ライフサイエンスコーパス: telomere

1 ong chromosomes and rises from centromere to telomere.

2 e, but the opposite is usually true near the telomeres.

3 he multi-protein complex that protects human telomeres.

4 cells with critically short and unprotected telomeres.

5 ntial for the protection of newly replicated telomeres.

6 ity defines a dividing line between DSBs and telomeres.

7 tter understanding of the shortest length of telomeres.

8 lly present at promoter regions of genes and telomeres.

9 in telomere volume showed DDR at nearly all telomeres.

10 s, which may thus recruit or regulate Blm at telomeres.

11 rmation and the protection of leading-strand telomeres.

12 res, common fragile sites, subtelomeres, and telomeres.

13 ected insight into telomerase interaction at telomeres.

14 nd TRF1 and the damage recruitment of WRN to telomeres.

15 elterin and how it performs its functions at telomeres.

16 aberrant DNA damage and repair responses at telomeres.

17 tates repair pathway choice of dysfunctional telomeres.

18 effects and preferentially affected GSCs and telomeres.

19 e TL, as well as the percent of the shortest telomeres.

20 ly reduces the replication efficiency at ALT telomeres.

21 s the repair pathway choice of dysfunctional telomeres.

22 Taz1-associated chromosomal arm regions and telomeres.

23 Protection of Telomere 1 (POT1) is an essential component of the shelt

24 Nek7 deficiency leads to telomere aberrations, long-lasting gammaH2AX and 53BP1 f

25 Dysfunctional telomeres activate DDR in ageing, cancer and an increasi

26 O ligase Siz1, which is required for de novo telomere addition in rad52Delta cells.

27 ns of these complex and structurally variant telomere-adjacent DNA regions.

28 ecruited to telomeres and stabilizes TRF1 at telomeres after damage in an ATM activation-dependent ma

29 rate that while association of Ku with plant telomeres also depends on this channel, Ku's requirement

30 Alternative lengthening of telomeres (ALT) is a telomerase independent telomere mai

31 Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere mai

32 14.1% to -3.1%) shorter cord blood leukocyte telomeres and 13.2% (95% CI, -19.3% to -6.7%) shorter pl

33 analysis revealed prominent contacts between telomeres and chromosomal arm regions containing replica

34 that ICF syndrome cells, which exhibit short telomeres and elevated TERRA levels, are enriched for hy

35 t helps resolve replication problems both at telomeres and genome-wide.

36 ed based on its association with deprotected telomeres and localized to sites of DNA damage in S phas

37 sm for CST to facilitate replication through telomeres and other GC-rich regions.

38 Nek7 is recruited to telomeres and stabilizes TRF1 at telomeres after damage

39 The dynamic properties of telomeres and telomerase render them difficult to study

40 been utilized to investigate the function of telomeres and telomerase.

41 r the evolution of the viral genome, for the telomere, and for the risk of disease associated with ca

42 promote its stabilization, association with telomeres, and resolution of cohesion.

43 Telomeres are found at the end of chromosomes and are im

44 Fly telomeres are protected by the terminin complex that inc

45 amage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage.

46 Telomeres are specialized chromatin structures that prot

47 therapeutic strategies to treat and prevent telomere-associated diseases, namely aging-related disea

48 guanine quadruplexes, including oncogene and telomere-associated DNA and RNA sequences.

49 De novo digenic mutations of telomere-associated proteins and inflammasomes initiate

50 actomics screen discovers previously unknown telomere-associated proteins and reveals how homologous

51 e function in vivo requires interaction with telomere-associated proteins.

52 Here, we examine the roles of telomeres at distinct stages of murine brain development

53 lated or familiar males and also showed less telomere attrition when living next to male kin.

54 xperiments revealed that TPMs do not prevent telomere attrition, resulting in cells with critically s

55 relate meiotic centromere dynamics and early telomere behaviour to the progression of synaptonemal co

56 re, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production

57 promoted apoptosis through cleaving PinX1, a telomere binding protein, and that this cleavage facilit

58 or instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of m

59 ct physical interactions between Blm and two telomere-binding proteins, which may thus recruit or reg

60 They then explore telomere biology and cell senescence.

61 ly valuable structural information regarding telomere biology.

62 e possibility that RMRP might play a role in telomere biology.

63 Short telomeres block the proliferative capacity of stem cells

64 early leptotene, leading to formation of the telomere bouquet.

65 time PD was associated with shorter maternal telomeres, but not with TL in newborns.

