ライフサイエンスコーパス: taste bud

1 nto the narrow extracellular spaces within a taste bud.

2 an elegant cellular organization within the taste bud.

3 ying integration of new taste cells into the taste bud.

4 ) and GABA(B) receptors are expressed in the taste bud.

5 mmunication and signal processing within the taste bud.

6 lular capillaries and tight junctions in the taste bud.

7 in regions of the tongue normally devoid of taste buds.

8 filiform and fungiform papillae, but also to taste buds.

9 xpressed in subsets of taste cells in murine taste buds.

10 esting that NTPDase2 is the dominant form in taste buds.

11 advantage of the expansion in the number of taste buds.

12 ique patterns of neuropeptide secretion from taste buds.

13 und tdTomato-positive innervation within all taste buds.

14 ut also in cells in the caudal brainstem and taste buds.

15 lls that support the papilla and specialized taste buds.

16 and epithelium including taste papillae and taste buds.

17 ved in the development of taste papillae and taste buds.

18 to measure transmitter release from isolated taste buds.

19 It is also expressed in adult taste buds.

20 ween papillae, and within papillae and early taste buds.

21 significantly diminished ATP secretion from taste buds.

22 at 6 dpi accelerates entry of new cells into taste buds.

23 -release machinery remains functional in DKO taste buds.

24 ilarly expressed in taste buds in WT and DKO taste buds.

25 ly also during growth and differentiation of taste buds.

26 and each target contained the same number of taste buds.

27 les in the development of taste papillae and taste buds.

28 l numbers of cells in anterior and posterior taste buds.

29 region in cavefish and later was confined to taste buds.

30 ectable by immunohistochemistry in fungiform taste buds.

31 been proposed to underlie umami detection in taste buds.

32 ATP and pannexin 1 hemichannels in mammalian taste buds.

33 hus ruling out a mesenchymal contribution to taste buds.

34 d no effect of cell-to-cell communication in taste buds.

35 e a neurotransmitter or paracrine hormone in taste buds.

36 sensing by a mechanism analogous to that in taste buds.

37 , polymodal nociceptors, rather than through taste buds.

38 are expressed in nerve fibers that penetrate taste buds.

39 ATP through pannexin 1 hemichannels in mouse taste buds.

40 eurotransmitter release in rat circumvallate taste buds.

41 hromogranin A (ChrgA), are also expressed in taste buds.

42 d no effect on taste-evoked ATP release from taste buds.

43 g during processing gustatory information in taste buds.

44 id oral lamina is competent to form teeth or taste buds.

45 inappropriate targets, leading to a loss of taste buds.

46 or patterning and morphogenesis of tooth and taste buds.

47 ecular differentiation process of endogenous taste buds.

48 for regulating TNF production and effects in taste buds.

49 are signals processed in sensory end organs, taste buds?

50 t GABA is an inhibitory transmitter in mouse taste buds, acting on GABA(A) and GABA(B) receptors to s

51 ATP has been shown to be a taste bud afferent transmitter, but the cells responsibl

52 sodium channel was conditionally deleted in taste buds (alphaENaC knockout).

53 Taste buds also robustly express plasma membrane transpo

54 at specific times in development showed that taste bud amplification and eye degeneration are sensiti

55 hyperactive Shh signaling increases oral and taste bud amplification in cavefish at the expense of ey

56 r normal Shh signaling in fungiform papilla, taste bud and filiform papilla maintenance was shown by

57 lator that maintains lingual taste papillae, taste bud and progenitor cell proliferation and differen

58 due to lateral transfer of the tracer in the taste bud and taste receptor expression in sensory gangl

59 To evaluate the end-organs, taste buds and a class of putative taste receptor cells

60 tantly, we find that P2X2 is expressed in WT taste buds and appears to function as an autocrine, posi

61 Up-regulation of TrkB transcripts in taste buds and elevated taste cell-specific TrkB phospho

62 y recording responses in cells isolated from taste buds and in taste cells in lingual slices to aceti

63 Diverse sensory organs, including mammalian taste buds and insect chemosensory sensilla, show a mark

64 chorda tympani (CT) nerve innervates lingual taste buds and is susceptible to damage during dental an

65 , pigment loss, increased size and number of taste buds and mechanosensory organs, and shifts in many

66 l be particularly relevant for cell types in taste buds and other tissues that can be identified only

67 Gustatory neurons innervate taste buds and project centrally to the rostral nucleus

68 Based on studies on isolated taste buds and single taste cells, we have postulated th

69 sory neurons innervating lingual and palatal taste buds and somatosensory neurons innervating the pin

70 Isolated taste cells, taste buds and strips of lingual tissue from taste papil

71 rt, we determined the targets of CGRP within taste buds and studied what effect CGRP exerts on taste

72 first to characterize adult mouse fungiform taste buds and subsequent degeneration after unilateral

73 We isolated mouse taste buds and taste cells, conducted functional imaging

74 ") to detect NE secreted from isolated mouse taste buds and taste cells.

