1 es represent what we believe to be the first
targeted disruption of a gene in C. parapsilosis and sho
2 Targeted disruption of a highly conserved distal enhance
3 loit nourseothricin resistance to detect the
targeted disruption of a hygromycin B resistance conferr
4 nfirmed by analysis of a mutant generated by
targeted disruption of a PKS gene, and by functional exp
5 We demonstrated that the
targeted disruption of ABCA1 increases amyloid depositio
6 LG-2) and the Sec31A proline-rich region: 1)
targeted disruption of ALG-2/Sec31A interactions caused
7 Here we demonstrate that
targeted disruption of Ant2 in mouse liver enhances unco
8 and IFN regulatory factor 1 since mice with
targeted disruption of any of the four genes failed to a
9 ed by antiandrogens, AR RNA interference, or
targeted disruption of AR.
10 stradiol-deficient or estradiol-resistant by
targeted disruption of aromatase (ArKO) or ERalpha (alph
11 Targeted disruption of ATF3 decreased the effects of eth
12 Targeted disruption of Axin2 in mice induces malformatio
13 Targeted disruption of Axin2 in mice induces skeletal de
14 BL/6 mouse CD8(+) T cells, we used mice with
targeted disruption of beta1i, beta2i, or beta5i/beta2i
15 Additionally,
targeted disruption of betacat blocked fgf18 expression
16 Boc is expressed by commissural neurons, and
targeted disruption of Boc in mouse results in the misgu
17 Mice bearing
targeted disruption of both alleles encoding AQP9 have e
18 atures with humans, we generated pigs with a
targeted disruption of both CFTR alleles.
19 Targeted disruption of both CRTC2 and CRTC3 in stromal c
20 Using cells with
targeted disruption of both the Akt1 and Akt2 genes, we
21 We have previously demonstrated that
targeted disruption of both the Gpx1 and Gpx2 genes (GPX
22 ed in mouse embryonic fibroblasts (MEF) with
targeted disruption of both the Mkk3 and Mkk6 genes, est
23 Using cells with
targeted disruption of both the Mkk3 and Mkk6 genes, we
24 Mice with a
targeted disruption of Brn3b (knockout Brn3b(-/-)) under
25 ype H-2b C57BL/6 (B6) mice or B6 mice with a
targeted disruption of c-Rel gene (c-Rel-/-) were used a
26 Targeted disruption of CatSperz reduces CatSper current
27 Here we show that
targeted disruption of Ccm2 in mice results in failed lu
28 s were also markedly impaired in mice with a
targeted disruption of CCR2.
29 Targeted disruption of CD39 impaired hepatocellular rege
30 Targeted disruption of Cdk2ap1 in mESCs resulted in abro
31 ion of cardiomyocyte electrophysiology after
targeted disruption of coupled myofibroblasts and by ces
32 Furthermore,
targeted disruption of Cripto expression by use of small
33 IV infection is associated with specific and
targeted disruption of critical macrophage TLR4 signalin
34 Here we show that
targeted disruption of Cstf2t in mice causes aberrant sp
35 Mice with
targeted disruption of Cyp4a14, a murine homologue of CY
36 Targeted disruption of D-Rap1 expression decreased both
37 Targeted disruption of decorin alone completely abolishe
38 In this report, we sought to determine if
targeted disruption of deregulated cap-dependent transla
39 Using cells with
targeted disruption of different STAT proteins and/or th
40 Here, we report expression analysis and
targeted disruption of Dmrt4 (also called DmrtA1) in the
41 Targeted disruption of Dot1l using a conditional knockou
42 Strikingly, the
targeted disruption of Dyn2 induced a dramatic four- to
43 aspase-deficient mutants were constructed by
targeted disruption of each of the two metacaspase genes
44 ter crescentus using a bioinformatic screen,
targeted disruptions of each histidine kinase and respon
45 Indeed, we find that mice with
targeted disruptions of each of four of these genes (Brs
46 Targeted disruption of either mdm2 or mdm4 genes in mice
47 Surprisingly,
targeted disruption of either Stat5a or Stat5b alone als
48 tioned place preference, we used mice having
targeted disruptions of either the AC1 or AC8 genes or b
49 lying this trafficking, we studied mice with
targeted disruptions of either the gene that encodes the
50 tivator-like effector nucleases (TALENs) for
targeted disruption of endogenous genes and cis-acting r
51 n developed to engineer some strains via the
targeted disruption of endogenous genes and/or transgene
52 of this hypothesis, here we have shown that
targeted disruption of EphA2 in a murine model of aggres
53 CYP2J2 and CYP2C8 epoxygenases and mice with
targeted disruption of Ephx2.