66 However, telomeres can be maintained by telomerases with lower th

67 lly reinforcing feedback loop exists between telomere capping and Wnt signalling, and telomere cappin

68 een telomere capping and Wnt signalling, and telomere capping can be impacted by extracellular cues i

69 l substrate for telomerase and the source of telomere catastrophe in Rtel1(-/-) cells.

70 DAXX complex involved in gene repression and telomere chromatin structure, and a DAXX-SETDB1-KAP1-HDA

71 lls exit mitosis and enter G1, ensuring that telomere cohesion is not resolved prematurely in S phase

72 orrent of DNA damage responses (DDRs) at the telomeres, culminating in karyotypic alterations with ma

73 s (G/AP) in quadruplexes formed by the human telomere d[AG3(TTAG3)3] (htel-22) and d[TAG3(TTAG3)3TT]

74 These findings suggest that telomere deficiency is implicated in the CHH disease phe

75 DDR activation and maintenance at telomeres depend on the biogenesis and functions of tDDR

76 p with dyskeratosis congenita, a well-known "telomere disorder." RMRP binds the telomerase reverse tr

77 to result from longer read-through into the telomere downstream of the active ES.

78 e review the molecular mechanisms underlying telomere-driven diseases and highlight recent advances i

79 Variance in telomere dynamics among individuals is the product of a

80 Investigating telomere dynamics may help us quantify individual variat

81 etection efficiencies, and tracking back the telomere dynamics of respective chromosomes in mouse emb

82 We demonstrate our approach by tracking telomere dynamics, identifying 12 unique subtelomeric re

83 We encourage more research investigating how telomere dynamics, immune defences, antioxidants and oxi

84 environments can be studied by investigating telomere dynamics.

85 F11 diminished the ATR signaling response to telomere dysfunction and genome-wide DNA damage, reduced

86 Here we show that, in mammals, telomere dysfunction induces the transcription of telome

87 erstood how WRN deficiency leads directly to telomere dysfunction.

88 e homologous to the 3'-telomeric overhang of telomeres, elicits potent DNA-damage responses in melano

89 ddition processivity and expression level on telomere elongation and length maintenance.

90 sively long telomeric overhangs derived from telomere elongation processes that mostly occur during S

91 Telomere elongation through telomerase enables chromosom

92 ng of how the TRF2(TRFH) domain orchestrates telomere end protection and reveals how the phosphorylat

93 es into the t-loop structure, thereby hiding telomere ends from double-stranded break repair and ATM

94 protects telomere integrity from damage and telomere erosion.

95 nic regions, as well as repetitive elements, telomeres, etc.

96 telomere replication and recombination-based telomere extension.

97 osome ends and regulates telomerase-mediated telomere extension.

98 NA damage response that occurs on functional telomeres following replication in G2.

99 th these results, we found that Ver-depleted telomeres form RPA and gammaH2AX foci, like the human te

100 Telomeres form specialized chromatin that protects natur

101 eveal a mechanism of efficient protection of telomeres from damage through Nek7-dependent stabilizati

102 ired to protect and prevent newly replicated telomeres from engaging in A-NHEJ mediated fusions that

103 individuals, are critical for understanding telomere function and its roles in human biology.

104 aryotypic alterations with massive arrays of telomere fusions.

105 up-regulation of telomerase, coinciding with telomere fusions.

106 ated telomere synthesis is important for the telomere G-overhang structure.

107 ligation assay, we found that most T. brucei telomere G-overhangs end in 5' TTAGGG 3', while a small

108 (TbTERT and TbTR) and TbKu are required for telomere G-overhangs that end in 5' TTAGGG 3' but do not

109 the first study on oxidative damage of human telomere G-quadruplexes without mediation of external mo

110 ndent mechanism for DNA breakage followed by telomere healing, with the formation of more accessible

111 refore, POT1 is not only required to promote telomere homeostasis, but also plays an essential role i

112 at are important in maintaining the S. pombe telomere in a non-extendible state.

113 e have previously suggested that blunt-ended telomeres in Arabidopsis thaliana are protected by Ku, a

114 e paradox, highlighting a regulatory role of telomeres in cancer.

115 ) technologies enables the quantification of telomeres in individual chromosomes, but the use of thes

116 We performed superresolution imaging of telomeres in mouse cells after conditional deletion of T

117 during pregnancy is associated with shorter telomeres in newborns supports the results of smaller pr

118 and population extinction risk, with shorter telomeres in populations facing high risk of extinction

119 ucleosome filament reflect those patterns on telomeres in vivo.

120 unction, play important roles in maintaining telomere integrity and length.

121 eal a novel mechanism as to how WRN protects telomere integrity from damage and telomere erosion.

