ライフサイエンスコーパス: telangiectasia

1 age-related macular degeneration and macular telangiectasia.

2 2 and other retinal diseases associated with telangiectasia.

3 leiotropic neurodegeneration disorder ataxia-telangiectasia.

4 athogenic dissection and treatment of ataxia telangiectasia.

5 AH is associated with hereditary hemorrhagic telangiectasia.

6 verall cosmesis and reduces the risk of skin telangiectasia.

7 etinal angiomatous proliferation and macular telangiectasia.

8 se states, including malignancies and ataxia telangiectasia.

9 genetic instability in patients with ataxia-telangiectasia.

10 e most common sequelae after involution were telangiectasias (145, 84.3%), fibrofatty tissue (81, 47.

11 of brain function, in 10 adults with ataxia-telangiectasia, 19 non-affected adult relatives (12 sibl

12 Ataxia-telangiectasia (A-T) is a cerebellar neurodegenerative d

13 Ataxia-telangiectasia (A-T) is a rare multi-system disorder cau

14 Ataxia telangiectasia (A-T) is a syndrome associated with loss

15 Ataxia-telangiectasia (A-T) is an autosomal recessive neurodege

16 ereditary autosomal recessive disease ataxia telangiectasia (A-T) is caused by mutation in the DNA da

17 Germline ATM inactivation causes ataxia-telangiectasia (A-T) syndrome with severe lymphocytopeni

18 on is a hallmark of the human disease ataxia-telangiectasia (A-T) that is caused by mutation of the A

19 for the autosomal recessive disease ataxia- telangiectasia (A-T) was localized to 11q22.3-23.1.

20 Ataxia telangiectasia (A-T), a rare autosomal recessive disorde

21 ase mutated in the rare human disease ataxia telangiectasia (A-T), has been the focus of intense scru

22 Participants with ataxia-telangiectasia also had higher metabolism in globus pall

23 The treatment of retinal telangiectasia and areas of retinal nonperfusion identif

24 ns, is substantially reduced in human ataxia-telangiectasia and Atm(-/-) mouse cerebellar Purkinje ce

25 , this pathogenesis appears common to ataxia-telangiectasia and Cockayne syndrome, two other DNA repa

26 e expression of genes involved in ATM/ataxia telangiectasia and Rad-3-related (ATR) signaling, apopto

27 ATR (ataxia telangiectasia and Rad-3-related) is a protein kinase th

28 s for the cell cycle checkpoint genes ATAXIA TELANGIECTASIA AND RAD3 RELATED (ATR) and ALUMINUM TOLER

29 manner that is partially dependent on ataxia telangiectasia and Rad3 related (ATR) but not cyclin T o

30 positive correlation between ERH and ataxia telangiectasia and Rad3 related (ATR) expression in live

31 G2-M checkpoints mediated by the ATR (ataxia telangiectasia and Rad3 related) and Chk1 kinases.

32 ers homology-directed repair and ATR (ataxia telangiectasia and Rad3 related)-dependent checkpoint ac

33 important for activation of the ATR (ataxia telangiectasia and Rad3 related)-regulated DNA damage si

34 motes PKA-mediated phosphorylation of ataxia telangiectasia and rad3-related (ATR) at Ser435 (ATR-pS4

35 The DNA damage response kinase ataxia telangiectasia and Rad3-related (ATR) coordinates much o

36 Both exposures induce ataxia telangiectasia and Rad3-related (ATR) kinase and poleta

37 e ataxia telangiectasia mutated (ATM)/ataxia telangiectasia and Rad3-related (ATR) kinases.

38 Ataxia telangiectasia and Rad3-related (ATR) mediates response

39 Ataxia-telangiectasia and RAD3-related (ATR) signals the accumu

40 involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, w

41 le-stranded telomeric DNA and prevent ataxia telangiectasia and Rad3-related kinase activation.

