ライフサイエンスコーパス: telomerase RNA

1 A, and mixed domain scaRNAs, as well as with telomerase RNA.

2 d in heterozygous combination with wild-type telomerase RNA.

3 een associated previously with the noncoding telomerase RNA.

4 act on the function of coexpressed wild-type telomerase RNA.

5 anscriptase protein (TERT) and the intrinsic telomerase RNA.

6 ment (helix II) from Tetrahymena thermophila telomerase RNA.

7 tending primers that form short hybrids with telomerase RNA.

8 bond with, for example, the P3 domain of the telomerase RNA.

9 OX4 paralogs, as well as Notch-1, LEF-1, and telomerase RNA.

10 lytic subunit in an inactive complex lacking telomerase RNA.

11 errant telomeres directed by mutant-template telomerase RNA.

12 s and upstream promoters similar to those of telomerase RNA.

13 al body on the intranuclear traffic route of telomerase RNA.

14 tment of the exosome to snoRNAs and to human telomerase RNA.

15 tending primers that form short hybrids with telomerase RNA.

16 incompatibility between human TERT and mouse telomerase RNA.

17 telomerase reverse transcriptase (TERT) and telomerase RNA.

18 ment found in ciliates is conserved in human telomerase RNA.

19 omerase reverse transcriptase (TERT) and the telomerase RNA.

20 snRNA, snoRNA, RNase P, RNase MRP, Y RNA or telomerase RNA.

21 r1 functions in processing intron-containing telomerase RNA.

22 ween this domain and a quadruplex from human telomerase RNA.

23 determine the overall architecture of human telomerase RNA.

24 hat spanned the template of the S. castellii telomerase RNA.

25 been identified in human, yeast and ciliate telomerase RNAs.

26 nduced by telomere-uncapping mutant template telomerase RNAs.

27 iliates, define a minimal universal core for telomerase RNAs.

28 izosaccharomyces pombe telomerase RNA, TER1 (telomerase RNA 1), also contains a STE, which is essenti

29 instance, for the pseudoknot domain of human telomerase RNA, a native-like and a misfolded hairpin in

30 E, mutation led to severe destabilization of telomerase RNA, a reduction in telomerase activity, and

31 hat affect telomere length act by modulating telomerase RNA abundance, we used real-time reverse tran

32 t of telomere length genes act by modulating telomerase RNA abundance.

33 A, and that genetic depletion of p65 reduces telomerase RNA accumulation in vivo.

34 ry structure thought to be involved in human telomerase RNA accumulation in vivo.

35 essential RNA element derived from the human telomerase RNA activation domain.

36 ancer cell line expressing a mutant-template telomerase RNA also had decreased growth rates.

37 e that contains an integral RNA subunit, the telomerase RNA and a catalytic protein subunit, the telo

38 ents of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the tel

39 of normal levels of the endogenous wild-type telomerase RNA and endogenous wild-type telomerase activ

40 o the architecture and coordination of human telomerase RNA and highlight where the RNA could be targ

41 report that at least a subfraction of human telomerase RNA and individual resident Cajal body RNAs i

42 Dyskerin binds the H/ACA box of human telomerase RNA and is a core telomerase subunit required

43 Here we show that the levels of the telomerase RNA and its association with the telomerase R

44 conclude that (i) quadruplex from the human telomerase RNA and its DNA analog both adopt a disc shap

45 .g., mRNA, ribosomal RNA, small nuclear RNA, telomerase RNA and so on).

46 tified that possessed all detectable cardiac telomerase RNA and telomerase activity.

47 nomers rather than higher-order multimers of telomerase RNA and telomerase reverse transcriptase.

48 ssential template/pseudoknot domain of human telomerase RNA and that inhibit telomerase function in v

49 osed of an RNA template known as hTER (human telomerase RNA) and a protein subunit named hTERT (human

50 cell extract is associated specifically with telomerase RNA, and that genetic depletion of p65 reduce

51 Disease-associated variants of the human telomerase RNA are expressed in heterozygous combination

52 These findings support loss of function of telomerase RNA as a general mechanism of human disease.

53 e TERT amino terminus is essential for human telomerase RNA binding as well.

54 In contrast, high-affinity telomerase RNA binding requires only a small region in t

55 oilin involvement in the processing of human telomerase RNA both in vitro and in vivo.

