コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 ons and transcript fusions and predictive of telomerase activity.
2 cit correlated with the mutations' impact on telomerase activity.
3 fected individuals on cART via inhibition of telomerase activity.
4 NA (hTR/TERC), thereby inhibiting endogenous telomerase activity.
5 t is not clear how these elements coordinate telomerase activity.
6 events have been shown previously to inhibit telomerase activity.
7 ed all detectable cardiac telomerase RNA and telomerase activity.
8 9 ribose 2'-OH as a potential contributor to telomerase activity.
9 sensors, aptasensors, and a sensor following telomerase activity.
10 ree specialized retroelements rather than by telomerase activity.
11 the effect of BCR stimulation on modulating telomerase activity.
12 ttractive strategy for the inhibition of the telomerase activity.
13 TERT serves as the major limiting agent for telomerase activity.
14 sence of very short telomeres despite normal telomerase activity.
15 p1 implicates these proteins in restraint of telomerase activity.
16 nce are located at telomeres irrespective of telomerase activity.
17 decreased ability to associate with TERC and telomerase activity.
18 homologs in related yeast species influence telomerase activity.
19 and thereby stimulating hTERT expression and telomerase activity.
20 icipate in the TPP1-dependent recruitment of telomerase activity.
21 n is a highly useful approach for modulating telomerase activity.
22 elusive because TRF1 has no direct effect on telomerase activity.
23 nd interhelical dynamics are correlated with telomerase activity.
24 en endogenous estrogens, telomere length and telomerase activity.
25 T mRNA and stabilizes it, leading to greater telomerase activity.
26 tential contribution that Est3 might make to telomerase activity.
27 cell cycle-regulated changes independent of telomerase activity.
28 in C33A cells had no effect on hTERT mRNA or telomerase activity.
29 sibly reversed by reactivation of endogenous telomerase activity.
30 e aspects of aging, including an increase in telomerase activity.
31 h numbers of telomere-bound proteins inhibit telomerase activity.
32 tards cytokine profile changes, and enhances telomerase activity.
33 atase inhibitor, blocked androgen effects on telomerase activity.
34 undetectable, yet these cells retain strong telomerase activity.
35 ith Myc protein, thereby increasing cellular telomerase activity.
36 oderate hyperthermia (43 degrees C) enhances telomerase activity.
37 s than in normal cells, which do not exhibit telomerase activity.
38 d lifestyle are associated with increases in telomerase activity.
39 , and they have opposing roles in regulating telomerase activity.
40 acts with a regulatory lncRNA that represses telomerase activity.
41 th upregulated TERT expression and enzymatic telomerase activity.
42 ease in TERT transcription with no impact on telomerase activity.
43 en the core and CR4/5 significantly increase telomerase activity.
44 sively pursued ligands for inhibition of the telomerase activity.
45 factor overexpression and/or a reduction in telomerase activity.
46 d is still used for routine determination of telomerase activity.
47 letion is independent of telomere length and telomerase activity.
48 ulated kinase 2 (Dyrk2) negatively regulates telomerase activity.
49 1 Vpr (viral protein R) negatively modulates telomerase activity.
50 P-dependent manner to compensate for reduced telomerase activities.
51 d unlimited self-renewal ability with robust telomerase activities.
52 s through simultaneous targeting of multiple telomerase activities.
53 number of telomerase-extended products (i.e. telomerase activity; 57.8 +/- 7.5) in a single HeLa cell
55 also show that recombinant Est3p stimulates telomerase activity above basal levels in vitro in a man
57 tion of telomerase activity in single cells, telomerase activity across several common telomerase pos
58 ons or insertions that eliminated or reduced telomerase activity also enhanced cell proliferation.
59 n of hTERT, resulting in cells with enhanced telomerase activities and increased telomere length.
