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1 ons and transcript fusions and predictive of telomerase activity.
2 cit correlated with the mutations' impact on telomerase activity.
3 fected individuals on cART via inhibition of telomerase activity.
4 NA (hTR/TERC), thereby inhibiting endogenous telomerase activity.
5 t is not clear how these elements coordinate telomerase activity.
6 events have been shown previously to inhibit telomerase activity.
7 ed all detectable cardiac telomerase RNA and telomerase activity.
8 9 ribose 2'-OH as a potential contributor to telomerase activity.
9 sensors, aptasensors, and a sensor following telomerase activity.
10 ree specialized retroelements rather than by telomerase activity.
11  the effect of BCR stimulation on modulating telomerase activity.
12 ttractive strategy for the inhibition of the telomerase activity.
13  TERT serves as the major limiting agent for telomerase activity.
14 sence of very short telomeres despite normal telomerase activity.
15 p1 implicates these proteins in restraint of telomerase activity.
16 nce are located at telomeres irrespective of telomerase activity.
17 decreased ability to associate with TERC and telomerase activity.
18  homologs in related yeast species influence telomerase activity.
19 and thereby stimulating hTERT expression and telomerase activity.
20 icipate in the TPP1-dependent recruitment of telomerase activity.
21 n is a highly useful approach for modulating telomerase activity.
22 elusive because TRF1 has no direct effect on telomerase activity.
23 nd interhelical dynamics are correlated with telomerase activity.
24 en endogenous estrogens, telomere length and telomerase activity.
25 T mRNA and stabilizes it, leading to greater telomerase activity.
26 tential contribution that Est3 might make to telomerase activity.
27  cell cycle-regulated changes independent of telomerase activity.
28 in C33A cells had no effect on hTERT mRNA or telomerase activity.
29 sibly reversed by reactivation of endogenous telomerase activity.
30 e aspects of aging, including an increase in telomerase activity.
31 h numbers of telomere-bound proteins inhibit telomerase activity.
32 tards cytokine profile changes, and enhances telomerase activity.
33 atase inhibitor, blocked androgen effects on telomerase activity.
34  undetectable, yet these cells retain strong telomerase activity.
35 ith Myc protein, thereby increasing cellular telomerase activity.
36 oderate hyperthermia (43 degrees C) enhances telomerase activity.
37 s than in normal cells, which do not exhibit telomerase activity.
38 d lifestyle are associated with increases in telomerase activity.
39 , and they have opposing roles in regulating telomerase activity.
40 acts with a regulatory lncRNA that represses telomerase activity.
41 th upregulated TERT expression and enzymatic telomerase activity.
42 ease in TERT transcription with no impact on telomerase activity.
43 en the core and CR4/5 significantly increase telomerase activity.
44 sively pursued ligands for inhibition of the telomerase activity.
45  factor overexpression and/or a reduction in telomerase activity.
46 d is still used for routine determination of telomerase activity.
47 letion is independent of telomere length and telomerase activity.
48 ulated kinase 2 (Dyrk2) negatively regulates telomerase activity.
49 1 Vpr (viral protein R) negatively modulates telomerase activity.
50 P-dependent manner to compensate for reduced telomerase activities.
51 d unlimited self-renewal ability with robust telomerase activities.
52 s through simultaneous targeting of multiple telomerase activities.
53 number of telomerase-extended products (i.e. telomerase activity; 57.8 +/- 7.5) in a single HeLa cell
54                                              Telomerase activity--a well-recognized universal cancer
55  also show that recombinant Est3p stimulates telomerase activity above basal levels in vitro in a man
56                    These mutations cause low telomerase activity, accelerated telomere shortening, an
57 tion of telomerase activity in single cells, telomerase activity across several common telomerase pos
58 ons or insertions that eliminated or reduced telomerase activity also enhanced cell proliferation.
59 n of hTERT, resulting in cells with enhanced telomerase activities and increased telomere length.
60 RISPR-Cas9 or siRNA knockdown led to reduced telomerase activities and shortened telomere length, sug
61 tion at 0.6 M NaCl, despite the retention of telomerase activity and a comparable yield of hTR.
