ライフサイエンスコーパス: tegument protein

1 H), ORF25 (major capsid protein) and ORF64 (tegument protein).

2 ding partner of the membrane-associated UL11 tegument protein.

3 67 tegument proteins, but virtually no ORF45 tegument protein.

4 portant, conserved enzymatic function of the tegument protein.

5 fficking, and interaction with UL16, another tegument protein.

6 This protein is also present in virions as a tegument protein.

7 for its inclusion as an abundant VZV virion tegument protein.

8 her the VP26 capsid protein or an individual tegument protein.

9 family and has been suggested to be a virion tegument protein.

10 ivity of the viral virion host shutoff (vhs) tegument protein.

11 th purified KSHV virions and appears to be a tegument protein.

12 ely due to its roles in virion assembly as a tegument protein.

13 hat a late 3.1 kb mRNA encodes a 130 kDa M25 tegument protein.

14 a gammaherpesvirus-specific immediate-early tegument protein.

15 y shrouding the pentons that we attribute to tegument proteins.

16 carboxyl termini of viral glycoproteins and tegument proteins.

17 iated with capsids, features common to inner tegument proteins.

18 Many interactions were detected among the tegument proteins.

19 s interactions with other viral packaging or tegument proteins.

20 rvations illustrated important properties of tegument proteins.

21 orms, as has been reported for several other tegument proteins.

22 east pp28 in virions and possibly additional tegument proteins.

23 ed subsequent entry into axons of capsid and tegument proteins.

24 high binding affinities to epitopes in HSV-2 tegument proteins.

25 Epstein-Barr virus (EBV) BPLF1 encodes a tegument protein (3,149 amino acids) that exhibits deubi

26 the herpesviridae contain within their large tegument protein a cysteine protease module that display

27 There results indicate that ORF52 is a tegument protein abundantly present in extracellular vir

28 Capsids, coated with tegument proteins, accumulate in the cytoplasm of mutant

29 Sequence alignment of the large tegument proteins across the family Herpesviridae indica

30 SV proteome, we observed that the HSV U(L)37 tegument protein activates NF-kappaB signaling in a TLR2

31 us; 2) the underlying capsid with associated tegument proteins along with fragments of the membrane;

32 After budding into the TGN, capsid and tegument proteins also encounter an oxidizing environmen

33 e most frequently recognized L Ag, the BNRF1 tegument protein, also recognized latently infected, gro

34 (KSHV) is an immediate-early phosphorylated tegument protein and has been shown to play important ro

35 the predominant virion protein was the pp65 tegument protein and that gM rather than gB was the most

36 also revealed redundant interactions between tegument proteins and envelope glycoproteins.

37 ore, genes encoding latent, early lytic, and tegument proteins and glycoproteins were found to contai

38 ameliorated by adding human cytomegalovirus tegument proteins and immediate-early protein 1.

39 the U(L)49 gene, is one of the most abundant tegument proteins and is conserved among the alphaherpes

40 rame 9 (ORF9) to ORF12 encodes four putative tegument proteins and is highly conserved in most alphah

41 teins, including 13 novel interactions among tegument proteins and one novel interaction between caps

42 lieved to involve interactions between outer tegument proteins and the cytoplasmic domains of envelop

43 ions between viral nucleocapsids coated with tegument proteins and the cytoplasmic domains of membran

44 rotein coprecipitated with the UL48 and UL69 tegument proteins and the UL86-encoded major capsid prot

45 prehensive investigation of the functions of tegument proteins and their roles in viral replication m

46 ot due to inefficient virus entry, since two tegument proteins and viral DNA moved to the nucleus equ

47 ream of ORF70 (thymidylate synthase), ORF19 (tegument protein), and ORF47 (glycoprotein L) uncovered

48 UL23 (thymidine kinase), UL25 (DNA packaging tegument protein), and UL52 (helicase-primase primase su

49 Actin was also a major tegument protein, and cofilin, tubulin, heat shock prote

50 proteins, eight envelope glycoproteins, six tegument proteins, and five proteins whose locations in

51 mpared with production of antibodies against tegument proteins, and this likely reduces the control o

52 transport never occurred without associated tegument proteins, anterograde-specific tegument protein

53 boxy-terminal amino acids of the VP1/2 large tegument protein are essential for viral propagation and

54 protein interactions involving virus-encoded tegument proteins are critical for virus assembly and ar