56 reverse transcriptase (TERT) protein and the telomerase RNA can be reconstituted into an active compl

57 he mutational analysis further suggests that telomerase RNA can function independent of the proposed

58 ss whether introducing 2'-O methylation into telomerase RNA can influence telomerase activity in vivo

59 ce for an interaction between the core tTERT/telomerase RNA complex and the p80 and p95 proteins.

60 complex controls the stability of the human telomerase RNA component (hTR/TERC).

61 In addition, we confirmed the telomerase RNA component (TERC) as a gene associated wit

62 r telomerase reverse transcriptase (Tert) or telomerase RNA component (Terc) genes.

63 The telomerase RNA component (TERC) is a critical determinan

64 d DC cells overcome a critical limitation in telomerase RNA component (TERC) levels to restore telome

65 lomerase reverse transcriptase (TERT) or the telomerase RNA component (TERC) telomerase genes.

66 telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC), and the TERC-binding pr

67 Telomerase RNA component (TERC), the RNA component and T

68 sm level in mice doubly null for Atm and the telomerase RNA component (Terc).

69 is required for the 3'-end maturation of the telomerase RNA component (TERC).

70 Here we show that genetic depletion of the telomerase RNA component (TR) in the zebrafish results i

71 of NP oligonucleotide (GRN163) against human telomerase RNA component as a telomerase inhibitor and p

72 yethyl oligonucleotides complementary to the telomerase RNA component diffuse across cell membranes w

73 stions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

74 1 (rs9419958 P = 9.1 x 10(-11)) and with the telomerase RNA component TERC (rs1317082, P = 1.1 x 10(-

75 Determination of the structure of the yeast telomerase RNA component TLC1 has been hampered by its l

76 DKC1, while heterozygous mutations in TERC (telomerase RNA component) and TERT (telomerase reverse t

77 h respect to both Wrn and Terc (encoding the telomerase RNA component), telomere dysfunction elicits

78 Overexpression of the telomerase RNA component, hTR, demonstrated that this pr

79 UC1 and PyMT (MMT mice) but deficient in the telomerase RNA component, mTerc, on the C57BL/6 backgrou

80 ns of telomerase-deficient mice null for the telomerase RNA component, mTERC.

81 s new function for TERT does not require the telomerase RNA component, which encodes the template for

82 copying a short template sequence within its telomerase RNA component.

83 locus that includes TERC, which encodes the telomerase RNA component.

84 he pseudoknot, and potentially the predicted telomerase RNA conformation, affects polymerization to c

85 All vertebrate telomerase RNAs contain a catalytically essential core d

86 n and the budding yeast Kluyveromyces lactis telomerase RNAs contain unusual triple-helical segments

87 reverse transcriptase to associate with the telomerase RNA depends on a highly structured region rat

88 The effects of various mutations on telomerase RNA dynamics are also investigated.

89 Here, we engineer human and Tetrahymena cis-telomerase RNAs, each having a DNA primer covalently lin

90 cate that sequence-specific interaction of a telomerase RNA element with the TERT RNA binding domain,

91 ng was only partially dependent on TER1, the telomerase RNA, even though Est1 bound nucleotides 415-5

92 luding, for example, TERC, which encodes the telomerase RNA, exhibit extensive hypermethylation, wher

93 support the potential use of mutant-template telomerase RNA expression as an antineoplastic strategy.

94 Telomerase RNA expression level may provide a clinically

95 suppression of mouse telomerase RNA reduced telomerase RNA expression, telomerase activity, and telo

96 , we identified seven conserved sequences in telomerase RNAs from Kluyveromyces budding yeasts.

97 e results, combined with previous studies on telomerase RNAs from other budding yeasts, vertebrates,

98 ed two mutations in the Kluyveromyces lactis telomerase RNA gene (TER1) template.

99 nd detected two novel point mutations in the telomerase RNA gene (TERC) in each family.

100 Even a low threshold level of expression of telomerase RNA gene constructs containing various mutant

101 New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MD

102 e carcinogenesis, recently, mutations in the telomerase RNA gene in humans have been associated with

103 a tlc1h mutant, the templating region of the telomerase RNA gene is altered so that telomerase adds t

104 yces cerevisiae, overexpression of TLC1, the telomerase RNA gene, disrupts telomeric structure.

105 splay anticipation and have mutations in the telomerase RNA gene.

106 Here, we generated TERC (telomerase RNA) gene knockouts in telomerase positive ce

107 ecular dynamics simulations of the wild-type telomerase RNA hairpin.