62 ence TERT expression, resulting in increased telomerase activity and aberrantly long telomeres.
63 ral infections and has been shown to inhibit telomerase activity and accelerate T cell differentiatio
64 rase activity or on the relationship between telomerase activity and antidepressant response.
65 exclusively associated with the reduction of telomerase activity and attrition of telomeres, whereas
66 e cGVHD have fewer Treg with lower levels of telomerase activity and Bcl-2 expression.
67                                 We show that telomerase activity and cardiomyocyte telomere length de
68   Tenofovir was the most potent inhibitor of telomerase activity and caused greatest shortening of TL
69 ne proximal signaling responses to HB57-dex, telomerase activity and cell proliferation, when inducib
70 n, whereas GRHL2 knockdown notably repressed telomerase activity and cell proliferation.
71 t tumor suppressor essential for maintaining telomerase activity and chromosome stability.
72 ive lifestyle changes significantly increase telomerase activity and consequently telomere maintenanc
73 stability and demonstrate proportionality of telomerase activity and expression with the number of ap
74  Our analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomer
75                       Estradiol (E2) induced telomerase activity and hTERT mRNA expression in the est
76  selective inhibitor of MEK1/MEK2, inhibited telomerase activity and hTERT mRNA expression induced by
77                    Depleting TERRA increases telomerase activity and induces telomeric pathologies, i
78                          We also used direct telomerase activity and nucleic acid binding assays to e
79 knockdown of PABPCs decreased hTERT mRNA and telomerase activity and overexpression of PABPC4 increas
80 stigated whether certain threshold levels of telomerase activity and processivity are required to mai
81 osome end-binding protein complex stimulates telomerase activity and processivity provide incentive f
82 ngs support motif 3 as a key determinant for telomerase activity and processivity.
83 s nucleic acid substrates leading to loss of telomerase activity and processivity.
84 on of TER1, but not TER2, leads to decreased telomerase activity and progressive telomere shortening
85 gated anti-mu mAb HB57 (HB57-dex), increased telomerase activity and promoted cell survival and proli
86  (telomerase reverse transcriptase) mRNA and telomerase activity and reduces cell proliferation.
87 ificant growth reserve as documented by high telomerase activity and relatively long telomeres.
88    Although both TER1 and TER2 copurify with telomerase activity and serve as templates for telomeras
89  injury, and, given the relationship between telomerase activity and stem cell populations, suggests
90                                              Telomerase activity and telomere length (TL) were measur
91                These variants might regulate telomerase activity and telomere length because it is th
92 f ZNF148 results in reduced TERT expression, telomerase activity and telomere length.
93 at BRCA1 overexpression caused inhibition of telomerase activity and telomere shortening in breast an
94 rch has demonstrated that HSV-1 can increase telomerase activity and that expression of the catalytic
95 nstream of the template may be important for telomerase activity and that the region could fold into
96 T mRNA and stabilizes it, leading to greater telomerase activity and the avoidance of cellular senesc
97             Third, NS depletion reduced both telomerase activity and the cellular level of pseudourid
98 omeric DNA replication stress is resolved by telomerase activity and the DDR in two parallel pathways
99 ompounds is a therapeutic path to regulating telomerase activity and thereby selectively inhibit canc
100 silencing of GRHL2 was essential in reducing telomerase activity and viability of tested cancer cells
101 ividuals with relatively lower pre-treatment telomerase activity and with relatively greater increase
102  10% to 15% of human cancers lack detectable telomerase activity, and a subset of these maintain telo
103       The relationship between NRTI, reduced telomerase activity, and accelerated aging requires furt
104 relation between thermodynamic stability and telomerase activity, and are consistent with the identif
105  in overall proliferative potential, reduced telomerase activity, and blunted IL-2 gene transcription
106 x17, Sox10 and S100beta, are cloneable, have telomerase activity, and can differentiate into neural c
107                                 Treg number, telomerase activity, and expression of Bcl-2 were each i
108 , population-doubling time, telomere length, telomerase activity, and insulin-like growth factor-1 re
109               Many cancer cells express high telomerase activity, and mutations in telomerase subunit
110 D27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferat
111 sponsible for reduced TERC levels, decreased telomerase activity, and short telomeres.