42 omains, which inhibits recruitment of Ataxia telangiectasia and Rad3-related protein (ATR) and reduce

43 PKA directly phosphorylates ataxia telangiectasia and Rad3-related protein (ATR) at Ser435,

44 e of UV-induced XPA nuclear import on ataxia telangiectasia and Rad3-related protein (ATR) in S-phase

45 the replication stress sensing kinase ataxia telangiectasia and Rad3-related protein (ATR) reduces th

46 on of a G2 checkpoint mediated by the ataxia telangiectasia and Rad3-related protein (ATR)-checkpoint

47 e stress leading to activation of the ataxia telangiectasia and Rad3-related protein (ATR)-mediated D

48 5C was regulated by activation of the ataxia telangiectasia and Rad3-related protein (ATR)/checkpoint

49 Further analysis of ataxia telangiectasia and Rad3-related protein (ATR)/Chk1 signa

50 oter region of DNA repair kinase ATR (ataxia-telangiectasia and Rad3-related protein) and acts as a t

51 ing of ataxia telangiectasia mutated, ataxia telangiectasia and Rad3-related protein, and DNA-depende

52 Mutations in ATR(ataxia telangiectasia and RAD3-related) cause Seckel syndrome (

53 Both compounds also lead to ataxia telangiectasia and Rad3-related- (ATR-) dependent produc

54 mplexes (Top1ccs) in murine models of ataxia telangiectasia and spinocerebellar ataxia with axonal ne

55 other brain areas in individuals with ataxia-telangiectasia and tested for brain changes in asymptoma

56 ther neurodegenerative disorders (eg, ataxia-telangiectasia), and DNA double-strand breaks are crucia

57 In START-B, breast shrinkage, telangiectasia, and breast oedema were significantly les

58 ART-A, moderate or marked breast induration, telangiectasia, and breast oedema were significantly les

59 axia-telangiectasia mutated (ATM) and ataxia-telangiectasia- and rad3-related (ATR) kinases.

60 protein kinase catalytic subunit and ataxia telangiectasia- and Rad3-related kinase.

61 the type of sequelae classified as residual telangiectasia, anetodermal skin, redundant skin, persis

62 Facial erythema and telangiectasia are commonly associated with the erythema

63 Cells isolated from patients with ataxia telangiectasia are exquisitely sensitive to ionizing rad

64 interaction with the development of retinal telangiectasia are identified.

65 were used to compare individuals with ataxia-telangiectasia, asymptomatic relatives, and unrelated co

66 Selective laser photocoagulation of retinal telangiectasia at the retinal vasoproliferative tumors'

67 own etiology are commonly observed in ataxia telangiectasia (AT) and Artemis deficiency.

68 Ataxia telangiectasia (AT) is a multisystem DNA-repair disorder

69 Ataxia-telangiectasia (AT) is a pleiotropic multisystem disorde

70 Ataxia telangiectasia (AT) is a progressive multisystem disorde

71 Biallelic mutations in ATM cause ataxia-telangiectasia (AT), a rare inherited disease with a hig

72 cause the neurodegenerative disorder ataxia-telangiectasia (AT).

73 nhibitors of ATM, the gene mutated in ataxia telangiectasia, can sensitize tumor cells to radiation t

74 e-phase disc leakage, central and peripheral telangiectasias, capillary anomalies, and capillary agen

75 (both associated with hereditary hemorrhagic telangiectasia), caveolin-1 (CAV1), and a gene (KCNK3) e

76 The ataxia telangiectasia group D complementing gene (ATDC, also ca

77 scribe a novel mouse model expressing ataxia telangiectasia group D complementing gene (ATDC, also kn

78 Ataxia-telangiectasia group D-associated gene (ATDC) mediated r

79 We found that participants with ataxia-telangiectasia had lower metabolism in cerebellar hemisp

80 ebellar metabolism, participants with ataxia-telangiectasia had widespread changes in metabolic rates

81 So far, murine models of ataxia telangiectasia have failed to accurately recapitulate ma

82 st-mortem studies in individuals with ataxia-telangiectasia have reported cerebellar atrophy; but abn

83 F-beta/BMP signaling: hereditary hemorrhagic telangiectasia (HHT) and cerebral cavernous malformation

84 Hereditary hemorrhagic telangiectasia (HHT) is a highly debilitating and life-t

85 Hereditary hemorrhagic telangiectasia (HHT) is a potentially life-threatening g

86 Hereditary hemorrhagic telangiectasia (HHT), the most common inherited vascular

87 ease, we investigated hereditary hemorrhagic telangiectasia (HHT), which is caused by mutations in TG

88 ALK1; ACVRL1), causes hereditary hemorrhagic telangiectasia (HHT).

89 ling manifestation of hereditary hemorrhagic telangiectasia (HHT).

