ライフサイエンスコーパス: telomere length

1 re lengthening, were associated with greater telomere length.

2 ced TERT expression, telomerase activity and telomere length.

3 association between mammographic density and telomere length.

4 DNA methylation controls the homeostasis of telomere length.

5 childhood and adulthood adversities on adult telomere length.

6 versity predicted 6% greater odds of shorter telomere length.

7 fork and regulation of origin firing affect telomere length.

8 ted human endothelial senescence by reducing telomere length.

9 tended to have nonsignificant relations with telomere length.

10 oter mutations are associated with increased telomere length.

11 to methyl methanesulfonate and shows reduced telomere length.

12 l carries with the published change in kb of telomere length.

13 (95% CI, -19.3% to -6.7%) shorter placental telomere length.

14 them to each other, in relation to salivary telomere length.

15 effects of starvation on the maintenance of telomere length.

16 cancer cell proliferation and shortening of telomere length.

17 owered proliferation potential and shortened telomere length.

18 omeres or in healthy myoblasts regardless of telomere length.

19 Responses did not correlate with baseline telomere length.

20 between depression and anxiety disorders and telomere length.

21 protein, telomerase enzymatic activity, and telomere length.

22 nship between aortic pulse wave velocity and telomere length.

23 elomere trimming, setting the upper limit of telomere length.

24 of PM2.5 gave birth to newborns with shorter telomere length.

25 through telomerase-catalyzed maintenance of telomere length.

26 gth as reflected by cord blood and placental telomere length.

27 tor, and interleukin 6 and shorter leukocyte telomere length.

28 eration of T cells or for the maintenance of telomere lengths.

29 opsis thaliana homolog of human Regulator of Telomere Length 1 (RTEL1), which functions in DNA replic

30 Regulator of telomere length-1 (RTEL1) and telomerase reverse transcr

31 ates with molecular markers of aging such as telomere length [2].

32 ntraclass correlation coefficients of 6% for telomere length, 3.4% for waking cortisol levels, and 5.

33 ive deaths, 50) than shorter donor leukocyte telomere length (5-year overall survival, 40%; number at

34 the relationship between early adversity and telomere length, a marker of cellular senescence.

35 her mammographic density is related to blood telomere length, a potential marker of susceptibility to

36 Telomere length, a reliable predictor of disease pathoge

37 er levels of short telomeres (vascular short telomere length abundance 35.1 +/- 2.5 vs. 48.2 +/- 2.6%

38 as dissociated from increased vascular short telomere length abundance.

39 ] 1.91, 95% CI 1.02-3.59, p=0.045) and short telomere length (adjusted OR per unit change in mean nat

40 es and the psychosomatic symptom survey--and telomere length, after adjusting for relevant behavioral

41 nificantly associated with shorter leukocyte telomere length (all P </= 0.03).

42 but there was no association between MD and telomere length among those not using antidepressants (b

43 persistent organic pollutants and leukocyte telomere length among U.S. adults in NHANES, 2001-2002.

44 Using telomere-length analysis and chromatin immunoprecipitati

45 The relationship between telomere length and aerobic and muscular fitness is not

46 girls and 35 boys) significant variation in telomere length and cortisol functioning was observed at

47 Primary biological outcomes were telomere length and cortisol functioning.

48 on timing, controlling nuclear architecture, telomere length and DNA repair.

49 hat increases the cancer stem cell pool, and telomere length and erosion as a mitotic counter for inh

50 We observed fluctuating changes in telomere length and fluctuations in the rates of chromos

51 RS resulted in an association between longer telomere length and increased NHL risk [four B-cell hist

52 ls harboring minishelterin display wild-type telomere length and intact subtelomeric silencing.