112 associated with increases in TERC stability, telomerase activity, and telomere elongation.
113 telomerase reverse transcriptase expression, telomerase activity, and telomere length; but studies ut
114  the triggering of senescence, a decrease in telomerase activity, and the down-regulation of genes in
115 ogressive infection, while high constitutive telomerase activities appears to contribute to maintenan
116             While most human cancers express telomerase activity, approximately 10%-15% employ a reco
117 prolonged exposure to estrogen and increased telomerase activity are associated with endometrial carc
118        Here we show that telomere length and telomerase activity are impaired in primary lymphocyte s
119      Inherited mutations in TERT that reduce telomerase activity are risk factors for acute myeloid l
120 ne synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfu
121  of this study, we report these increases in telomerase activity as a significant association rather
122 g individual subunits, which increased total telomerase activity as measured by the direct enzyme ass
123                   Somatic stem cells require telomerase activity, as evidenced by progressive stem ce
124 ral interactions that are also important for telomerase activity, as previously observed for the Kluy
125                  To develop a new method for telomerase activity assay that is fast, simple, and cost
126 is structured and has unexpected base pairs, telomerase activity assays with nucleotide substitutions
127 he structural basis of human and Tetrahymena telomerase activity, assembly, and interactions.
128 ave found that CIRP is necessary to maintain telomerase activities at both 32 degrees C and 37 degree
129 xist as a complex and that FEN1 can regulate telomerase activity at telomeres in mammalian cells.
130 ces cellular senescence but does not inhibit telomerase activity at the nanomolar dosage levels requi
131                                 By measuring telomerase activity at the single-cell level using quant
132     In yeast grown at elevated temperatures, telomerase activity becomes limiting: haploid cell popul
133                       Moreover, TSI requires telomerase activity but is independent of the functional
134 ine-modification of P6.1 slightly attenuates telomerase activity but slightly increases processivity
135 d porcine OCT4, NANOG, and SOX2 and had high telomerase activity, but also continued to express the 4
136 nked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and
137                  We found that Vpr inhibited telomerase activity by down-regulating TERT protein, a c
138        Our results suggest that Vpr inhibits telomerase activity by hijacking the host E3 ligase comp
139 ermore, our study implies that inhibition of telomerase activity by some G-quadruplex ligands is not
140 measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplificat
141                                      Whereas telomerase activity can be reconstituted in vitro with o
142  suppressing c-Myc expression, or inhibiting telomerase activity, caused telomere dysfunction and pro
143  response in U-CLL than M-CLL cells, whereas telomerase activity, cell survival, and proliferation we
144 derived CD34(+) cells to androgens increased telomerase activity, coincident with higher TERT mRNA le
145  an isoform of gamma-TERT that has increased telomerase activity compared with wild-type (WT) TERT.
146 vascular flow-mediated dilation, and loss of telomerase activity contributes to the change of mediato
147 identifies the cells responsible for cardiac telomerase activity, demonstrates a significant diminuti
148         Despite the biomedical importance of telomerase activity, detailed structural models for the
149 , this approach affords high sensitivity for telomerase activity detection and it can be regarded as
150 werful tool for cost-effective and sensitive telomerase activity detection in urinary bladder cancer.
151 wed by native gel electrophoresis and in-gel telomerase activity detection to query the composition o
152 how that the mechanisms underlying excessive telomerase activity differ markedly between taz1Delta an
153 e telomerase enzyme, MST-312, to investigate telomerase activity during HSV infection.
