ライフサイエンスコーパス: tautomerase

1 rly zebrafish melanoblast marker, dopachrome tautomerase.

2 gulatory protein as well as a phenylpyruvate tautomerase.

3 an inhibitor of the enzyme 4-oxalocrotonate tautomerase.

4 DH) and Rpa1177, a putative 4-oxalocrotonate tautomerase.

5 h two bacterial isomerases, 4-oxalocrotonate tautomerase (4-OT) and 5-(carboxymethyl)-2-hydroxymucona

6 us to the bacterial enzymes 4-oxalocrotonate tautomerase (4-OT) and 5-carboxymethyl-2-hydroxymuconate

7 4-Oxalocrotonate tautomerase (4-OT) and trans-3-chloroacrylic acid dehalo

8 nhibitors of three enzymes: 4-oxalocrotonate tautomerase (4-OT) and vinylpyruvate hydratase (VPH) fro

9 4-Oxalocrotonate tautomerase (4-OT) and YwhB, a 4-OT homologue found in B

10 e reaction catalyzed by the 4-oxalocrotonate tautomerase (4-OT) enzyme has been studied using a quant

11 62 amino acid member of the 4-oxalocrotonate tautomerase (4-OT) family, was pro-immunogenic in mice w

12 d with other members of the 4-oxalocrotonate tautomerase (4-OT) family.

13 e amino-terminal proline of 4-oxalocrotonate tautomerase (4-OT) functions as the general base catalys

14 lyst Pro-1 (pK(a) = 6.4) in 4-oxalocrotonate tautomerase (4-OT) has been ascribed to both a low diele

15 r the kinetic parameters of 4-oxalocrotonate tautomerase (4-OT) have been measured using 2-hydroxy-2,

16 YwhB, a 4-oxalocrotonate tautomerase (4-OT) homologue in Bacillus subtilis, has n

17 The crystal structure of 4-oxalocrotonate tautomerase (4-OT) inactivated by the active site-direct

18 4-Oxalocrotonate tautomerase (4-OT) is a bacterial enzyme that is compris

19 4-Oxalocrotonate tautomerase (4-OT) is a multimeric, bacterial enzyme com

20 4-Oxalocrotonate tautomerase (4-OT) isozymes play prominent roles in the

21 jor families represented by 4-oxalocrotonate tautomerase (4-OT), 5-(carboxymethyl)-2-hydroxymuconate

22 tion secondary structure of 4-oxalocrotonate tautomerase (4-OT), a 41 kDa homohexamer with 62 residue

23 4-Oxalocrotonate tautomerase (4-OT), a homohexameric enzyme, converts the

24 lecular weight 47,547), and 4-oxalocrotonate tautomerase (4-OT), an (alpha)(6) homohexamer, distingui

25 nd the bacterial isomerase, 4-oxalocrotonate tautomerase (4-OT), thereby distinguishing CaaD from a n

26 cluding carbonic anhydrase, 4-oxalocrotonate tautomerase (4OT) analogue, and SecB, a chaperone from E

27 de backbone interactions in 4-oxalocrotonate tautomerase (4OT) catalysis has been investigated using

28 of the homohexameric enzyme 4-oxalocrotonate tautomerase (4OT).

29 , Tyr, Tyr-related protein 1, and dopachrome tautomerase accumulated in enlarged granules distributed

30 Selected compounds that bind in the tautomerase active site also inhibit biological function

31 ytometry, concluding a critical role for the tautomerase active site in receptor binding.

32 ian MIFs, it has critical differences in the tautomerase active site that account for the different i

33 y docking 2.1 million compounds into the MIF tautomerase active site.

34 l-molecular-weight inhibitor targeting MIF's tautomerase activity (SCD-19) significantly reduces the

35 In addition, it exhibits a catalytic tautomerase activity amenable to the design of high affi

36 een described recently to exhibit dopachrome tautomerase activity and to be structurally homologous t

37 For instance, the IC(50) inhibition of MIF tautomerase activity by aromatic amino acid Schiff base

38 To investigate the role of MIF's tautomerase activity in a murine model of Pseudomonas ae

39 ine oxidation drop rapidly, while DOPAchrome tautomerase activity increases and dihydroxyindole carbo

40 MIF-tautomerase activity may provide a novel therapeutic tar

41 ted for biaryltriazoles as inhibitors of the tautomerase activity of human macrophage migration inhib

42 ibitors of the p-hydroxyphenylpyruvate (HPP) tautomerase activity of MIF and an allosteric binding si

43 Epoxyazadiradione inhibited the tautomerase activity of MIF of both human (huMIF) and ma

44 pyruvate, a substrate for the phenylpyruvate tautomerase activity of MIF.

45 ame as the catalytic site for the dopachrome tautomerase activity of MIF.