75 y degraded to adenosine within mouse vallate taste buds and that this nucleoside acts as an autocrine

76 were positioned against mouse circumvallate taste buds and the taste buds were stimulated with KCl (

77 orphogenesis, innervation and maintenance of taste buds and their stem/progenitor cells.

78 Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory

79 epresent only a small fraction of cells in a taste bud, and numerous ion channels with no role in sou

80 strong evidence for communication within the taste bud, and resolve the paradox of broad taste cell t

81 e of taste organs, the fungiform papilla and taste bud, and surrounding lingual cells.

82 ere identified in type II taste cells of the taste bud, and VIP knockout mice exhibit enhanced taste

83 organs, including teeth, taste papillae, and taste buds, and is essential for these processes to occu

84 muli are transduced by receptor cells within taste buds, and like epidermal cells, taste cells are re

85 Taste buds are aggregates of 50-100 polarized neuroepith

86 When intact mammalian taste buds are apically stimulated with umami tastants,

87 Taste buds are assemblies of elongated epithelial cells,

88 Cells in taste buds are closely packed, with little extracellular

89 aquatic animals like bony fishes, teeth and taste buds are colocalized one next to the other.

90 Taste buds are dependent on innervation for normal morph

91 These SHH-induced ectopic taste buds are found in regions of the adult tongue prev

92 the geniculate ganglion and nerve fibers in taste buds are GFP-positive.

93 The remaining taste buds are hyperinnervated, demonstrating a disrupti

94 Taste buds are innervated by neurons whose cell bodies r

95 Teeth and taste buds are iteratively patterned structures that lin

96 Taste buds are minimally affected when Shh is lost from

97 However, taste buds are more sensitive to BDNF than NT-4 removal.

98 In addition, the overall number and size of taste buds are normal in Entpd2-null mice.

99 he same early developmental period, although taste buds are not formed until much later.

100 Taste buds are unusual in requiring ATP as a transmitter

101 ificant reductions in the number and size of taste buds, as well as in the number of taste receptor c

102 lion subpopulations separately and remaining taste buds at birth within each target field in wild-typ

103 to 4 gustatory neurons and contained 3 to 16 taste buds at birth, indicating that some taste buds rem

104 ral-pharyngeal constructive traits (jaws and taste buds) at the expense of eyes in the blind cavefish

105 etween a variety of cells located within the taste buds before signal propagation to the brain.

106 thelial progenitors shared with anteriormost taste buds, before establishing within slow-cycling cell

107 In addition to ovoid-shaped taste buds, big tube-shaped taste buds were observed in

108 is not only endogenously expressed in mouse taste buds but also in lung airway epithelial cells, whi

109 Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract.

110 ins, has been implicated in ATP release from taste buds, but it has not been evaluated for a function

111 ection eliminated all labeled innervation to taste buds, but most of the additional innervation in th

112 of this ectonucleotidase in the function of taste buds by examining gene-targeted Entpd2-null mice g

113 ted that some gut peptides are released from taste buds by prolonged application of particular taste

114 ver and skew the representation of different taste bud cell types, leading to the development of tast

115 ion triggered Ca(2+) influx in CD36-positive taste bud cells (TBCs) purified from mouse CVP.

116 ires Fyn-Src kinase and lipid rafts in human taste bud cells (TBCs).

117 ve shown previously there are two classes of taste bud cells directly involved in gustatory signaling

118 Taste bud cells express G-protein-coupled receptors for

119 ther with previous reports for the origin of taste bud cells from local epithelium in postnatal mouse

120 The recent cloning of RGS21 from taste bud cells has implicated this protein in the regul

121 In the field of taste biology, taste bud cells have been described as arising from "loc

122 GLP-1 was released immediately from taste bud cells in response to sweet compounds but not t

123 stes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter

124 ls, from placode and apical papilla cells to taste bud cells only, a surrounding population of Ptch1

125 orm taste buds were smaller due to a loss of taste bud cells rather than changes in taste bud morphol

126 ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gusta

127 In response to gustatory stimulation, taste bud cells release a transmitter, ATP, that activat

128 Receptor (type II) taste bud cells secrete ATP during taste stimulation.

129 Together, these findings indicate that taste bud cells secrete NE when they are stimulated.

130 factor sonic hedgehog (Shh) and give rise to taste bud cells that differentiate around birth.