90 life in patients with hereditary hemorrhagic telangiectasia (HHT; also known as Osler-Weber-Rendu dis

91 ical manifestations including oculocutaneous telangiectasia, immune disorders, increased susceptibly

92 ne has been extended to patients with ataxia-telangiectasia in whom it seems to reduce slow-phase vel

93 ary density was significantly reduced around telangiectasias in both SCP (P = .021) and DCP (P = .042

94 pre-RT photographs) and clinical assessment (telangiectasia, induration, edema, and pigmentation).

95 that showed increased sensitivity to ataxia telangiectasia inhibition, and a neuroendocrine-associat

96 ent due to concurrent hereditary hemorrhagic telangiectasia: iron deficiency impairs hypoxemia compen

97 Ataxia telangiectasia is a devastating neurodegenerative diseas

98 Ataxia-telangiectasia is a recessive genetic disorder (ATM is t

99 A long-standing mystery surrounding ataxia-telangiectasia is why it is mainly cerebellar neurons, P

100 a more lateral distribution of erythema and telangiectasia, less neurogenic mast cell activation, an

101 Mutations throughout MRE11 cause ataxia-telangiectasia-like disorder (ATLD) featuring cerebellar

102 editary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD).

103 r death, Muller and microglia activation and telangiectasia-like vascular remodelling-features that w

104 Nuclear protein, ataxia-telangiectasia locus (NPAT) and FLICE-associated huge pr

105 T/Myb-like domain of nuclear protein, ataxia-telangiectasia locus (NPAT), a transcriptional co-activa

106 ods were used to study the stages of macular telangiectasia (MACTEL): Power-Doppler optical coherence

107 or the diagnostic criteria of CM, removal of telangiectasia macularis eruptiva perstans from the curr

108 Using an ataxia-telangiectasia mouse model, we compared lymphoma inciden

109 Ataxia telangiectasia mutant (ATM) is an S/T-Q-directed kinase

110 ects, particularly TP53 and biallelic ataxia telangiectasia mutated (ATM) aberrations, are associated

111 Nuclear PKR antagonizes ataxia-telangiectasia mutated (ATM) activation by a mechanism d

112 phosphorylated at S455 downstream of ataxia telangiectasia mutated (ATM) and AKT following DNA damag

113 naling cascades via activation of the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia-

114 s critical for activating the kinases ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (A

115 by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (A

116 ng with DNA-damage checkpoint kinases ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (

117 tions of the key DNA repair molecules ataxia-telangiectasia mutated (ATM) and checkpoint kinase 2 (CH

118 ring V(D)J recombination activate the Ataxia Telangiectasia mutated (ATM) and DNA-dependent protein k

119 tive DDR-associated proteins, such as ataxia telangiectasia mutated (ATM) and H2AX, was induced as ea

120 coordinate recognition of DNA damage, ataxia-telangiectasia mutated (ATM) and PARP-1, were induced.

121 e 1 (Chk1) phosphorylation in an ATR [ataxia-telangiectasia mutated (ATM) and Rad3-related]-dependent

122 duced SMR5/SMR7 expression depends on ATAXIA TELANGIECTASIA MUTATED (ATM) and SUPPRESSOR OF GAMMA RES

123 gatively regulating the expression of ataxia telangiectasia mutated (ATM) and the subsequent DNA dama

124 ine signaling pathways, including the ataxia telangiectasia mutated (ATM) and transforming growth fac

125 suppresses miR-205 expression through ataxia telangiectasia mutated (ATM) and zinc finger E-box bindi

126 The ataxia telangiectasia mutated (ATM) checkpoint is the central s

127 TP53 and ataxia telangiectasia mutated (ATM) defects are associated with

128 ial cell as well as activation of the ataxia telangiectasia mutated (ATM) DNA repair pathway that in

129 caused by biallelic mutations in the ataxia-telangiectasia mutated (ATM) gene, but heterozygous carr

130 Mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a kinas

131 r disorder caused by mutations in the ataxia telangiectasia mutated (ATM) gene.

132 , is caused by a defective or missing ataxia telangiectasia mutated (ATM) gene.