122 Since fly telomere integrity is guaranteed by a different mechanis

123 data suggest that TRF2 in shelterin remodels telomeres into the t-loop structure, thereby hiding telo

124 We now show that the active ES-adjacent telomere is transcribed.

125 Telomerase action at telomeres is essential for the immortal phenotype of ste

126 ecruitment of BRCA1 and BLM to these damaged telomeres is interdependent and is regulated by both ATR

127 However, how repair is initiated at telomeres is largely unknown.

128 RF2 prevents MRN activation at dysfunctional telomeres is unclear.

129 form RPA and gammaH2AX foci, like the human telomeres lacking the ssDNA-binding POT1 protein.

130 In the second phase, the critically short telomeres lead to genome instability and telomerase is f

131 be at increased risk for cancer, since short telomeres lead to genomic instability - a hallmark of ca

132 Acentrics segregate with either telomeres leading or lagging in equal frequency and are

133 Leukocyte telomere length (LTL) was measured with the use of quant

134 We studied the associations of leukocyte telomere length (LTL) with all-cause, cardiovascular dis

135 onal associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic

136 association of sedentary time with leukocyte telomere length (LTL).

137 re, we investigated the relationship between telomere length (TL) and aortic stiffness in well-charac

138 Shorter childhood telomere length (TL) and more rapid TL attrition are wid

139 ational studies have found shorter leukocyte telomere length (TL) to be a risk factor for coronary he

140 Telomere length (TL) trajectories in somatic tissues dur

141 girls and 35 boys) significant variation in telomere length and cortisol functioning was observed at

142 We observed fluctuating changes in telomere length and fluctuations in the rates of chromos

143 Decline in both telomere length and physical fitness over the life cours

144 Also, significant increases in telomere length and TERT were observed in the silica gro

145 to assess the effect of silica inhalation on telomere length and the regulation of RTEL1 and TERT.

146 enylalanine concentration is associated with telomere length and, therefore, potentially with the agi

147 between prenatal air pollution exposure and telomere length at birth could provide new insights in t

148 Telomere length at birth has been related to life expect

149 Telomerase maintains telomere length at the ends of linear chromosomes using

150 home was associated with a decrease in mean telomere length by 0.004 for each additional liquor stor

151 WS cells exhibit shorter telomere length compared to normal cells, but it is not

152 tion in hPSCs and cancer cells, resulting in telomere length defects.

153 say can be used to identify and characterize telomere length distributions of 30-35 discrete telomere

154 r postnatal influences of factors decreasing telomere length during life.

155 Telomere length has been correlated with various disease

156 These findings reveal a critical role for telomere length in a mouse model of age-dependent human

157 factors that are associated with changes in telomere length in an aging population.

158 merase activity and genomic alterations with telomere length in cancer.

159 copy-gene-sequence ratio method to determine telomere length in genomic DNA extracted from buccal sme

160 ut molecular mechanisms of how ALT maintains telomere length in human cancer is poorly understood.

161 gh several methods have been used to measure telomere length in tissues as a whole, the assessment of

162 ive technique to test hypotheses implicating telomere length in various cardiac pathologies.

163 erved between aortic pulse wave velocity and telomere length in younger and older individuals suggest

164 Telomere length is a marker of biological aging that may

165 This study provides evidence that shortened telomere length is associated with familial risk for BD.

166 n the shortest telomeres with more sensitive telomere length measurement assays, we show that only a

167 In this group, telomere length positively correlated with TP53 and RB1

168 whole, the assessment of cell-type-specific telomere length provides valuable information on individ

169 no significant association with age-adjusted telomere length reduction was documented.

170 Telomere length was also shorter in relatives (regardles

171 Telomere length was not associated with percent mammogra

172 In the entire sample, telomere length was positively associated with left and

173 Telomere length was positively associated with temporal

174 ed lag models, both cord blood and placental telomere length were associated with average weekly expo

175 ns, cord blood and placental tissue relative telomere length were measured.

176 In 641 newborns, cord blood and placental telomere length were significantly and inversely associa

177 Early adversity and telomere length were significantly associated (Cohen's d

178 the relationship between early adversity and telomere length while exploring factors affecting the as

179 ntraclass correlation coefficients of 6% for telomere length, 3.4% for waking cortisol levels, and 5.

180 her mammographic density is related to blood telomere length, a potential marker of susceptibility to

181 ation between telomere length, the change in telomere length, and circulating amino acids.

182 tor, interleukin 1beta, 6, and 10, leukocyte telomere length, chronic disease status, and frailty.

