ライフサイエンスコーパス: telomere elongation

1 tivity is regulated in vivo to ensure proper telomere elongation.

2 a negative regulator of telomerase-mediated telomere elongation.

3 that human POT1 controls telomerase-mediated telomere elongation.

4 repression by the homolog may thus regulate telomere elongation.

5 unction in telomere protection as well as in telomere elongation.

6 mere length, and induced rapid and extensive telomere elongation.

7 1 released TRF1 from telomeres and promoted telomere elongation.

8 omere capping independent of its function in telomere elongation.

9 -circle mechanism for telomerase-independent telomere elongation.

10 main is involved in other aspects of in vivo telomere elongation.

11 telomeric protein that negatively regulates telomere elongation.

12 omerase RNA, TLC1, by recombination-mediated telomere elongation.

13 p1p binding site led to immediate and severe telomere elongation.

14 ric terminus is not sufficient to deregulate telomere elongation.

15 e telomere-nontelomere junction and prevents telomere elongation.

16 s reverse transcriptase activity and role in telomere elongation.

17 his mechanism is also important in wild-type telomere elongation.

18 vation of telomerase-independent pathways of telomere elongation.

19 es with certain oligonucleotides resulted in telomere elongation.

20 nteraction of Trt1 with Tpz1 is critical for telomere elongation.

21 rase and scaRNAs to nucleoli, and failure of telomere elongation.

22 erase subunits to telomeres and in promoting telomere elongation.

23 ates the ability of POT1(DeltaOB) to promote telomere elongation.

24 fective in the association with TRF2 induced telomere elongation.

25 rolling circle mechanism is the key event in telomere elongation.

26 n trans these two proteins induced extensive telomere elongation.

27 in TERC stability, telomerase activity, and telomere elongation.

28 dition processivity of telomerase and caused telomere elongation.

29 nits form a telomerase holoenzyme capable of telomere elongation.

30 DNA damage response and telomerase-mediated telomere elongation.

31 teins or hnRNP C remain fully functional for telomere elongation.

32 t kinase Cdk1 (Cdc28) in cell-cycle-specific telomere elongation.

33 y of TRF1, resulting in telomerase-dependent telomere elongation.

34 Cdk1 at double-strand breaks also prevented telomere elongation.

35 butes to transformation independently of net telomere elongation.

36 omere length: the frequency or the extent of telomere elongation.

37 reas TR(+/-) heterozygotes were deficient in telomere elongation.

38 ding (OB) folds nor the telomerase-dependent telomere elongation activity mediated by the COOH-termin

39 d some other subunits of the complex induced telomere elongation and altered telomere position effect

40 e transcriptase complementary DNA results in telomere elongation and an additional 2- to 10-fold decr

41 rase catalytic subunit that is essential for telomere elongation and cell immortalization in vivo but

42 ect mechanistic link between coordination of telomere elongation and cell-cycle progression in vivo.

43 en TRF1 and telomerase inhibition to prevent telomere elongation and help maintain telomere homeostas

44 cing genes SIR3 and SIR4) result in moderate telomere elongation and improved telomeric silencing.

45 capping of telomeres, manifested by dramatic telomere elongation and increased length heterogeneity (

46 Our results identify TRF1 as a suppressor of telomere elongation and indicate that TRF1 is involved i

47 The telomeric protein Pin2/TRF1 controls telomere elongation and its expression is tightly regula

48 ddition processivity and expression level on telomere elongation and length maintenance.

49 ls with the NOS inhibitor L-NAME resulted in telomere elongation and prevention of apoptosis.

50 dna2-defective strains are impaired in both telomere elongation and sequential 5'-CA resection.

51 es reveal and resolve multiple TPP1 roles in telomere elongation and stem cell telomere length homeos

52 enes caused a synergistic effect on aberrant telomere elongation and t-circle accumulation, suggestin

53 ation in family-matched control cells allows telomere elongation and telomere length maintenance, whi

54 Our results suggest that coupling of telomere elongation and telomere replication is a univer

55 hPOT1 mutations also result in telomere elongation and the formation of transplantable

56 TPP1 TEL patch is genetically essential for telomere elongation and thus long-term cell viability.

57 merase inhibitor PinX1, negatively regulates telomere elongation, and specifically affects mitotic pr

58 heckpoint kinase, plays an important role in telomere elongation, as cells lacking Tel1p have short t

59 separation-of-function alleles in a de novo telomere elongation assay, we found, surprisingly, that