133 Involvement of tumor suppressor ataxia telangiectasia mutated (ATM) in the TGF-beta1 pathway re

134 Ataxia telangiectasia mutated (ATM) is a protein kinase and a m

135 Ataxia telangiectasia mutated (ATM) is activated upon DNA doubl

136 The protein kinase ataxia telangiectasia mutated (ATM) is an important proximal re

137 Ataxia telangiectasia mutated (ATM) is an important signaling m

138 monstrated that in replicating cells, ataxia telangiectasia mutated (ATM) is predominantly a nuclear

139 kinases (PI3KKs) involved in the DDR: ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3-rel

140 Here we identify ataxia-telangiectasia mutated (ATM) kinase as a modulator of th

141 Inhibitors of ataxia telangiectasia mutated (ATM) kinase decreased manganese-

142 The ataxia telangiectasia mutated (ATM) kinase is involved in the r

143 e DNA damage response mediated by the Ataxia Telangiectasia Mutated (ATM) kinase may affect the relat

144 Strikingly, we found that the ataxia telangiectasia mutated (ATM) kinase regulates the intera

145 one Igkappa allele signal through the ataxia telangiectasia mutated (ATM) kinase to feedback-inhibit

146 , we reported that the absence of the ataxia telangiectasia mutated (ATM) kinase, a critical DNA dama

147 sly reported a novel inhibitor of the ataxia-telangiectasia mutated (ATM) kinase, which is a target f

148 imized as selective inhibitors of the ataxia telangiectasia mutated (ATM) kinase.

149 sible for the efficient activation of ataxia-telangiectasia mutated (ATM) kinase.

150 that DNA damage signaling through the ataxia telangiectasia mutated (ATM) pathway induces the translo

151 irst time, to our knowledge, that the ataxia telangiectasia mutated (ATM) pathway, involved in DNA da

152 Upon DNA damage, the protein kinase ataxia-telangiectasia mutated (ATM) phosphorylates 53BP1 and re

153 Ataxia-telangiectasia mutated (ATM) plays a unique yet incomple

154 The ataxia-telangiectasia mutated (ATM) protein is an apical kinase

155 The ataxia-telangiectasia mutated (ATM) protein kinase is a master

156 Ataxia-telangiectasia mutated (ATM) protein kinase regulates th

157 ection of multiple cell lines lacking ataxia telangiectasia mutated (ATM) protein produced wild-type

158 Ataxia-telangiectasia mutated (ATM) regulates the DNA damage re

159 ermediate state activate differential ataxia telangiectasia mutated (ATM) signaling where CHK2 is not

160 dependent protein kinase (DNA-PK) and Ataxia telangiectasia mutated (ATM) signaling.

161 ciated feedback loop between DDB2 and ataxia telangiectasia mutated (ATM) was observed in infected ce

162 epair factors histone H2AX (H2AX) and ataxia telangiectasia mutated (ATM) were examined in pancreatic

163 Ataxia-telangiectasia mutated (ATM), a member of the phosphatid

164 anism: DIM caused rapid activation of ataxia-telangiectasia mutated (ATM), a nuclear kinase that regu

165 EMIS, DNA-PKcs, DNA ligase IV (LIG4), Ataxia telangiectasia mutated (ATM), and ATM- and Rad3-related

166 IDs, autosomal recessive mutations in ataxia-telangiectasia mutated (ATM), autosomal dominant mutatio

167 ment is independent of the DDR sensor ataxia telangiectasia mutated (ATM), but dependent on poly (ADP

168 d by the DNA damage response protein, ataxia telangiectasia mutated (ATM), in cytokine-induced NF-kap

169 TIP damage sites, DDR factors such as ataxia telangiectasia mutated (ATM), MDC1, WRN, and FANCD2 are

170 -regulation and/or phosphorylation of ataxia telangiectasia mutated (ATM), phosphorylated H2AX (gamma

171 lation of the major DNA damage kinase Ataxia telangiectasia mutated (ATM), thereby triggering cellula

172 red DSB-induced checkpoint integrity, Ataxia Telangiectasia Mutated (ATM)-deficient mice harboring th

173 These 3 responses are ataxia telangiectasia mutated (ATM)-dependent and promote quies

174 The ataxia telangiectasia mutated (ATM)-interacting protein ATMIN m

175 strand breaks (DSBs), as indicated by ataxia telangiectasia mutated (ATM)-mediated H2AX phosphorylati

176 lymphocytic leukemia (CLL) where the ataxia telangiectasia mutated (ATM)-p53 pathway is inactivated

177 e of the DNA damage response mediator ataxia telangiectasia mutated (ATM).

