ライフサイエンスコーパス: teicoplanin

1 ns that achieve site-selective alteration of teicoplanin.

2 imics the biological mechanism of action for teicoplanin.

3 in, amoxicillin/clavulanate, vancomycin, and teicoplanin.

4 le to linezolid, daptomycin, vancomycin, and teicoplanin.

5 ated derivatives (GtfC, D) of vancomycin and teicoplanin.

6 observed in combination with vancomycin and teicoplanin.

7 keratoplasty received ciprofloxacin 0.3% or teicoplanin 1%.

8 Nine linezolid trials (vancomycin [7]; teicoplanin [2]) were included (n = 2329).

9 crog/ml), amphotericin B (10 microg/ml), and teicoplanin (4 microg/ml) (CAT medium; Oxoid Limited, Ha

10 ne than the two other sugar rings present in teicoplanin (9.3 and 20.3 A, respectively).

11 dentified were glycopeptide antibiotics, but teicoplanin, a membrane-anchored glycopeptide, failed to

12 is study, we used the macrocyclic antibiotic teicoplanin, a molecule consisting of an aglycone peptid

13 Teicoplanin A2-2 (Tei)/A40926 is the last-line antibioti

14 a site-selective peptide catalyst moiety and teicoplanin A2-2 complex.

15 lective phosphorylation reaction involving a teicoplanin A2-2 derivative.

16 lation of the N-acetylglucosamine sugar in a teicoplanin A2-2 derivative.

17 s within the complex glycopeptide antibiotic teicoplanin A2-2.

18 7 A, based on the X-ray crystal structure of teicoplanin A2-2.

19 onstruct was crystallized in the presence of teicoplanin A2-2.

20 ripeptide precursor to the common vancomycin/teicoplanin ABCD ring system and sequential DE macrocycl

21 tudies leading to the total synthesis of the teicoplanin aglycon are provided.

22 It was found that only teicoplanin aglycon CSP provided sufficient resolution o

23 ) = 60 min(-1)), and an unnatural substrate, teicoplanin aglycone (k(cat) = 20 min(-1)).

24 Using the teicoplanin aglycone and the 3 sulfotransferases found i

25 dy we investigate the first two reactions in teicoplanin aglycone maturation catalyzed by the enzymes

26 enosine 5'-phosphate, and Teg12 bound to the teicoplanin aglycone.

27 r = 0.3 min(-1), for an alternate substrate, teicoplanin aglycone.

28 iological activity of the new phosphorylated teicoplanin analogs and compare the results to the natur

29 five compounds were better separated on the teicoplanin and aglycone CSPs, respectively.

30 The binding constants for the interaction of teicoplanin and vancomycin with the fluorescent peptide

31 faecium isolate was highly resistant to both teicoplanin and vancomycin, corresponding to the VanA ph

32 ancomycin, 0.25 microM and 0.25-2 microM for teicoplanin, and 1 microM and 1-8 microM for telavancin.

33 meropenem and teicoplanin, moxifloxacin and teicoplanin, and ciprofloxacin and teicoplanin, gave the

34 , trimethoprim-sulfamethoxazole, vancomycin, teicoplanin, and linezolid.

35 susceptibility panels containing vancomycin, teicoplanin, and six oral antibiotics of potential use i

36 three glycopeptide antibiotics, vancomycin, teicoplanin, and telavancin, as model compounds, we demo

37 ing site in the maturation of vancomycin and teicoplanin antibiotic scaffolds, were expressed in Esch

38 The glycopeptides vancomycin and teicoplanin are clinically important antibiotics.

39 Vancomycin and teicoplanin are not associated with more renal dysfuncti

40 alter reaction selectivities, certain bromo-teicoplanins are accessible.

41 MarR family transcriptional regulator of the teicoplanin-associated locus TcaR, DNA-binding protein I

42 -bonded silica, Pirkle-type, vancomycin, and teicoplanin-bonded silica particles were evaluated for r

43 de antibiotics vancomycin, ristocetin A, and teicoplanin can all be used as chiral selectors in capil

44 Although in contrast to teicoplanin ciprofloxacin shows good corneal penetration

45 t sugar forms of both the vancomycin and the teicoplanin class of glycopeptide antibiotics.

46 Teicoplanin combined with meropenem, ciprofloxacin, or m

47 e resulting 2.3 A resolution protein-peptide-teicoplanin complex crystal structure revealed that the

48 In the chemical assay, teicoplanin could not be detected in the cornea or aqueo

49 free energy between the aglycone CSP and the teicoplanin CSP was between 0.3 and 1 kcal/mol for amino

50 no acid compounds were separated only on the teicoplanin CSP.