154 vity and with relatively greater increase in telomerase activity during treatment, showed superior an
155                        Moreover, significant telomerase activity elevation was also measured from pat
156                          Restoring defective telomerase activity emerges as a therapeutic target in r
157 ll phenotype defined by long telomeres, high telomerase activity, enhanced cell proliferation, and at
158 g protocol and achieves ultrafast detection: telomerase activity equivalent to a single HeLa cancer c
159                 Here, we show that targeting telomerase activity eradicates AML LSCs.
160 lastic somatic cells are mortal, express low telomerase activity, expand for an extensive but finite
161                          Differences between telomerase activity expression levels or telomere length
162                     Using this strategy, the telomerase activity extracted from 10 cultured cancer ce
163 ree, and highly sensitive detection of human telomerase activity, extracted from A549 cells.
164 mplexes with similar CD spectra and enhances telomerase activity for all DNA substrates tested, regar
165 vel cancer detection platform which measures telomerase activity from live CTCs captured on a parylen
166  might make to enzyme catalysis, we compared telomerase activity from wild type and est3-Delta strain
167 memory cells, and the levels of IL-7-induced telomerase activity had a significant inverse correlatio
168                                  At 5 years, telomerase activity had decreased from baseline by 0.25
169 er assembly of TERT and TER is essential for telomerase activity; however, a detailed understanding o
170 ormal somatic cells, which show little or no telomerase activity, immune cells up-regulate telomerase
171 ated for 4 mo with MZ-5-156 showed increased telomerase activity, improvement in some measures of oxi
172 pacts on many biological functions including telomerase activities in the telomere region.
173 abine, and tenofovir significantly inhibited telomerase activity in activated PBMCs in vitro.
174 -27, but there are no significant changes of telomerase activity in both Alt and non-Alt cells.
175 , and reliable in vitro method for measuring telomerase activity in cell extracts.
176                                          Low telomerase activity in circulating peripheral blood mono
177 es, the binding of additional Rap1p inhibits telomerase activity in cis.
178      This is the first report characterizing telomerase activity in depressed individuals.
179 eportedly shortened in major depression, but telomerase activity in depression has not been previousl
180                  In the prolonged absence of telomerase activity in dividing cells, telomeres eventua
181 n the MAPK pathway and estrogen induction of telomerase activity in endometrial cancer cells.
182 multicolor DNA detection and the analysis of telomerase activity in extracts from cancer cells.
183 s loss coincided with a dramatic decrease in telomerase activity in G2 atr mutants.
184                     In contrast, the reduced telomerase activity in highly differentiated CD8+CD28(-)
185 on of PI3K or AKT signaling pathways reduced telomerase activity in HTLV-I cells.
186 omprehensive lifestyle changes and increased telomerase activity in human immune-system cells.
187  the first demonstration of the detection of telomerase activity in human urine on the chip-based sys
188 abilities, to increase hTERT mRNA levels and telomerase activity in keratinocytes expressing HPV16 E6
189 s, flap endonuclease I (FEN1), in regulating telomerase activity in mammalian cells.
190 o data showing dGTP-dependent stimulation of telomerase activity in multiple organisms and suggest th
191  predict that crowding can partially restore telomerase activity in mutants with decreased PK stabili
192  we found that IL-7 induced higher levels of telomerase activity in naive cells than in memory cells,
193 ntify the cell types responsible for cardiac telomerase activity in neonatal, adult, and cryoinjured
194 s resulted in a significant reduction of the telomerase activity in OSCC cells.
195 s the dominant mechanism conferring the high telomerase activity in proliferating cells, such as embr
196 ns we observe demonstrate indefinite somatic telomerase activity in proliferating stem cells during r
197 lomerase activity, including quantitation of telomerase activity in single cells, telomerase activity
198 lines were treated with imetelstat in vitro, telomerase activity in the bulk tumor cells and CSC subp
199 e reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers.
200 ngth of HT use was not associated with TL or telomerase activity in this study.
201 f telomerase, is limiting for reconstituting telomerase activity in tumors.
202 NA has been demonstrated to be important for telomerase activity in vertebrates, ciliates, and yeast.
203 tutions that disrupt the base triples reduce telomerase activity in vitro NMR studies also reveal tha
204 doknot (t/PK) and CR4/5 domains required for telomerase activity in vitro.