46 To identify small-molecule inhibitors of the tautomerase activity of PfMIF, virtual screening has bee

47 MIF inhibitors has focused on monitoring the tautomerase activity using l-dopachrome methyl ester or

48 The most potent inhibitor of MIF tautomerase activity was 2-[(4-hydroxybenzylidene)amino]

49 Inhibition of MIF tautomerase activity was also established for many of th

50 t lacks oxidoreductase activity but exhibits tautomerase activity with a specific activity of 19.3 mu

51 rongly correlated with the inhibition of MIF tautomerase activity, a connection not made previously t

52 oxycinnamate, a competitive inhibitor of the tautomerase activity, has been determined to 1.8 A resol

53 Here, we show that TvMIF has tautomerase activity, inhibits macrophage migration, and

54 The effect of a specific inhibitor of MIF-tautomerase activity, ISO-1, was investigated in PBMCs.

55 teins were compared using in vitro assays of tautomerase activity, macrophage migration, and binding

56 er (ISO-1), an inhibitor of MIF d-dopachrome tautomerase activity, reveals that ISO-1 binds to the sa

57 As for other MIF orthologues, PfMIF has tautomerase activity, whose inhibition may influence the

58 elatively nonspecific 1,3- and 1,5-keto-enol tautomerase activity, with the former activity prevailin

59 e significantly reduced or no phenylpyruvate tautomerase activity.

60 city to interact with this cytokine's unique tautomerase activity.

61 lines, which show in vitro inhibition of MIF tautomerase activity.

62 a covalent complex with MIF and inhibits the tautomerase activity.

63 macrophage migration inhibitory factor (MIF) tautomerase activity.

64 pro-inflammatory activities by targeting MIF tautomerase activity.

65 We designed small molecules to inhibit this tautomerase activity; a lead molecule, "ISO-1 ((S,R)-3-(

66 elanogenic enzymes tyrosinase and dopachrome tautomerase, all major players in melanogenesis.

67 hancer required for expression of dopachrome tautomerase, an enzyme that functions in melanin synthes

68 ve site similar to those of 4-oxalocrotonate tautomerase and 5-carboxymethyl-2-hydroxymuconate isomer

69 t of two microbial enzymes (4-oxalocrotonate tautomerase and 5-carboxymethyl-2-hydroxymuconate isomer

70 inhibitory factor (MIF) is both a keto-enol tautomerase and a cytokine associated with numerous infl

71 of benzaldehyde derivatives that inhibit MIF tautomerase and biological activities.

72 d mechanism of action, the protein is also a tautomerase and has a catalytically active N-terminal pr

73 and tyrosinase-related protein 2/dopachrome tautomerase and increased protection from a lethal chall

74 als that, unusually for a cytokine, exhibits tautomerase and oxidoreductase enzymatic activities.

75 pment and pigmentation, including dopachrome tautomerase and tyrosinase.

76 se, tyrosinase-related protein-1, dopachrome tautomerase, and Pmel17, are known, the function of MART

77 -associated transcription factor, dopachrome tautomerase, and tyrosinase promoters, leading to an inc

78 tein encoded by the homologous, D-dopachrome tautomerase (D-DT) gene.

79 itory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor CD74 may c

80 IF) and its functional homolog, d-dopachrome tautomerase (d-DT), have protumorigenic functions in non

81 d its only known family member, D-dopachrome tautomerase (D-DT), promote the expression of proangioge

82 tory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to th

83 TRP1) and 3,4-dihydroxyphenylalanine-chrome tautomerase (Dct or TRP2) encoded at the Tyrp1/brown and

84 Tyrosinase and dopachrome tautomerase (DCT) activities were found exclusively in s

85 DOPAchrome tautomerase (Dct) functions downstream of tyrosinase in

86 The melanin synthesis enzyme dopachrome tautomerase (DCT) is involved in intracellular calcium a

87 tyrosinase minigene driven by the dopachrome tautomerase (Dct) promoter region.

88 pment in transgenic mice from the dopachrome tautomerase (Dct) promoter.

