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3 nd the posteromedial portions of the ventral tegmental area (pmVTA) and the medial nucleus acumbens s
4 3-rich regions: the substantia nigra/ventral tegmental area (SN/VTA) (+20%; p=0.02), ventral striatum
5 ponse slopes in the Substantia Nigra/Ventral Tegmental Area (SN/VTA) and ventral striatum were steepe
6 eflected in the substantia nigra and ventral tegmental area (SN/VTA), medial temporal lobe, or subseq
7 GABAergic neurons in the tail of the ventral tegmental area (tVTA), also called the rostromedial tegm
8 ulation of the dorsal raphe (DR) and ventral tegmental area (VTA) activates the fibres of the same re
10 edial temporal lobe regions with the ventral tegmental area (VTA) after a paired associate encoding t
13 ne-evoked synaptic plasticity in the ventral tegmental area (VTA) and nucleus accumbens (NAc) is caus
14 -synthesizing neurons project to the ventral tegmental area (VTA) and nucleus accumbens (NAc); howeve
15 lead to aberrant DA activity in the ventral tegmental area (VTA) and projection areas such as nucleu
16 ve focused on its projections to the ventral tegmental area (VTA) and rostromedial tegmental nucleus
17 rs, the population of neurons in the ventral tegmental area (VTA) and substantia nigra (SN) has been
19 gh striatum-targeting efferents from ventral tegmental area (VTA) and substantia nigra pars compacta
20 ral midbrain: one located within the ventral tegmental area (VTA) and the other in the substantia nig
21 ection between the DA neurons of the ventral tegmental area (VTA) and the suprachiasmatic nucleus (SC
23 hat potassium (K(+)) channels in the ventral tegmental area (VTA) are an active mediator of resilienc
24 CE STATEMENT Dopamine neurons in the ventral tegmental area (VTA) are critical substrates of drug rew
27 tantia nigra pars compacta (SNc) and ventral tegmental area (VTA) are involved in various brain funct
28 her projections from the mPOA to the ventral tegmental area (VTA) are sensitive to estrogen signaling
32 at the CRF1 receptor (CRF1R) in the ventral tegmental area (VTA) can modulate ethanol consumption in
33 sensitive mutant mice and found that ventral tegmental area (VTA) Cav1.3 channels mediate cocaine-rel
34 re-driver rodent lines for targeting ventral tegmental area (VTA) cell types has generated important
35 In addition to dopamine neurons, the ventral tegmental area (VTA) contains GABA-, glutamate- and co-r
37 tivated GIRK currents (IBaclofen) in ventral tegmental area (VTA) DA neurons of mice, but the mechani
38 nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-rel
41 xcitatory synaptic transmission onto ventral tegmental area (VTA) dopamine (DA) neurons is a critical
42 cocaine-evoked synaptic changes onto ventral tegmental area (VTA) dopamine (DA) neurons leads to long
44 not known whether FAs are sensed by ventral tegmental area (VTA) dopamine (DA) neurons to control fo
45 excitatory synaptic transmission in ventral tegmental area (VTA) dopamine (DA) neurons, which is ass
49 irst, both PD patients and mice with ventral tegmental area (VTA) dopamine depletion had attenuated d
51 (LAD) mice have dramatically higher ventral tegmental area (VTA) dopamine neuron firing and burst ac
52 reported fewer spontaneously active ventral tegmental area (VTA) dopamine neurons (ie, reduced dopam
53 increase in the AMPAR/NMDAR ratio in ventral tegmental area (VTA) dopamine neurons in midbrain slices
55 ases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequentl
58 ides with abnormal daytime spikes in ventral tegmental area (VTA) dopaminergic activity, tyrosine hyd
59 gh which chronic opioids disrupt the ventral tegmental area (VTA) dopaminergic circuitry that contrib
60 terpeduncular circuit, consisting of ventral tegmental area (VTA) dopaminergic neurons projecting to
62 terminals of the LH GABA neurons in ventral-tegmental area (VTA) facilitates learning about reward-p
63 hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processin
65 in releasing factor (CRF) within the ventral tegmental area (VTA) has emerged as a likely candidate m
66 gy suggests that the activity of the ventral tegmental area (VTA) helps regulate reinforcement learni
67 alters synaptic transmission in the ventral tegmental area (VTA) in a manner that enhances dopaminer
68 rs to selectively delete mTOR in the ventral tegmental area (VTA) in adult male mTOR(loxP/loxP) mice,
69 exon-specific Bdnf expression in the ventral tegmental area (VTA) in response to chronic opiate expos
70 he firing of dopaminergic neurons in ventral tegmental area (VTA) in rodents performing an RL task.