183 Telomere length, RTEL1 and TERT expression may serve as

184 We studied the longitudinal relation between telomere length, the change in telomere length, and circ

185 udinal changes in individuals' body mass and telomere length, we demonstrated that the fitness costs

186 Regulator of telomere length-1 (RTEL1) and telomerase reverse transcr

187 By proposing that the 1st Hit is largely telomere length-independent, while the 2nd Hit is largel

188 nship between aortic pulse wave velocity and telomere length.

189 elomere trimming, setting the upper limit of telomere length.

190 ced TERT expression, telomerase activity and telomere length.

191 (95% CI, -19.3% to -6.7%) shorter placental telomere length.

192 ocol provides comparative cell-type-specific telomere-length measurements in relatively small human c

193 d, chromosome instability increased and when telomeres lengthened, chromosome instability decreased.

194 tional trigger" in Poz1 leads to unregulated telomere lengthening.

195 s to measure the shortest (not just average) telomere lengths (TLs) are needed.

196 infection as indices of immune function, and telomere lengths as an overall measure of metabolic cost

197 ulation and are capable of maintaining their telomere lengths during induced proliferation.

198 We report telomere lengths in 18,430 samples, including tumors and

199 ric lagging strands leading to heterogeneous telomere lengths observed in most ALT cancers.

200 ta with a large longitudinal dataset of mean telomere lengths, consisting of 1,808 samples from 22 co

201 p nor familiarity was linked to body mass or telomere loss in female territory owners.

202 The observed telomere loss in newborns by prenatal air pollution expo

203 whereas deletion of both engendered similar telomere loss, suggesting that the repair proteins help

204 ssociates with two other cochaperones, TEL2 (Telomere maintenance 2) and TTI1 (Tel2-interacting prote

205 <0.02) gene sets related to DNA replication, telomere maintenance and elongation, cell cycle progress

206 Insufficient telomere maintenance can cause stem cell and tissue fail

207 Telomere maintenance critically depends on the distinct

208 pacts of different levels of processivity on telomere maintenance have not been examined.

209 Telomere maintenance in STAG2 mutant tumor cells occurre

210 of several recombination/repair proteins to telomere maintenance in Ustilago maydis, a fungus that b

211 human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.

212 telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset o

213 telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in approximat

214 roteins have been identified as critical for telomere maintenance, DNA repair, transcription and othe

215 bination can provide an alternative means of telomere maintenance.

216 gators, highlights the importance of POT1 in telomere metabolism.

217 mutually dependent for their localization at telomeres, Moi neither binds ssDNA nor facilitates Ver b

218 Recruitment of yeast telomerase to telomeres occurs through its Ku and Est1 subunits via in

219 TRF1 expression markedly sensitizes cells to telomere oxidative damage as well as XRCC1 inhibition.

220 ments (PICh) technique to purify deprotected telomeres, PHF11 was enriched as cells mounted a DNA dam

221 ns that localize and function exclusively at telomeres, protecting them from fusion events.

222 teins associate with telomeric DNA to confer telomere protection and length regulation.

223 sites for Taz1, a component of the Shelterin telomere protection complex.

224 or DNA binding differ between DNA repair and telomere protection.

225 strating a novel mechanism for WRN's role in telomere protection.

226 Inactivation of POT1 telomere protective functions in mouse models lacking p5

227 We find that TbRAP1, a telomere protein essential for VSG silencing, suppresses

228 STAG2 mutant tumor cells occurred by either telomere recombination or telomerase activation mechanis

229 etween telomerase, telomere replication, and telomere recombination.

230 erse transcriptase (TERT), genes involved in telomere regulation and function, play important roles i

231 trong resemblance to mammals with respect to telomere regulation and recombination mechanisms.

232 Germline coding mutations in different telomere-related genes have been linked to autosomal-dom

233 We identified TERT, RTEL1, and PARN-three telomere-related genes previously implicated in familial

234 Laboratory mice have longer telomeres relative to humans, potentially protecting aga

235 we found that the damage response of WRN at telomeres relies on its RQC domain, which is different f

236 e assessed by using quantitative PCR and the telomere repeat amplification protocol from PBMCs and en

237 We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the promoter

238 Telomere repeat DNA forms a nucleo-protein structure tha

239 ERRA transcription acts in cis to facilitate telomere repeat replication and chromosome stability.

240 subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (TERRA), but the role of tr

241 Transcription of telomere repeats can initiate at subtelomeric CTCF-bindi

242 yndrome protein (WRN) suppresses the loss of telomeres replicated by lagging-strand synthesis by a ye

243 and repair factors are known to promote both telomere replication and recombination-based telomere ex

244 he role of transcription, CTCF, and TERRA in telomere replication is not known.

