ライフサイエンスコーパス: taste receptor

1 eas Tas1r1/Tas1r3 act as the principal umami taste receptor.

2 cose polymers may be mediated by a different taste receptor.

3 n the interacting side of thaumatin with the taste receptor.

4 on of lactisole and cyclamate with the umami taste receptor.

5 f multiple ligand binding sites on the sweet taste receptor.

6 tify and characterize a mammalian amino-acid taste receptor.

7 th the presence of a distinct polysaccharide taste receptor.

8 e oral cavity, where they function as bitter taste receptors.

9 ough expression analysis of all 68 gustatory taste receptors.

10 sm of positive allosteric modulations of T1R taste receptors.

11 )C(7) triolein) to avoid activation of mouth taste receptors.

12 nockout studies has shown their functions as taste receptors.

13 will focus on events downstream of the umami taste receptors.

14 n intestinal sensing system based on lingual taste receptors.

15 roposed receptors and/or as-yet-undiscovered taste receptors.

16 3 and PKD2L1 heteromers may function as sour taste receptors.

17 nction in combination as heterodimeric sweet taste receptors.

18 s coexpress many members of the Gr family of taste receptors.

19 1R3, a member of the T1R family of candidate taste receptors.

20 port the characterization of mammalian sweet taste receptors.

21 family is likely to encode both odorant and taste receptors.

22 mily encodes a large and divergent family of taste receptors.

23 o show that specific T2Rs function as bitter taste receptors.

24 at the IR20a clade encodes a class of larval taste receptors.

25 "orphan" taste neurons that express no known taste receptors.

26 ch may both be regulated by intestinal sweet taste receptors.

27 e T1R3 subunit common to the sweet and umami taste receptors.

28 ncated metabotropic glutamate receptor 1, or taste receptor 1 (T1R1) and T1R3 dimers], taken alone, d

29 though the heteromeric combination of type 1 taste receptors 2 and 3 (T1r2 + T1r3) is well establishe

30 maining Gr genes are likely to encode bitter taste receptors [9-11], albeit some function as pheromon

31 ue to nutrient absorption, rather than sweet taste receptor activation.

32 sensory cells (SCCs) that express T2R bitter taste receptors along with their downstream signaling co

33 using a cell-based assay for the human sweet taste receptor and a panel of selected sweeteners.

34 ate no functional amiloride-insensitive salt taste receptor and no salt taste sensitivity to vanilloi

35 ause T1R3 is the common subunit in the sweet taste receptor and the umami taste receptor, we tested t

36 rethral brush cells express bitter and umami taste receptors and downstream components of the taste t

37 ice and Drosophila have identified candidate taste receptors and examined the logic of taste coding i

38 , only a fraction of which express genes for taste receptors and intracellular signaling proteins.

39 cortex respond solely to sensory input from taste receptors and lingual somatosensory receptors.

40 properties for participating in signaling in taste receptors and other excitable cells.

41 rom both molecular studies of genes encoding taste receptors and other taste-signaling components, an

42 TAS1R taste receptors and their associated heterotrimeric G pr

43 ceptors do not also express sweet-responsive taste receptors and vice versa.

44 These chemosensory cells express T2R "bitter-taste" receptors and alpha-gustducin, a G protein involv

45 ell line NCI-H716 expresses alpha-gustducin, taste receptors, and several other taste signaling eleme

46 TAS1R3, a component of sweet and amino acid taste receptors, and the gustducin alpha-subunit GNAT3 l

47 For example, transcripts of taste receptors appear only or predominantly in late-sta

48 T2R bitter and T1R sweet taste receptors are coupled through G-proteins, alpha-gu

49 Taste receptors are expressed not only in taste buds but

50 Because bitter, sweet, and umami taste receptors are G protein-coupled receptors (GPCRs),

51 Insect odor and taste receptors are highly sensitive detectors of food,

52 T1R taste receptors are present throughout the gastrointesti

53 Bitter taste receptors as targets for tocolytics in preterm lab

54 subunits in the heteromeric T1R2:T1R3 sweet taste receptor binds sweet stimuli though with distinct

55 mutant protein unresponsive to activation by taste receptor, but left its other functions intact.

