30 weeks.
4 equencing and recombineering to identify the target of a Mycobacterium tuberculosis growth inhibitor,
6 y have clinical significance, as therapeutic targeting of a signaling pathway such as NG2/CSPG4 may h
9 knockdown of ATGL, the best-known molecular target of ABHD5, impeded the proliferation and invasion,
10 e of the entire SAGA complex where the major target of activator binding, the 430 kDa Tra1 protein, i
16 on: the latter a biomarker of senescence and target of anti-senescence therapeutics, or senolytics.
17 bacterial species potentially may qualify as targets of anti-virulence therapy and that ajoene could
22 ic acetylcholine receptor (nAChR) is a major target of autoantibodies in myasthenia gravis (MG), an a
27 tor tyrosine kinase AXL is a transcriptional target of BCL6 in GBM and mediates partially the regulat
28 lly, the mitosis regulator LIN9 was a direct target of BET proteins that mediated the effects of BET
33 d focal adhesion kinase (FAK) as proteolytic targets of calpain in Xenopus laevis spinal cord neurons
34 We next uncovered that HDAC2 is a direct target of cAMP response element-binding protein (CREB) t
35 y reduced expression of Axin2, an endogenous target of canonical Wnt signaling, in the developing pal
42 y complex molecules by small interfering RNA targeting of class II transactivator can reduce the capa
43 ization properties of ClC-4 permit regulated targeting of ClC-4 to various endosomal compartment syst
44 sterols in eukaryotic cells and is the major target of clinical drugs for managing fungal pathogens,
45 ic, glucagon-like peptide-1 (GLP-1), and the target of clinical investigation, gastric inhibitory pol
46 id lysophosphatidic acid (LPA) and is a drug target of considerable interest for numerous pathologies
47 ch reveals that mitochondria are a bona fide target of Coxiella effectors and MceA is a complex-formi
55 d as a model illustrating how interdependent targeting of different silencing pathways can potentiate
58 sed on target 35S::MIMICRY172 (MIM172), 35S::TARGET OF EARLY ACTIVATION TAGGED 1 (TOE1)-miR172-resist
61 found that both alpha- and beta-cells become targets of endogenous TH signaling during the larval-to-
63 ty, which allowed us to classify chromosomal targets of epigenetic regulation into (i) single copy an
67 h outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and
68 ability of LT-scanner to identify the known targets of FDA-approved kinase inhibitors based on templ
69 2 mutations in BBDS, which amplify nucleolar targeting of FGFR2, activate ribosomal DNA (rDNA) transc
70 s genes, including Sox17, shifts the genomic targeting of Fli1 to favour nearby Sox consensus sites a
72 ical autophagy pathway in DCs as a molecular target of Foxp3+ Treg-mediated suppression that leads to
75 eal for the first time a collection of brain targets of Galphat-S-ir neurons, suggesting they might m
76 2 Ser-409 phosphorylation inhibited synaptic targeting of GluK1 because, unlike WT Neto2 and the phos
82 allelic regulatory activity, and CRISPR/Cas9 targeting of human chondrocytes demonstrates that the re
86 more progress, with the hope that principled targeting of identified thalamic circuits can be uniquel
87 utes to multiple types of muscle atrophy via targeting of IGF-1 and PI3K(p85alpha), and that suppress
89 T cells, indicating that these cells can be targets of IL-33, and gammadelta T cell deficiency reduc
90 ace protein expression than typical oncology targets of immunoPET, can serve as an imaging biomarker
92 thelium, but keratinocytes were the earliest targets of infection and made up 60% of infected cells o
94 n social influence has focused mainly on the target of influence (e.g., consumer and voter); thus, th
96 These findings identify a new route for the targeting of inner membrane proteins in bacteria and hig
98 insulin signaling pathways and identify new targets of insulin signaling that could serve as potenti
99 al effects on intra-neuronal microtubules, a target of interest due to their potential role in post-o
101 Mecp2 KO neurons provides potentially novel targets of intervention for improving hippocampal functi
108 hese results strongly suggest that selective targeting of KDM1A using NCL-1 and NCD-38 is a promising
109 ent) than among those who were assigned to a target of less than 140 mm Hg (standard treatment).
