ライフサイエンスコーパス: tautomerization

1 epwise transfer mechanism is dominant in the tautomerization.

2 cannot be accounted for purely by keto-enol tautomerization.

3 n indirect and unexpected route: a keto-enol tautomerization.

4 ow pK(a), as the general base in a keto-enol tautomerization.

5 H(18)O-Fe(V)=O species, and then oxo-hydroxo tautomerization.

6 including some that invoke a novel keto-enol tautomerization.

7 asic residues are not involved in dopachrome tautomerization.

8 r through a hydrazido(2-)/isodiazene valence tautomerization.

9 ) nanoclusters that catalyze stereoselective tautomerization.

10 t the enolate oxygen followed by a keto-enol tautomerization.

11 general base to promote the imine to enamine tautomerization.

12 on of SO2 , 1,4-addition, diazotization, and tautomerization.

13 n the products by alkali-catalyzed keto-enol tautomerizations.

14 ramolecular transition state for the 2S, 2SH tautomerization (2TS) lies 25 (CBS-Q) to 30 kcal/mol (CC

15 formed into the pyrrole via a gold-catalyzed tautomerization, [3,3]-sigmatropic rearrangement, and cy

16 s enol, resulting from an extended keto-enol tautomerization across a benzene ring, is described.

17 MIF can be functionally dissociated from its tautomerization activity.

18 on energy was obtained for the triplet-state tautomerization affording 3.

19 intermolecular addition of water followed by tautomerization and cyclization to give 2a,c.

20 /retro-Diels-Alder reaction of 5 followed by tautomerization and elaboration of R to give silylated f

21 Enol-keto tautomerization and enzyme-mediated hydrolytic cleavage

22 rangement, oxy-Cope rearrangement, enol-keto tautomerization and finally an intramolecular carbonyl e

23 cts a proton from Ser112, thereby completing tautomerization and generating a serinate for nucleophil

24 ve a sugar enamine intermediate, which after tautomerization and hydrolysis to release ammonia yields

25 Gly(491) work in tandem to promote keto-enol tautomerization and increase the acidity of the C2 hydro

26 h a neutral nitrosoaryl radical, followed by tautomerization and intramolecular condensation between

27 ue shape shifting ability that utilizes both tautomerization and protonation.

28 s adopt a Watson-Crick-like geometry through tautomerization and/or ionization of the bases.

29 The unexpected azido-tetrazolo tautomerizations and irreversible tetrazolo transformati

30 gh Pd(II)-catalyzed aromatic C-H activation, tautomerization, and a 1,3-shift of the palladacycle-lig

31 y orchestrated steps: addition, formylation, tautomerization, and dehydration, with CuCN catalyzing a

32 ion followed by beta-elimination of bromide, tautomerization, and in situ trapping of the resulting 1

33 tive of 8-azidoadenosine cannot undergo this tautomerization, and instead, it fragments upon photolys

34 O(4))(2), presumably to facilitate keto-enol tautomerization, and is greatly improved by the use of c

35 ental insights into the aromatic properties, tautomerization, and reactivity of porphyrins and relate

36 ith Schiff base formation, ketimine/aldimine tautomerization, and transimidation etc.

37 show how the reaction pathway and barrier of tautomerization are modified in the presence of a copper

38 paramount to understanding these compounds' tautomerization behavior, which may impact their reactiv

39 hase and solvent dependent preference of the tautomerization between 2-pyridinethiol (2SH) and 2-pyri

40 fragmentation data were rationalized due to tautomerization between imine and enamine substructures.

41 e 3-substituents inhibited His-265-catalyzed tautomerization by 5 orders of magnitude.

42 enzimidazolones, which through acid-promoted tautomerization convert to their corresponding (Z)-isome

43 anthrol (6) equilibrium, with an enthalpy of tautomerization, Delta(t)H, of 3.8 kcal mol(-1).

44 roles of primer-template stability and base tautomerization during misincorporation.

45 sCO found in species of Bacilli catalyze the tautomerization ("enolization") of 2,3-diketo-5-methylth

46 Electrical control over the tautomerization equilibrium of immobilized SHQ governs t

47 applied to the electrode surface governs the tautomerization equilibrium of the immobilized ligand, p

48 of immobilized SHQ through control over the tautomerization equilibrium, to produce an electrically

49 This ligand tautomerization event is assisted by the pi-bound indole

50 6)D(6)) calorimetric enthalpy for the 2S/2SH tautomerization favoring the thione.