131 gs lead to a new concept about derivation of taste bud cells that include a NC origin.

132 are detected by dedicated subpopulations of taste bud cells that use distinct combinations of sensor

133 alts from other taste stimuli was deleted in taste bud cells throughout development.

134 We isolated individual taste bud cells to identify the origin of NE release.

135 -gamma significantly increased the number of taste bud cells undergoing programmed cell death.

136 l infection-induced IFNs can act directly on taste bud cells, affecting their cellular function in ta

137 Here, we show that differentiation of new taste bud cells, but not progenitor proliferation, is in

138 showed NE does not appear to act on adjacent taste bud cells, or at least on receptor cells.

139 that although it is expressed in nearly all taste bud cells, the function of KCNQ1 is not required f

140 In taste bud cells, two different T1R heteromeric taste rec

141 lease from sweet-, bitter- and umami-sensing taste bud cells.

142 ically in sweet/bitter/umami-sensing type II taste bud cells.

143 erent fibers and also stimulates neighboring taste bud cells.

144 e larger due to an increase in the number of taste bud cells.

145 ctively, altered gene expression patterns in taste bud cells.

146 erferon (IFN)-mediated signaling pathways in taste bud cells.

147 Within the taste bud, ChrgA is found only in presynaptic cells and

148 ip of the tongue retained nearly half of its taste buds compared to intact mice.

149 Taste buds consist of at least three principal cell type

150 peripheral afferent nerve fibers innervating taste buds contain calcitonin gene-related peptide (CGRP

151 Taste buds contain multiple cell types with each type ex

152 Taste buds contain two types of cells that directly part

153 Surviving taste buds could not be explained by an apparent innerva

154 Fungiform taste bud degeneration after chorda tympani nerve injury

155 ing a positive correlation between tooth and taste bud densities.

156 Wnt signaling couples tooth and taste bud density and BMP and Hh mediate distinct organ

157 oss cichlid species with divergent tooth and taste bud density, and were expressed in the development

158 nstrated that the morphological integrity of taste buds depends on their innervation.

159 ogists do not fully understand how teeth and taste buds develop from undifferentiated epithelium or h

160 in signaling centers throughout papilla and taste bud development and differentiation.

161 These studies further suggest that mammalian taste bud development is very distinct from that of othe

162 function of KCNQ1 is not required for gross taste bud development or peripheral taste transduction p

163 signaling has an important role in oral and taste bud development.

164 poral functions of beta-catenin in fungiform taste bud development.

165 Taste buds differentiate at birth within epithelial appe

166 followed by taste papilla morphogenesis and taste bud differentiation, but the degree to which these

167 ithelium act in concert to support continued taste bud differentiation.

168 r innervation to drive the entire program of taste bud differentiation.

169 While almost all taste buds disappeared in more posterior fungiform papil

170 Combined with other features of chicken taste buds, e.g., uniquely patterned array and short tur

171 at the neural crest does not supply cells to taste buds, either embryonically or postnatally, thus ru

172 neurotransmitter that has been implicated in taste buds, elicits calcium mobilization in Receptor (Ty

173 knockout mice all cell types are present in taste buds, even those cells normally expressing NTPDase

174 Previously we have shown that taste buds express various molecules involved in innate

175 oupled receptors, mGluR4 and mGluR1, and the taste bud-expressed heterodimer T1R1+T1R3.

176 le knockout mice showed, however, that their taste buds fail to release ATP, suggesting the possibili

177 orm, diverts lingual epithelial cells from a taste bud fate.

178 ained candidate genes expressed in tooth and taste bud fields.

179 hosphate (cAMP), is known to be modulated in taste buds following exposure to gustatory and other sti

180 e of endogenous taste buds, however, ectopic taste buds form independently of both gustatory and soma

181 ransduced signals act in tongue, papilla and taste bud formation and maintenance, it is necessary to

182 buds and studied what effect CGRP exerts on taste bud function.

183 nally, we also defined the source of GABA in taste buds: GABA is synthesized by GAD65 in type I taste

184 ors that function as carbohydrate sensors in taste buds, gut, and pancreas.

185 ionship between placodes, papillae and adult taste buds has not been defined.

186 ids, but variants of two mGluRs expressed in taste buds have also been implicated.

187 The roles of these neurotransmitters in taste buds have not been fully elucidated.

188 Mammalian taste buds have properties of both epithelial and neuron

189 l-established nerve dependence of endogenous taste buds, however, ectopic taste buds form independent

190 ing cells in mouse circumvallate and foliate taste buds: IL-10 expression was found exclusively in th

191 e suggest that GABA may serve function(s) in taste buds in addition to synaptic inhibition.