60 tion to their well-characterized function in telomere elongation, both CaEst1p and CaEst2p mediate so

61 Telomerase inhibitor prevents telomere elongation but induces RAD51/HR, which contribu

62 proliferation can be uncoupled not only from telomere elongation, but also from other telomerase acti

63 Telomere elongation by BIR appears to often occur throug

64 rent way: Pif1p inhibits telomerase-mediated telomere elongation by directly removing telomerase from

65 Telomere elongation by human telomerase is inhibited in

66 a telomere-associated protein that inhibits telomere elongation by its binding to telomere repeats,

67 ing Zscan4 expression, a critical factor for telomere elongation by recombination.

68 propose Cdk1 activity controls the timing of telomere elongation by regulating the single-strand over

69 AS may play an important role in controlling telomere elongation by repressing HeT-A promoter activit

70 We demonstrate that telomere elongation by tankyrase 1 requires the catalyti

71 eover, using metaphase analysis we show that telomere elongation by telomerase can significantly redu

72 Previous studies in yeast have shown that telomere elongation by telomerase is cell cycle dependen

73 controlled by a feedback mechanism in which telomere elongation by telomerase is limited by the accu

74 nt of the TRF1 protein complex that controls telomere elongation by telomerase.

75 t the phenotype was not due to inappropriate telomere elongation by telomerase.

76 t a regulatory mechanism exists for limiting telomere elongation by telomerase.

77 nate multiple telomere activities, including telomere elongation by telomerase.

78 Variants in TERC and TERT can impede telomere elongation causing stem cells to enter prematur

79 mosome ends examined, demonstrating that the telomere elongation characteristic of rap1-17 and rif2 s

80 -) heterozygotes had no detectable defect in telomere elongation compared to wild-type controls, wher

81 Ectopic expression of Tbx3 results in telomere elongation, consistent with a role for Zscan4 i

82 nd tankyrases modulates chromatin structure, telomere elongation, DNA repair, and the transcription o

83 by blocking telomerase assembly and disrupts telomere elongation during reprogramming.

84 ones with short telomeres were used to study telomere elongation dynamics, which differed dramaticall

85 expression of these proteins can reverse the telomere elongation effect of overexpression of the Rap1

86 e variant repeats, we can directly visualize telomere elongation events in human cells.

87 cdc17-1 strains that would normally undergo telomere elongation failed to do so in the absence of te

88 s of telomeric repeats, that recombinational telomere elongation generates a repeating pattern common

89 ariant in the gene encoding for regulator of telomere elongation helicase 1 (RTEL1) that segregated w

90 h HHS, in the gene encoding the regulator of telomere elongation helicase 1 (RTEL1).

91 , mutations in the DNA helicase Regulator of Telomere Elongation Helicase1 (RTEL1) lead to Hoyeraal-H

92 , recognize chromosome ends, and orchestrate telomere elongation in a highly regulated fashion.

93 c13-Est2 fusion protein to promote extensive telomere elongation in an est1-Delta strain.

94 This result implies that telomere elongation in cdc17-1 mutants is mediated by th

95 To investigate the cause of telomere elongation in cdc17/pol1 (DNA polymerase alpha)

96 inX1 to localize to telomeres and to inhibit telomere elongation in cells even though neither has any

97 1 binds to telomeric DNA and acts to inhibit telomere elongation in cis.

98 Strikingly, NBS promotes telomere elongation in conjunction with TERT in NBS fibr

99 ults demonstrate that reprogramming restores telomere elongation in DC cells despite genetic lesions

100 RF1 in vitro, and its overexpression induces telomere elongation in human cancer cells.

101 r results indicate that tankyrase can induce telomere elongation in human cells.

102 2/TRF1 protein levels and causes progressive telomere elongation in human cells.

103 In our study, treatment with danazol led to telomere elongation in patients with telomere diseases.

104 for rapid elongation by telomerase and that telomere elongation in T. brucei is not regulated by a p

105 1 depletion caused a rapid growth arrest and telomere elongation in the absence of cell division.

106 Delta mutants, suggesting a role for Dna2 in telomere elongation in the absence of Pif1.

107 efect but are capable of promoting extensive telomere elongation in the presence of a Cdc13-Est2 fusi

108 transformed cells to escape crisis and that telomere elongation in these cells occurs in a tightly r

109 at tankyrase acts as a positive regulator of telomere elongation in vivo, apparently by inhibiting TR

110 and overexpression of the tbf1 gene leads to telomere elongation in vivo, which is dependent upon the

111 these motifs are important for catalysis of telomere elongation in vivo.

