ライフサイエンスコーパス: target protein

1 0) before stochastic en bloc transfer to the target protein.

2 nhancing yield or functional activity of the target protein.

3 and selective biosensor response towards the target protein.

4 cal signals within the microenvironment of a target protein.

5 ulating the conformational dynamics of their target protein.

6 omatin separately immunoprecipitated for the target protein.

7 ways that regulate the fate of an individual target protein.

8 alternative contact with the surface of the target protein.

9 srupt the activity of only one domain in the target protein.

10 ds to generate a pool of conformations for a target protein.

11 itination and proteasomal degradation of the target protein.

12 are capable of covalent attachment with the target protein.

13 ell are the prerequisite for its function on target protein.

14 he tyrosine-protein kinase Yes as an example target protein.

15 eractions of hits using the structure of the target protein.

16 ty and the contact prediction scores for the target protein.

17 ular signaling pathways and sulfhydration of target proteins.

18 nd (iii) the characterization of the evolved target proteins.

19 SUMOs to -amino groups of lysine residues in target proteins.

20 d function as second messengers that oxidize target proteins.

21 mmune signaling, often via ubiquitination of target proteins.

22 riches for interactions mediated by specific target proteins.

23 ate in the ligation of biotin to its cognate target proteins.

24 ation and thereby the fate of many different target proteins.

25 ing lead compounds in complex with difficult target proteins.

26 slation and set thresholds for expression of target proteins.

27 ective binding between GO-NTA sheets and non-target proteins.

28 ed generation of high-quality decoys for any target proteins.

29 lding, maturation, and activation of diverse target proteins.

30 quences containing the SUMO-acceptor site of target proteins.

31 peted by natural or synthetic ligands of the target proteins.

32 xpress GPC3 might also express different off-target proteins.

33 larly and extracellularly, and conjugated to target proteins.

34 inity and selectivity between ligands to the target proteins.

35 s in cellular function by regulating various target proteins.

36 ct binding interfaces for different cellular target proteins.

37 s binding of calcium (Ca(2+)) and endogenous target proteins.

38 ensus sequence, and cellular localization of target proteins.

39 ties in the production of stable, unliganded target proteins.

40 and noteworthy selectivity against other non-target proteins.

41 s) sequentially add monosaccharides onto the target proteins.

42 RsgA, RbgA, Era, HflX, and ObgE--as (p)ppGpp target proteins.

43 and deconjugation of SUMO molecules to/from target proteins.

44 d in quantitative FA imaging and analysis of target proteins.

45 xidising specific amino acid residues of key target proteins.

46 miRNA levels and the upregulation of miR-223 target proteins.

47 ions, affected by the binding of calcium and target proteins.

48 e removal of Nedd8 protein modification from target proteins.

49 rmations required for interaction with their target proteins.

50 E3 ligase activity to induce degradation of target proteins.

51 ING/HECT hybrid mechanism to conjugate Ub to target proteins.

52 aptic actions through a series of downstream target proteins.

53 eron-stimulated gene product 15 (ISG15) from target proteins.

54 ymes, and the effect of this modification on target proteins.

55 interactions between the Vpu TMD and several target proteins.

56 ted to regulate the activity of the modified target proteins.

57 controlling expression of miR-471-5p and its target proteins.

58 hat induce selective degradation of specific target proteins.

59 he stability or functionality of its cognate target proteins.

60 tal biological events through conjugation to target proteins.

61 localization, activity, and lifespan of its target proteins.

62 EMERA (HMR) is a nuclear and plastidial dual-targeted protein.

63 protein 3 (NS3), NS2A, and NS5 were the most targeted proteins.

64 y disrupts PKCalpha interaction with the PKC-targeting protein A-kinase anchoring protein (AKAP) 79 a

65 s in sliding windows along the sequence of a target protein, accounting for non-discriminative domain

66 successfully imaging sumoylation of several target proteins, achieving significant FLuc complementat

67 in their lifespan and through alterations of target protein activity, localization, protein-protein i

68 LC8-binding modulates target protein activity, often through induced dimerizat

69 xpression levels of various miRNAs and their target proteins along the crypt-villi axis in the jejunu

70 was demonstrated by measuring three diverse target proteins: an alpha-helical protein (calmodulin),

71 can take into account the flexibility of the target protein and can be started from a seed to mimic R

72 nd directly on sequence homology between the target protein and entries in the fold library to genera

73 pe FADA biosensor for in situ detection of a target protein and protein-protein interactions was deve

74 using this method, MS identification of the target protein and several dozen interacting proteins is

75 ft assay quantified interactions between the target protein and the inhibitor, and a novel DNase prot

76 eins to compete with those of the host for a target protein and thereby alter the host signaling.