51 m) of different surface chemistries, namely, teicoplanin, cyclofructan, silica, and quinine, were pac

52 al assignment of the distinct phosphorylated teicoplanin derivatives.

53 ing the HILIC mechanism and cyclodextrin- or teicoplanin-derivatized stationary phases, effective res

54 e to ampicillin, gentamicin, vancomycin, and teicoplanin developed.

55 resistance detection (GRD) using vancomycin-teicoplanin double-sided gradient test strips on Mueller

56 The complex antibiotic teicoplanin eradicates bacterial infections.

57 onsible for the production of the vancomycin/teicoplanin family of antibiotic natural products.

58 ials that tested linezolid vs. vancomycin or teicoplanin for treatment of nosocomial pneumonia were i

59 ffinity between the glycopeptide antibiotics teicoplanin from Actinoplanes teicomyceticus and vancomy

60 xacin and teicoplanin, and ciprofloxacin and teicoplanin, gave the lowest mean FICs for S. aureus, wi

61 antimicrobial agents, such as vancomycin and teicoplanin, have emerged in the United States and elsew

62 Teicoplanin is the most distinct of the three and is the

63 nsferases (Teg12, -13, and -14) that sulfate teicoplanin-like glycopeptides at three unique sites.

64 linical trials suggest that nitazoxanide and teicoplanin may be alternative options to standard thera

65 ealing that selective chemical alteration of teicoplanin may lead to analogues with attenuated or enh

66 C/CLSI), Mueller-Hinton agar with 5 mg/liter teicoplanin (MHA5T) (European Antimicrobial Resistance S

67 ially positive for 68 isolates (1.6%; all by teicoplanin MIC >/= 8 mug/ml at 24 or 48 h).

68 MICs were > or =4 microg/ml or for which the teicoplanin MICs were > or =8 microg/ml and 24 control s

69 MICs were < or =2 microg/ml or for which the teicoplanin MICs were < or =4 microg/ml to determine the

70 hromosome mec allotyping, and vancomycin and teicoplanin MICs were performed on 821 consecutive MRSA

71 In contrast, there were no increases in teicoplanin MICs.

72 epared in a similar way, one with the native teicoplanin molecule and the other with the aglycone.

73 ng sites for the "capture" of vancomycin and teicoplanin molecules, which may be part of the mechanis

74 s meropenem and ciprofloxacin, meropenem and teicoplanin, moxifloxacin and teicoplanin, and ciproflox

75 993 had agar dilution MICs of vancomycin and teicoplanin of 128 and 4 microg/mL, respectively.

76 g of vancomycin per liter and > or =8 microg teicoplanin per ml or > or =12 microg of teicoplanin per

77 rog teicoplanin per ml or > or =12 microg of teicoplanin per ml.

78 antibiotics (GPAs), including vancomycin and teicoplanin, represent the most important class of anti-

79 f at position 261 in the mutant selected for teicoplanin resistance.

80 Both vancomycin- and teicoplanin-resistant laboratory mutants of Staphylococc

81 rties, in particular against vancomycin- and teicoplanin-resistant strains.

82 yses for 16,749 isolates using vancomycin or teicoplanin results to categorize dalbavancin susceptibi

83 aglycone (GtfC and GtfD) or the glucosylated teicoplanin scaffold, 7 (GtfD).

84 Teicoplanin shows relatively poor corneal penetration th

85 rization immunoassay (FPIA) kit in detecting teicoplanin spiked in human blood samples.

86 aa peptide motif that is known to target the teicoplanin structure in a specific manner.

87 n 6 micro g of vancomycin/ml, vancomycin and teicoplanin susceptibility, API 20S assay, and genotypin

88 . aureus (VISA) and vancomycin-resistant and teicoplanin-susceptible (VanB phenotype) E. faecalis wer

89 d (i) Etest macromethod using vancomycin and teicoplanin test strips, brain heart infusion (BHI) agar

90 For teicoplanin, the mean (median) concentration in the corn

91 cally relevant glycopeptides, vancomycin and teicoplanin, threatens to undermine the usefulness of th

92 pi-vancosamine, to synthesize a novel hybrid teicoplanin/vancomycin glycopeptide.

93 ibility of the enterococci to vancomycin and teicoplanin was determined using an Etest (AB Biodisk, S