178 howed a synergistic relationship with ataxia telangiectasia mutated (ATM).

179 e in the bone marrow regulated by the ataxia telangiectasia mutated (ATM)/ataxia telangiectasia and R

180 an up-regulation of components of the ataxia telangiectasia mutated (ATM)/Chek1/p53 pathway in miR-15

181 plication stress), which activate the ataxia telangiectasia mutated (ATM)/p53-dependent tumor barrier

182 BS1 expression and epirubicin-induced ataxia-telangiectasia mutated (ATM)phosphorylation in breast ca

183 amage response marker, phosphorylated ataxia telangiectasia mutated (pATM), were quantified in circul

184 Under these conditions, ataxia-telangiectasia mutated activation and accumulation of DN

185 ngle strand DNA, the key platform for ataxia telangiectasia mutated and Rad3-related (ATR) activation

186 nt in PKA-mediated phosphorylation of ataxia telangiectasia mutated and Rad3-related (ATR) at S435, a

187 immediate phosphorylation of Chk1 by ataxia telangiectasia mutated and Rad3-related (ATR) in the pre

188 The ataxia telangiectasia mutated and Rad3-related (ATR) kinase is

189 ATRIP, the regulatory partner of the ataxia telangiectasia mutated and Rad3-related (ATR) kinase, at

190 eta and ISG induction is dependent on ataxia-telangiectasia mutated and Rad3-related (ATR) kinase, bu

191 The ataxia telangiectasia mutated and Rad3-related (ATR)-checkpoint

192 V also produced maximal activation of ataxia telangiectasia mutated and Rad3-related (Atr)-mediated D

193 e is mediated by additive activity of ATAXIA TELANGIECTASIA MUTATED AND RAD3-RELATED and ATAXIA TELAN

194 chromosomal anomalies (trisomy-12 or ataxia telangiectasia mutated anomaly + del13q14) and negativel

195 hich led to the downregulation of the ataxia-telangiectasia mutated DNA damage pathway and the chemok

196 nases DNA-dependent protein kinase or ataxia-telangiectasia mutated enhanced GDC-0973/GDC-0941-mediat

197 the number of nuclear phosphorylated ataxia telangiectasia mutated foci in the post-LVAD hearts.

198 angiogenesis through the silencing of ataxia telangiectasia mutated in neighboring target cells.

199 ancer cells, comparable to effects of Ataxia Telangiectasia Mutated inhibition.

200 Here we report that ataxia-telangiectasia mutated kinase (ATM) plays a major role i

201 lar epithelial cells, as indicated by ataxia telangiectasia mutated kinase (ATM)-dependent phosphoryl

202 Upon IR, CHK2 is activated by ataxia telangiectasia mutated kinase and regulates the S-phase

203 erase activity, but is independent of ataxia-telangiectasia mutated kinase function.

204 because of functional redundancy with ataxia telangiectasia mutated kinase, a protein that also has s

205 cle checkpoints via activation of the ataxia-telangiectasia mutated kinase.

206 IECTASIA MUTATED AND RAD3-RELATED and ATAXIA TELANGIECTASIA MUTATED kinases, which cause postreplicat

207 To further investigate this, ataxia telangiectasia mutated KO (Atm(-/-)) mice, which develop

208 The association of Tcl1 and Ataxia Telangiectasia Mutated leads to activation of the NF-kap

209 mediated in part by activation of the ataxia-telangiectasia mutated pathway, which is preliminarily a

210 tric cancer, especially in those with ataxia-telangiectasia mutated protein (ATM)-negative tumours.