77 BacTAG', (i) for the fluorescent labeling of target proteins and biologics using click chemistries, (

78 CaM and CML regulate a wide range of target proteins and cellular responses.

79 otin-linked derivatives revealed a number of target proteins and complexes, which exhibit an armadill

80 otic signaling pathways by dephosphorylating target proteins and contains a catalytic (C) subunit, a

81 ansferase (OGT) catalyzes O-GlcNAcylation of target proteins and regulates numerous biological proces

82 an impose a novel localization on GFP-tagged target proteins and results in their controlled mislocal

83 lter the physical and chemical properties of target proteins and that controls many important cellula

84 de an extensive map of sites associated with target proteins and with human disease and correlate the

85 s the interplay among transcription factors, targeted proteins and strain-generated signaling molecul

86 s with very low affinity to the C termini of target proteins, and a necessary simultaneous lateral in

87 n to inhibit biological functions of cognate target proteins, and they are identifiable by an in vitr

88 istance to therapy, via loss of cell surface target proteins (antigenic modulation), as well as a pro

89 A molecules are labeled by hybridization and target proteins are concurrently stained using immunoflu

90 ggesting that the degradation rates of miRNA target proteins are the dominant rate-limiting factors f

91 erved G-protein elements become ordered upon target protein association, creating the molecular pathw

92 mune disease mediated by autoantibodies that target proteins at the neuromuscular junction, primarily

93 er' (SUMO) is post-translationally linked to target proteins at the varepsilon-amino group of lysine

94 multaneous binding of multiple aptamers to a target protein based on fluorescence signals and sort in

95 the noncovalent interactions between Trx and target proteins before S-S reduction using isothermal ti

96 We found that PB-Gly-Taxol bound the target protein beta-tubulin with both high affinity in v

97 When target proteins bind the small molecule, they are direct

98 OTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder con

99 ce or a fragment thereof was conjugated to a target protein-binding domain that was capable of bindin

100 or example, heme chaperones insert heme into target proteins but have been studied only for the forma

101 fidelity signal transducer for more than 300 target proteins, but diversity among its four Ca(2+)-bin

102 actors that are constructed and delivered to target proteins by elaborate biosynthetic machinery.

103 achinery to modulate the activity of various target proteins by posttranslational modification, typic

104 st, facilitating selective ubiquitylation of target proteins by the E3 ubiquitin ligase, Rsp5.

105 receptor that can be tuned toward different target proteins by various cereblon-binding agents.

106 While a target protein can be modified with monoubiquitin, it ca

107 g that a few amino acid changes in the viral target protein can mediate escape from MxA restriction i

108 fic chemogenomics database, including drugs, target proteins, chemicals, and associated pathways.

109 of PROTACs to form the ternary ligase-PROTAC-target protein complex and a MSD assay to measure cellul

110 address how these powerful enzymes recognize target protein complexes.

111 uitable as sustained release formulation for targeted protein constructs such as pPB-HSA.

112 water may be locally removed from around the target protein crucially influences LO decisions.

113 ential primary metabolism processes, such as targeted protein degradation and peptidoglycan synthesis

114 offers one of the most promising avenues for targeted protein degradation in cancer therapy, but cere

115 Targeted protein degradation is a powerful tool in deter

116 The N-end rule pathway of targeted protein degradation is an important regulator o

117 Targeted protein degradation through ubiquitination is a

118 Targeted protein degradation, using bifunctional small m

119 relevance to other drug discovery efforts in targeted protein degradation.

120 al genetic strategy was developed to achieve targeted protein degradation.

121 to irreversibly inhibit protein function by targeting protein destruction through recruitment to the

122 ction and evolutionary history, we find that targeted protein diversification is a pronounced trait o

123 also forms multiple disulfides with unknown target proteins during H2O2 treatment, the formation of

124 d high rates (88-100%) of mutagenesis in the target protein-encoding sites of MSTN.

125 It additionally allowed in silico-designed targeted protein engineering that unlocked the path to a

126 of detection (LOD) of 2.0 attomoles for the target protein (equivalent to 2.0 pg/mL of protein prese

127 In addition, AcK incorporation into two target proteins (Escherichia coli malate dehydrogenase a

128 sing an enzymatic Tenase assay, the level of target protein expression by Western blot analysis, plat

129 targeting Beclin1 significantly depleted the target protein expression levels in brain tissues with n

130 uses residue coevolution information in the target protein family, but also that in the related fami

131 se results, we suggest MOSPD2 as a potential target protein for treating diseases in which monocyte a

132 roteases that catalytically alter or destroy target proteins for biotechnological and therapeutic app

133 some, and that all 11 identified domains can target proteins for degradation.

