ライフサイエンスコーパス: teichoic acid

1 lycan) and lipid III (precursor of cell wall teichoic acid).

2 cine (concentrations of cross-links and wall teichoic acids).

3 D-alanyl ester residues between LTA and wall teichoic acid.

4 ntity of capsular polysaccharide rather than teichoic acid.

5 arked reduction in the amounts of glucose on teichoic acid.

6 m with less capsular polysaccharide and more teichoic acid.

7 paring the incorporation of [3H]choline into teichoic acid.

8 s due to differences in cell wall-associated teichoic acid.

9 e had 2.1- to 3.8-fold more immunodetectable teichoic acid.

10 lently bound to the phosphorylcholine of the teichoic acid.

11 to the septum in a manner dependent on wall teichoic acid.

12 peptidoglycan and a covalently attached wall teichoic acid.

13 ocess of choline decoration of S. pneumoniae teichoic acid.

14 n hydrolase and decreased expression of wall-teichoic acids.

15 the dlt operon controlling d-alanylation of teichoic acids.

16 tive system responsible for D-alanylation of teichoic acids.

17 hree-component conjugates in which cell wall teichoic acid (a common antigen capable of T cell activa

18 bone of the partially glycosylated cell wall teichoic acid, a minor Ldb17 cell envelope component.

19 dification of N-acetylmuramic acid with wall teichoic acid, a ribitol-phosphate polymer tethered to m

20 combinant GP12 using chemically defined wall teichoic acid analogs.

21 m with more capsular polysaccharide and less teichoic acid and an avirulent form with less capsular p

22 hosphorylcholine residues from the cell wall teichoic acid and lipoteichoic acid.

23 Teichoic acids and acidic capsular polysaccharides are m

24 toxic as 16:1Delta9 in a strain lacking wall teichoic acids and led to growth arrest and enhanced rel

25 lower amounts of C polysaccharide (cell wall teichoic acid) and in this study were shown to have a hi

26 ein), ywnJ, the dlt operon (D-alanylation of teichoic acids), and the pss ybfM psd operon (phosphatid

27 the synthesis of cell wall anionic polymer, teichoic acid, and teichuronic acid, respectively, in Ba

28 ppendages to the phage, digest the cell wall teichoic acids, and bind irreversibly to the host, respe

29 ynthesis, reduction of ester-linked D-Ala in teichoic acids, and reduction of peptidoglycan cross-lin

30 change in the structure and/or metabolism of teichoic acids appears to be an important component of t

31 Unique to Gram-positive bacteria, wall teichoic acids are anionic glycopolymers cross-stitched

32 Wall teichoic acids are cell wall polymers that maintain the

33 polysaccharide did not affect the amount of teichoic acid as measured by a capture enzyme-linked imm

34 sal colonization have implicated capsule and teichoic acid as staphylococcal surface factors that pro

35 pecies Listeria innocua was found to express teichoic acid-associated surface antigens that were othe

36 fective in the synthesis of polyribitol wall teichoic acid attached to the cell wall envelope, displa

37 can modification, and choline-mediated (lipo)teichoic-acid attachment contribute to the high selectiv

38 ross-reactive opsonic antibodies bind to the teichoic acid backbone.

39 al inhibition of both peptidoglycan and wall teichoic acid biosyntheses in S. aureus.

40 The demonstration of regulated wall teichoic acid biosynthesis has implications for cell env

41 catalyzes the synthesis of CDP-glycerol for teichoic acid biosynthesis in certain Gram-positive bact

42 biosynthetic pathway that is associated with teichoic acid biosynthesis, as well as operons for five

43 tion mutants suggest the involvement of wall teichoic acid but not of staphylococcal protein A.

44 hese results indicate that the decoration of teichoic acid by the LicD enzymes is a membrane-associat

45 lycan catalyzed by OatA and D-alanylation of teichoic acids by DltABCDE.

46 Modification of teichoic acids by esterification with D-alanine and inco

47 We also established a method to isolate wall teichoic acid chains and show that the most abundant cha

48 lyzing P-choline incorporation and export of teichoic acid chains under conditions in which the nativ

49 ce for glycosylated poly(glycerol phosphate) teichoic acid compared with non-glycosylated.

50 titative (or qualitative) change in the wall teichoic acid component of resistant isolates.

51 suring the changes of peptidoglycan and wall teichoic acid compositions using solid-state NMR.