108 eudoknot formation in the core region of the telomerase RNA has been demonstrated to be important for

109 A common secondary structure of vertebrate telomerase RNA has been proposed based on a phylogenetic

110 Vertebrate telomerase RNAs have three essential domains: the templa

111 ng RNA (siRNA) knockdown of endogenous human telomerase RNA (hTer) with expression of a mutant-templa

112 the core domain (residues 1 to 210) of human telomerase RNA (hTER).

113 ns an intrinsic templating RNA moiety (human telomerase RNA; hTER) and the core protein (human telome

114 Human telomerase RNA (hTERC) is thought to function as a dimer

115 merase RNP and its two key components, human telomerase RNA (hTR) and human telomerase reverse transc

116 The telomerase RNA (hTR) and reverse transcriptase (hTERT) p

117 Expression of the core telomerase RNA (hTR) and reverse transcriptase (hTERT) s

118 wo essential components of human telomerase, telomerase RNA (hTR) and telomerase reverse transcriptas

119 subcellular localization of endogenous human telomerase RNA (hTR) and telomerase reverse transcriptas

120 can be reconstituted in vitro with only the telomerase RNA (hTR) and telomerase reverse transcriptas

121 We determined previously that a novel human telomerase RNA (hTR) antagonist, GRN163L, inhibited the

122 Thermal denaturation of the human telomerase RNA (hTR) DeltaU177 pseudoknot and hTR p2b ha

123 The H/ACA motif of human telomerase RNA (hTR) directs specific pathways of endoge

124 g target, and hTR-P2b is a part of the human telomerase RNA (hTR) essential for its activity.

125 It has been proposed that human telomerase RNA (hTR) interacts with dyskerin, prior to a

126 studies of disease-linked variants of human telomerase RNA (hTR) or telomerase reverse transcriptase

127 unit of telomerase (hTERT) in the absence of telomerase RNA (hTR) or telomeric DNA.

128 igate the kinetic folding pathways for human telomerase RNA (hTR) pseudoknot.

129 Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other

130 The biological accumulation of human telomerase RNA (hTR) requires hTR H/ACA domain assembly

131 telomerase reverse transcriptase (hTERT) and telomerase RNA (hTR) subunits.

132 presence of an H/ACA motif within the human telomerase RNA (hTR) suggested that telomerase might uti

133 The total level of human telomerase RNA (hTR) was invariant across the cell cycle

134 Here, we describe a motif of human telomerase RNA (hTR), not previously characterized in a

135 e transcriptase (hTERT) and associated human telomerase RNA (hTR).

136 icroscopy to study the folded state of human telomerase RNA (hTR).

137 demonstrate the canonical nuclear RNA [human telomerase RNA (hTR)] is not present in human mitochondr

138 eta-deletion protein competed for binding to telomerase RNA (hTR/TERC), thereby inhibiting endogenous

139 These telomerase RNAs identified from filamentous fungi displa

140 are as follows: (1) Ku specifically binds to telomerase RNA in a distinct, yet related, manner to how

141 ed macronuclei, p43 largely colocalizes with telomerase RNA in discrete foci.

142 er cell cycle-dependent sequestration of the telomerase RNA in nucleoli, a process that excludes telo

143 he function of the alignment domain of human telomerase RNA in sustaining catalytic activity in vitro

144 e recent identification of the gene encoding telomerase RNA in the fission yeast Schizosaccharomyces

145 ns have all been shown to have low levels of telomerase RNA in their peripheral blood, providing dire

146 erase activity reconstitution with wild-type telomerase RNA in vitro.

147 umor strategy: expression of mutant-template telomerase RNAs in human cancer cells.

148 upport of spliceosomes generating 3' ends of telomerase RNAs in other fungi.

149 We expressed mutant-template human telomerase RNAs in prostate (LNCaP) and breast (MCF-7) c

150 Nevertheless, nearly all telomerase RNAs, including those of H. sapiens and S. ce

151 (DC), wherein PARN deficiency leads to human telomerase RNA instability.

152 hibits telomerase by dissociating DNA primer-telomerase RNA interactions.