71 inputs onto dopamine neurons of the ventral tegmental area (VTA) induced by cocaine exposure allows
72 opamine (DA) neurons in the midbrain ventral tegmental area (VTA) integrate complex inputs to encode
79 ed glutamatergic transmission in the ventral tegmental area (VTA) may contribute to the increased mot
80 Dopaminergic (DA) neurons in the ventral tegmental area (VTA) mediate the positive reinforcing ef
82 the discovery of the localization in ventral tegmental area (VTA) neurons opens new vistas for a pote
84 Dopamine transmission from midbrain ventral tegmental area (VTA) neurons underlies behavioral proces
86 s synaptic potentiation (LTP) in the ventral tegmental area (VTA) of MRD, but not MHFD offspring.
87 ing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-in
88 paminergic system emanating from the ventral tegmental area (VTA) plays a key role in regulating rewa
89 ioid receptor (MOR) localized in the ventral tegmental area (VTA) plays a key role in the reinforcing
90 ioid receptor (MOR) localized in the ventral tegmental area (VTA) plays a key role in the reinforcing
91 e lateral hypothalamic area (LHA) to ventral tegmental area (VTA) projection is an important neural p
93 e peptide-1 (GLP-1) receptors in the ventral tegmental area (VTA) reduces intake of highly palatable
94 inhibitor of dopamine neurons in the ventral tegmental area (VTA) reported to influence neurobiologic
95 mediated expression of GIRK3 in the ventral tegmental area (VTA) reversed the phenotype of GIRK3 KO
96 exposed to amphetamine IP or in the ventral tegmental area (VTA) showed a sensitized locomotor respo
97 mPOA neurons that interface with the ventral tegmental area (VTA) to form a socially engaged reward c
98 E STATEMENT Dopaminergic inputs from ventral tegmental area (VTA) to striatum encode reward predictio
99 nergic neurons that project from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) fire
100 basal ganglia, substantia nigra, and ventral tegmental area (VTA) where they regulate firing patterns
101 OP receptor function in the midbrain ventral tegmental area (VTA) which contains dopaminergic neurons
102 fied dopamine neurons in the lateral ventral tegmental area (VTA) while mice performed classical cond
103 identified in situ in slices of rat ventral tegmental area (VTA) with MAPK activation and two additi
104 of inhibitory synapses in the adult ventral tegmental area (VTA), a brain region important for the p
105 e that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward c
108 antia nigra pars compacta (SNpc) and ventral tegmental area (VTA), and compared these findings with c
109 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocain
111 brain DA neurons are impaired in the ventral tegmental area (VTA), but not in the substantia nigra (S
112 ong-acting antagonist nor-BNI in the ventral tegmental area (VTA), but not the infralimbic prefrontal
113 the lateral hypothalamus (LH) to the ventral tegmental area (VTA), containing both GABAergic and glut
115 elated positively with volume of the ventral tegmental area (VTA), habenula, periaqueductal gray, cer
116 f cocaine reduced p-eIF2alpha in the ventral tegmental area (VTA), potentiated synaptic inputs to VTA
118 onto substance P (SP) neurons in the ventral tegmental area (VTA), subsequently increasing SP release
119 pathways, with strong projections to ventral tegmental area (VTA), subthalamic nucleus (STN), lateral
120 oss in the substantia nigra (SN) and ventral tegmental area (VTA), supporting an important function o
121 activity of dopamine neurons in the ventral tegmental area (VTA), that may also influence drug rewar
122 d significant hypoactivations of the ventral tegmental area (VTA), the bilateral striatum and bilater
123 od vs non-food visual stimuli in the ventral tegmental area (VTA), the origin of the mesolimbic dopam
124 trary, the ontogeny of inputs to the ventral tegmental area (VTA), the source of mesocorticolimbic do
125 to glutamate neurons of the midbrain ventral tegmental area (VTA), where Cbln1 deletions impair socia
126 urons projecting from the LHA to the ventral tegmental area (VTA), which may affect dopamine signalin
127 ine (DA) signaling originates in the ventral tegmental area (VTA), which sends afferents to various t
128 GABA) ), which densely innervate the ventral tegmental area (VTA), with modulation of food reward and
129 riptional alterations that prime the ventral tegmental area (VTA)-a brain reward region-to be in a de
130 revealed that activity dynamics of a ventral tegmental area (VTA)-to-nucleus accumbens (NAc) projecti
156 l midbrain structures, including the ventral tegmental area and hindbrain structures such as the locu
159 ic neuronal activity measured in the ventral tegmental area and psychotomimetic behavioral analyses.