112 Primary SJL mouse brain endothelial cells (a target of MAV-1 in vivo) infected ex vivo with MAV-1 had
114 (SPON2) as a prominent downstream signaling target of metastasis-associated in colon cancer 1 (MACC1
125 eptides 7 and 8 (ilp7 and ilp8) are putative targets of miR-277; RNA immunoprecipitation and a lucife
127 studies show that the levels of two putative targets of miR-424 that function in DNA damage repair, C
128 ER+ breast cancer cell lines, to reveal the targets of miR-500a-5p after experimental modulation of
129 We performed in silico analyses to identify targets of MIR122 and chromatin immunoprecipitation quan
130 formed to determine whether IRG1 is a direct target of miR93 revealed that IRG1 is not an miR93 targe
135 gens identified by serological screening are targets of multifunctional cellular immune responses tha
138 marker for this treatment.Significance: Dual targeting of MYC-regulated homologous recombination and
143 particle that mediates the co-translational targeting of newly synthesized proteins to cellular memb
146 ork by Taniguchi et al. (2017) suggests that targets of nuclear HDAC5 mediate the behavioral effects
152 APAF-1 apoptosome and XIAP as intracellular targets of P. gingivalis, contributing to the deteriorat
155 ese results demonstrate that NRF2 is a major target of p53-independent tumor suppression by ARF and a
158 uminate strategies for selective therapeutic targeting of PGC1alpha-dependent LRH-1 signaling pathway
159 ugh the activation of energy signaling, both targets of photomorphogenesis action, but the organ deve
162 icient strategy, accomplishing the selective targeting of point-mutated KRAS in vitro and in vivo.
165 d DBP immunogens, we validate that the prime targets of protective immunity are conformational epitop
169 ocytic recycling requires active mechanistic target of rapamycin (aka mammalian target of rapamycin)
170 ssed 2 serine/threonine kinase and mammalian target of rapamycin (both molecules involved in sensing
171 ition, stress kinase activation, mechanistic target of rapamycin (mTOR) activation, loss of glutamate
175 or pharmacologic inhibition of the mammalian target of rapamycin (mTOR) kinase, promotes glutamate se
176 8a is a novel regulator of the Akt/mammalian target of rapamycin (mTOR) pathway downstream of multipl
177 However, given that the PI3K/Akt/mechanistic target of rapamycin (mTOR) pathway is also known to regu
180 NF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibit
181 c acid priming, with NF-kappaB and mammalian target of rapamycin (mTOR) signaling strongly increased.
183 propionic acid (AMPA) receptor and mammalian target of rapamycin (mTOR) signaling, respectively.
184 ell as manipulations of insulin, mechanistic target of rapamycin (mTOR), AMP-activated protein kinase
185 on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two complexes, m
186 correlated with upregulation of mechanistic target of rapamycin (mTOR), proinflammatory, and anti-ap
189 el chemoresistance mediated by the mammalian target of rapamycin (mTOR)/sphingosine-kinase-1 (SK1) pa
191 ting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling are being inve
192 re we show that Protein Kinase B-mechanistic Target of Rapamycin (PKB/AKT-mTOR) signaling controls th
193 tween the pheromone response pathway and the target of rapamycin (TOR)-regulated ribosomal biogenesis