89 sinase-related protein-1 (Tyrp1), dopachrome tautomerase (Dct), and LAMP1 and 3 localization in HPS-3

90 al precursor cells (line Ntva) or dopachrome tautomerase (DCT)-expressing melanoblasts (line DCTtva)

91 elated protein-1 (TYRP1/gp75) and dopachrome tautomerase (DCT/TYRP2) belong to a family of melanocyte

92 nt work by others has described D-dopachrome tautomerase (DDT) as a functional homologue of MIF with

93 D-dopachrome tautomerase (DDT) is an enzyme that lacks physiologic su

94 identify the function of TenI as a thiazole tautomerase, describe the structure of the enzyme comple

95 (olfactory receptors, OR) and phenylpyruvate tautomerase/dopachrome isomerase activity (MIF and DDT g

96 4-Oxalocrotonate tautomerase (EC 5.3.2-; 4-OT), a hexamer consisting of 6

97 the quaternary structure of 4-oxalocrotonate tautomerase (EC 5.3.2; 4OT), and four analogues prepared

98 tophilus, and M. aeruginosa RLPs function as tautomerases/enolases in a methionine salvage pathway (M

99 It possesses unique tautomerase enzymatic activity.

100 F) is a proinflammatory mediator with unique tautomerase enzymatic activity; the precise function has

101 The expression of the dopachrome tautomerase gene (Dct) and its protein product, tyrosina

102 nt within an intron of the bovine dopachrome tautomerase gene.

103 base, Pro-1, of the enzyme 4-oxalocrotonate tautomerase has been mutated to Gly, Ala, Val, and Leu,

104 hysiological investigations (e.g. dopachrome tautomerase in melanogenesis).

105 found at the active site of 4-oxalocrotonate tautomerase in the X-ray structure of the affinity-label

106 Three were found to be potent PfMIF tautomerase inhibitors with K(i) of approximately 40 nM;

107 mpounds are likely the most potent known MIF tautomerase inhibitors; the most active ones are more th

108 MIF contains a catalytic site resembling the tautomerase/isomerase sites of microbial enzymes.

109 l-Dopachrome tautomerase (l-DCT), also called tyrosinase-related prot

110 y have evolved from a short 4-oxalocrotonate tautomerase-like ancestor followed by gene duplication a

111 equence in each that had been annotated as a tautomerase-like protein but lacked Pro-1.

112 ro-1, but the sequence is not annotated as a tautomerase-like protein.

113 used in MIF wild-type mice (mif(+/+)) and in tautomerase-null, MIF gene knockin mice (mif (P1G/P1G)).

114 be activated by MITF, including dautochrome tautomerase, pMel 17/Silver and tyrosinase-related prote

115 on the mRNA levels of tyrosinase, dopachrome tautomerase, Pmel17, or MITF mRNA levels.

116 egulatory protein, exhibits a phenylpyruvate tautomerase (PPT) activity.

117 Phenylpyruvate tautomerase (PPT) has been studied periodically since it

118 gulation of a melanocyte-specific dopachrome tautomerase promoter.

119 ith Grm1 expression driven by the dopachrome tautomerase promoter.

120 Although the tautomerase site of D-DT and its homologue MIF are bioph

121 ecules that bind at the catalytically active tautomerase site of MIF and tested the complex for MIF b

122 olecule MIF inhibitors typically bind in the tautomerase site of the MIF trimer, often covalently mod

123 homology with significant differences in the tautomerase sites of the human and hookworm proteins.

124 The tautomerase superfamily (TSF) consists of more than 11,0

125 The tautomerase superfamily consists of three major families

126 at the evolution of new functions within the tautomerase superfamily could be quite facile, requiring

127 This is the first reported observation of a tautomerase superfamily member functioning by covalent c

128 d trans-3-chloroacrylic acid dehalogenase, a tautomerase superfamily member preceding MSAD in the tra

129 (MSAD) from Pseudomonas pavonaceae 170 is a tautomerase superfamily member that converts malonate se

130 ot exhibit the low-level activity of another tautomerase superfamily member, the heterohexamer trans-

131 d for Pro1 and the conserved arginine in all tautomerase superfamily members characterized thus far,

132 ino-terminal proline, conserved in all known tautomerase superfamily members, functioning as a genera

133 characterized member of a new family in the tautomerase superfamily that probably resulted from an i

134 acid dehalogenase (CaaD) are members of the tautomerase superfamily, a group of structurally homolog

135 4-OT isozyme and the founding member of the tautomerase superfamily.

136 e of three known enzymatic activities in the tautomerase superfamily.

137 minal region suggested a relationship to the tautomerase superfamily.

138 nce to implicate MSAD as a new member of the tautomerase superfamily.

139 t irreversible inhibitor of 4-oxalocrotonate tautomerase than is 2-OP suggest that Arg-39" and the or

140 f the functions assigned to MIF is that of a tautomerase that interconverts the enol and keto forms o

141 H from dopachrome is catalyzed by dopachrome tautomerase, that the melanogenic protein tyrosinase-rel

142 melanocortin receptor (MC1R), and dopachrome tautomerase (TRP-2).

143 tyrosinase-related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and transactiva

144 that 4-OT might function as a 1,5-keto-enol tautomerase using 2-hydroxy-2,4-hexadienedioate.

145 One of those enzymes is 4-oxalocrotonate tautomerase, with which CaaD seems to share a common evo