60 RISPR-Cas9 or siRNA knockdown led to reduced telomerase activities and shortened telomere length, sug
63 ral infections and has been shown to inhibit telomerase activity and accelerate T cell differentiatio
65 exclusively associated with the reduction of telomerase activity and attrition of telomeres, whereas
68 Tenofovir was the most potent inhibitor of telomerase activity and caused greatest shortening of TL
69 ne proximal signaling responses to HB57-dex, telomerase activity and cell proliferation, when inducib
72 ive lifestyle changes significantly increase telomerase activity and consequently telomere maintenanc
73 stability and demonstrate proportionality of telomerase activity and expression with the number of ap
74 Our analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomer
76 selective inhibitor of MEK1/MEK2, inhibited telomerase activity and hTERT mRNA expression induced by
79 knockdown of PABPCs decreased hTERT mRNA and telomerase activity and overexpression of PABPC4 increas
80 stigated whether certain threshold levels of telomerase activity and processivity are required to mai
81 osome end-binding protein complex stimulates telomerase activity and processivity provide incentive f
84 on of TER1, but not TER2, leads to decreased telomerase activity and progressive telomere shortening
85 gated anti-mu mAb HB57 (HB57-dex), increased telomerase activity and promoted cell survival and proli
88 Although both TER1 and TER2 copurify with telomerase activity and serve as templates for telomeras
89 injury, and, given the relationship between telomerase activity and stem cell populations, suggests
93 at BRCA1 overexpression caused inhibition of telomerase activity and telomere shortening in breast an
94 rch has demonstrated that HSV-1 can increase telomerase activity and that expression of the catalytic
95 nstream of the template may be important for telomerase activity and that the region could fold into
96 T mRNA and stabilizes it, leading to greater telomerase activity and the avoidance of cellular senesc
98 omeric DNA replication stress is resolved by telomerase activity and the DDR in two parallel pathways
99 ompounds is a therapeutic path to regulating telomerase activity and thereby selectively inhibit canc
100 silencing of GRHL2 was essential in reducing telomerase activity and viability of tested cancer cells
101 ividuals with relatively lower pre-treatment telomerase activity and with relatively greater increase
102 10% to 15% of human cancers lack detectable telomerase activity, and a subset of these maintain telo
104 relation between thermodynamic stability and telomerase activity, and are consistent with the identif
105 in overall proliferative potential, reduced telomerase activity, and blunted IL-2 gene transcription
106 x17, Sox10 and S100beta, are cloneable, have telomerase activity, and can differentiate into neural c
108 , population-doubling time, telomere length, telomerase activity, and insulin-like growth factor-1 re
110 D27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferat
113 telomerase reverse transcriptase expression, telomerase activity, and telomere length; but studies ut
114 the triggering of senescence, a decrease in telomerase activity, and the down-regulation of genes in
115 ogressive infection, while high constitutive telomerase activities appears to contribute to maintenan
117 prolonged exposure to estrogen and increased telomerase activity are associated with endometrial carc
119 Inherited mutations in TERT that reduce telomerase activity are risk factors for acute myeloid l
120 ne synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfu
121 of this study, we report these increases in telomerase activity as a significant association rather
122 g individual subunits, which increased total telomerase activity as measured by the direct enzyme ass
124 ral interactions that are also important for telomerase activity, as previously observed for the Kluy
126 is structured and has unexpected base pairs, telomerase activity assays with nucleotide substitutions
128 ave found that CIRP is necessary to maintain telomerase activities at both 32 degrees C and 37 degree
129 xist as a complex and that FEN1 can regulate telomerase activity at telomeres in mammalian cells.
130 ces cellular senescence but does not inhibit telomerase activity at the nanomolar dosage levels requi
132 In yeast grown at elevated temperatures, telomerase activity becomes limiting: haploid cell popul
134 ine-modification of P6.1 slightly attenuates telomerase activity but slightly increases processivity
135 d porcine OCT4, NANOG, and SOX2 and had high telomerase activity, but also continued to express the 4
136 nked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and
139 ermore, our study implies that inhibition of telomerase activity by some G-quadruplex ligands is not
140 measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplificat
142 suppressing c-Myc expression, or inhibiting telomerase activity, caused telomere dysfunction and pro
143 response in U-CLL than M-CLL cells, whereas telomerase activity, cell survival, and proliferation we
144 derived CD34(+) cells to androgens increased telomerase activity, coincident with higher TERT mRNA le
145 an isoform of gamma-TERT that has increased telomerase activity compared with wild-type (WT) TERT.