53 there was a significant interaction between telomere length and MDA in their association with mammog

54 gs provide evidence for a link between short telomere length and metabolic compromise in the etiology

55 Telomere length and mitochondrial DNA (mtDNA) copy numbe

56 While both telomere length and mtDNA amount were associated with ad

57 These findings suggest that telomere length and mtDNA copy number may hold the poten

58 There was no association between donor telomere length and neutrophil engraftment at 28 days (c

59 erformed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL ca

60 ent would best reveal a relationship between telomere length and NHL risk.

61 Decline in both telomere length and physical fitness over the life cours

62 s will assess long-term associations between telomere length and progression of subclinical atheroscl

63 We replicate prior work on telomere length and psychopathology and show that this e

64 reporting the association between leukocyte telomere length and stroke, myocardial infarction, and t

65 Here we show that telomere length and telomerase activity are impaired in

66 Telomere length and telomere proteins play important rol

67 Telomere length and telomere shortening are associated w

68 Also, significant increases in telomere length and TERT were observed in the silica gro

69 Leukocyte telomere length and the percentage of short telomeres di

70 At a mean age of 68 y, telomere length and the percentage of short telomeres wa

71 to assess the effect of silica inhalation on telomere length and the regulation of RTEL1 and TERT.

72 enylalanine concentration is associated with telomere length and, therefore, potentially with the agi

73 ing, milk and basal cell subpopulations have telomere lengths and cell division kinetics that are not

74 is were increased TERT expression, decreased telomere length, and activation of cell-cycle programs.

75 ation between telomere length, the change in telomere length, and circulating amino acids.

76 i telomerase plays a key role in maintaining telomere length, and T. brucei telomeres terminate in a

77 relationship between depression, anxiety and telomere length, and to assess whether this relationship

78 L1 mutation carriers had shortened leukocyte telomere lengths, and we observed epigenetic inheritance

79 rate that changes in the amount of mtDNA and telomere length are consequences of stress and entering

80 itamin D status, lower adiposity, and longer telomere length are each reportedly associated with lowe

81 n D (25(OH)D) concentration), adiposity, and telomere length are not well established.

82 sure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental

83 infection as indices of immune function, and telomere lengths as an overall measure of metabolic cost

84 matic stress, ethnographic observations, and telomere length assessment [telomere-fluorescence in sit

85 g a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphis

86 es telomere length by weighing the number of telomere length-associated variant alleles an individual

87 l the patients (11 of 12, 92%) had a gain in telomere length at 24 months as compared with baseline (

88 between prenatal air pollution exposure and telomere length at birth could provide new insights in t

89 Telomere length at birth has been related to life expect

90 Telomerase maintains telomere length at the ends of linear chromosomes using

91 btelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level.

92 ological aging, operationalized as shortened telomere length, before they had experienced an onset of

93 umber (beta = -0.178, p = 0.001), and longer telomere length (beta = 0.111, p = 0.071) before the 8-w

94 Analyses of telomere lengths between iciHHV-6- without angina, iciHH

95 d beta-galactosidase activity, lower average telomere lengths but retained the capacity to undergo mu

96 r tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telome

97 home was associated with a decrease in mean telomere length by 0.004 for each additional liquor stor

98 ificantly associated with a decrease in mean telomere length by 0.006 for each additional report of v

99 inversely associated with a decrease in mean telomere length by 0.007 for each additional report of d

100 We also describe how to quantify telomere length by means of the fluorescence intensity a

101 ch uses existing genotype data and estimates telomere length by weighing the number of telomere lengt

102 is the first study to identify predictors of telomere length change over the short period of a year.

103 ons of adversity demonstrated more extensive telomere length changes.

104 tor, interleukin 1beta, 6, and 10, leukocyte telomere length, chronic disease status, and frailty.