54 Mice with
targeted disruption of ERM have a loss of maintenance of
55 isms, we generated Mtdh knock-out mice via a
targeted disruption of exon 3.
56 escribe that CD4(+) T cells from mice with a
targeted disruption of exons 2 and 3 of Ly108 (Ly108(Del
57 Targeted disruption of F10 and other common pathway fact
58 trations in pregnant mice can be affected by
targeted disruption of fetal H19(Delta13).
59 Here, we show that
targeted disruption of Foxe3 results in abnormal develop
60 Targeted disruption of Foxn4 largely eliminates amacrine
61 Targeted disruption of FoxO3 also resulted in downregula
62 Targeted disruption of Gal-1-N-glycan interactions elimi
63 T cells with a
targeted disruption of GCN2 were not susceptible to IDO-
64 Targeted disruption of Gimicroa results in mislocalizati
65 Osteoblast-
targeted disruption of glucocorticoid signaling signific
66 We examine the impact of
targeted disruption of growth hormone-releasing hormone
67 Here, we show that
targeted disruption of H3f3b results in a number of phen
68 Recently, it has been shown that
targeted disruption of Hap1 in mice results in early pos
69 both wild-type and mutant p53, we found that
targeted disruption of HDAC8 expression remarkably trigg
70 on phenotype in mouse embryos homozygous for
targeted disruption of Hey2 revealed an expanded AVC dom
71 d tfr-2, we have studied mice homozygous for
targeted disruption of HFE, beta(2)-microglobulin, and f
72 Targeted disruption of HIF-2alpha in the intestine inhib
73 c-euglycemic clamp studies demonstrated that
targeted disruption of HIF1alpha in adipocytes enhanced
74 Targeted disruption of IGF-IR signaling combined with cy
75 in mice lacking IL-12, but not in mice with
targeted disruption of IL-23 or both IL-12 and IL-23.
76 rin activity of VP2 and VP3 was inhibited by
targeted disruptions of individual hydrophobic domains a
77 null mutant (NBC1-/-) mice were prepared by
targeted disruption of its gene (Slc4a4).
78 Thus,
targeted disruption of kcne2 has revealed a novel cardia
79 Targeted disruption of Kcne2 in mice impaired thyroid io
80 The
targeted disruption of Lck gene in mice results in sever
81 ary fibrosis, respectively, in a strain with
targeted disruption of leukotriene C(4) synthase to prev
82 Others have demonstrated that the
targeted disruption of LFA-1:ICAM interactions, either b
83 Targeted disruption of Lmo4 resulted in the dysmorphogen
84 Here we report
targeted disruption of lpa(4) in mice.
85 Targeted disruption of LTC(4) synthase, the pivotal enzy
86 e proapoptotic effects of a protocol causing
targeted disruption of lysosomes.
87 nterpart, mArt, and generated a mouse with a
targeted disruption of mArt.
88 Targeted disruption of matrix adhesion promotes uniform
89 y hyaluronidase and cytochalasin D displayed
targeted disruption of matrix and cytoskeletal networks,
90 e the usefulness of this protocol, we report
targeted disruptions of members of the cadherin gene fam
91 Targeted disruption of mitochondria-hexokinase (HK) inte
92 ng a proteomic approach, we demonstrate that
targeted disruption of mitochondrial Hsp90 chaperone fun
93 ition of Mnk or experiments using cells with
targeted disruption of Mnk1 and Mnk2 genes.
94 Targeted disruption of mouse Kcnq1 models JLNS in that m
95 ogic role of mPGES1 in the kidney, mice with
targeted disruption of mPges1 gene were studied, with a
96 Surprisingly, embryos with a
targeted disruption of Mtb died prior to the initiation
97 Here we show that
targeted disruption of murine CatSper3 or CatSper4 also
98 he in vivo relevance of OATP1B transporters,
targeted disruption of murine Slco1b2 gene was carried o
99 hese findings were confirmed using MEFs with
targeted disruption of NF-kappaB signaling, in which Rel
100 Mice with
targeted disruption of NF90 were engineered.