146 vascular flow-mediated dilation, and loss of telomerase activity contributes to the change of mediato
147 identifies the cells responsible for cardiac telomerase activity, demonstrates a significant diminuti
149 , this approach affords high sensitivity for telomerase activity detection and it can be regarded as
150 werful tool for cost-effective and sensitive telomerase activity detection in urinary bladder cancer.
151 wed by native gel electrophoresis and in-gel telomerase activity detection to query the composition o
152 how that the mechanisms underlying excessive telomerase activity differ markedly between taz1Delta an
154 vity and with relatively greater increase in telomerase activity during treatment, showed superior an
157 ll phenotype defined by long telomeres, high telomerase activity, enhanced cell proliferation, and at
158 g protocol and achieves ultrafast detection: telomerase activity equivalent to a single HeLa cancer c
160 lastic somatic cells are mortal, express low telomerase activity, expand for an extensive but finite
164 mplexes with similar CD spectra and enhances telomerase activity for all DNA substrates tested, regar
165 vel cancer detection platform which measures telomerase activity from live CTCs captured on a parylen
166 might make to enzyme catalysis, we compared telomerase activity from wild type and est3-Delta strain
167 memory cells, and the levels of IL-7-induced telomerase activity had a significant inverse correlatio
169 er assembly of TERT and TER is essential for telomerase activity; however, a detailed understanding o
170 ormal somatic cells, which show little or no telomerase activity, immune cells up-regulate telomerase
171 ated for 4 mo with MZ-5-156 showed increased telomerase activity, improvement in some measures of oxi
179 eportedly shortened in major depression, but telomerase activity in depression has not been previousl
187 the first demonstration of the detection of telomerase activity in human urine on the chip-based sys
188 abilities, to increase hTERT mRNA levels and telomerase activity in keratinocytes expressing HPV16 E6
190 o data showing dGTP-dependent stimulation of telomerase activity in multiple organisms and suggest th
191 predict that crowding can partially restore telomerase activity in mutants with decreased PK stabili
192 we found that IL-7 induced higher levels of telomerase activity in naive cells than in memory cells,
193 ntify the cell types responsible for cardiac telomerase activity in neonatal, adult, and cryoinjured
195 s the dominant mechanism conferring the high telomerase activity in proliferating cells, such as embr
196 ns we observe demonstrate indefinite somatic telomerase activity in proliferating stem cells during r
197 lomerase activity, including quantitation of telomerase activity in single cells, telomerase activity
198 lines were treated with imetelstat in vitro, telomerase activity in the bulk tumor cells and CSC subp
199 e reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers.
202 NA has been demonstrated to be important for telomerase activity in vertebrates, ciliates, and yeast.
203 tutions that disrupt the base triples reduce telomerase activity in vitro NMR studies also reveal tha
207 rom telomere elongation, but also from other telomerase activities, including cellular lifespan exten
208 of a droplet digital TRAP (ddTRAP) assay for telomerase activity, including quantitation of telomeras
209 remature vascular aging, as shown by reduced telomerase activity, increased beta-galactosidase-positi
210 helial cancer cell line results in decreased telomerase activity, indicating the mutation is causal f
211 er telomeres and in general possessed higher telomerase activity indicative of greater proliferative
216 ation and experimental results indicate that telomerase activity is maximized on AuNP surface under g
217 These findings suggest that E2-induction of telomerase activity is mediated via the MAPK pathway in
218 ivity in multiple organisms and suggest that telomerase activity is modulated in vivo by dGTP levels.
223 transcriptase (Tert), which is essential for telomerase activity, is limiting in many types of cells
224 fovir at therapeutic concentrations, inhibit telomerase activity leading to accelerated shortening of
229 ning was not accompanied by changes in total telomerase activity, localization of TIN2, or telomere e
231 ease increases with age, telomere length and telomerase activity may play a role in its progression.