153 However, in the context of the full-length telomerase RNA, interference by other parts of the RNA p

154 gth and cell growth defects, suggesting that telomerase RNA is a critical direct or indirect Paf1C ta

155 Telomerase RNA is an essential component of telomerase,

156 Telomerase RNA is an integral component of telomerase.

157 A pseudoknot structure in the human telomerase RNA is conserved in all vertebrates and is es

158 How the mature 3' end of telomerase RNA is generated has so far remained elusive.

159 he functionally essential domains in ciliate telomerase RNA is stem-loop IV, which strongly stimulate

160 ical for TERT binding and that the 5' end of telomerase RNA is sufficient for TERT binding.

161 A (snRNA), small nucleolar RNA (snoRNA), and telomerase RNA, is further hypermethylated at the exocyc

162 STE), which was discovered 13 y ago in human telomerase RNA, is required for telomerase activity, yet

163 Here we have demonstrated that such telomerase RNA knockdown in cancer cells does not cause

164 d not cause chromosome end-to-end fusions in telomerase RNA knockout mouse embryos despite progressiv

165 Mouse telomerase RNA lacks helix P1b, and the boundary is esta

166 Twofold reductions in telomerase RNA levels cause telomere shortening in both

167 hermore, DKC1(S485G) mutation does not alter telomerase RNA levels.

168 undergoes the first cleavage reaction during telomerase RNA maturation.

169 point requires telomerase and indicate that telomerase RNA may be limiting in vivo.

170 ient overexpression of mutant-template human telomerase RNA (MT-hTer) to add mutant DNA to telomeres

171 in normal and neoplastic cells derived from telomerase RNA null (mTERC(-/-)) mice.

172 wild-type mice, similar to the reductions in telomerase RNA observed in TR heterozygotes.

173 Although telomerase RNAs of different organisms are very diverse

174 By alignment of telomerase RNAs of Saccharomyces cerevisiae and six Kluy

175 r G4 formation in full-length cellular human telomerase RNA, offering important insights into its cel

176 Disruption of the helix P1b in human telomerase RNA or alteration of its distance from the te

177 articles are essential for ribosomal RNA and telomerase RNA processing and metabolism.

178 Ku binding to yeast telomerase RNA promotes telomere lengthening and telomer

179 describe a set of interactions between human telomerase RNA, protein domains, and the substrate DNA t

180 ions on the structure and stability of human telomerase RNA pseudoknot and CR7 domains by using NMR a

181 complementary pair of catalytically inactive telomerase RNA pseudoknot mutants in combination with a

182 that the distance between the 3' end of the telomerase RNA pseudoknot region and the 5' end of the D

183 base changes in a highly conserved putative telomerase RNA pseudoknot.

184 erved for the Kluyveromyces lactis and human telomerase RNA pseudoknots.

185 interfering RNA specifically targeting human telomerase RNA rapidly inhibits the growth of human canc

186 able, ribozyme-mediated suppression of mouse telomerase RNA reduced telomerase RNA expression, telome

187 ncoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant d

188 hering Sir4 directly to Ku-binding-defective telomerase RNA restores otherwise-shortened telomeres to

189 cleotide pseudoknot from a distantly related telomerase RNA results in a functional telomerase enzyme

190 Phylogenetic comparison of telomerase RNA sequences from several budding yeasts rev

191 enerally, our results support a role for the telomerase RNA serving as a scaffold for binding key pro

192 Mammalian H/ACA small nucleolar RNAs and telomerase RNA share common sequence and secondary struc

193 nt to the template region of human and mouse telomerase RNA significantly altered telomerase processi

194 The 3' end of Schizosaccharomyces pombe telomerase RNA (SpTER1) is generated by spliceosomal cle

195 Binding of Tetrahymena telomerase RNA stem IV to TERT enhances nucleotide addit

196 Ps) we have identified a region of the human telomerase RNA subunit (hTR) approximately 100 nt downst

197 in vitro have revealed sequences within the telomerase RNA subunit (TER) that are required to establ

198 identified a precursor of the fission yeast telomerase RNA subunit (TER1) and demonstrated that the

199 study, we establish additional roles of the telomerase RNA subunit by demonstrating that RNA motifs

200 Saccharomyces cerevisiae and in humans, the telomerase RNA subunit is bound by Ku, a ring-shaped pro

201 The Saccharomyces cerevisiae telomerase RNA subunit is encoded by the TLC1 gene.

202 The integral telomerase RNA subunit templates the synthesis of telome

203 stion, we engineered two mutant forms of the telomerase RNA subunit that contain DNA only in the temp

204 ubunit, hTERT, and key elements of the human telomerase RNA subunit, hTR.