55 However, several tegument proteins are known to be essential for proper p

56 n which the homologues of all three of these tegument proteins are not incorporated into the virion u

57 s, for the first time, how capsid-associated tegument proteins are organized in a gammaherpesvirus, w

58 Several of the major tegument proteins are phosphoproteins (pp), including pp

59 As no other tegument proteins are retained in significant amounts, i

60 ellular localization patterns of other HSV-1 tegument proteins are similar to that observed with VP22

61 The functions of most tegument proteins are still poorly understood.

62 n living neurons, we demonstrate that viral "tegument" proteins are complexed to capsids moving in ax

63 e 52 (ORF52), a multifunctional and abundant tegument protein, as being the only virally encoded comp

64 , we show that the viral protein 1/2 (VP1/2) tegument protein associates with the dynein/dynactin mic

65 (HSV) capsid docks at the nuclear pore, the tegument protein attached to the capsid must be cleaved

66 protease domain embedded within their large tegument protein, based on homology with the correspondi

67 In summary, the EBV tegument protein BGLF2, which is delivered to the cell a

68 We identified a viral tegument protein, BGLF2, which activates members of the

69 Here, we demonstrate that the EBV tegument protein BNRF1 binds the histone H3.3 chaperone

70 We show that the EBV tegument protein BNRF1 functions to regulate chromatin a

71 We propose that EBV tegument protein BNRF1 replaces ATRX to reprogram Daxx-m

72 We report that EBV tegument protein BNRF1, discovered by other investigator

73 iminate envelope-anchored glycoproteins from tegument proteins, both in purified virions and in virio

74 ed to bind directly to the capsid with other tegument proteins bound indirectly by way of UL36.

75 A herpes simplex virus tegument protein brought into the cell during infection

76 nd to the virion nucleocapsid than the ORF45 tegument protein but could be dissociated from particles

77 nserved capsid proteins, the ORF64 and ORF67 tegument proteins, but virtually no ORF45 tegument prote

78 a prominent betaherpesvirus-conserved virion tegument protein, called pp150 (basic phosphoprotein/ppU

79 Certain tegument proteins can also regulate viral processes.

80 We propose that the hypophosphorylation of tegument proteins causes their destabilization within ne

81 found that MHV-68 ORF52 encodes an abundant tegument protein conserved among gammaherpesviruses.

82 We find that HCMV virion binding and tegument protein delivery are insufficient for HCMV-medi

83 Simultaneous tracking of capsids and tegument proteins demonstrated that the composition of a

84 abolishes the USP activity of the MDV large tegument protein diminishes MDV replication in vivo, and

85 el of viral bidirectional transport in which tegument proteins direct capsid traffic to specific intr

86 a hub protein and play a role in recruiting tegument proteins during tegumentation and virion assemb

87 , little is known about the function of many tegument proteins during virus replication.

88 ol, the role in VZV replication of the major tegument protein encoded by ORF9 was investigated.

89 For example, the pp71 tegument protein encoded by the UL82 gene of human cytom

90 Putative tegument proteins encoded by open reading frame 21 (ORF2

91 The tegument proteins encoded by ORF11 and ORF9 of varicella

92 subset of viral glycoproteins, capsids, and tegument proteins enter and localize to the axon ineffic

93 d but lacking a membrane and depleted of all tegument proteins except UL36 and a second high-molecula

94 Whether and how such tegument proteins exist in gammaherpesviruses have been

95 The removal of a subset of tegument proteins from capsids invariably preceded retro

96 Here we focus on two tegument proteins from herpes simplex virus 1 (HSV-1), p

97 Our study focuses on two tegument proteins from herpes simplex virus 1 that are c

98 lease are blocked in mutants deleted for the tegument protein gene UL36 or UL37, leading to the accum

99 However, no such tegument proteins have been identified for gammaherpesvi

100 Capsid-associated tegument proteins have been identified in alpha- and bet

101 Several capsid-associated tegument proteins have been identified in the alpha- and

102 Thus, these inner tegument proteins have differing functions, with pUL36 b

103 Tegument proteins have important roles in assembling vir

104 cytomegalovirus (HCMV) high-molecular-weight tegument protein (HMWP, pUL48; 253 kDa) and the HMWP-bin

105 Five nucleocapsid protein homologues, the tegument protein homologue encoded by open reading frame

106 d provide evidence for a direct role of this tegument protein in the late stages of assembly, such as

107 ted in particles that contained six distinct tegument proteins in addition to the expected capsid str

108 Systematic exploration of the roles of tegument proteins in capsid trafficking requires detaile

109 the U(L)49 gene, is one of the most abundant tegument proteins in HSV-1 virions.