233 CD8+ T cells increased their proliferation, telomerase activity, mitochondrial biogenesis, and fitne
235 ugh both anti-BCR stimuli induced comparable telomerase activity, normal CD5(+) B cells preferentiall
237 this study, we examined telomere length and telomerase activity of Treg and conventional CD4(+) T ce
238 se assays, which measure telomere length and telomerase activity of tumor extracts, are conventionall
241 reports of the effects of antidepressants on telomerase activity or on the relationship between telom
242 t units of telomers allowed the detection of telomerase activity originating from 380 +/- 20 cancer 2
243 e CD4 T cells are defective in up-regulating telomerase activity (P < 0.0001) due to insufficient ind
245 lanced not only by temporal expansion of the telomerase activity period, but also by markedly increas
247 ng effects of PinX1 loss appear to depend on telomerase activity, raising new models and questions fo
248 Consistently, addition of Pop1 allows for telomerase activity reconstitution with wild-type telome
253 e show that 2'-O methylation at U809 reduces telomerase activity, resulting in telomere shortening, w
255 sion of telomerase reverse transcriptase and telomerase activity significantly increased cell death o
256 .06, Wald chi(2)=3.7, p=0.04) and with lower telomerase activity (standardized beta=-0.09, Wald chi(2
258 esence of secondary structures necessary for telomerase activity, such as a yeast-like template bound
259 ocin treatment also triggered a reduction in telomerase activity, suggesting that the prolonged absen
261 Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lym
262 e combination of shorter telomeres with high telomerase activity (TA) may be indicative of active cel
263 leukocyte telomere length (TL) and leukocyte telomerase activity (TA), in 434 men and women from the
266 eletion of Fancc (Fancc(-/-)) did not affect telomerase activity, telomere length or telomeric end-ca
267 Telomere length, cellular senescence rate, telomerase activity, telomeric aberration, and DNA repai
268 aining cART (n = 39) had significantly lower telomerase activity than HIV-uninfected patients (n = 47
269 s that are ADA(+) have significantly greater telomerase activity than those that do not express ADA a
270 unmutated IGHV genes (U-CLL) exhibit greater telomerase activity than those with mutated IGHV genes (
271 e, we uncovered an unanticipated gradient of telomerase activity that also enables isolation of more
273 elterin protein, TPP1, which also influences telomerase activity through interaction with the Est2p h
274 uman papillomavirus (HPV) E6 protein induces telomerase activity through transcriptional activation o
276 to human fibroblasts and myoblasts increases telomerase activity transiently (24-48 h) and rapidly ex
277 trogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, i
278 nt core and CR4/5 domains completely abolish telomerase activity, unveiling mechanistically critical
279 t only a subset of CD28+ T-cells have robust telomerase activity upon stimulation and are capable of
280 tor biosensor to detect label-free, PCR-free telomerase activity using telomerase extracted from two
281 Psis could have a subtle influence on human telomerase activity via impact on TER-TERT or TER-TER in
282 ough an increase in both telomere length and telomerase activity was achieved in antigenic-peptide-st
283 Peripheral blood mononuclear cell (PBMC) telomerase activity was assessed in 20 medication-free d
285 Treg telomere length was shorter and Treg telomerase activity was increased compared with Tcon (P
288 n an open-label manner for 8 weeks, and PBMC telomerase activity was reassessed in 15 of these indivi
290 uish the two SCC telomere phenotypes, as did telomerase activity, we found a trend for a higher degre
293 iated through a p16-dependent suppression of telomerase activity, which has been implicated in key ce
294 e describe a strategy to detect CTC based on telomerase activity, which is elevated in nearly all tum
295 corresponded to high levels of constitutive telomerase activity, which was associated with preservat
296 us for telomerase mutations had low baseline telomerase activity, which was restored to normal levels
297 ates of several cell types without enhancing telomerase activity, while decreasing the endogenous exp
298 rget recognition, embodied by assay of human telomerase activity with DNA-conjugated gold nanoparticl
300 ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown.
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。