205 of the four conserved elements in the yeast telomerase RNA subunit, TLC1, disrupts activity, the RNA

206 py only a short template sequence within the telomerase RNA subunit.

207 Telomerase RNA subunits are phylogenetically highly dive

208 ractions of PCBP2 KH1 with telomeric DNA and telomerase RNA suggest that PCBPs may participate in mec

209 Inhibition of telomerase activity with human telomerase RNA-targeted antisense agents, and in particu

210 se consists of two essential components, the telomerase RNA template (TR) and telomerase reverse tran

211 -methoxyethyl oligonucleotide that binds the telomerase RNA template and acts as a potent inhibitor.

212 We observe that LNAs complementary to the telomerase RNA template are potent and selective inhibit

213 Heterozygous mutations of the human telomerase RNA template gene (TERC) have been described

214 t repeats defining the ends of the K. lactis telomerase RNA template in telomerase translocation, we

215 overexpression of TERT in cells lacking the telomerase RNA template is also ineffective in preventin

216 ce lacking telomerase (for example, mTR(-/-) telomerase RNA template mutants) provide a model for inv

217 Our results suggest that telomerase RNA template sequence is a key determinant of

218 thology in later-generation mice lacking the telomerase RNA template Terc, including acceleration of

219 yet poorly understood, mechanism whereby the telomerase RNA template translocates and realigns with t

220 erase catalytic component) and TERC/hTR (the telomerase RNA template) were measured using quantitativ

221 d in a cells lacking TERT but containing the telomerase RNA template, increases their resistance to a

222 ion occurs between DNA interactions with the telomerase RNA template, the active site in the telomera

223 bozymes to target the telomerase mRNA or the telomerase RNA template.

224 relia stereotypically misincorporates TTP at telomerase RNA templating nucleotide C52, accounting for

225 ends of linear chromosomes using an integral telomerase RNA (TER) and telomerase reverse transcriptas

226 peat DNA at their 3'-ends, using an integral telomerase RNA (TER) and telomerase reverse transcriptas

227 Telomerase reverse transcriptase (TERT) and telomerase RNA (TER) assemble as part of a holoenzyme th

228 rein the binding of p65 to stems I and IV of telomerase RNA (TER) causes a conformational change that

229 ase is a ribonucleoprotein with an intrinsic telomerase RNA (TER) component.

230 Telomerase reverse transcriptase (TERT) and telomerase RNA (TER) function together to create a uniqu

231 telomerase reverse transcriptase (TERT) and telomerase RNA (TER) have been hypothesized to account f

232 ven proteins and the TERT-binding regions of telomerase RNA (TER) have been localized by affinity lab

233 Telomerase RNA (TER) is an essential component of the te

234 Telomerase RNA (TER) provides the template for replicati

235 na telomerase comprises a ternary complex of telomerase RNA (TER), telomerase reverse transcriptase (

236 ain a telomerase reverse transcriptase and a telomerase RNA (TER), which together provide the minimal

237 telomerase reverse transcriptase (TERT) and telomerase RNA (TER).

238 (TERT) copies a template within the integral telomerase RNA (TER).

239 odification and for cellular accumulation of telomerase RNA (TER).

240 anscriptase (TERT) protein and an associated telomerase RNA (TER).

241 omerase reverse transcriptase (TERT) and the telomerase RNA (TER).

242 elomerase reverse transcriptase (TERT) and a telomerase RNA (TER).

243 se transcriptase requires a multidomain RNA (telomerase RNA, TER), which includes an integral RNA tem

244 The fission yeast telomerase RNA (TER1) precursor harbors an intron immedi

245 In the yeast Kluyveromyces lactis, the telomerase RNA (Ter1) template has 30 nucleotides of per

246 vage reaction generates the mature 3' end of telomerase RNA (TER1, the functional RNA encoded by the

247 We report that the Schizosaccharomyces pombe telomerase RNA, TER1 (telomerase RNA 1), also contains a

248 Human telomerase RNA TERC occupies telomeres and Wnt pathway g

249 Mutations in the human telomerase RNA (TERC) occur in autosomal dominant dysker

250 ng the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin.

251 due to a mutation in the gene-encoding human telomerase RNA (TERC), resulting in telomere shortening.

252 wever, the occurrence of colon carcinomas in telomerase RNA (Terc)-null, p53-mutant mice has revealed

253 ed region in the CR4-CR5 domain of mammalian telomerase RNA, termed P6.1.