56 ng digestion, activation of intestinal sweet taste receptors by natural sugars and artificial sweeten

57 We propose that dynamic regulation of taste receptors by ubiquitin-mediated protein degradatio

58 onds to low pH and was proposed to be a sour taste receptor candidate.

59 or indirect effects on taste transduction or taste receptor cell excitability.

60 Notably, a single taste receptor cell expresses a large repertoire of T2Rs

61 Since a single taste receptor cell expresses a large repertoire of T2Rs

62 A model for immune modulation of taste receptor cell function is proposed based on these

63 To identify genes important for taste receptor cell function, we analyzed the sequences

64 gues that this signaling cascade may specify taste receptor cell lineages within an already specified

65 ion patterns of clones isolated from a mouse taste receptor cell-enriched cDNA library.

66 ent of intracellular pH (pH(i)) in polarized taste receptor cells (TRCs) and by chorda tympani (CT) t

67 Specific subsets of taste receptor cells (TRCs) are activated upon tastant s

68 the operation of taste buds with individual taste receptor cells (TRCs) communicating with one anoth

69 ste buds of the circumvallate papillae, some taste receptor cells (TRCs) express YRs localized primar

70 cludes: (1) PAA on [In(OH)(bdc)]n mimics the taste receptor cells (TRCs) for their structural flexibi

71 e produced when acidic stimuli interact with taste receptor cells (TRCs) on the dorsal surface of the

72 wed that each taste is detected by dedicated taste receptor cells (TRCs) on the tongue and palate epi

73 Here we show that acid-sensing taste receptor cells (TRCs) that were previously suggest

74 regarding the direct effect of capsaicin on taste receptor cells (TRCs).

75 on of neuronal Shh expression causes loss of taste receptor cells (TRCs).

76 apical Na+ fluxes in polarized rat fungiform taste receptor cells and by chorda tympani taste nerve r

77 ember of this subfamily, TRPM5, functions in taste receptor cells and has been reported to be activat

78 ctivated cation channel expressed in type II taste receptor cells and pancreatic beta-cells.

79 nd alpha-gustducin, suggesting that both the taste receptor cells and synapse-forming cells in the ta

80 Taste receptor cells are chemical detectors in the oral

81 Taste receptor cells are continuously replaced during th

82 situ calcium-imaging findings imply that rat taste receptor cells are more narrowly tuned to respond

83 independently of sweet and amino acids, and taste receptor cells are not broadly tuned across these

84 hly novel conclusions: potassium currents in taste receptor cells are significantly modulated by PIP2

85 m intracellular transduction cascades within taste receptor cells but also from cell-to-cell communic

86 Taste receptor cells constitute a highly specialized cel

87 Taste receptor cells detect chemicals in the oral cavity

88 In the tongue, distinct classes of taste receptor cells detect the five basic tastes; sweet

89 e tongue, PKD2L1 is expressed in a subset of taste receptor cells distinct from those responsible for

90 somatosensory neurons, retinal neurons, and taste receptor cells do not appear to express physiologi

91 ic tracing originating from umami and bitter taste receptor cells does not selectively label taste qu

92 ACh is an autocrine transmitter secreted by taste Receptor cells during gustatory stimulation, enhan

93 c tastes are mediated by separate classes of taste receptor cells each finely tuned to a single taste

94 tinct and strictly segregated populations of taste receptor cells encode each of the taste qualities.

95 appetitive responses to NaCl are mediated by taste receptor cells expressing the epithelial sodium ch

96 Taste receptor cells harbor functional similarities to n

97 We examined calcium responses of rat taste receptor cells in situ to a panel of bitter compou

98 3 and PKD2L1, are coexpressed in a subset of taste receptor cells in specific taste areas.

99 r-tasting" ligands are coexpressed in single taste receptor cells in taste buds, leading to the predi

100 he detection of bitter and sweet tastants by taste receptor cells in the mouth is likely to involve G

101 In mammals, information from taste receptor cells in the tongue is transmitted throug

102 ry discovered in specialized neuroepithelial taste receptor cells of the lingual epithelium is operat

103 in-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia.