101 Here we report that
targeted disruption of NFPC function in RGC axons or the
102 eta production in neuroblastoma culture, and
targeted disruption of NgR expression increases transgen
103 Here we report that the
targeted disruption of Nocturnin (Ccrn4l) in mice, a gen
104 Here, we report that
targeted disruption of Nrf2 causes regenerative immune-m
105 Recently
targeted disruption of Omi/HtrA2 has been found to cause
106 ebral vascular growth, we examined mice with
targeted disruption of one (heterozygous) or both (homoz
107 Targeted disruption of p300-mediated histone acetylation
108 Exploring the
targeted disruption of PGE2 synthesis and signaling to o
109 Moreover,
targeted disruption of PI3K blunted the suppression of f
110 Here we show that
targeted disruption of PIP5KIgamma causes widespread dev
111 tive in embryonic fibroblasts from mice with
targeted disruption of PKC-delta (Pkc-delta(-)(/)(-)), p
112 Targeted disruption of pre-cardiac cell-matrix adhesion
113 Here we show that mouse embryos with a
targeted disruption of PRMT3 are small in size but survi
114 Methods for the
targeted disruption of protein function have revolutioni
115 Targeted disruption of protein retrotranslocation causes
116 Here we show that
targeted disruption of PTEN leads to neoplastic transfor
117 In this system we find that
targeted disruption of Rb leads to little overt change i
118 In support of this,
targeted disruption of Rhox5 increased male germ cell ap
119 Targeted disruption of RIIbeta-protein kinase A (PKA) in
120 Through the
targeted disruption of RIPK1 kinase activity, which sele
121 Targeted disruption of Roc1b causes male sterility that
122 We have generated a
targeted disruption of Sall3 in mice.
123 Mice with a
targeted disruption of Scd1 gene locus are lean and disp
124 lterations in the SAN following heterozygous-
targeted disruption of Scn5a thus closely resemble those
125 Targeted disruption of Scyl2 in mice caused perinatal le
126 Targeted disruption of selected ETS family members such
127 Consequently, the
targeted disruption of semaphorin 6D receptor-ligand int
128 Targeted disruption of signal transducer and activator o
129 oth human and mouse breast cancer cells, the
targeted disruption of Sin3 function by introduction of
130 SIRT6 deficiency, we generated mice carrying
targeted disruption of SIRT6.
131 Targeted disruption of Smad3 abrogated TGF-beta1-mediate
132 Targeted disruption of SOCS3 revealed embryonic lethalit
133 wever, due to the non-viability of mice with
targeted disruption of Socs3, the importance of Socs3 in
134 Our studies demonstrated that
targeted disruption of Sox4 or Sox11 in retinas caused a
135 We generated a strain of mice carrying a
targeted disruption of Stat3 gene in the liver (L-Stat3(
136 Targeted disruption of Stat3 in bulge region KSCs at the
137 ously shown that therapeutic intervention or
targeted disruption of Stat4 was effective in ameliorati
138 icated in erythroid disorders, and show that
targeted disruption of such elements results in altered
139 T cells with combined
targeted disruption of T-bet and RORgammat have defectiv
140 Targeted disruption of Tcf7l2 in mice led to severe defe
141 sociated with increased TCR avidity, whereas
targeted disruption of TCR avidity enhancement eliminate
142 a the Bmp6/Smad1,5,8 pathway using mice with
targeted disruption of Tfr2, Hfe, or both genes.
143 The
targeted disruption of TgCPC1 does not affect the invasi
144 We report that
targeted disruption of TGF-beta superfamily receptor ALK
145 gnificance of TSP3, we generated mice with a
targeted disruption of Thbs3.
146 ember in apoptosis, mice were generated with
targeted disruption of the 14-3-3tau gene.
147 We therefore characterized mice with
targeted disruption of the ABCA3 gene.
148 ogical roles of ACE2, we generated mice with
targeted disruption of the Ace2 gene.
149 null mutant (AE2(-/-)) mice were prepared by
targeted disruption of the AE2 (Slc4a2) gene.