192 nistic studies on the development of chicken taste buds in association with their feeding behaviors.

193 There is not an easy way to visualize all taste buds in chickens.

194 to study the relationship between nerve and taste buds in fungiform papillae.

195 highly efficient method for labeling chicken taste buds in oral epithelial sheets using the molecular

196 ickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-3

197 geal nerve (IX), three nerves that innervate taste buds in the oral cavity, prominently occupy the gu

198 We show that taste buds in these mice are significantly larger and ha

199 of ATP secretion, are similarly expressed in taste buds in WT and DKO taste buds.

200 ical microvilli of the chemosensory cells of taste buds including the epithelium of lips and olfactor

201 BDNF also orchestrates and maintains taste bud innervation.

202 eural crest-derived neurons do not innervate taste buds; instead, neurites of these sensory neurons t

203 ancer treatments, disrupts taste papilla and taste bud integrity and can eliminate responses from tas

204 A mouse fungiform taste bud is innervated by only four to five geniculate

205 s in our understanding of how the pattern of taste buds is established in embryos and discuss the cel

206 The integrity of taste buds is intimately dependent on an intact gustator

207 ate, the specific stimulus for NE release in taste buds is not well understood, and the identity of t

208 ate ganglion that are available to innervate taste buds is regulated by neurotrophin-4 (NT-4) and bra

209 T-PCR, we show the abundance of ROMK mRNA in taste buds is vallate > foliate > > palate > > fungiform

210 geniculate ganglion neurons, which innervate taste buds, is reduced by one-half.

211 In the peeled epithelial sheets, taste buds labeled with antibodies against Vimentin and

212 helial and neural supply of Shh are removed, taste buds largely disappear.

213 statory innervation, neurotrophic support of taste buds likely involves a complex set of factors.

214 Neurons of the geniculate ganglion innervate taste buds located in two spatially distinct targets, th

215 sense of taste is mediated by multicellular taste buds located within taste papillae on the tongue.

216 Taste bud loss was not as profound in the NT-4 null mice

217 nsduction, and that IFN-induced apoptosis in taste buds may cause abnormal cell turnover and skew the

218 usly undescribed inhibitory route within the taste bud mediated by the classic neurotransmitter GABA

219 sms in other tissues, such as CAII-PDK2L1 in taste buds, might also have similar roles to play in the

220 ss of taste bud cells rather than changes in taste bud morphology.

221 rming and maintaining fungiform papillae and taste buds, most likely via stage-specific autocrine and

222 including hair follicles, sebaceous glands, taste buds, nails and sweat ducts.

223 Within the taste bud NET, a specific NE transporter, is expressed i

224 e relationship between eye size and jaw size/taste bud number, supporting a link between oral-pharyng

225 oncert, cavefish show amplified jaw size and taste bud numbers as part of a change in feeding behavio

226 istochemistry reveals no reaction product in taste buds of knockout mice, suggesting that NTPDase2 is

227 e-gated potassium channel KCNQ1 in mammalian taste buds of mouse, rat, and human.

228 In taste buds of the circumvallate papillae, some taste rec

229 such system, the taste papillae and sensory taste buds of the mouse tongue.

230 gulatory hierarchy that configures teeth and taste buds on mammalian jaws and tongues may be an evolu

231 re repeated epithelial structures that house taste buds on the anterior tongue.

232 of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate r

233 tion in mammals: teeth on the jaw margin and taste buds on the tongue.

234 We observed no additional postnatal loss of taste buds or neurons in Ntf4(-/-) mice.

235 owever, did not alter the gross structure of taste buds or the expression of taste signaling molecule

236 is required for SHH expression by endogenous taste buds, our data suggest that SHH can replace the ne

237 roups and continue to increase the number of taste buds over stages after hatch.

238 This unique sensory organ includes taste buds, papilla epithelium and lateral walls that ex

239 unted under a light microscope and many more taste buds, patterned in rosette-like clusters, were fou

240 s, sonic hedgehog (SHH) negatively regulates taste bud patterning, such that inhibition of SHH causes

241 Taste placodes comprise taste bud precursor cells, which express the secreted fa

242 rs during papilla morphogenesis also expands taste bud precursors and accelerates Type I cell differe

243 a day later within Shh(+) placodes, expands taste bud precursors directly, but enlarges papillae ind

244 SHH causes the formation of more and larger taste bud primordia, including in regions of the tongue

245 ste buds, we demonstrate that Shh-expressing taste bud progenitors are specified and produce differen

246 Shh-expressing embryonic taste placodes are taste bud progenitors, which give rise to at least two d

247 enitors form cell type-replete, onion-shaped taste buds, rather than non-taste, pseudostratified epit

248 n (5-HT) are neurotransmitters secreted from taste bud receptor (type II) and presynaptic (type III)

249 Taste bud receptor (Type II) cells have been identified

250 ATP is a transmitter secreted from taste bud receptor (Type II) cells through ATP-permeable

251 rmaceutical Ingredient (API) and oral cavity taste bud regions.