104 e 2 taste receptors [T2Rs]) are expressed in taste receptor cells of the tongue, where they play an i

105 We determined that 8-10% of the taste receptor cells of the vallate papilla were Bax pos

106 e of taste buds, as well as in the number of taste receptor cells per taste bud, suggesting that IL-1

107 either potassium current from rat posterior taste receptor cells produced essentially parallel resul

108 unication reports the novel observation that taste receptor cells respond to adrenergic stimulation.

109 cal studies, however, reveal that individual taste receptor cells respond to stimuli representing mul

110 ACh biosensors confirmed that, indeed, taste Receptor cells secrete acetylcholine during gustat

111 en validated against responses recorded from taste receptor cells that are the native detectors of um

112 that taste buds use separate populations of taste receptor cells that coincide with sweet/umami and

113 T2Rs are exclusively expressed in taste receptor cells that contain the G protein alpha su

114 s, produces several physiological actions on taste receptor cells that include inhibition of KIR and

115 Sour taste is detected by taste receptor cells that respond to acids through yet p

116 esponsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet

117 ferential screening of cDNAs from individual taste receptor cells to identify candidate taste transdu

118 ssion is traditionally thought to occur from taste receptor cells to the afferent nerve.

119 Taste receptor cells use a variety of mechanisms to tran

120 d-organs, taste buds and a class of putative taste receptor cells were counted from progeny of BDNF-O

121 physiological actions of cholecystokinin on taste receptor cells were observed.

122 tatory renewing epithelium, we observed that taste receptor cells were selectively immunopositive for

123 ecystokinin (CCK) is expressed in subsets of taste receptor cells, and that it may play a signaling r

124 w not only out of information ascending from taste receptor cells, but also from the cycling of infor

125 n (alpha(t-rod)), which is also expressed in taste receptor cells, plays a role in any of the taste r

126 encing of synapses in defined populations of taste receptor cells, we demonstrated that the sour-sens

127 ferent neurotransmitter (ATP) secretion from taste Receptor cells.

128 (GlucR) are coexpressed in a subset of mouse taste receptor cells.

129 vocally identify TRPM5-dependent currents in taste receptor cells.

130 genetic ablations of selected populations of taste receptor cells.

131 pression is highly restricted to a subset of taste receptor cells.

132 is also selectively expressed in a subset of taste receptor cells.

133 eceptor (IP(3)R3) as the dominant isoform in taste receptor cells.

134 tastants are thought to stimulate different taste receptor cells.

135 ormation about taste quality is extracted by taste receptor cells.

136 istry localized noradrenaline to a subset of taste receptor cells.

137 ess the issue of quality detection in murine taste receptor cells.

138 ke human TAS1R3, is expressed selectively in taste receptor cells.

139 transgenes in bitter or sweet/umami-sensing taste receptor cells.

140 r, bitter and umami-are mediated by separate taste-receptor cells (TRCs) each tuned to a single taste

141 buds typically contain 50-100 tightly packed taste-receptor cells (TRCs), representing all five basic

142 affeine and related methylxanthines activate taste-receptor cells through inhibition of a cyclic nucl

143 a receptor-based, positive, off-response in taste-receptor cells, ultimately inducing a gustatory pe

144 class C G protein-coupled receptor T1R1/T1R3 taste receptor complex is an early amino acid sensor in

145 We then show that expression of a bitter taste receptor confers sensitivity to selected aversive

146 suggest the existence of a wider Ca(2+) and taste receptor-coordinated transport network incorporati

147 ive allosteric modulators of the human sweet taste receptor could help reduce the caloric content in

148 hat taste cells expressing bitter-responsive taste receptors do not also express sweet-responsive tas

149 mosensory receptors (including olfactory and taste receptors), exhibit increased rates of evolution r

150 Artificial sweeteners, acting on sweet taste receptors expressed on enteroendocrine GLUTag cell

151 Moreover, we visualized for the first time taste receptor-expressing cells in the PNS and CNS.

152 We focused on the impact of obesity on taste receptor expression in brain areas involved in ene

153 transfer of the tracer in the taste bud and taste receptor expression in sensory ganglia and brain.

154 ifferences in terms of gustatory anatomy and taste-receptor families, these gustatory systems share a

155 ein known to be a member of the invertebrate taste receptor family.