52 Thus, wall teichoic acids contribute to the structure-specific anti

53 asive serotype M1 GAS isolate led to loss of teichoic acid d-alanylation and an increase in net negat

54 Thus, teichoic acid d-alanylation may contribute in multiple w

55 ide gel electrophoresis for analysis of wall teichoic acid extracted from gene deletion mutants, a re

56 mes involved in bacterial lipopolysaccharide/teichoic acid formation and eukaryotic N-linked glycosyl

57 cA, which has been shown to be essential for teichoic acid glycosylation in L. monocytogenes serotype

58 s and enzymology of the biosynthesis of wall teichoic acid have been the extensively studied, however

59 B. anthracis does not elaborate wall teichoic acids; however, its genome harbors tagO and tag

60 We have studied the wall teichoic acid hydrolase activity of pure, recombinant GP

61 phage varphi29 has been implicated as a wall teichoic acid hydrolase.

62 The GP12 protein had potent wall teichoic acid hydrolytic activity in vitro and demonstra

63 r system, including (i) the d-alanylation of teichoic acids, (ii) the incorporation of lysyl-phosphat

64 Despite the central role of wall teichoic acid in S. aureus virulence, details concerning

65 lcholine (PC), a major haptenic component of teichoic acid in the S. pneumoniae cell wall, and lipote

66 n in contradiction to the prevailing view of teichoic acids in metal binding.

67 and presence of glucose substituents in the teichoic acids in the cell wall.

68 ion of d-alanine (d-Ala) groups of bacterial teichoic acid is a central, yet untested, paradigm of mi

69 toward S. aureus when D-alanylation of (lipo)teichoic acids is limiting.

70 t of capsular polysaccharide rather than the teichoic acid ligand.

71 lyses indicated they were identical glycerol teichoic acid-like molecules with a carbohydrate backbon

72 rs include the peptidoglycan cell wall, wall-teichoic acids, lipoteichoic acids, and capsular polysac

73 Excess teichoic acid, LTA-0, antibodies to phosphocholine, or a

74 Degradation of cell wall teichoic acid occurs according to an exolytic mechanism,

75 tcA, involved in the decoration of cell wall teichoic acid of Listeria monocytogenes serotype 4b with

76 l antibody c74.22, lacked galactose from the teichoic acid of the cell wall, and were resistant to th

77 his hypothesis is based on findings that (i) teichoic acid of the pneumococcal cell wall interact wit

78 D-alanylation of (lipo) teichoic acids of S. aureus increases bacterial resistan

79 osphorylcholine (ChoP) is a component of the teichoic acids of Streptococcus pneumoniae and has been

80 nal in serotype 4b-like glycosylation of the teichoic acids of these organisms.

81 Inhibition studies using teichoic acid oligomers indicated that cross-reactive op

82 y dextran, dextran sulfate, heparin, ribitol teichoic acid, or soluble low molecular weight PGN fragm

83 y to the putative polyribitol phosphate wall teichoic acid pathway in Bacillus subtilis.

84 of the pneumococcal pce gene encoding for a teichoic acid phosphorylcholine esterase (Pce), an enzym

85 biosynthetic pathway of the predominant wall teichoic acid polymer are lacking, and workers have reli

86 ith 100% confidence onto TagF, a GT-B folded teichoic acid polymerase from Staphylococcus epidermidis

87 psA-Psr (LCP) proteins are thought to attach teichoic acid polymers and capsular polysaccharides.

88 Undecaprenyl pyrophosphate and also teichoic acid precursors are bound with lower affinity a

89 process presumably occurring at lipid-linked teichoic acid precursors.

90 Ribitol teichoic acid (RTA) (1 microg/ml) induced a twofold incr

91 ilar technique comparing the amount of total teichoic acid showed that the transparent phenotype had

92 emonstrated that SAL inhibited production of teichoic acid, slime-associated proteins, and type 1 ant

93 aride (phosphorylcholine [PC] determinant of teichoic acid)-specific immunoglobulin (Ig) isotype resp

94 LTA-0 (or pneumococcal teichoic acid) stimulated neither CHO/CD14/TLR2 nor CHO/

95 Thus, the NMR-based description of teichoic acid structure resolves the contradictory model

96 In contrast, when the teichoic acid structure was altered by replacing choline

97 nd LicD2, enzymes responsible for loading of teichoic acid subunits with choline, are also membrane-a

98 A) synthesis while simultaneously repressing teichoic acid synthesis (TA).

99 ibed, encode genes responsible for cell wall teichoic acid synthesis in Bacillus subtilis.