150 Here, we utilize murine models with
targeted disruption of the akt2 or the akt1 genes to dem
151 Mice with a
targeted disruption of the alpha-switch region and 5' H
152 Here we evaluated, by
targeted disruption of the APN gene, whether APN partici
153 By
targeted disruption of the Atac2 locus in mice, we demon
154 Targeted disruption of the BCL2-PARP1 interaction theref
155 Mice with a
targeted disruption of the c-Cbl gene displayed increase
156 Targeted disruption of the c-myb gene resulted in a crit
157 Here we report that mice homozygous for
targeted disruption of the Cacna2d2 gene exhibit growth
158 ressure overload stimulation were blocked by
targeted disruption of the calcineurin Abeta gene.
159 Targeted disruption of the calcium-activated chloride ch
160 Targeted disruption of the capsid motor interaction may
161 Herein, we demonstrate that the
targeted disruption of the cbp gene in mice has no effec
162 s in the doublecortin (DCX) gene in human or
targeted disruption of the cdk5 gene in mouse lead to si
163 We have shown that
targeted disruption of the Ceacam1a (MHVR) gene resultin
164 We show that
targeted disruption of the cell surface Cripto/GRP78 com
165 or interfere with integrin binding may allow
targeted disruption of the cells lining Schlemm's canal
166 Swollenin was shown to promote
targeted disruption of the cellulosic structure at fiber
167 Similarly, a
targeted disruption of the circadian clock within the he
168 adian rhythms by food and light in mice with
targeted disruption of the clock gene Bmal1, which lack
169 clockworks in mammals, we determined whether
targeted disruption of the clock genes, Per1 and/or Per2
170 Mouse lines with
targeted disruption of the cocaine amphetamine-related t
171 generating CDK11(p110/p58)-null mice through
targeted disruption of the corresponding gene using homo
172 n of a mouse with complete CPN deficiency by
targeted disruption of the CPN1 gene.
173 Mice that have a
targeted disruption of the crest gene are viable but dis
174 The
targeted disruption of the Cul7 gene in mice results in
175 Mice heterozygous for a
targeted disruption of the cystathionine beta-synthase g
176 onic, injury was attenuated in a strain with
targeted disruption of the cysteinyl leukotriene 1 (CysL
177 Mice with
targeted disruption of the Darc gene (Darc(E2) ) or WT m
178 Targeted disruption of the distal enhancer led to a loss
179 In this study, we have investigated how
targeted disruption of the DNA methyltransferases Dnmt3a
180 althy control mice and PARP-1(-/-) mice with
targeted disruption of the DNA repair enzyme, poly(ADP-r
181 e norepinephrine (NE) and epinephrine due to
targeted disruption of the dopamine beta-hydroxylase gen
182 al gene-targeting approach, we show that the
targeted disruption of the entire E2F activator subclass
183 ice deficient in all the isoforms of Ing1 by
targeted disruption of the exon that is common for all i
184 bsorption syndrome that we developed through
targeted disruption of the first 3 coding exons of the m
185 oid hormone receptors (SMRT)(mRID1) in which
targeted disruption of the first receptor interaction do
186 Targeted disruption of the Fli1 gene results in embryoni
187 Targeted disruption of the Friend leukemia integration 1
188 ere engineered to lack the alpha4 subunit by
targeted disruption of the Gabra4 gene.
189 ck-out mouse (Gal-3KO), we demonstrated that
targeted disruption of the galectin-3 gene significantly
190 Its identity was established by
targeted disruption of the gene cluster as well as by he
191 We used mice with
targeted disruption of the gene encoding alpha-syntrophi
192 We used mice with
targeted disruption of the gene encoding alpha-syntrophi
193 Targeted disruption of the gene encoding D4Rs reduces th
194 1/2) dephosphorylation plays in vivo through
targeted disruption of the gene encoding dual-specificit
195 However, mice with
targeted disruption of the gene encoding IL-6 (IL-6-/-)
196 Targeted disruption of the gene encoding KDM1B had no ef
197 the Bernard-Soulier syndrome generated by a
targeted disruption of the gene encoding the glycoprotei
198 Targeted disruption of the gene in D. discoideum resulte
199 t genetic inactivation of hCDC4, by means of
targeted disruption of the gene in karyotypically stable
200 Targeted disruption of the gene that encodes ghrelin res
201 we used embryonic fibroblasts from mice with
targeted disruption of the genes encoding for both the p
202 Targeted disruption of the genes encoding mitochondrial
203 Mice with adipocyte-specific
targeted disruption of the genes encoding the HIF1 oblig
204 and survival rate were studied in mice with
targeted disruption of the genes for PTGS and PGE recept
205 tations this elicits, we generated mice with
targeted disruption of the GLUT4 glucose transporter in
206 topoietic cell-specific GPI-AP deficiency by
targeted disruption of the GPI biosynthesis gene PigA.