160 loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor ort
161 h as substantia nigra pars compacta, ventral tegmental area and retrorubal field, that regulate motor
163 erging: it includes afferents to the ventral tegmental area and substantia nigra; the dopamine system
164 te firing of dopamine neurons in the ventral tegmental area and to increase dopamine levels in the nu
165 subthalamic nucleus and also to the ventral tegmental area are necessary for these forms of reinstat
166 he firing of dopamine neurons in rat ventral tegmental area at the time of reward are sufficient to m
167 actions between the substantia nigra/ventral tegmental area complex (SN/VTA) and the hippocampus.
169 adache attacks underwent ipsilateral ventral tegmental area deep brain stimulation in a specialist un
170 ries of 11 new patients treated with ventral tegmental area deep brain stimulation in an uncontrolled
172 alian hippocampus and neurons of the ventral tegmental area defined by both genetic and wiring proper
173 Optogenetic manipulation of the ventral tegmental area demonstrates that the experience-dependen
174 frontal cortex (vmPFC) inversely and ventral tegmental area directly track the gradient of perceptual
176 tudy demonstrates that activation of ventral tegmental area dopamine neurons during sexual experience
177 ing appreciation for diversity among ventral tegmental area dopamine neurons, much less is known rega
179 ophysiological recordings first from ventral tegmental area dopaminergic (DA) neurons and second from
180 n part from dysregulated activity of ventral tegmental area dopaminergic (TH(VTA)) neurons, as well a
181 excitatory synaptic transmission in ventral tegmental area dopaminergic neurons more readily in adol
183 neuroplastic changes observed in the ventral tegmental area following benzodiazepine administration.
184 Preventing dopamine neurons in the ventral tegmental area from firing for 5 s beginning before and
185 Finally, bilaterally stimulating ventral tegmental area GABA neurons dramatically reduces anticip
186 ompacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson disease (PD); the specific a
189 ly explain in vivo observations that ventral tegmental area neurons exhibit longer aversive pauses re
190 ations from in vivo experiments that ventral tegmental area neurons tend to exhibit longer aversive p
191 ing, operating at the level of local ventral tegmental area neurons, MORs also moderate motivation fo
192 ntine into the nucleus accumbens and ventral tegmental area of control mice, and a rescue of the muta
195 ss magnetothermal stimulation in the ventral tegmental area of mice evoked excitation in subpopulatio
196 fied dopamine neurons in the lateral ventral tegmental area of mice respond to aversive events in dif
198 uclei of the dorsal thalamus and the ventral tegmental area of the midbrain, as well as a major expan
199 igra pars compacta (SNc), but not in ventral tegmental area or substantia nigra pars lateralis, consi
201 aviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens.