134 ers with three or more cysteines defines the target proteins for oxidation by ROS.

135 neighborhood networks to guide selection of target proteins for pathway enzymes, we applied both in

136 re, we report on the identification of seven target proteins for the stringent response nucleotides i

137 hnology employs small molecules that recruit target proteins for ubiquitination and removal by the pr

138 yme termed ubiquitin ligase E3A (E6-AP) that targets proteins for degradation by the 26S proteasome.

139 C/C), is a ubiquitin ligase that selectively targets proteins for degradation in mitosis and the G1 p

140 at cleaving K48-linked polyUb, a signal that targets proteins for degradation.

141 Ligand binding usually moves the target protein from an ensemble of inactive states to a

142 Generating tertiary structural models for a target protein from the known structure of its homologou

143 tion (IP) is a common method for isolating a targeted protein from a complex sample such as blood, se

144 pelagophytes and dictyochophytes, in plastid-targeted proteins from another major algal lineage, the

145 of function in a biological context in which target protein function is essential.

146 format to quantify drug engagement with the target proteins fused to Nanoluc luciferase.

147 maize (Zea mays) induced aggregation of the target proteins, giving rise to plants displaying consti

148 keto-acid and amino acids in helix-4 of the target proteins, GyrA (gyrase) and ParC (topoisomerase I

149 The addition of ubiquitin to a target protein has long been implicated in the process o

150 ll Ubiquitin-like Modifier) conjugation onto target proteins has emerged as a very influential class

151 ly incorporates ncAAs into specific sites of target proteins, has been applied in many organisms.

152 hairless mice induced expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protect

153 ated through shRNA-mediated knockdown of the target protein, HNF1beta, in five high- and low-HNF1beta

154 on through down-regulated phosphorylation of target proteins (HSP27 and CREB) associated with intimal

155 e ligands of interest to assess possible off-target proteins, human variants and pathway information

156 quantitative proteomics approach to identify target proteins impacted by DDX3 inhibition.

157 dite the synthetic process and to obtain the target protein in high yield.

158 ting a candidate drug's interaction with its target protein in live cells is of pivotal relevance to

159 fingerprints of HMO anions released from the target protein in the gas phase.

160 llular signals by binding to a wide range of target proteins in a Ca(2+)-dependent manner.

161 uccessfully predicts the overall fold of the target proteins in about 50% of the test cases and perfo

162 chaperones conformationally remodel specific target proteins in an ATP-dependent manner is not well u

163 onstrate efficient and specific labelling of target proteins in confined intercellular and organotypi

164 incorporation of unnatural amino acids into target proteins in diverse mammalian cells, and we revea

165 the distribution of specific PRMTs and their target proteins in flagella and demonstrate that PRMTs a

166 d mitochondria and the lack of processing of target proteins in icp55 were complemented by transforma

167 FET based biosensors, allowing detection of target proteins in physiological solutions without sampl

168 Here, we identified core FtsH target proteins in S. aureus.

169 ranslational modification (PTM) profiling of targeted protein in biofluid.

170 tion profile, with both endoperoxide classes targeting proteins in the glycolytic, hemoglobin degrada

171 as demonstrated potential to precisely trace target proteins, in live mammalian cells, by super-resol

172 For several target proteins, including the NTB-A and PVR receptors a

173 erative screening contest method to identify target protein inhibitors.

174 er and, for proteins, the integration of the target protein into a polyprotein.

175 Pathogens target proteins involved in autophagy to inhibit immune

176 eloma (MM), by controlling the expression of target proteins involved in cell cycle, differentiation

177 eed, recent studies in mice demonstrate that targeting proteins involved in apoptosis protects oocyte

178 ion of both CIA2 isoforms with a single Fe/S target protein is unprecedented in the CIA pathway.

179 ubiquitin (Ub) or Ub-like (UBL) proteins to target proteins is achieved by parallel but distinct cas

180 ctivity determines the eventual abundance of target proteins is complex and poorly understood.

181 Which of these target proteins is functionally compromised in PPS is un

182 of the small protein modifier ubiquitin to a target protein, is an important and frequently studied p

183 n epitope-specific antibody binding with the target protein Keap1, by grafting pre-defined structural

184 re 43 different isoforms, facilitate this by targeting protein kinase A to specific substrates.

185 Sotrastaurin, a small molecule targeting protein kinase C isoforms, failed to provide a

186 slightly reduce the mean expression of most targeted proteins, leading to speculation about their ro

187 racterization of LINC00152 in regulating its target proteins may provide a novel therapeutic target o

188 These plastid-targeted proteins may originate from the endosymbiont, t

189 assessed the reproducibility of multiplexed targeted protein measurements in DBS compared to serum.