110 mplex formation with IE62 and possibly other tegument proteins in the cytoplasm at late times in infe

111 and packaged through interactions with other tegument proteins in the cytoplasm or viral envelope pro

112 mensional structure of the capsid-associated tegument proteins in the prototypical member of gammaher

113 ORF64 was found to interact with several tegument proteins including ORF11, ORF21, ORF33, ORF45,

114 providing a flexible scaffold to which other tegument proteins, including UL37, bind.

115 As might be expected for a tegument protein, interactions were identified that sugg

116 The incorporation of tegument proteins into the herpes simplex virus 1 (HSV-1

117 support the notion that the incorporation of tegument proteins into the herpesviruses is a very compl

118 PTAP motif within pp150/ppUL32, an essential tegument protein involved in the last steps of viral mat

119 eins required for cellular entry, as well as tegument proteins involved in regulating lytic replicati

120 entities of viral membrane glycoproteins and tegument proteins involved in these processes are not we

121 The VP1/2 tegument protein is critical for the propagation of all

122 sly shown that the virion host shutoff (Vhs) tegument protein is largely insoluble in HSV-infected ce

123 xpression and localization of MDV pUL47-EGFP tegument protein is potentially important for the unique

124 We demonstrate that the VP1/2 tegument protein is required for processive microtubule-

125 ral mutants, which showed that each of these tegument proteins is critical for processing, transport,

126 t the organization of KSHV capsid-associated tegument proteins is highly similar to that in alphaherp

127 Through its interactions with pUL47, another tegument protein, it spares from degradation viral mRNAs

128 Hence, these tegument proteins join a growing number of proteins that

129 gG responses were frequently detected to the tegument proteins KSHV ORF38 and EBV BBRF and BGLF2 and

130 first time that these conserved herpesvirus tegument proteins localize to focal adhesions in additio

131 s of both the major capsid protein (M86) and tegument protein M25 were reduced in the absence of the

132 on and extends our understanding of the HCMV tegument protein network that is required to interface t

133 ne gammaherpesvirus 68, ORF52 is an abundant tegument protein of 135 residues that is required for th

134 VP22, a tegument protein of bovine herpesvirus 1, accumulates in

135 The UL16 tegument protein of herpes simplex virus (HSV) is conser

136 UL16 is a tegument protein of herpes simplex virus (HSV) that is c

137 The UL16 tegument protein of herpes simplex virus 1 (HSV-1) is co

138 d as a protease domain embedded in the large tegument protein of herpes simplex virus 1 (HSV-1), is c

139 The largest tegument protein of herpes simplex virus 1 (HSV-1), UL36

140 the UL36 gene product, the largest (3164 aa) tegument protein of herpes simplex virus 1 (HSV-1).

141 The UL16 tegument protein of herpes simplex virus is conserved th

142 The UL11 tegument protein of herpes simplex virus plays a critica

143 sly shown that ORF45, an immediate-early and tegument protein of Kaposi's sarcoma-associated herpesvi

144 vity-based profiling, we show that the large tegument protein of murine gammaherpesvirus (MHV-68) ORF

145 The ORF75c tegument protein of murine gammaherpesvirus 68 (MHV68) p

146 a KSHV immediate-early protein as well as a tegument protein of virions, interacts with IRF-7 and in

147 The UL11 and UL16 tegument proteins of herpes simplex virus are conserved

148 Tegument proteins of herpes simplex virus type 1 (HSV-1)

149 The tegument proteins of herpesviruses, including Kaposi's s

150 One of the most abundant tegument proteins of HSV-1 is the U(L)49 gene product, V

151 UL46 is one of the most abundant tegument proteins of HSV-1, but a well-established funct

152 Transient expression of the viral tegument proteins of pp71 and UL26 reduced NICD1 and Jag

153 se (DUB) activity, embedded within the large tegument protein open reading frame (ORF)64, gained the

154 may provide flexibility in interacting with tegument proteins or the DNA-packaging machinery at the

155 posi's sarcoma-associated herpesvirus (KSHV) tegument proteins ORF33 and ORF45 is crucial for progeny

156 , we show that the gammaherpesvirus-specific tegument protein ORF52 is critical for maturation of RRV

157 tease (USP) domain embedded within the large tegument protein ORF64, as do all other herpesviruses.