105 Recipient and donor pre-HCT leukocyte telomere length classified into long (third tertile) and

106 WS cells exhibit shorter telomere length compared to normal cells, but it is not

107 ta with a large longitudinal dataset of mean telomere lengths, consisting of 1,808 samples from 22 co

108 end joining (NHEJ), plays important roles in telomere length control and is involved in transcription

109 our results suggest that parental effects on telomere length could contribute to the known poor perfo

110 ected from lymphocyte and granulocyte sorted telomere length data of 356 healthy individuals, includi

111 Ovarian telomere length declines more rapidly in the exposed gra

112 w that telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hear

113 We found that telomere length decreases with cross-sectional and longi

114 tion in hPSCs and cancer cells, resulting in telomere length defects.

115 Shortened leukocyte telomere length demonstrates a significant association w

116 Telomere length differed between TERC(-/-) and TERT(-/-)

117 and second tertiles combined) based on donor telomere length distribution.

118 Our predictions are tested against measured telomere length distributions in humans across all ages,

119 say can be used to identify and characterize telomere length distributions of 30-35 discrete telomere

120 In particular, we analyze the shape of telomere length distributions underlying stem cell behav

121 r postnatal influences of factors decreasing telomere length during life.

122 ulation and are capable of maintaining their telomere lengths during induced proliferation.

123 Telomere length dynamics in early life: the blood-and-mu

124 Cancer cells maintain telomere length equilibrium to avoid senescence and apop

125 analyses of oxidative stress, DNA damage and telomere length exhibit the retention of age-associated

126 We found that telomere length fluctuation is associated with transient

127 proximately 90% of human cancers to maintain telomere length for cell immortalization.

128 telomere content (TC), a validated proxy for telomere length, from remission bone marrow samples obta

129 The analysis of the telomere length GRS resulted in an association between l

130 Telomere length has been correlated with various disease

131 Telomere length has been hypothesized to be a marker of

132 Telomere length has been recognized as a marker of biolo

133 Importantly, both MDD and telomere length have been associated independently with

134 on, giving rise to aberrant t-loop excision, telomere length heterogeneity, and loss of the telomere

135 her to safeguard chromosome ends and promote telomere length homeostasis is a matter of great interes

136 left unrepaired can lead to dysregulation of telomere length homeostasis.

137 tical for chromosome capping and maintaining telomere length homeostasis.

138 omerase-mediated telomere synthesis and thus telomere length homeostasis.

139 tion between muscle mass in advanced age and telomere length, however, has rarely been examined.

140 re of the relation between MDD and shortened telomere length, however, is not clear.

141 We use qPCR to measure relative telomere length in 389 blood samples (n = 318 individual

142 els in response to a laboratory stressor and telomere length in 97 healthy young daughters of mothers

143 These findings reveal a critical role for telomere length in a mouse model of age-dependent human

144 t study (to our knowledge) to link stress to telomere length in a non-WEIRD population, our research

145 er level of DNA oxidation and a reduction in telomere length in adipose tissue of mice fed a high-fat

146 factors that are associated with changes in telomere length in an aging population.

147 merase activity and genomic alterations with telomere length in cancer.

148 ke receptor subfamily G member 1 and shorter telomere length in CD8(+) T cells (2225 versus 3397 bp;

149 Here, we investigate telomere length in connection to familial risk and disea

150 copy-gene-sequence ratio method to determine telomere length in genomic DNA extracted from buccal sme

151 ut molecular mechanisms of how ALT maintains telomere length in human cancer is poorly understood.

152 itive abnormalities associated with aberrant telomere length in humans.

153 kocyte telomere length (LTL), which reflects telomere length in other somatic tissues, is a complex g

154 rmined that overexpression of TERC increased telomere length in PARN-deficient cells and hypothesized

155 is associated with a significant increase in telomere length in peripheral blood and bone marrow cell

156 (MUC5B rs35705950 and TOLLIP rs5743890) and telomere length in peripheral blood leucocytes, and asse

157 e current study was to investigate leukocyte telomere length in relation to prenatal famine exposure.

158 Pretransplant leukocyte telomere length in the recipients was not associated wit

159 gh several methods have been used to measure telomere length in tissues as a whole, the assessment of

160 ive technique to test hypotheses implicating telomere length in various cardiac pathologies.

