ライフサイエンスコーパス: telomere function

1 protein, DNA, and RNA molecules required for telomere function.

2 inding complex implicated in both aspects of telomere function.

3 binding as an efficient means of disrupting telomere function.

4 st testable models for the roles of TERRA in telomere function.

5 best known for their role in maintenance of telomere function.

6 ion of HHV-6A or 19q genes or else disrupted telomere function.

7 processes such as genomic translocations and telomere function.

8 e effects of affinity from repeat spacing on telomere function.

9 their inhibitory effect on telomerase and/or telomere function.

10 omeric DNA are thought to play a role in the telomere function.

11 omeric DNA and regulates numerous aspects of telomere function.

12 change, studies that will shed more light on telomere function.

13 Length regulation is central to telomere function.

14 ase or recombination is utilized to maintain telomere function.

15 protein Rap1p is thought to be essential for telomere function.

16 when DNA lesions are created by the loss of telomere function.

17 hing an essential role for these proteins in telomere function.

18 catalytic activity was proposed to regulate telomere function.

19 tside this range are associated with altered telomere function.

20 taining the cap complex essential for normal telomere function.

21 e of the protein that differentially mediate telomere function.

22 be are bound by Taz1, a regulator of diverse telomere functions.

23 ranscriptional activation, and silencing and telomere functions.

24 and several molecular mechanisms involved in telomere functions.

25 ent function of Nmd2p/Rlf4p, is required for telomere functions.

26 els of specific mRNAs that are important for telomere functions.

27 l telomeres restored telomerase activity and telomere function, alleviated cirrhotic pathology, and i

28 entified in a screen for mutants that affect telomere function and alter the localization of the telo

29 either positive or negative contributions to telomere function and cell viability, depending on wheth

30 Exo1 activity was also capable of enhancing telomere function and consequently cell proliferation, b

31 omplex formation between hRap1 and hTRF2 for telomere function and end protection.

32 oining of telomeric DNA, can lead to loss of telomere function and genomic instability.

33 Telomere integrity is critical for telomere function and genomic stability.

34 n contrast, reducing miR-155 levels improved telomere function and genomic stability.

35 lomere length is an important determinant of telomere function and has a strong genetic basis.

36 ty and processivity are required to maintain telomere function and immortalize human cells with limit

37 Reactivation of telomerase maintains telomere function and is considered critical to immortal

38 individuals, are critical for understanding telomere function and its roles in human biology.

39 ciated with mutations in genes involved with telomere function and maintenance; however, the genetic

40 Correspondingly, the loss of telomere function and p53 deficiency cooperated to initi

41 f HSCs, thereby preventing premature loss of telomere function and providing added replicative capaci

42 rocomplex are known to participate in native telomere functions and also regulate the de novo telomer

43 ex structures are believed to play a role in telomere functions and considered as targets for antican

44 Changes in telomere functions and the associated chromosomal abnorm

45 omatin is critical for proper centromere and telomere function, and it plays a key role in the transc

46 mmary tumors is not linked to global loss of telomere function but involves multiple regulatory event

47 fission yeast Taz1 protein regulates diverse telomere functions but is not essential for growth under

48 ing the direct modulation of cell telomerase/telomere function by an oncogenic virus and suggest its

49 Rap1 could orchestrate telomere function by binding multiple telomere array sit

50 Loss of telomere function can induce cell cycle arrest and apopt

51 Regardless of the mechanism, loss of telomere function can result in sister chromatid fusion

52 The loss of telomere function can result in the fusion of telomeres

53 Loss of telomere function causes cell-cycle arrest or cell death

54 these nucleotides on telomerase activity or telomere function could contribute to the mechanism of a

55 Paradoxically, telomere function depends on checkpoint proteins such as

56 Loss of telomere function did not elicit a full spectrum of clas

57 g against a role for the nuclear envelope in telomere function during interphase.

58 however, the importance of these factors for telomere function has not been understood.

59 ults described here demonstrate that loss of telomere function in a cancer-prone mouse model possessi

60 leomycin, underscoring an essential role for telomere function in AEC2s for alveolar repair.

61 d to telomeric DNA in vitro, suggesting that telomere function in human cells is regulated by poly(AD

62 Loss of telomere function in metazoans results in catastrophic d

63 will allow a more complete understanding of telomere function in the cell.

64 ms of telomeric DNA interaction in vitro and telomere function in vivo.

65 hanism(s) by which recombination can restore telomere function in yeast, and suggest future experimen

66 Telomere functions in somatic cells involve complexes be

67 and SIR4, genes which influence a variety of telomere functions in yeast, also had no effect.

68 nd neck (SCCHN), need telomerase to maintain telomere function; inhibition of the enzyme can lead to

69 Loss of telomere function is an important mechanism for the chro

70 Loss of telomere function is associated with rampant genetic ins

71 When telomere function is disrupted, a potentially lethal DNA

72 somal abnormalities in the absence of proper telomere function is implicated in human aging and cance

73 etabolism and will provide insights into how telomere function is linked to many other cellular proce

74 Human telomere function is mediated by shelterin, a six-subuni

75 lication, providing additional evidence that telomere function is sequence-specific.

76 irement of heterochromatin proteins for most telomere functions is unknown.

77 s review we consider whether manipulation of telomere function may selectively sensitise SCCHN to rad

78 a variety of biological processes including telomere function, meiotic recombination and gene regula

79 otyping (SKY) analysis revealed that loss of telomere function occurred preferentially on chromosomes

80 (Terc), to assess the role of telomerase and telomere function on the cellular and organismal respons

81 that influence either telomere structure or telomere function (or both), although in many cases the

82 Molecular mechanisms of telomere functions remain unknown in large part due to l

83 ) is a multifunctional protein that controls telomere function, silencing and the activation of glyco

84 ction has a clinically significant impact on telomere function, suggesting the existence of "telo-miR

85 Strikingly, in cells with compromised telomere function (taz1Delta), SpEst1p loss confers a le

86 In the present study, an essential telomere function, the ability to cap and thereby protec

87 t of chromosome segregation and that loss of telomere function through progressive telomere shortenin

88 component of telomerase, serves to maintain telomere function through the de novo addition of telome

89 t the GCN5-containing SAGA complex regulates telomere function via deubiquitination and stabilization

90 le of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null

91 o determine how the TIN2-DC mutations affect telomere function, we generated mice with the equivalent

92 Using a screen for genes that affect telomere function, we isolated sir3-P898R, an allele of