245 s harbor more fragile telomeres representing telomere replication problems.

246 analyzing the interplays between telomerase, telomere replication, and telomere recombination.

247 proteins help to resolve similar problems in telomere replication.

248 T complex (CTC1-STN1-TEN1) also functions in telomere replication.

249 , we show that ALT cells harbor more fragile telomeres representing telomere replication problems.

250 Binding of TZAP to long telomeres represents the switch that triggers telomere t

251 alorimetry (ITC), with binding preference to telomere RNA (TERRA) sequences.

252 We used quantitative PCRs and a telomere-sequence to single-copy-gene-sequence ratio met

253 037 with the N-terminal acidic domain of the telomere shelterin protein TRF1 and demonstrating a nove

254 several generations of telomerase deficiency telomeres shorten to the point of uncapping, causing def

255 osome instability phenotypes, such that when telomeres shortened, chromosome instability increased an

256 Insofar as telomere shortening and replicative senescence prevent g

257 g-term treatment with BRD4 inhibitors caused telomere shortening in both mouse and human cells, sugge

258 Here, we demonstrate that telomere shortening in NOTCH1-haploinsufficient mice is

259 Telomere shortening induces chromosomal instability that

260 shorten in response to oxidative stress, and telomere shortening is correlated with reduced survival

261 ows all of the hallmarks of aging, including telomere shortening, cellular senescence, activation of

262 of existing G-quadruplexes which can lead to telomere shortening.

263 Individuals with short telomeres should be at increased risk for cancer, since

264 omere length distributions of 30-35 discrete telomeres simultaneously and accurately.

265 se oligonucleotides allows the unprecedented telomere-specific DDR inactivation in cultured cells and

266 inding activity of RPA complexes, unlike the telomere-specific DNA binding of Teb1 or the TEB heterot

267 By generating localized telomere-specific DNA damage in a real-time fashion and

268 Using the telomere-specific single-molecule analysis of replicated

269 erhangs, indicating that telomerase-mediated telomere synthesis is important for the telomere G-overh

270 ential mechanism of ALT is homology-directed telomere synthesis, but molecular mechanisms of how ALT

271 t advances in the preclinical development of telomere-targeted therapies using mouse models.

272 AGGG)n tract length at the end of each large telomere-terminal DNA segment.

273 edge of subtelomere variation and long-range telomere-terminal haplotypes in individuals, are critica

274 1, and BLM are actively recruited to the ALT telomeres that are experiencing replication stress and t

275 TZAP binds preferentially to long telomeres that have a low concentration of shelterin com

276 d HHV-6B have the capacity to integrate into telomeres, the essential capping structures of chromosom

277 Telomeres, the protective caps at the ends of chromosome

278 Telomeres, the protective ends of linear chromosomes, sh

279 tion and distribution of these hybrids among telomeres, their regulation and their cellular effects r

280 ole of TNKS1 in facilitating SSBR at damaged telomeres through PARylation of TRF1, thereby protecting

281 which dismantles DNA secondary structures at telomeres to facilitate replisome progression.

282 elomeres represents the switch that triggers telomere trimming, setting the upper limit of telomere l

283 telomeres, TZAP triggers a process known as telomere trimming, which results in the rapid deletion o

284 When localized at telomeres, TZAP triggers a process known as telomere tri

285 Upon shelterin removal, telomeres underwent 53BP1-dependent clustering, potentia

286 TNKS1 is recruited to damaged telomeres via its interaction with TRF1, which subsequen

287 TRF2, we observed only minor changes in the telomere volume in most of our experiments.

288 Upon codeletion of TRF1 and TRF2, the telomere volume increased by varying amounts, but even t

289 en those samples exhibiting small changes in telomere volume showed DDR at nearly all telomeres.

290 ng at least in part the apparent increase in telomere volume.

291 H1 haploinsufficiency in mice with shortened telomeres were concordant with proosteoblast and proinfl

292 Telomeres were shorter in tumors than in normal tissues

293 Human telomeres were shown to form hybrids with the lncRNA TER

294 with low processivity dramatically elongate telomeres when overexpressed.

295 ately caused shortened but stably maintained telomeres, whereas deletion of both engendered similar t

296 Telomeres, which are involved in cell division, carcinog

297 se DNA damage foci tended to colocalize with telomeres, which contain repetitive G4-forming sequences

298 roteins XRCC1 and polymerase beta at damaged telomeres, while the PARP1/2 inhibitor only has such an

299 P) and by monitoring changes in the shortest telomeres with more sensitive telomere length measuremen

300 ts that Ku physically sequesters blunt-ended telomeres within its DNA binding channel, shielding them