156 ne that encodes a member of the TAS2R bitter taste receptor family.

157 opts the stimulus-response properties of the taste receptor field it cross-reinnervates.

158 salt discrimination task is dependent on the taste receptor field origin of the input as well as the

159 cSNP), K172N, in hTAS2R16, a gene encoding a taste receptor for bitter beta -glucopyranosides, shows

160 tification by Laugerette et al. of CD36 as a taste receptor for fatty acids provides insight into the

161 o MSG taste suggests that this receptor is a taste receptor for glutamate.

162 th T1R1 or T1R3, can serve as a low-affinity taste receptor for l-glutamate in the presence of IMP.

163 eterodimer is thought by many to be the only taste receptor for sugars.

164 T1R2 and T1R3 proteins serves as the primary taste receptor for sweeteners, there is growing evidence

165 discovery and characterization of vertebrate taste receptors from the T1R and T2R families, which are

166 We propose that changing taste receptor function enabled hummingbirds to perceive

167 ide strong support for the view that loss of taste receptor function in mammals is widespread and dir

168 ted to common variants of the TAS2R31 bitter taste receptor gene and to NNS intake.

169 -specific neuronal circuits and reveal local taste receptor gene expression in the gustatory ganglia

170 esis through cross-mammal analyses of bitter taste receptor gene repertoires.

171 r signal of positive selection at the bitter-taste receptor gene TAS2R16.

172 Here we identified putative taste receptor gene transcripts in the gastrointestinal

173 Here we describe a candidate taste receptor gene, T1r3, that is located at or near th

174 morphic trait mediated by the TAS2R38 bitter taste receptor gene.

175 mong adults due to polymorphisms in a bitter taste receptor gene.

176 reference) locus is identical to the Tas1r3 (taste receptor) gene.

177 found a significant interaction between two taste receptor genes (i.e., TAS2R16 and TAS2R38) in affe

178 te qualities, given the staged expression of taste receptor genes and taste transduction elements in

179 It is assumed that the orthologous bitter taste receptor genes mediate the recognition of bitter t

180 m discovery and study of the TAS2R family of taste receptor genes, hand in hand with genetic linkage

181 es generated species-specific sets of bitter taste receptor genes.

182 o smaller surviving mammals with more bitter taste receptor genes.

183 on of berries as well as children's hTAS2R38 taste receptor genotypes on liking.

184 y, the expression of sweet G protein-coupled taste receptor (GPCTR) subunits (T1R2 and T1R3) and bitt

185 that interspecies mating is inhibited by the taste receptor Gr32a (Gustatory receptor 32a) and a neur

186 terior tongue (glossopharyngeal), or palatal taste receptors (greater superficial petrosal) or in whi

187 The discovery of two families of mammalian taste receptors has provided important insights into tas

188 ive allosteric modulators of the human sweet taste receptor have been developed as a new way of reduc

189 emonstrated that sequence-orthologous bitter taste receptors have distinct agonist profiles.

190 ngle taste bud cells express multiple bitter taste receptors have reignited a long-standing controver

191 Thus, LITE-1, a taste receptor homolog, represents a distinct type of ph

192 A human taste receptor, hT2R4, and an olfactory receptor of Caen

193 t, we tested the role of the candidate umami taste receptor hTAS1R1-hTAS1R3 in a functional expressio

194 dogenous alpha-gustducin's interactions with taste receptors, i.e., it acted as a dominant-negative.

195 Most of these cells also express the T1R3 taste receptor implicated in sweet and/or umami taste.

196 how that mice engineered to express a bitter taste receptor in 'sweet cells' become strongly attracte

197 on in combination as a heteromeric glutamate taste receptor in humans.

198 olleagues investigate the role of the bitter taste receptors in airway epithelial cells, and find tha

199 identification of the first insect odor and taste receptors in Drosophila melanogaster, these recept

200 nsporter-1, glucose transporter-2, and sweet taste receptors in humans and mice.

201 ares luminal nutrient receptors with lingual taste receptors in order to detect the five basic tastes

202 jury on taste responses from anterior tongue taste receptors in sodium-restricted rats.