205                                 Furthermore, telomerase activity in vivo depends on a functional MRT-
206 ethylation into telomerase RNA can influence telomerase activity in vivo.
207 rom telomere elongation, but also from other telomerase activities, including cellular lifespan exten
208 of a droplet digital TRAP (ddTRAP) assay for telomerase activity, including quantitation of telomeras
209 remature vascular aging, as shown by reduced telomerase activity, increased beta-galactosidase-positi
210 helial cancer cell line results in decreased telomerase activity, indicating the mutation is causal f
211 er telomeres and in general possessed higher telomerase activity indicative of greater proliferative
212                 The determination of urinary telomerase activity is a promising tool for the diagnosi
213                                     Notably, telomerase activity is affected in a gene dose-dependent
214                           However, increased telomerase activity is associated with approximately 90%
215                                              Telomerase activity is characterized by the expression o
216 ation and experimental results indicate that telomerase activity is maximized on AuNP surface under g
217  These findings suggest that E2-induction of telomerase activity is mediated via the MAPK pathway in
218 ivity in multiple organisms and suggest that telomerase activity is modulated in vivo by dGTP levels.
219                                              Telomerase activity is not readily detected in resting h
220                                        Human telomerase activity is often determined by the expressio
221       It is possible that a small deficit in telomerase activity is sufficient to cause telomere shor
222                            Typical assay for telomerase activity is the telomeric repeat amplificatio
223 transcriptase (Tert), which is essential for telomerase activity, is limiting in many types of cells
224 fovir at therapeutic concentrations, inhibit telomerase activity leading to accelerated shortening of
225                                     Although telomerase activity levels were unperturbed, telomeres w
226 if1alpha levels, as well as Tert expression, telomerase activity levels, and telomere length.
227 mpanied by a reduction in both Tert mRNA and telomerase activity levels.
228 fore plays an important role in establishing telomerase activity levels.
229 ning was not accompanied by changes in total telomerase activity, localization of TIN2, or telomere e
230              These results suggest that high telomerase activity may be a better marker of aggressive
231 ease increases with age, telomere length and telomerase activity may play a role in its progression.
232                                         PBMC telomerase activity might reflect a novel aspect of depr
233  CD8+ T cells increased their proliferation, telomerase activity, mitochondrial biogenesis, and fitne
234              We examined the hypothesis that telomerase activity modulates microvascular flow-mediate
235 ugh both anti-BCR stimuli induced comparable telomerase activity, normal CD5(+) B cells preferentiall
236           Most importantly, E6 increases the telomerase activity of human foreskin fibroblasts transd
237  this study, we examined telomere length and telomerase activity of Treg and conventional CD4(+) T ce
238 se assays, which measure telomere length and telomerase activity of tumor extracts, are conventionall
239                Several TER mutants exhibited telomerase activity only in the presence of p65, reveali
240  in protein-protein interactions, regulating telomerase activity or DNA-binding.
241 reports of the effects of antidepressants on telomerase activity or on the relationship between telom
242 t units of telomers allowed the detection of telomerase activity originating from 380 +/- 20 cancer 2
243 e CD4 T cells are defective in up-regulating telomerase activity (P < 0.0001) due to insufficient ind
244  cells even though neither has any effect on telomerase activity per se.
245 lanced not only by temporal expansion of the telomerase activity period, but also by markedly increas
246 s on FEN1 depletion, suggesting that ongoing telomerase activity protected telomeres.
247 ng effects of PinX1 loss appear to depend on telomerase activity, raising new models and questions fo
248    Consistently, addition of Pop1 allows for telomerase activity reconstitution with wild-type telome
249  natural compound with anti-carcinogenic and telomerase activity-reducing properties.
250 n-expressing neuronal precursors even though telomerase activity remained high.