51 Additionally, unique tautomerization features exhibited by 5-(4-nitrophenylaz

52 ese hydrogen-bonded systems is hydrazone-azo tautomerization followed by rotation around a C-N single

53 Tautomerization, followed by isomerization, of the initi

54 eory in vacuo and aqueous phases) formulated tautomerization for RS-stereoisomers of ascorbic acids (

55 for the pH dependence of the open and closed tautomerization forms of PD156707 was demonstrated by an

56 Catalyst release and tautomerization gives the final beta-lactamic product.

57 at the first step of the reaction, keto-enol tautomerization, had become rate-limiting, indicating th

58 Although electronic excited-state tautomerization has been widely studied, experimental wo

59 diazaquinodimethane, the product of nitrene tautomerization, has a lifetime of ca. 1 min or longer i

60 Here, we report force-induced tautomerization in a single porphycene molecule on a Cu(

61 Tautomerization in porphycenes, constitutional isomers o

62 Due to KuQs structural features, keto-enol tautomerization in solution likely occurs, leading to th

63 traction reaction, which enables a keto-enol tautomerization in the substrate.

64 ve nonradical pathways including a keto-enol tautomerization induced by electronic excitation of the

65 4-hydroxyquinone-2-methide, undergoes rapid tautomerization into methyl p-quinone.

66 major pathway involves gamma-proton removal, tautomerization into the PLP ring, followed by Michael a

67 Although the imine to enamine tautomerization is crucial to inhibition of the enzyme,

68 effects strongly suggest that excited-state tautomerization is not an important nonradiative decay p

69 This tautomerization is reversible under flash vacuum thermol

70 vides a direct measurement of the nanosecond tautomerization kinetics.

71 Fe-4S cluster, and that this binding-induced tautomerization may have important mechanistic ramificat

72 ely precedes product formation, ruling out a tautomerization mechanism.

73 quilibrium process, followed by irreversible tautomerization/neutralization providing the driving for

74 nism also involves gamma-proton removal, but tautomerization occurs through the vinyl group, followed

75 ile; (iv) under lambda = 240 nm irradiation, tautomerization of 3-hydroxypropenenitrile to 3-oxopropa

76 of an ortho-quinone intermediate, derived by tautomerization of a bis-benzoquinone, readily accessed

77 ttributed to an isotope effect of 5.1 on the tautomerization of a dienone intermediate to tyrosine wi

78 The isotope effect on the subsequent tautomerization of a dienone intermediate was determined

79 rimental evidence of excited-state keto-enol tautomerization of a firefly fluorophore, and it could b

80 e is generated through a surprisingly facile tautomerization of a para-quinone.

81 d by their ability to catalyze the keto-enol tautomerization of a pyruvyl moiety.

82 The thermokinetics for the tautomerization of a series of methylenedihydroacenes to

83 ct for hydroxylation by PheH being masked by tautomerization of an enedione intermediate to tyrosine.

84 ction is not observed, consistent with rapid tautomerization of enolpyruvate.

85 ments (assessing the state of ionization and tautomerization of enzyme-bound ThDP-related intermediat

86 c substrates is limited by the non-oxidative tautomerization of ethylnitroante to nitroethane at high

87 Knowledge of the state of ionization and tautomerization of heteroaromatic cofactors when enzyme-

88 is based on the dual acid-base property and tautomerization of indazole.

89 This residue also is involved in aci-nitro tautomerization of nitroalkanes, the first example of a

90 of the nanosecond ground-state lactam-lactim tautomerization of pyridone derivatives in aqueous solut

91 ic preference to form ketones as a result of tautomerization of surface-bound enol intermediates.

92 profiles are consistent with a rate-limiting tautomerization of the 1,2-enediol of ribulose 5-phospha

93 Exchange through tautomerization of the bases is no observed, although mo

94 ic monomer brought about by solvent, induced tautomerization of the hydrogen-bonding unit.

95 The noncatalyzed thermal tautomerization of the methylenedihydroacene in an inert

96 MIF also catalyzes the tautomerization of the non-naturally occurring D-isomer

97 ssible mechanisms, including the amino-imino tautomerization of the substrate base that may explain h

98 ng a zwitterionic intermediate formed by the tautomerization of the thiadiazepine ring followed by di

99 ar-cognate complex is reconciled by possible tautomerization of the wobble base pair in mRNA-tRNA.

100 opens retro-ene pathways followed by either tautomerization or Claisen rearrangement.

101 among many mispairing possibilities, either tautomerization or ionization of bases might allow a DNA

102 tronate were used to propose a non-oxidative tautomerization pathway, in which the enzyme catalyzes t

103 e fluorophore formation via an imine-enamine tautomerization pathway.

104 t Hsp90-mediated trans-cis isomerization via tautomerization plays an important role in subsequent Hs

105 e is subject to histidine-mediated enol-keto tautomerization prior to hydrolysis.

106 pVTZ) higher in energy than either tautomer, tautomerization probably occurs in the hydrogen bonded d

107 netic characterization and conclude that the tautomerization proceeds through a two-state concerted m

108 obtained, the latter of which results from a tautomerization process.