158 d PML degradation was mediated by the virion tegument protein ORF75c, which shares homology with the

159 Tegument proteins play both structural and regulatory fu

160 These tegument proteins play essential roles in viral propagat

161 Viral tegument proteins play important roles in maintaining th

162 The HCMV virion tegument protein pp150 (ppUL32) is an essential protein

163 ) of infected cells co-localizing with virus tegument protein pp150 and the formation of vAC was comp

164 P, Tri1, Tri2, and SCP and the HCMV-specific tegument protein pp150-totaling 4000 molecules and 62 d

165 Tegument proteins pp150 and pUL96 function at a late ste

166 pecifically interact with RNA, including the tegument protein pp28, were found within HCMV virions.

167 g trafficking to the AC of another essential tegument protein, pp28, or the viral glycoprotein comple

168 reading frame encodes a 190-amino-acid (aa) tegument protein, pp28, that is myristoylated and phosph

169 virus requires the function of at least one tegument protein, pp28, the product of the UL99 open rea

170 he deletion of IE2 40, and expression of the tegument protein pp65 (ppUL83) is affected by the deleti

171 seen in the absence of the immunomodulatory tegument protein pp65 (pUL83).

172 Localization of the major tegument protein pp65 (UL83) is also altered in these p5

173 he aggregates were formed principally of the tegument proteins pp65 and ppUL25 but also contained add

174 ents an antagonistic effect of the main HCMV tegument protein, pp65, on NKp30, a natural cytotoxicity

175 we demonstrate that the HCMV transactivator tegument protein pp71 accumulates at ND10 before the pro

176 s (HCMV) immediate early protein IE1 and the tegument protein pp71 are required for efficient infecti

177 The human cytomegalovirus tegument protein pp71 is important for transactivation o

178 The human cytomegalovirus tegument protein pp71 is the product of the UL82 gene.

179 E protein IE1 targets PML and Sp100, and its tegument protein pp71 targets hDaxx and ATRX.

180 Tegument protein pp71 was cytoplasmic, and immediate-ear

181 start of lytic infection by the HCMV virion tegument protein pp71, which upon viral entry traffics t

182 In contrast, the expression of the tegument protein ppUL69 was higher in drug-treated sampl

183 The human cytomegalovirus tegument protein, pTRS1, appears to function at several

184 d the conserved, multifunctional HCMV virion tegument protein pUL103 as important for cVAC biogenesis

185 We previously showed that the HCMV tegument protein pUL103 is required for cVAC biogenesis.

186 capsid protein pUL25 and the capsid-tethered tegument protein pUL36.

187 oteins, pUL17 and pUL25, and the large inner tegument protein pUL36.

188 cruited to HSV-1 capsids by the capsid-bound tegument protein pUL37 to promote efficient cytoplasmic

189 ons in the genes for pUL36 and another inner tegument protein, pUL37, to analyze the contributions of

190 cent protein (EGFP) to the C terminus of the tegument protein pUL47 (vUL47-EGFP) or pUL49 (vUL49-EGFP

191 lex in infected cells with another conserved tegument protein, pUL7.

192 The HCMV tegument protein pUL83 inhibits this response by interac

193 The virion host shutoff (VHS) RNase tegument protein released into cells by infecting virus

194 How alphaherpesvirus capsids acquire tegument proteins remains a key question in viral assemb

195 intense investigation, the function of many tegument proteins remains unknown.

196 rus (HCMV) UL99-encoded pp28 is an essential tegument protein required for envelopment and production

197 re--the first for any alphaherpesvirus inner tegument protein--reveals an elongated molecule of a com

198 new protein-protein interactions among HCMV tegument proteins, some of which are likely important fo

199 During primary infection, tegument protein-specific B cells expressed an activated

200 h and similar frequencies of gB-specific and tegument protein-specific B cells following primary HCMV

201 equency and the phenotype of gB-specific and tegument protein-specific B cells were studied in a coho

202 This screening demonstrates that EBV LF2 tegument protein specifically interacts with the central

203 ORF52, an abundant gammaherpesvirus-specific tegument protein, subverts cytosolic DNA sensing by dire

204 ail, virion packaging of UL11, but not other tegument proteins such as VP22 and VP16, was reduced by