100 tions, teichuronic acid is synthesized while teichoic acid synthesis is inhibited.

101 the role of Pho-P in the switch process from teichoic acid synthesis to teichuronic acid synthesis, b

102 metal transport, ferrous iron transport, and teichoic acid synthesis.

103 l tagO mutants, which are defective for wall teichoic acid synthesis.

104 line is an important bioactive adduct to the teichoic acid (TA) and lipoteichoic acid (LTA) of the su

105 Lipoteichoic acid (LTA) and wall teichoic acid (TA) isolated from the mutant were free of

106 Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and

107 s, whereas binding to cell walls depleted of teichoic acid (TA) was decreased.

108 Teichoic acid (TA), a crucial cell wall constituent of t

109 scribes the developments in the synthesis of teichoic acids (TA) - glycosylated poly(alditolphosphate

110 Lipoteichoic and wall teichoic acids (TA) are highly anionic cell envelope-ass

111 Teichoic acids (TAs) are anionic polymers that constitut

112 phoretically distinct polyribitol-containing teichoic acid that we designate K-WTA.

113 nd polyanionic properties of cell wall (lipo)teichoic acids that promote attack of membrane phospholi

114 , additionally, no evidence for a shift from teichoic acid to teichuronic acid synthesis.

115 A in trans restored galactose and glucose on teichoic acid to wild-type levels.

116 e synthesis of the linkage unit that tethers teichoic acids to the peptidoglycan layer.

117 ng an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and

118 ules, such as peptidoglycan, lipoprotein, or teichoic acid, triggering innate host immune responses t

119 e of the cell wall polymers microcapsule and teichoic acid was measured by both gas chromatography-ma

120 thesis while the incorporation of D-Ala into teichoic acids was inhibited.

121 r serotype-specific sugar substituent in the teichoic acid, was not affected.

122 e reduction, respectively, of glucose in the teichoic acid, whereas galactose, the other serotype-spe

123 ogen-oxygen ion pair configuration providing teichoic acid with a positive charge to repel CAMPs.

124 all negative charge by substitution of (lipo)teichoic acids with d-alanine reduces antibacterial acti

125 ia, LytR-CpsA-Psr (LCP) proteins attach wall teichoic acid (WTA) and polysaccharide capsule to peptid

126 id II(A)(WTA), substrates in the PG and wall teichoic acid (WTA) biosynthetic pathways.

127 Wall teichoic acid (WTA) comprises a class of glycopolymers c

128 tivity of targocil, an inhibitor of the wall teichoic acid (WTA) flippase in Staphylococcus aureus.

129 ylglucosamine (GlcNAc) moieties on cell wall teichoic acid (WTA) for adsorption.

130 l phages, Podoviridae require a precise wall teichoic acid (WTA) glycosylation pattern for infection.

131 glycan, thereby promoting attachment of wall teichoic acid (WTA) in bacilli and staphylococci and cap

132 olecules designed to identify bioactive wall teichoic acid (WTA) inhibitors, we identified one hit, w

133 identified an insertional mutant of the wall teichoic acid (WTA) synthesis gene tagB in E. faecalis V

134 enzyme in the biosynthetic pathway for wall teichoic acid (WTA) synthesis.

135 ol-linked biosynthetic intermediates of wall teichoic acid (WTA) to the peptidoglycan of Gram-positiv

136 ) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to play redundan

137 ell wall component of S. aureus, termed wall teichoic acid (WTA).

138 can and the phosphate-rich glycopolymer wall teichoic acid (WTA).

139 pneumoniae, is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteic

140 Wall teichoic acids (WTAs) and membrane lipoteichoic acids (L

141 Wall teichoic acids (WTAs) are anionic polymers that coat the

142 Wall teichoic acids (WTAs) are major polyanionic polymer comp

143 Wall teichoic acids (WTAs) are the most abundant glycopolymer

144 Anionic glycopolymers known as wall teichoic acids (WTAs) functionalize the peptidoglycan la

145 and anionic cell wall polymers such as wall teichoic acids (WTAs), is the major determinant of cell

146 zed with anionic glycopolymers known as wall teichoic acids (WTAs).

147 tionalized with anionic polymers called wall teichoic acids (WTAs).

148 lpha- and beta-O-GlcNAc residues on its wall teichoic acids (WTAs).