251                                    Sustained telomerase activity represents one of the oncogenic step
252                                   Minimally, telomerase activity requires a templating RNA and a cata
253 e show that 2'-O methylation at U809 reduces telomerase activity, resulting in telomere shortening, w
254                                      Loss of telomerase activity results in shortening of telomeric D
255 sion of telomerase reverse transcriptase and telomerase activity significantly increased cell death o
256 .06, Wald chi(2)=3.7, p=0.04) and with lower telomerase activity (standardized beta=-0.09, Wald chi(2
257 urally occurring AS TERT variants which lack telomerase activity stimulate cell proliferation.
258 esence of secondary structures necessary for telomerase activity, such as a yeast-like template bound
259 ocin treatment also triggered a reduction in telomerase activity, suggesting that the prolonged absen
260         Signaling via this pathway inhibited telomerase activity, T cell proliferation and the expres
261    Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lym
262 e combination of shorter telomeres with high telomerase activity (TA) may be indicative of active cel
263 leukocyte telomere length (TL) and leukocyte telomerase activity (TA), in 434 men and women from the
264  activating hTERT transcription and inducing telomerase activity (TA).
265 bally profile the contribution of kinases to telomerase activity (TA).
266 eletion of Fancc (Fancc(-/-)) did not affect telomerase activity, telomere length or telomeric end-ca
267   Telomere length, cellular senescence rate, telomerase activity, telomeric aberration, and DNA repai
268 aining cART (n = 39) had significantly lower telomerase activity than HIV-uninfected patients (n = 47
269 s that are ADA(+) have significantly greater telomerase activity than those that do not express ADA a
270 unmutated IGHV genes (U-CLL) exhibit greater telomerase activity than those with mutated IGHV genes (
271 e, we uncovered an unanticipated gradient of telomerase activity that also enables isolation of more
272              We report a new assay for human telomerase activity that relies on polyvalent oligonucle
273 elterin protein, TPP1, which also influences telomerase activity through interaction with the Est2p h
274 uman papillomavirus (HPV) E6 protein induces telomerase activity through transcriptional activation o
275            The therapeutic value of altering telomerase activity thus provides ample impetus to study
276 to human fibroblasts and myoblasts increases telomerase activity transiently (24-48 h) and rapidly ex
277 trogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, i
278 nt core and CR4/5 domains completely abolish telomerase activity, unveiling mechanistically critical
279 t only a subset of CD28+ T-cells have robust telomerase activity upon stimulation and are capable of
280 tor biosensor to detect label-free, PCR-free telomerase activity using telomerase extracted from two
281  Psis could have a subtle influence on human telomerase activity via impact on TER-TERT or TER-TER in
282 ough an increase in both telomere length and telomerase activity was achieved in antigenic-peptide-st
283     Peripheral blood mononuclear cell (PBMC) telomerase activity was assessed in 20 medication-free d
284                                              Telomerase activity was evaluated by a telomeric repeat
285    Treg telomere length was shorter and Treg telomerase activity was increased compared with Tcon (P
286 rs into telomerase-deficient cell lines, and telomerase activity was measured in cell lysates.
287             Conversely, limited constitutive telomerase activity was observed in HIV-1-specific CD8+
288 n an open-label manner for 8 weeks, and PBMC telomerase activity was reassessed in 15 of these indivi
289                                Pre-treatment telomerase activity was significantly elevated in the de
290 uish the two SCC telomere phenotypes, as did telomerase activity, we found a trend for a higher degre
291           Higher proliferation potential and telomerase activity were observed in the P-MSCs compared
292 e aryl hydrocarbon receptor (AhR) and induce telomerase activity, which elongates LTL.
293 iated through a p16-dependent suppression of telomerase activity, which has been implicated in key ce
294 e describe a strategy to detect CTC based on telomerase activity, which is elevated in nearly all tum
295  corresponded to high levels of constitutive telomerase activity, which was associated with preservat
296 us for telomerase mutations had low baseline telomerase activity, which was restored to normal levels
297 ates of several cell types without enhancing telomerase activity, while decreasing the endogenous exp
298 rget recognition, embodied by assay of human telomerase activity with DNA-conjugated gold nanoparticl
299 ric hybrid G-quadruplex and strongly inhibit telomerase activity with IC50 of 600 nM.
300 ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown.

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