207 In the present study, mice with
targeted disruption of the growth hormone (GH) receptor
208 Mutant mice bearing a
targeted disruption of the heparan sulfate (HS) modifyin
209 sf4 gene causes cataract, and mice bearing a
targeted disruption of the hsf4 gene exhibit defects in
210 I kappa BNS in TCR triggering, we created a
targeted disruption of the I kappa BNS gene.
211 Recent studies showed that
targeted disruption of the IA-2 gene in mice resulted in
212 Anergy was prevented by
targeted disruption of the IDO gene in the DCs or by adm
213 ated in severely immunodeficient mice with a
targeted disruption of the IL2Rgammac gene have recently
214 Targeted disruption of the inhibin alpha gene (Inha(-)(/
215 Targeted disruption of the interaction between EB1 and p
216 This regulatory effect was abolished by
targeted disruption of the interactions of Ezh2 with the
217 Exploiting mice with a
targeted disruption of the Kvbeta1 gene (Kvbeta1-/-), th
218 Targeted disruption of the lipid droplet protein, perili
219 ed for the malic enzyme metabolic pathway by
targeted disruption of the maeE or maeK gene in ABSA dem
220 Here we show using a mouse model with a
targeted disruption of the MAGL gene that MAGL is the ma
221 Here we show that mice with a
targeted disruption of the Maml1 gene have severe muscul
222 Here, we show that
targeted disruption of the Men1 gene leads to enhanced c
223 Using mice with a
targeted disruption of the Mgmt gene, we tested whether
224 sing mouse embryonic fibroblasts (MEFs) with
targeted disruption of the Mkk3 and Mkk6 genes (MKK3-/-
225 -induced apoptosis is enhanced in cells with
targeted disruption of the Mnk1 and/or Mnk2 genes, sugge
226 Targeted disruption of the mouse Hus1 cell cycle checkpo
227 Targeted disruption of the mouse Rev3L gene causes letha
228 r, we generated a knockout mouse from a gene-
targeted disruption of the murine ABCA2 gene.
229 on of each enzyme, we studied the effects of
targeted disruption of the murine CA genes, called Car5A
230 Targeted disruption of the murine gene Gp6 on a mixed 12
231 Using
targeted disruption of the murine GRP94 gene, we show th
232 Targeted disruption of the murine Iqgap2 gene resulted i
233 Targeted disruption of the murine kindlin-2 gene resulte
234 Here, we examined the effect of
targeted disruption of the murine Mlk3 gene.
235 in detail, we generated a mouse model with a
targeted disruption of the murine ortholog ClC-K2.
236 Targeted disruption of the murine suppressor of fused ge
237 ification of small organic molecules for the
targeted disruption of the NFAT-calcineurin interaction
238 appaB p50/RelA heterodimers, and genetically
targeted disruption of the NFkappaB p50 gene in mice sig
239 -null mutant (NHE4-/-) mice were prepared by
targeted disruption of the NHE4 (Slc9a4) gene.
240 Here, we show that
targeted disruption of the novel gene Rnase10 encoding a
241 Mice carrying a
targeted disruption of the Npr1 gene (coding for guanyly
242 antioxidant response, we examined mice with
targeted disruption of the Nrf2 gene.
243 Targeted disruption of the onecut transcription factor,
244 ied its functions in epidermis of mice, with
targeted disruption of the orai1 gene, human skin sectio
245 of ORAI1 deficiency, we generated mice with
targeted disruption of the Orai1 gene.
246 eport on the characterization of mice with a
targeted disruption of the organic anion transporting po
247 Mice with
targeted disruption of the P2X(7) gene were used to eval
248 Such activation is defective in cells with
targeted disruption of the p38alpha MAPK gene, indicatin
249 Mice homozygous for
targeted disruption of the PAPPA gene were viable but 60
250 Here, we have reported that
targeted disruption of the Pbp/Pparbp gene in hepatocyte
251 Targeted disruption of the PE_PGRS47 (Rv2741) gene led t
252 These observations suggest that
targeted disruption of the peptide YY gene does not pert
253 In this study, we show that autoimmune-
targeted disruption of the pituitary-ovarian axis leads
254 euromuscular system, we examined mice with a
targeted disruption of the pro-death gene Bax.