202 e substantia nigra pars compacta and ventral tegmental area regulate behaviours such as reward-relate
203 e substantia nigra pars compacta and ventral tegmental area regulate extrapyramidal movement and impo
205 ma-aminobutyric acid) neurons in the ventral tegmental area reveals that these neurons are a source o
206 e in either the nucleus accumbens or ventral tegmental area selectively decreased dependent, excessiv
207 ychosocial stress may be mediated by ventral tegmental area signaling molecules independent of brain-
209 neurons project more profusely than ventral tegmental area TH(+) neurons to the hippocampus, optogen
210 dopaminergic neurons located in the ventral tegmental area that expresses the basic helix-loop-helix
211 duced effects on GABA release in the ventral tegmental area that were not due to changes in drug pote
212 , the dopaminergic pathways from the ventral tegmental area to the rostral and caudal regions of the
214 T) and dopamine (DA) activity in the ventral tegmental area using in vivo electrophysiological record
215 posterior SNpc, locus coeruleus, and ventral tegmental area were determined, and normalized neuromela
216 with extracellular recordings in the ventral tegmental area while mice engaged in classical condition
218 apses within dopamine neurons of the ventral tegmental area, a key region for a broad range of motiva
219 electrophysiology recordings in the ventral tegmental area, and molecular analyses to characterize t
220 nal connectivity of dorsal striatum, ventral tegmental area, and precuneus with frontal, visual, sens
221 en systemically or directly into the ventral tegmental area, attenuates the ability of cocaine to ele
222 central nucleus of the amygdala, and ventral tegmental area, consistent with the view that brain rewa
223 his region, now understood to be the ventral tegmental area, for this disorder are limited to a total
224 ncompassing the substantia nigra and ventral tegmental area, in 18 daily smokers (7 women, 11 men) an
226 e mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal
227 r terminals in the substantia nigra, ventral tegmental area, periaqueductal gray, parabrachial nucleu
228 e hypothalamus and reward circuitry (ventral tegmental area, prefrontal cortex, and nucleus accumbens
229 olved in the control of food intake (ventral tegmental area, striatum, hypothalamus, and thalamus), w
230 he interpeduncular nucleus, the rostromedial tegmental area, the rhabdoid nucleus, the mesencephalic
231 also increased TrkB signaling in the ventral tegmental area, where the dopaminergic projections origi
232 bstantia nigra pars compacta and the ventral tegmental area, which form the nigrostriatal, mesolimbic
233 d was mediated by projections to the ventral tegmental area, which is consistent with an aversive "te
249 ional connectivity of the PCC to the ventral tegmental area/pontine reticular formation and thalamus,
250 In addition, response to value in ventral tegmental area/substantia nigra (VTA/SN) shows context-s
256 the pedunculopontine (PPN) and laterodorsal tegmental (LDT) nuclei indirectly influence the activity
257 the pedunculopontine (PPT) and laterodorsal tegmental (LTD) nuclei of the mesopontine tegmentum (MPT
258 luding the pedunculopontine and laterodorsal tegmental nuclei (PPN and LDT), provides major cholinerg
261 type is highly expressed in the laterodorsal tegmental nucleus (LDTg), a brainstem cholinergic center
262 lated that amylin acts in the lateral dorsal tegmental nucleus (LDTg), an understudied neural process
263 l forebrain bundle (MFB) or pedunculopontine tegmental nucleus (PPTg) activation of VTA inputs to the
266 focused on activity in the pedunculopontine tegmental nucleus (PPTg), a mesencephalic region that pr
267 pVTA, and the newly recognized rostromedial tegmental nucleus (RMTg) are similarly or differently or
271 he ventral tegmental area (VTA)/rostromedial tegmental nucleus (RMTg) regions were activated by perip
272 ion of GABAergic neurons in the rostromedial tegmental nucleus (RMTg), a region that receives dense p
274 entral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg), which contain gamma-aminobutyr
275 s, is mediated by the GABAergic rostromedial tegmental nucleus (RMTg), which strongly innervates dopa
279 support a critical role for pedunculopontine tegmental nucleus glutamate neurotransmission in modulat
280 .SIGNIFICANCE STATEMENT The pedunculopontine tegmental nucleus is the source of cholinergic innervati
281 cholinergic nuclei and a large laterodorsal tegmental nucleus of the pons that has both parvocellula
283 ics to demonstrate that the pedunculopontine tegmental nucleus sends glutamatergic projections to VTA
284 al area (tVTA), also called the rostromedial tegmental nucleus, are important for behavioral response
285 this inhibition occurs via the rostromedial tegmental nucleus, but this hypothesis has yet to be tes
286 ula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transm
287 periventriculare of the optic tectum, dorsal tegmental nucleus, granular regions of the cerebellar bo
288 Ca(2+) imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neur
293 dial cholinergic neurons in the laterodorsal tegmental nucleus; lateral noradrenergic neurons in the
296 al optic tectum arises instead from a nearby tegmental region that receives input from the ipsilatera
297 GABA-sensitive cell cluster is centered on a tegmental (reticular) field traversed by fibers of the s
298 the red nucleus; the location of the central tegmental tract; and the region of the inferior olive.
299 t KOR activation of p38alpha MAPK in ventral tegmental (VTA) dopaminergic neurons was required for co
300 the evoked release of dopamine from ventral tegmental (VTA) synaptic inputs to the nucleus accumbens
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