211 yocyte nuclear foci of phosphorylated ataxia telangiectasia mutated protein, an upstream regulator of

212 e yeast Ataxia telangiectasia mutated/Ataxia telangiectasia mutated Rad3-related checkpoint regulator

213 nase catalytic subunit (DNA-PKcs) and ataxia-telangiectasia mutated respond primarily to DNA double-s

214 nd break repair is the recruitment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to

215 Knock down of ataxia telangiectasia mutated suppressed gammaH2AX and CHK2 pho

216 Ataxia telangiectasia mutated was activated but not its 53BP1 a

217 ethylation conferred compromised ATM (ataxia telangiectasia mutated) activation, decreased efficiency

218 on of proteins (H2AX, protein 53, and ataxia telangiectasia mutated) after SPECT.

219 ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) a

220 uced selectively by DSBs through ATM (ataxia telangiectasia mutated) as a unique mechanism to attenua

221 Ai)-based screen that identified ATM (ataxia telangiectasia mutated) as being synthetic lethal with F

222 ere it interacted with activated ATM (ataxia-telangiectasia mutated) at sites of DNA repair.

223 nteracting factor 1 (Rif1) as an ATM (ataxia-telangiectasia mutated) phosphorylation-dependent intera

224 s provided by the protein kinase ATM (ataxia telangiectasia mutated) that is capable of commanding a

225 by the consecutive activation of ATM (ataxia telangiectasia mutated), Chk2, and p53.

226 trol (poly(ADP)-ribose polymerase and ataxia telangiectasia mutated), those within the cell metabolis

227 her systems is known to activate ATM (ataxia telangiectasia mutated)-mediated DNA damage response (DD

228 aks, as well as in activation of ATM (ataxia telangiectasia mutated).

229 T3 induces a rapid activation of ATM (ataxia telangiectasia mutated)/PRKAA (adenosine monophosphate-a

230 However, silencing of ataxia telangiectasia mutated, ataxia telangiectasia and Rad3-r

231 the master DNA damage response kinase Ataxia telangiectasia mutated, revealing potential mechanistic

232 genes requires ATR and ALT2, but not ATAXIA TELANGIECTASIA MUTATED, thus demonstrating that in respo

233 Both 1 and 3 induce ataxia telangiectasia mutated- (ATM-) and DNA-dependent protein

234 chanistic links between PALB2 and the Ataxia telangiectasia mutated-dependent DNA damage responses.

235 ine array analysis identified several ataxia-telangiectasia mutated-dependent senescence-associated s

236 damage, and this dissociation may be ataxia telangiectasia mutated-dependent.

237 a novel interaction between Tcl1 with Ataxia Telangiectasia Mutated.

238 ent kinase (CDK), and Mec1, the yeast Ataxia telangiectasia mutated/Ataxia telangiectasia mutated Rad

239 ndent kinase, encoded by PRKDC), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related)

240 e DNA damage-activated protein kinase ataxia-telangiectasia-mutated (ATM) and casein kinase1 (CK1) an

241 damage by the coordinated actions of ataxia-telangiectasia-mutated (ATM) and casein kinases (CKs) 1

242 the DNA damage response downstream of ataxia telangiectasia-mutated (ATM) and p38/MK2 and promotes ce

243 neration process critically involving ataxia telangiectasia-mutated (ATM) and p53.

244 eplication stress in malignant cells (ataxia telangiectasia-mutated (ATM) and Rad3-related-checkpoint

245 results in reduced activation of the ataxia telangiectasia-mutated (ATM) checkpoint kinase, ineffici

246 translocations that are a hallmark of ataxia telangiectasia-mutated (ATM) deficiency.

247 tant for Chaos3 and components of the ataxia telangiectasia-mutated (ATM) double-strand break respons

248 is process in cells deficient for the ataxia telangiectasia-mutated (ATM) DSB response factor.

249 cyclobutane pyrimidine dimers in the ataxia telangiectasia-mutated (ATM) gene in human fibroblasts i

250 y contrast, loss of the DSB signaling ataxia telangiectasia-mutated (ATM) kinase did not significantl

251 lation of KAP1-Serine 824 (Ser824) by ataxia-telangiectasia-mutated (ATM) kinase is necessary for rep

252 The Ataxia Telangiectasia-Mutated (ATM) protein kinase is recruited

253 colony formation required NF-kappaB, ataxia telangiectasia-mutated (ATM), and the inhibitor of kappa

254 reased levels of p53, but not Hdm2 or ataxia telangiectasia-mutated (ATM), were seen after expression

255 he DNA damage response protein kinase ataxia telangiectasia-mutated (ATM)- and Rad-3-related (ATR) in

256 -cell lymphomas that arise in certain ataxia telangiectasia-mutated (ATM)-deficient compound mutant m

257 int activation involves activation of ataxia telangiectasia-mutated (ATM)/ATM- and rad3-related (ATR)

258 replication damage checkpoint kinase ataxia telangiectasia-mutated and rad3-related homolog.