203 multiple members of the T2R family of bitter taste receptors in the antral and fundic gastric mucosa

204 To assess the importance of the sweet-taste receptors in the brain, we conducted transcriptomi

205 detection by the entire repertoire of sweet taste receptors in the fly and lay the foundation for st

206 s view, including reports on the presence of taste receptors in the gastrointestinal lumen and the st

207 mary means of controlling stimulus access to taste receptors in the mouth.

208 Thaumatin interacts with taste receptors in the oral cavity eliciting a persisten

209 These findings (i) demonstrate that bitter taste receptors in the stomach and the oral cavity are i

210 C. elegans and implicate the function of a 'taste receptor' in phototransduction.

211 ter than three glucose moieties, stimulate a taste receptor independent of the T1R2+3 heterodimer.

212 oviding chemical biology tools for thaumatin:taste receptor interaction studies.

213 y, we identified a large family of mammalian taste receptors involved in bitter taste perception (the

214 indicate that the amiloride-insensitive salt taste receptor is a constitutively active non-selective

215 The umami taste receptor is a heteromeric complex of 2 class C G-p

216 onclude that the mammalian non-specific salt taste receptor is a VR-1 variant.

217 The amiloride-insensitive salt taste receptor is the predominant transducer of salt tas

218 ste bud cells, two different T1R heteromeric taste receptors mediate signal transduction of sugars (t

219 The T1R family of taste receptors mediates 2 taste qualities: T1R2/T1R3 fo

220 The type 1 taste receptor member 3 (T1R3) is a G protein-coupled re

221 The two Caenorhabditis elegans taste receptor neurons "ASE left" (ASEL) and "ASE right"

222 ditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (A

223 rectional asymmetry displayed by the two ASE taste receptor neurons, ASE left (ASEL) and ASE right (A

224 The taste receptors of larvae fed on host plants show an enh

225 results demonstrate the expression of bitter taste receptors of the T2R family in the mouse and rat g

226 ts increase the receptive range of the sweet taste receptor, offering a functional mechanism for phen

227 the Gr genes, and predicted that they encode taste receptors on the basis of their structure and spec

228 odium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both.

229 onclusion, it appears that some signals from taste receptor proteins binding with sugars and some L-a

230 believed that the receptive ranges of bitter taste receptor repertoires match the profiles of bitter

231 l evidence that one Gr gene, Gr5a, encodes a taste receptor required for response to the sugar trehal

232 umami taste and suggest that sweet and umami taste receptors share a common subunit.

233 prolonged food deprivation in the absence of taste-receptor signaling.

234 n) the adsorption energy of each molecule on taste receptor sites.

235 Sweet taste receptor stimulation only increased GLP-1 secretio

236 Glucose is a natural ligand for sweet taste receptors (STRs) that are expressed on the tongue

237 iously established that the intestinal sweet taste receptors (STRs), T1R2 and T1R3, were expressed in

238 ion, we identify members of the Gr5a-related taste receptor subfamily that are coexpressed in sugar n

239 Here, we show that the sweet taste receptor subunit T1R3 and the taste G protein gust

240 ockout mice that lack gustducin or the sweet taste receptor subunit T1r3 have deficiencies in secreti

241 ntly associated with expression of the sweet taste receptor subunit, Tas1r2.

242 e human sweet receptor (a heterodimer of two taste receptor subunits: hT1R2 + hT1R3) responds to cycl

243 ken together our data suggest that the sweet-taste receptor system plays an important neurotrophic ro

244 posed to function as a component of the salt-taste-receptor system.

245 response implicates the luminal-based sweet-taste receptor T1R2/T1R3, with the reflex apparently inv

246 aphy matched the expression profile of sweet taste receptor T1R2/T1R3.

247 Here we report that sweet taste receptors T1R2 and T1R3 are expressed throughout a

248 The sweet taste receptors T1R2 and T1R3 are G protein-coupled rece

249 Furthermore, sweet taste receptor (T1R2/3) activation suppressed T2R-mediat

250 ransduction of sugars (the canonical "sweet" taste receptor, T1R2 + T1R3) and L-amino acids (the T1R1

251 e largely independent of the classical sweet taste receptors, T1R2 and T1R3.