190 gh ubiquitination and degradation of the CIA-targeting protein MMS19.

191 This biosensor successfully detected the target protein (model analyzed here is IgG) with a limit

192 ly in cells, but ensuing time-dependent, off-target protein modification can erode selectivity and di

193 o significantly reduce the activity of their target protein, mouse decapping exoribonuclease (DXO).

194 in the phosphorylation of CaMKII downstream target proteins (n>/=11).

195 ering the expression of its subunits or Nrf2 target proteins (NQO1 and HO-1), suggesting a post-trans

196 Depending on the target protein of interest, nanodisc assembly and purifi

197 Analysing the target protein of the competition, YPL067C, uncovered a

198 of myofibroblasts by showing that it is the target protein of the myofibroblast-reacting mAb PR2D3.

199 Here, we show that Notch3 is a novel target protein of the prolyl-isomerase Pin1, which is ab

200 with mutations in the binding regions of the target proteins of both drugs during treatment of an imm

201 f Ca(2+) sensors and identification of novel target proteins of CMLs deserve special attention.

202 ng biochemical screens employing an isolated target protein or by utilizing cell-based phenotypic ass

203 isotope-labeled analogous standards for each target protein or peptide under study, which in turn mus

204 itin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their activity, st

205 equires thorough binding-site mapping of the target protein particular in regions remote from the cat

206 t can artificially display a wide variety of targeting protein/peptide ligands and directly encapsula

207 signaling pathways and disease pathologies, targeting protein phosphatases remains an underexplored

208 n E3 ubiquitin ligase that modifies specific target proteins, priming their degradation via the ubiqu

209 Through this one-pot assay, a comprehensive target protein profile comprised of protein expression a

210 red the role of the onco-miR, miR-21 and its target protein, programmed cell death 4 (PDCD4) in arsen

211 assay to measure cellular degradation of the target protein promoted by PROTACs.

212 By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and prote

213 For three target proteins, protein fold change and absolute copy p

214 iven a pre-existing crystal structure of the target protein-protein interaction, hotspots grafting wi

215 Targeting protein-protein interaction (PPI) is rapidly b

216 e of strategies to regulate TLR signaling by targeting protein-protein interactions, or ubiquitin cha

217 Mono- and poly-SUMOylations of target proteins provide docking sites for distinct adapt

218 ns between components of the library and the target protein (PT) are identified from changes in the r

219 the labeled protein is released, simplifying target protein purification and labeling to a single ste

220 upon high-resolution tandem mass spectra for targeted protein quantification, incorporation of multip

221 osure of hydrophobic regions responsible for target protein recognition.

222 nels represent a large and growing family of target proteins regulated by gasotransmitters such as ni

223 iquitination in stress adaptation, involving targeted protein removal through the ubiquitin-proteasom

224 ctionality, including a wide range of T-cell target proteins, response sizes, and participant ages.

225 ands that passed the test were docked to the target protein resulting in a few ligands with high scor

226 een peptides were observed regardless of the target protein's subcellular localization.

227 encoded, nonreducible covalent staples in a target protein scaffold using computational design.

228 t was capable of binding to a portion of the target-protein sequence.

229 ADPr that is attached to serine residues in target proteins (Ser-ADPr) and showed that this PTM is s

230 quired for DUB activity and interaction with targeting proteins SHMT2 and RAP80.

231 ecific constructs were all able to bind both target proteins simultaneously.

232 hroughput screening studies of intracellular target-protein/small-molecule binding.

233 -derived exosomes downregulated the miR-133a targets proteins Smarcd1 and Runx2, confirming that thes

234 However, it was significantly related to target protein specificity.

235 unctionally-inactivated point mutants of two target proteins (staphylococcal nuclease and ribose bind

236 r of amino acid sequences that can fold to a target protein structure, known as the "sequence capacit

237 sociates with the translocation machinery to target protein substrates to the membrane is unclear.

238 e most cellular functions by phosphorylating targeted protein substrates through a highly conserved c

239 stically, Atox1(-/-) mice show reduced Atox1 target proteins such as p47phox NADPH oxidase and cyclin

240 y with known MTG substrates or commonly used target proteins, such as antibodies.