252 Taste buds release ATP to activate ionotropic purinocept

253 16 taste buds at birth, indicating that some taste buds remain even when all innervation is lost.

254 ves are a source of sonic hedgehog (Shh) for taste bud renewal.

255 In mice, individual taste buds reside in fungiform papillae, which develop a

256 Mammalian taste buds respond to these diverse compounds via membra

257 tial convergence of taste information in the taste bud, resulting in taste cells that would respond b

258 We propose that in taste buds, ROMK in type I/glial-like cells may serve a

259 g chambers, permitting apical stimulation of taste buds; secreted peptides were collected from the ba

260 Taste buds (sensory structures embedded in oral epitheli

261 Each barbel carries taste buds, solitary chemosensory cells, and epithelial

262 se the CT usually regenerates to reinnervate taste buds successfully within a few weeks, a persistenc

263 as in the number of taste receptor cells per taste bud, suggesting that IL-10 plays critical roles in

264 Sonidegib treatment led to rapid loss of taste buds (TB) in both fungiform and circumvallate papi

265 ed tracer production and transfer within the taste buds (TBs).

266 Broiler-type, female-line males have more taste buds than other groups and continue to increase th

267 We recently identified many more taste buds than previously appreciated in chickens using

268 ique patterns of neuropeptide secretion from taste buds that are correlated with those perceptual qua

269 helium of mammalian tongue hosts most of the taste buds that transduce gustatory stimuli into neural

270 d of an epithelium that includes specialized taste buds, the basal lamina, and a lamina propria core

271 via pannexin 1 hemichannels acts within the taste bud to excite neighbouring presynaptic (Type III)

272 d aminergic transmitters function within the taste bud to modulate gustatory signaling in these perip

273 le in transmission of taste information from taste buds to nerves.

274 Moreover, applying CGRP caused taste buds to secrete serotonin (5-HT), a Presynaptic (T

275 imaging and lingual slices containing intact taste buds to test the hypothesis of purinergic signalli

276 of nerves that carry taste information from taste buds to the nucleus of the solitary tract (NST) in

277 emonstrate a new role for acetylcholine as a taste bud transmitter.

278 Activation of taste buds triggers the release of several neurotransmit

279 In mammals, taste buds typically contain 50-100 tightly packed taste

280 Vertebrate taste buds undergo continual cell turnover.

281 Mammalian taste buds use ATP as a neurotransmitter.

282 These findings suggest that taste buds use separate populations of taste receptor ce

283 null mice, which lose neurons that innervate taste buds, we demonstrate that Shh-expressing taste bud

284 unocytochemistry, subsets of TRCs within rat taste buds were identified as expressing GABA, and its s

285 cts of nerve transection were also observed; taste buds were larger due to an increase in the number

286 to ovoid-shaped taste buds, big tube-shaped taste buds were observed in the chicken using 2-photon m

287 NE biosensor responses evoked by stimulating taste buds were reversibly blocked by prazosin, an alpha

288 By 5 days after nerve transection taste buds were smaller and fewer on the side of the ton

289 Degenerating fungiform taste buds were smaller due to a loss of taste bud cells

290 ainst mouse circumvallate taste buds and the taste buds were stimulated with KCl (50 mm) or a mixture

291 orm papillae had labeled innervation only in taste buds, whereas 43% of the fungiform papillae also h

292 sense of taste, or gustation, is mediated by taste buds, which are housed in specialized taste papill

293 tion of the CT results in a disappearance of taste buds, which can be accompanied by taste disturbanc

294 newal relies on progenitor cells adjacent to taste buds, which continually supply new cells to each b

295 between embryonic taste placodes with adult taste buds, which is independent of mesenchymal contribu

296 gustatory and chemosensory afferents inside taste buds will help explain how a coherent output is fo

297 Stimulating taste buds with forskolin (Fsk; 1 microm) + isobutylmeth

298 s an important component of the operation of taste buds with individual taste receptor cells (TRCs) c

299 Our protocol for labeling taste buds with molecular markers will factilitate futur

300 e II cells and taste-evoked ATP release from taste buds without affecting the excitability of taste c