195 Trex1-deficient cells have reduced mammalian target of rapamycin complex 1 (mTORC1) activity, althoug
203 Pase, which binds to and activates mammalian target of rapamycin complex 1 (mTORC1) when GTP loaded.
205 red by T cell help activates the mechanistic target of rapamycin complex 1 (mTORC1), which promotes t
207 scle myostatin expression, reduced mammalian target of rapamycin complex 1 function, and hyperammonem
208 tarate-dependent inhibition of the mammalian target of rapamycin complex 1, and deficiency of autopha
211 ibe the relationship between the mechanistic target of rapamycin complex 1/2 protein subunit regulato
212 of Pdcd4 increases the activity of mammalian target of rapamycin complex 2 (mTORC2) and thereby upreg
215 phosphatidylinositol 3-kinase and mammalian target of rapamycin inhibitors in breast cancer, and inh
219 ltering both energy production and mammalian target of rapamycin signaling in human liver cancer cell
220 s was required to fully suppress mechanistic target of rapamycin signaling, a known effector of NF1 l
221 ns in the proteins associated with mammalian target of rapamycin signalling were detected in the PFC
222 chanistic target of rapamycin (aka mammalian target of rapamycin) (mTORC1), a master metabolic sensor
223 e measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and devel
224 starvation or by inhibition of the mammalian target of rapamycin, enhanced lysosomal clearance of C99
225 d protein kinase B, phosphorylated mammalian target of rapamycin, phosphorylated eukaryotic translati
226 kinase and increased expression of mammalian target of rapamycin, suggesting reduced amino acid catab
227 novel mechanistic insights into simultaneous targeting of receptor-mediated proliferation and cell de
228 phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (R
229 ainable Development Goal 3, setting a global target of reducing tobacco use and premature mortality f
236 ons why germ plasm might be neither a direct target of selection nor causally linked to accelerated a
237 mmunization activities (SIAs) continued, the targeting of settlements at high risk for polio transmis
239 However, the extent to which a chloroplast target of SIG5 is regulated by light-induced changes in
244 in vitro and in vivo Notably, pharmacologic targeting of SPHK1 or YAP/TAZ was sufficient to inhibit
246 regions which apparently constitute the main target of stabilizing extra-retinal oculomotor influence
249 prehensively analyse the HDM-derived protein targets of T cell responses in HDM-allergic individuals,
254 atography experiments identified the primary target of the compounds as the T3SS needle pore protein
255 Finally, we show that Satb1 is a downstream target of the Fgf signalling pathway, linking chromatin
257 Here we demonstrate that DCs are a principal target of the immune modulating activity of triterpenoid
258 tory neurons in the barrel cortex, the major target of the somatosensory thalamus (VPM), respond to t
260 ing sensor (ALPS) motif within HOPS Vps41, a target of the vacuolar kinase Yck3, is dispensable for t
262 ape response neuronal circuit, by increasing targeting of the gap junctional protein innexin shaking-
263 hen the evidence base supporting therapeutic targeting of the gut microbiota for brain-gut axis disor
265 uppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX.
266 e, we report that genetic or pharmacological targeting of the oncogenic MUC1 subunit MUC1-C is suffic
267 pproximately 6,000 yeast mutants for loss of targeting of the subpopulation marker Pdr16 and identifi
268 s; accordingly, we hypothesize that specific targeting of the tumor microenvironment may constitute a
274 d photoaffinity probes to reveal the protein targets of the peptide in live bacteria via chemical pro
277 arameters, as well as molecular and efferent targets, of the LH GLP-1R activation were also evaluated
278 on of their scaffolding abilities and direct targeting of their interaction interfaces to modulate GP
279 s control of B cell homeostasis, and it is a target of therapeutic intervention in autoimmune disease
281 structural insights into the HIV trimer, the target of these quaternary antibodies, has created inval
286 ABPs that competitively bind to inflammatory targets of TTP in both endometriotic and endometrial epi
288 cipated role of Cln1 in regulating lysosomal targeting of V0a1 and suggest that varying factors adver
289 aring imprinted silica nanoparticles against targets of varying molecular mass (melamine, vancomycin
290 , was identified and validated for selective targeting of VHL-deficient CC-RCC in multiple genetic ba
292 leads to a significant decrease in membrane targeting of viral components, resulting in the severe l
293 viral latency through cellular SCF E3 ligase targeting of viral replication proteins is a unique form
294 ammalian antiviral immunity including direct targeting of viruses and their individual components, an
296 ibrissal motor cortex, vM1 (a frontal cortex target of vS1), while rats compared the intensity of two
297 )=0.358, permutation-based p=0.039, the gene targets of which were enriched for intracellular signali
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