205 ding genes encoding latent, early lytic, and tegument proteins, such as substitutions within transmem

206 the incorporation of ORF45, as well as other tegument proteins, suggesting that ORF52 is important fo

207 By using viruses expressing tegument proteins tagged with fluorescent proteins, we p

208 plex virus type 1 (HSV-1) is a 96-amino-acid tegument protein that accumulates on the cytoplasmic fac

209 A second tegument protein that binds to VP1/2, UL37, was necessar

210 0) of varicella-zoster virus (VZV) encodes a tegument protein that enhances transactivation of VZV ge

211 have now revealed this species to be UL21, a tegument protein that has been implicated in the transpo

212 gammaherpesvirus 68 (MHV68), which encodes a tegument protein that induces PML degradation.

213 ific mAb for VZV ORF9, a membrane-associated tegument protein that interacts with glycoprotein E (gE)

214 consistent with an enzymatic function of the tegument protein that is beneficial to the virus during

215 Human cytomegalovirus UL103 encodes a tegument protein that is conserved across herpesvirus su

216 ng event was found during studies of UL16, a tegument protein that is conserved among all the herpesv

217 Activation of NF-kappaB by a virion tegument protein that is delivered into the host cell cy

218 We demonstrate here that UL94 is a tegument protein that is expressed with true-late kineti

219 simplex virus type 1 encodes a 96-amino-acid tegument protein that is myristylated, palmitylated, and

220 herpesvirus (KSHV) is an immediate-early and tegument protein that plays critical roles in antagonizi

221 pp150 is a capsid-proximal tegument protein that preserves the integrity of nucleoc

222 ral other IE gene products as well as virion tegument proteins that act early during infection to pre

223 Furthermore, viruses lacking tegument proteins that are nonessential for virus propag

224 mechanism of reactivation in the absence of tegument proteins that enable gene expression in product

225 irst steps toward elucidating the network of tegument proteins that UL11 links to membranes.

226 t by similar antibodies specific for UL37 (a tegument protein), the major capsid protein (VP5), or VP

227 Of the five gammaherpesvirus-specific tegument proteins, three have no known function.

228 ated herpesvirus, ORF52 is a highly abundant tegument protein tightly associated with the capsid.

229 P1/2 carboxy terminus is to anchor the VP1/2 tegument protein to capsids.

230 elopment and that it interacts with the UL37 tegument protein to facilitate cytoplasmic virion envelo

231 systematically evaluated the ability of KSHV tegument proteins to modulate the activation of an integ

232 s function of gE requires the cooperation of tegument proteins UL11, UL16, and UL21.

233 a protein similar to alpha-herpesvirus minor tegument protein UL14 with heat shock functions.

234 The HSV-1-encoded tegument protein UL16 is involved in multiple events of

235 Tegument proteins UL16 and UL11 of herpes simplex virus

236 ise, the steady-state level of the essential tegument protein UL32 (pp150) was reduced.

237 The tegument proteins UL36 and UL37 are known to be transpor

238 Here we report that the large tegument protein UL36p is essential for this trafficking

239 Inner tegument protein UL37 is conserved among all three subfa

240 detected by the colocalization of the virion tegument protein UL37, with dynein required for loading

241 ucture of the N-terminal half of a conserved tegument protein, UL37, from HSV-1.

242 rpesviruses, two capsid-associated, or inner tegument, proteins, UL37 and UL36, control cytosolic tra

243 s gD and gB and the novel T cell antigen and tegument protein UL40, and we compared this vaccine to a

244 We found that (i) HSV-1 tegument protein UL46 interacts with and colocalizes wit

245 ne of the least-studied proteins of HSV, the tegument protein UL46, and that function involves the ev

246 l proteins interacting with PABPC1 including tegument protein UL47 and infected-cell protein ICP27.