254 ve identified nucleotide determinants in the telomerase RNA that are responsible for this difference

255 Motifs have been defined within the telomerase RNA that contribute to mature RNA accumulatio

256 al residues in the alignment domain of human telomerase RNA that contribute to the activity and proce

257 Here, we identify a region of telomerase RNA that is necessary for both correct 5' tem

258 ement of a 95-nucleotide region of the yeast telomerase RNA that is required for Est2 interaction wit

259 tant nucleotides in the pseudoknot domain of telomerase RNA that potentially mediate the incompatibil

260 tTERT), the catalytic protein component, and telomerase RNA that provides the template for telomere r

261 periments identify essential residues of the telomerase RNA that regulate telomerase activity and pro

262 other yeast species were found to also have telomerase RNAs that encode relatively long 7- to 10-nuc

263 for mediating protein interactions with the telomerase RNA TLC1 have been identified.

264 time that the yeast Saccharomyces cerevisiae telomerase RNA TLC1 likewise forms dimers in vitro.

265 rase protein Est2p even in cells lacking the telomerase RNA TLC1, or the telomerase-associated protei

266 p sequencing, we show that the budding yeast telomerase RNA (TLC1 RNA) is spatially segregated to the

267 r telomeres to determine the levels of their telomerase RNA (TLC1) abundance.

268 1 subunits via independent interactions with telomerase RNA (TLC1) and telomeric proteins Sir4 and Cd

269 s cerevisiae, distinct regions of the 1.2-kb telomerase RNA (TLC1) bind to the catalytic subunit Est2

270 inding to double-stranded DNA (dsDNA) and to telomerase RNA (TLC1) promotes Ku's telomeric functions

271 acterization of the Saccharomyces cerevisiae telomerase RNA (TLC1) pseudoknot identified tertiary str

272 ntral domain of the Saccharomyces cerevisiae telomerase RNA (TLC1) that are important for telomerase

273 oknot structure) of Saccharomyces cerevisiae telomerase RNA (TLC1).

274 s at template positions 474-476 of the yeast telomerase RNA, TLC1.

275 o Cajal bodies, resulting in misdirection of telomerase RNA to nucleoli, which prevents telomerase fr

276 L), a time when Cajal bodies fail to deliver telomerase RNA to telomeres.

277 the telomerase reverse transcriptase (TERT), telomerase RNA (TR) and other telomerase-associated prot

278 omposition and only moderately correlated to telomerase RNA (TR) binding.

279 e transcriptase (RT) containing an intrinsic telomerase RNA (TR) component.

280 Telomerase RNA (TR) from different groups of species var

281 ver capable of predicting core structures of telomerase RNA (TR) in yeast genomes.

282 er of the two core components of telomerase, telomerase RNA (TR) or the catalytic protein component t

283 ends of linear chromosomes using an integral telomerase RNA (TR) template.

284 telomerase reverse transcriptase (TERT) and telomerase RNA (TR) that provides the template for telom

285 everse transcriptase containing an intrinsic telomerase RNA (TR) which provides the template for telo

286 rse transcriptase (TERT) and template in the telomerase RNA (TR), thereby helping to maintain genome

287 leoprotein complex, where the RNA component [telomerase RNA (TR)] not only provides the template for

288 a reverse transcriptase and an RNA subunit (telomerase RNA [TR]).

289 re we show that in Schizosaccharomyces pombe telomerase RNA transcripts must be processed to generate

290 Reconstitution of V867M hTERT and telomerase RNAs (TRs) with mutated template sequences re

291 te the biological function of disease-linked telomerase RNA variants and their impact on the function

292 We find that telomerase RNA variants discovered in patients with dysk

293 between BC200 and the quadruplex-containing telomerase RNA was confirmed by pull-down assays of the

294 permuted variants of Tetrahymena thermophila telomerase RNA, we identify the features that allow reco

295 tein p65 induces structural rearrangement of telomerase RNA, which in turn directs the binding of the

296 rRNA, U small nuclear RNA (snRNA), and human telomerase RNA, which is altered upon treatment with DNA

297 Recombinant p43 binds telomerase RNA with low-nanomolar affinity in vitro, rec

298 iation with vaults, while the association of telomerase RNA with the telomerase complex is independen

299 Mouse telomerase RNAs with mutations that disrupted base pairi

300 used to determine the global organization of telomerase RNA within catalytically active holoenzymes.