241 charged molecule substrates or ligands with target proteins, such as channels, transporters, enzymes

242 electively to a specific conformation of the targeted protein, such that binding leads to a fluoresce

243 tein that binds a triggering molecule, and a target protein that undergoes a domain swap in response

244 dition, we can overcome these challenges for target proteins that are, or can be, methionine-depleted

245 To identify target proteins that control both virulence and antibiot

246 We found 376 target proteins that significantly changed in the blood

247 re, we identify and characterise 770 plastid-targeted proteins that are conserved across the ochrophy

248 te synthase (hTS) is an important anticancer target protein, the efficacy of the few anti-hTS drugs c

249 From a suitable cysteine mutant of the target protein, the entire procedure for this chemical p

250 g binding affinity of DNA aptamers for their target proteins, the DNA/AgNCs probe was successfully ap

251 The design of cell-targeted protein therapeutics can be informed by natural

252 in turn before re-engaging further along the target protein, thereby unfolding it.

253 no-ubiquitin or poly-ubiquitin chains from a target protein through different mechanisms and mode of

254 s covalently attached to a lysine residue in target proteins, thus resembling ubiquitination in eukar

255 nal molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subseque

256 s studies that link structural dynamics of a target protein to its cellular behavior.

257 ation efficiency to over 95 % by linking the target protein to SrtA using the SpyTag-SpyCatcher pepti

258 the use of ITP to preconcentrate and deliver target proteins to a surface decorated with specific ant

259 e, posttranslational modification that helps target proteins to cellular membranes.

260 or other posttranslational modifications of target proteins to control their function.

261 Ub has been proposed to target proteins to IBs for degradation via autophagy, bu

262 s is that DJ-1 Cys-106 forms disulfides with target proteins to limit oxidant-induced cell death.

263 plasma membrane in neurons, scaffolds PKA to target proteins to mediate downstream signal.

264 pecific promoter, SUC2 and with signals that target proteins to peroxisomes, actin, and the nucleus.

265 ntaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival.

266 hat mediate binding to acetylated lysines on target proteins to regulate gene expression.

267 , which further reduces disulfide bridges in target proteins to regulate their structure and function

268 nd then used this interaction to translocate target proteins to specific cellular compartments, such

269 his paper was whether the efficiency of drug target proteins to spread perturbations in the human int

270 Ubiquitin and some of its homologues target proteins to the proteasome for degradation.

271 ses, one major function of this system is to target proteins to the proteasome for degradation.

272 the C2 domain of PLCZ1, a domain involved in targeting proteins to cell membranes.

273 and to examine the role of Ub conjugation in targeting proteins to IBs that are composed of an N-term

274 myloid-converting motif (ACM), is capable of targeting proteins to the A-bodies by interacting with r

275 cific and so should be very useful tools for targeting proteins to the seed coat epidermis.

276 teome-wide detection of SUMOylation sites on target proteins typically requires ectopic expression of

277 hat new approaches, like decreasing the DNMT targeting protein, UHRF1, can augment the DNA demethylat

278 d T-cell expansions have focused on dominant target proteins UL83 or UL123, and the T-cell activation

279 he ISG15 protein is covalently conjugated to target proteins upon activation of the interferon respon

280 be an approach of progressive unfolding of a target protein using a gradient of denaturant urea to re

281 bodies, it can be applied to a wide range of target proteins using off-the-shelf reagents.

282 We set out to uncover additional targeting proteins using unbiased high-content screening

283 boxytetrazole (ACT), that interacts with the target protein via a unique mechanism in which the photo

284 ike protein Pup to lysine side chains of the target protein via an isopeptide bond.

285 The detection of the target protein was achieved in two ways: (1) optomagneti

286 Production of many of the target proteins was significantly upregulated when co-ex

287 defined wells for absolute quantification of targeted proteins, was developed and combined with isoto

288 sses, pathways and related diseases of these target proteins were analyzed by STRING database.

289 xisome proliferator-activated receptor alpha target proteins were suppressed by hypoxia, but activate

290 es form a point cloud for each position of a target protein, which are represented by a three-dimensi

291 e capability to other ET methods in tracking target proteins while maintaining optimized beam coheren

292 By expressing the target protein with SpyTag C-terminal to the SrtA recogn

293 s that change conformation upon binding to a target protein with the results read out by gel electrop

294 tiplexed replica exchange simulations of the target proteins with a recently improved UNRES force fie

295 es the covalent attachment of DNA handles to target proteins with a selection step for functional and

296 mide adenine dinucleotide (NAD(+)) to modify target proteins with ADP-ribose.

297 all the unique molecular interactions to the target proteins with available three-dimensional structu

298 t can image, localize, and mechanically load targeted proteins with high spatiotemporal resolution.

299 bilizing clinically favored conformations of target proteins, with orally available, bona fide small

300 ks and unaffected by the presence of soluble target proteins, yet readily competed by natural or synt