255 eterozygous haploinsufficient mouse model by
targeted disruption of the promoter and exon 1 regions o
256 Targeted disruption of the Puralpha gene reduced NHE act
257 oxisomal membrane channel Pxmp2, mice with a
targeted disruption of the Pxmp2 gene were generated.
258 icity by testing the antibodies on mice with
targeted disruption of the relevant genes.
259 Targeted disruption of the retinoblastoma (Rb) tumour su
260 of RhoG, we generated mice homozygous for a
targeted disruption of the RhoG gene.
261 STAT activation is diminished in cells with
targeted disruption of the Rictor gene, whose protein pr
262 Mice with a
targeted disruption of the SCD1 gene are deficient in ti
263 Mice with a
targeted disruption of the SCD1 isoform have reduced bod
264 in hearts from adult mice with heterozygous
targeted disruption of the Scn5a gene to clarify the rol
265 den infant death syndrome (SIDS).Mice with a
targeted disruption of the serotonin transporter (5-HTT)
266 In characterizing mice with
targeted disruption of the SerpinB2 gene, we observed an
267 Here, we report that
targeted disruption of the Slc4a5 gene encoding the elec
268 Mice with a
targeted disruption of the stearoyl-CoA desaturase 1 (SC
269 Targeted disruption of the sterol 12alpha-hydroxylase ge
270 Functionally,
targeted disruption of the STM1 gene results in rapamyci
271 age lymphoma cells rendered SYK-deficient by
targeted disruption of the syk gene.
272 espectively, in macrophages from mice with a
targeted disruption of the TBK1 gene.
273 By analyzing mice with
targeted disruption of the Tet2 catalytic domain, we sho
274 Conversely,
targeted disruption of the TG-hydrolyzing enzyme lipopro
275 VS fails to label cells lacking TgCPL due to
targeted disruption of the TgCPL gene in two different p
276 olled by adenosine, we generated mice with a
targeted disruption of the third coding exon of Cd73 to
277 tes, TPST-2-deficient mice were generated by
targeted disruption of the Tpst2 gene.
278 We have generated mice harboring a
targeted disruption of the UbC gene.
279 One of the phenotypes of mice with
targeted disruption of the uncoupling protein-2 gene (Uc
280 Targeted disruption of the Ush2a gene in mice leads to p
281 ements for YAP, we generated mice carrying a
targeted disruption of the Yap gene.
282 and a dramatic reduction of CAA occurs after
targeted disruption of the Znt3 gene in these mice.
283 esponses by electroretinography in mice with
targeted disruptions of the genes encoding them.
284 ion of photoreceptor axonemes from mice with
targeted disruptions of the Rp1 gene shows that Rp1 prot
285 Targeted disruption of these genes in exposed cells comp
286 e deficient in BLT1 and BLT2 by simultaneous
targeted disruption of these genes.
287 Targeted disruption of these labile copper stores by acu
288 Targeted disruption of this association impairs the abil
289 further assess the candidacy of Adamts16 by
targeted disruption of this gene in a rat genetic model
290 orylated beta-catenin and pSmad2 and suggest
targeted disruption of this interaction as a potential t
291 omeostasis by studying the consequences of a
targeted disruption of this kinase.
292 RIP-B7.1 mice homozygous for
targeted disruption of TLR9, TLR3, and myeloid different
293 Targeted disruption of TSC-22 in wild-type mice enhanced
294 ion of apoptosis is diminished in cells with
targeted disruption of TSC2, a negative upstream effecto
295 CC with high penetrance using liver-specific
targeted disruption of tumor suppressors SMAD4 and PTEN.
296 Thus,
targeted disruption of tylU reduced tylosin yields by ab
297 Here we report that
targeted disruption of Ubb results in male and female in
298 Previously, we showed that
targeted disruption of Wnt5a results in over-branching o
299 Here we show using null mice produced by
targeted disruption of Zan that zonadhesin confers speci
300 Targeted disruption of Zbtb1 recapitulated the T(-)B(+)N