247 The human cytomegalovirus tegument protein UL69 has been shown to be required for

248 The human cytomegalovirus (HCMV) tegument protein UL69 is important for efficient viral r

249 rated that UL99 interacts with the essential tegument protein UL94 in infected cells as well as in th

250 ic assembly complex shows that the essential tegument protein UL99 (pp28) exhibits aberrant localizat

251 The HCMV tegument protein UL99 (pp28) is essential for viral repl

252 ionally, a deletion of the gene encoding the tegument protein Vhs ablated most of the depletion of AT

253 The herpes simplex virus (HSV) tegument protein VP1-2 contains an N-terminal nuclear lo

254 e of the herpes simplex virus type 1 (HSV-1) tegument protein VP1-2 originated from the analysis of t

255 (ii) The tegument protein VP1-2, the product of the U(L)36 gene,

256 enuated by antibodies specific for the viral tegument protein VP1/2 (UL36 gene) but not by similar an

257 the direct interaction between two essential tegument proteins VP1/2 and VP16 is required for connect

258 major HSV-1 capsid protein VP5; and the HSV tegument proteins VP11/12 (pU(L)46) and VP13/14 (pU(L)47

259 fic to three epitopes derived from the HSV-1 tegument protein VP13/14 (VP13/14286-294,VP13/14504-512,

260 cytoplasmic localization, whereas the major tegument protein VP13/14 localizes to nuclear replicatio

261 nity and UL19 (capsid protein VP5) and UL47 (tegument protein VP13/14) as T cell immunogens.

262 munogens UL19 (capsid protein VP5) and UL47 (tegument protein VP13/14) would enhance the protection p

263 We observed that tegument proteins VP13/14, vhs, and VP16 localized to th

264 s indicate that the nuclear localizations of tegument proteins VP13/14, VP16, and vhs do not appear t

265 microscopy was used to determine whether the tegument proteins VP13/14, VP22, and VP16 of herpes simp

266 t with this model, we previously showed that tegument protein VP16 can specifically interact with the

267 ents and fluorescence detection of the HSV-1 tegument protein VP16 were used to analyze the mechanism

268 Nuclear transport of the viral tegument protein VP16, transport of viral capsids to the

269 viral particles contained normal amounts of tegument proteins VP16, vhs, and VP22, they displayed a

270 d analysis of the radial distribution of the tegument proteins VP16, VP1/2 and pUL37, and envelope pr

271 ansfected with plasmids expressing two other tegument proteins, VP16 and VP22.

272 We demonstrate that the tegument protein VP22 bridges a complex between glycopro

273 Herpesvirus tegument protein VP22 can enhance the effect of therapeu

274 s, we previously demonstrated that the major tegument protein VP22 exhibits a cytoplasmic localizatio

275 The role of the herpes simplex virus tegument protein VP22 is not yet known.

276 However, levels of the tegument protein VP22 were also dramatically reduced in

277 relates with the nuclear localization of the tegument protein VP22.

278 orporation is a specific event requiring the tegument protein VP22.

279 ts of the gE CT domain were used to identify tegument proteins VP22 and UL11 as binding partners, and

280 hown that the two major herpes simplex virus tegument proteins VP22 and VP16 are able to interact, al

281 We identified most capsid proteins, a tegument protein (VP22), a glycoprotein (gD), and a cell

282 The ORF64-encoded large tegument protein was found to be associated with capsid

283 while expression of the nonglycosylated IE62 tegument protein was unchanged.

284 en tegument and envelope proteins, and among tegument proteins was tested for possible binary interac

285 Using 33 known capsid and tegument proteins, we tested 1,089 pairwise combinations

286 Virions lacking the M25 tegument protein were of smaller size because the tegume

287 d that although wild-type levels of the pp28 tegument protein were present in UL26 deletion mutant vi

288 virus 8 replication and uptake of the ORF45 tegument protein were tested in human retinal pigment ep

289 ated tegument proteins, anterograde-specific tegument proteins were competent to travel to the distal

290 In addition, several tegument proteins were found in high-molecular-weight co

291 ons, the UL99-coded pp28 and UL83-coded pp65 tegument proteins were present in reduced amounts at the

292 These results indicate that a viral tegument protein which is delivered to cells upon infect

293 unknown but are expected to be either viral tegument proteins, which are a group of capsid-associate

294 implex virus 1 UL11 and cytomegalovirus UL99 tegument proteins, which are involved in the final envel

295 IG-I)-deficient cells and that KSHV ORF64, a tegument protein with deubiqutinase (DUB) activity, supp

296 virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and

297 to regulate not just the interaction of this tegument protein with its viral binding partners but als

298 s report, we further characterize ORF52 as a tegument protein with vital roles during KSHV lytic repl

299 ruses (alpha, beta, and gamma) encode unique tegument proteins with specialized functions.

300 e viruses is controlled by capsid-associated tegument proteins, yet their specific roles have not yet