109 ovel one-pot Ugi-azide/SNAr/ring-chain azido-tautomerization process.

110 bke-Blackburn-Bienayme/SNAr/ring-chain azido-tautomerization process.

111 standing of proton transfer and ring closure tautomerization processes.

112 It is also found that the tautomerization rate is increased by vibrational excitat

113 Quantifying the tautomerization rate is paramount to understanding these

114 etical and experimental study of the initial tautomerization rate of a range of phosphinylidene compo

115 E selectivity is a sensitive function of the tautomerization rate of an alkenyl anion intermediate.

116 Initial tautomerization rates are found to decrease in the order

117 The tautomerization rates are temperature independent below

118 to a porphycene molecule, we found that the tautomerization rates could be tuned up and down in a co

119 in the neighbouring molecule influences the tautomerization reaction in a given porphycene, with pos

120 dence in favor of an active site facilitated tautomerization reaction is provided by the fact that th

121 addition, Y150 acts as a general acid in the tautomerization reaction of the wild-type enzyme and rep

122 y provide insight regarding a related flavin tautomerization reaction that has been proposed as a key

123 g that 4-OT may not catalyze a 1,3-keto-enol tautomerization reaction using this dienol.

124 ilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single ste

125 somerization reaction and the YwhB-catalyzed tautomerization reaction.

126 a mechanism for the observed YdcE-catalyzed tautomerization reaction.

127 mechanism is proposed for the MIF-catalyzed tautomerization reaction.

128 cts as a general acid to protonate C3 in the tautomerization reaction.

129 e Y150F mutant enzyme, replacing Y150 in the tautomerization reaction.

130 ree dienols examined, 1,3- and 1,5-keto-enol tautomerization reactions are only observed for 2-hydrox

131 control of intramolecular hydrogen-transfer (tautomerization) reactions in single molecules using sca

132 s(pentafluorophenyl)corrole) induces valence tautomerization resulting in the formation of (tpfc(+*))

133 Zn(2+) to (TBP(8)Cz)Mn(V)(O) induces valence tautomerization, resulting in the formation of [(TBP(8)C

134 phthoquinone spiroketal rearrangement, and a tautomerization sequence.

135 s between the two proteins in the N-terminal tautomerization site are evident, and we provide evidenc

136 To determine the precise ionization/tautomerization states of ThDP during various stages of

137 with a p K a of 9.5 and likely catalyzes the tautomerization step by donating a proton to the enol to

138 The final tautomerization step to the acyloxime can be considered

139 be directly involved in the product-forming tautomerization step.

140 se a catalytic mechanism involving substrate tautomerization, substrate-assisted activation of water

141 d cyclization and a series of quinone-quinol tautomerizations that are followed by cycles of O2/H2O2-

142 Accompanying the tautomerization, the ionic properties of the COF can be

143 is transformation, alkylquinone 26 undergoes tautomerization to a quinone methide, which is intercept

144 a highly selective pyranose to furanose ring tautomerization to access an advanced intermediate, and

145 nitrosyl group then occurs followed by rapid tautomerization to amide.

146 erized by UV/Vis and IR spectroscopy and its tautomerization to CH2SO3H observed upon irradiation wit

147 nd 2 degrees alkylazides are unstable toward tautomerization to copper(I) imine complexes [Cu](HN hor

148 d to the discovery of a likely strain-driven tautomerization to cyclohexadienone intermediates.

149 s an initial transamination step followed by tautomerization to form a stable aromatic adduct, a sche

150 rangement of the product enamines occurs via tautomerization to imines, followed by a 1,3-trimethylsi

151 ation), degradation to undesired products or tautomerization to other isomers.

152 this reaction proceeds via rate-determining tautomerization to the allene-eneyne form followed by ve

153 so compound (R'ON --> O=NR'), and subsequent tautomerization to the more stable oxime.

154 ons tune photoisomerization and ground state tautomerizations to enable long-wavelength depopulation

155 ions then led to 13, which in turn underwent tautomerizations to give 8.

156 In the present work, we have studied the tautomerization using absorption spectroscopy in 15 diff

157 2,4-dioxo-carboxylate moiety, their solution tautomerization was investigated using both NMR and high

158 reaction product HDMF is prone to extensive tautomerization, whereas its precursor HMMF is chemicall

159 the mono- and dianhydride undergo ring-shift tautomerization, which is in the latter case shifted tow

160 scopy quantifies the force needed to trigger tautomerization with submolecular spatial resolution.

161 1,2-CHD is known to undergo a keto-enol tautomerization, with the monoenol being the primary equ

162 ervation of a double hydrogen atom transfer (tautomerization) within a single porphycene molecule on