259 ases p53 stability as demonstrated by ataxia telangiectasia-mutated kinase activation, increased Ser-

260 Ataxia telangiectasia-mutated kinase activity can compensate fo

261 lication even in the presence of ATM (ataxia telangiectasia-mutated kinase) and Chk2 phosphorylation

262 a-S-phase arrest is regulated by ATM (ataxia telangiectasia-mutated kinase) signaling in a p53-indepe

263 Activation of the ATM (ataxia telangiectasia-mutated kinase)-dependent DNA damage resp

264 d this was abrogated by inhibition of ataxia-telangiectasia-mutated signaling, suggesting that DNA da

265 Kcs also acts in concert with MRN and ataxia telangiectasia-mutated to regulate resection and thus DN

266 oinositide 3-kinase-like kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related) a

267 ding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Can

268 Following UV irradiation, ataxia telangiectasia-mutated- and Rad3-related protein phospho

269 The ATR (ATM [ataxia telangiectasia-mutated]- and Rad3-related) checkpoint is

270 mplications included cataract (n = 13), iris telangiectasia (n = 5), corneal epithelial defect (n = 4

271 may therefore be a driving force in macular telangiectasia, neovascular AMD and other retinal diseas

272 hort stature, hearing loss, premature aging, telangiectasia, neurodegeneration, and photosensitivity,

273 l degeneration associated with early retinal telangiectasia, neuronal alterations, and loss of retina

274 Examination revealed telangiectasias on the labial mucosa and nail folds.

275 nical correlate for the formation of retinal telangiectasia or Coats-like vasculopathy in patients wi

276 68; 95% CI, 0.48 to 0.96; P = .027) and skin telangiectasia (OR, 0.58; 95% CI, 0.36 to 0.92; P = .021

277 or both overall cosmesis (P = .038) and skin telangiectasia (P = .031).

278 cipants with ETR tended to have erythema and telangiectasia primarily on the central face (79%), wher

279 ere calculated inside 100-mum circles around telangiectasias, projected over superficial (SCP) and de

280 , such as lentigines, hyperpigmentation, and telangiectasias, should be considered.

281 the ALK1 gene cause hereditary haemorrhagic telangiectasia type 2 (HHT2), a disabling disease charac

282 Macular telangiectasia type 2 (MacTel 2) is a rare disease in wh

283 Muller glial cells resembling human macular telangiectasia type 2 (MacTel 2), which is a retinal dis

284 Macular Telangiectasia Type 2 (MacTel) is an uncommon, late-onse

285 chloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4).

286 two relatively rare clinical units, macular telangiectasia type 2 and solitary astrocytic hamartoma

287 To present a coincidence of macular telangiectasia type 2 and solitary retinal astrocytic ha

288 the case of a 69-year-old woman with macular telangiectasia type 2 in whom multimodal fundus imaging

289 Macular telangiectasia type 2 is a bilateral disease with charac

290 cavitation similar in appearance to macular telangiectasia type 2 on spectral-domain optical coheren

291 safe and well tolerated in eyes with macular telangiectasia type 2.

292 he clinical features of this case of macular telangiectasia type 2.

293 oveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular d

294 Here we present a model of human ataxia telangiectasia using induced pluripotent stem cells, and

295 lit lamp or during pars plana vitrectomy for telangiectasia visible at the retinal vasoproliferative

296 veally in both eyes, leakage from parafoveal telangiectasia was apparent.

297 ns, direct endolaser photocoagulation of the telangiectasia was required.

298 of capillary changes (dilation, pruning, and telangiectasia) was also substantial (ICC 0.712 for the

299 In MT1 eyes, fewer telangiectasias were identified with OCTA than with FA (

300 ding 403 [90.5%] with hereditary hemorrhagic telangiectasia) were recruited to a prospective series.