252 tamate receptors (mGluRs), sweet and "umami" taste receptors (T1Rs), and the extracellular calcium-se

253 Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defens

254 In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds of stru

255 These candidate taste receptors (T2Rs) are organized in the genome in cl

256 Bitter taste receptors (T2Rs) in the human airway detect harmfu

257 body through stimulation of extraoral type 2 taste receptors (T2Rs).

258 -sensing G protein-coupled receptors (type 2 taste receptors [T2Rs]) are expressed in taste receptor

259 putative pheromone receptors, V1Rs, and the taste receptors, T2Rs.

260 The putative human taste receptor TAS1R1-TAS1R3 responds specifically to l-

261 et taste is primarily mediated by the type 1 taste receptor Tas1r2/Tas1r3, whereas Tas1r1/Tas1r3 act

262 blished the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models.

263 We hypothesize that human bitter taste receptor (TAS2R) genes might be relaxed from selec

264 n coupled receptors (GPCRs) including bitter taste receptors (TAS2R) agonists and prostaglandin EP4 r

265 Polymorphisms in the bitter-taste receptor TAS2R38 explain the majority of phenotypi

266 rrin and deficient functioning of the bitter taste receptor TAS2R38.

267 al cells from human and mouse express bitter taste receptors (TAS2Rs) and their canonical signaling c

268 Bitter taste receptors (TAS2Rs) are G-protein-coupled receptors

269 Although bitter taste receptors (TAS2Rs) are important for human health,

270 Bitter taste receptors (TAS2Rs) enable animals to detect and av

271 ngly, activation of G-protein-coupled bitter taste receptors (TAS2Rs) in airway smooth muscle (ASM) c

272 Bitter taste receptors (TAS2Rs) on the tongue probably evolved

273 We found that type 2 taste receptors (TAS2Rs), which are activated by bitter-

274 s are recognized by G-protein-coupled bitter taste receptors (TAS2Rs).

275 We recently identified bitter taste receptors (taste family type 2 receptors, or T2Rs)

276 dicate that many different G-protein-coupled taste receptors that bind with "bitter-tasting" ligands

277 T1Rs are candidate mammalian taste receptors that combine to assemble two heteromeric

278 imeric receptors, we propose that Drosophila taste receptors that function in avoidance of bitter com

279 TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a nat

280 Duodenal L cells express sweet taste receptors, the taste G protein gustducin, and seve

281 ow that human duodenal L cells express sweet taste receptors, the taste G protein gustducin, and seve

282 te acts via amino acid and glucose via sweet taste receptors to coordinate regulation of PepT1 and ap

283 ficity is at least partly due to a tuning of taste receptors to indioside D.

284 orter-1 and glucose transporter-2) and sweet taste receptor transcripts.

285 l. show that mice lacking functional "sweet" taste receptors (trpm5-/-) develop a preference for sucr

286 We demonstrate that fructose activates sweet taste receptors (TRs) on beta cells and synergizes with

287 se transporter-1, glucose transporter-2, and taste receptor type 1 member 2 (T1R2) transcripts.

288 ults indicated that olfactory receptor (OR), taste receptor type 2, and vomeronasal receptor type 1 g

289 gh gustatory stimulation mobilizes Ca(2+) in taste Receptor (Type II) cells from DKO mice, as from wi

290 Taste Receptor (type II) cells secrete ATP via gap junct

291 whether non-sugar nutrients are regulated by taste receptors using perfused rat jejunum in vivo.

292 is representing crucial features of the T1R2 taste receptor VFTM binding site.

293 A polymorphism in a bitter taste receptor was recently associated with refractory C

294 it in the sweet taste receptor and the umami taste receptor, we tested the interaction of lactisole a

295 properties of the amiloride-insensitive salt taste receptor were investigated by RT-PCR, by the measu

296 nsporter (SGLT) family members and the sweet taste receptor were tested, and measurements of the port

297 Tas1R2 and Tas1R3 is a broadly acting sweet taste receptor, which mediates mammalian sweet taste tow

298 Drosophila olfactory receptors and mammalian taste receptors, which are monomeric or dimeric receptor

299 ound that these cells express sensory bitter taste receptors, which localized on motile cilia.

300 By challenging 34 mouse bitter taste receptors with 128 prototypical bitter substances