112 ts of the telomerase holoenzyme required for telomere elongation in vivo.

113 Four independent BRD4 inhibitors blocked telomere elongation, in a dose-dependent manner, in mous

114 ant versions of Cdc13 or Est1 confer similar telomere elongation, indicating that close physical prox

115 on of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to

116 ly ectopic expression of POT1 suppressed the telomere elongation induced by POT1(DeltaOB).

117 enhanced telomeric silencing in response to telomere elongation is associated with increased repress

118 th homeostasis in which telomerase-dependent telomere elongation is blocked by sequestration of the 3

119 Telomere elongation is cell-cycle regulated and requires

120 st despite the fact that the biochemistry of telomere elongation is completely different in the two m

121 Because telomere elongation is crucial for self-renewal of hPSCs

122 In the yeast Saccharomyces cerevisiae, telomere elongation is negatively regulated by the telom

123 Telomere elongation is regulated at multiple levels, inc

124 Telomere elongation is responsive to both the number of

125 Here, we have demonstrated that this telomere elongation is telomerase dependent.

126 g [3,4], indicating that telomerase-mediated telomere elongation is tightly regulated.

127 We provide evidence that telomere elongation might be the primary event that caus

128 ught to be limited to the late S phase, when telomere elongation occurs.

129 Different types of recombinational telomere elongation pathways have been identified in yea

130 over from senescence via two recombinational telomere elongation pathways.

131 validate this approach by in situ mapping of telomere elongation patterns within individual nuclei an

132 omeric sequence hampers in situ detection of telomere elongation patterns.

133 For both genes, the telomere elongation phenotype is allele specific and app

134 sively long telomeric overhangs derived from telomere elongation processes that mostly occur during S

135 fective in regulating telomerase, leading to telomere elongation rather than the telomere shortening

136 t was recently proposed that recombinational telomere elongation (RTE) in a telomerase-deletion mutan

137 mutants lacking telomerase, recombinational telomere elongation (RTE) is induced at short telomeres

138 Recombinational telomere elongation (RTE) known as alternate lengthening

139 ic mutations such as a specific regulator of telomere elongation (RTEL1) mutation causing isolated na

140 i and suggest a roll-and-spread mechanism of telomere elongation similar to that seen in previous obs

141 e lengthening of telomeres (ALT) pathway for telomere elongation, SMARCAL1 deficiency does not yield

142 n telomeric protein POT1 induces significant telomere elongation, suggesting that at least one critic

143 ssion of tankyrase 1 in the nucleus promotes telomere elongation, suggesting that tankyrase 1 regulat

144 ear overexpression leads to loss of TRF1 and telomere elongation, suggesting that tankyrase1 is a pos

145 her hand, genetic depletion of Skp1p induced telomere elongation, suggesting that this protein plays

146 tein in telomerase-positive cells results in telomere elongation, supporting the idea that hPot1 is a

147 telomeres due to a dominant mutation in the Telomere elongation (Tel) gene.

148 tion in telomerase levels blunts the natural telomere elongation that accompanies reprogramming.

149 TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA re

150 e of RTE that results in much more extensive telomere elongation that is reminiscent of human ALT cel

151 sed of Acc repeats invariably showed extreme telomere elongation, they often also initially showed pe

152 utation, whereas sexual animals only achieve telomere elongation through sexual reproduction.

153 Telomere elongation through telomerase enables chromosom

154 merase is a ribonucleoprotein that catalyzes telomere elongation through the addition of TTAGGG repea

155 1 appears to act upstream of TRF1, promoting telomere elongation through the removal of TRF1.

156 me domain of Rap1p also negatively regulates telomere elongation, through an unknown mechanism.

157 ifferentiation phenotype could be rescued by telomere elongation via reintroduction of Tert, via supp

158 Conversely, telomere elongation was induced by expression of a domin

159 The telomere elongation was telomerase dependent in the repl

160 nd DNA polymerase alpha that cause increased telomere elongation were unable to compensate for the lo

161 and Poz1 function as negative regulators of telomere elongation, whereas Pot1 and Tpz1 are critical

162 a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 fu

163 ruption of this linkage leads to unregulated telomere elongation while still retaining the shelterin

164 Telomerase is a nuclear regulator of telomere elongation with recent reports suggesting a rol