161 g Rif1 and Rif2 proteins negatively regulate telomere length in yeast.

162 determined endothelial function and vascular telomere length in young (4 mo) and aged (15 mo) adult o

163 iety disorders were directly associated with telomere length in young adults.

164 erved between aortic pulse wave velocity and telomere length in younger and older individuals suggest

165 We report telomere lengths in 18,430 samples, including tumors and

166 DNA methylation are associated with shorter telomere lengths in youth, which may decrease genome sta

167 al function of which consists of maintaining telomere length, in association with the RNA template mo

168 Almost 400 genes affect yeast telomere length, including Est1, which is critical for r

169 this overall pattern of shortening, bouts of telomere length increase occur in some individuals.

170 By proposing that the 1st Hit is largely telomere length-independent, while the 2nd Hit is largel

171 Fifteen per cent of cancers maintain telomere length independently of telomerase by the homol

172 Telomere length is a marker of biological aging that may

173 Telomere length is a marker of cell aging that appears t

174 Telomere length is associated with early adversity and w

175 This study provides evidence that shortened telomere length is associated with familial risk for BD.

176 Variation in telomere length is heritable and is currently considered

177 Shortened leukocyte telomere length is hypothesized to be a novel biomarker

178 Telomere length is regulated around an equilibrium set p

179 Telomere length less than the tenth percentile for age w

180 ically treated MD is associated with shorter telomere length, likely reflecting the more severe natur

181 of principle for a novel method to estimate telomere lengths linked to distinguishable telomeric hap

182 Telomere length, long-term black carbon exposure, and co

183 ions in cellular aging, indexed by leukocyte telomere length (LTL) and mitochondrial DNA copy number

184 e and anxiety disorders to shorter leukocyte telomere length (LTL) as an indicator of cellular aging.

185 Short leukocyte telomere length (LTL) has become a hallmark characterist

186 We characterized leukocyte telomere length (LTL) in a Chuvash population that was c

187 RATIONALE: Leukocyte telomere length (LTL) is a biological marker of aging, a

188 Leukocyte telomere length (LTL) is a biological marker of aging, a

189 Leukocyte telomere length (LTL) is a putative biological marker of

190 Leukocyte telomere length (LTL) is an emerging marker of aging at

191 e at conception (PAC) on offspring leukocyte telomere length (LTL) is well established, with older fa

192 Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy indivi

193 Leucocyte telomere length (LTL) shortening is associated with card

194 /height (m)(2)) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 parti

195 Leukocyte telomere length (LTL) was defined as relative telomere t

196 Leukocyte telomere length (LTL) was measured with the use of quant

197 We studied the associations of leukocyte telomere length (LTL) with all-cause, cardiovascular dis

198 onal associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic

199 ted biphenyls (PCBs) may influence leukocyte telomere length (LTL), a biomarker associated with chron

200 ases, but their relationships with leukocyte telomere length (LTL), a marker of cellular aging, are p

201 Leukocyte telomere length (LTL), which reflects telomere length in

202 association of sedentary time with leukocyte telomere length (LTL).

203 nstrate that functional CST is essential for telomere length maintenance due to its role in mediating

204 In addition, mutations in telomere length maintenance genes and in shelterin compo

205 Thus, Tnks inhibitors impact telomere length maintenance independently of their affec

206 tissue-engineering agendas, their impact on telomere length maintenance remains unclear.

207 nked to secondary TERT function unrelated to telomere length maintenance.

208 d C-strand fill-in are equally important for telomere length maintenance.

209 s (ALT), a recombination-based mechanism for telomere-length maintenance.

210 rvational study suggest that donor leukocyte telomere length may have a role in long-term posttranspl

211 that a genetic background that favors longer telomere length may increase NHL risk, particularly risk

212 small number of studies suggests that longer telomere length measured in peripheral leukocytes is ass

213 n the shortest telomeres with more sensitive telomere length measurement assays, we show that only a

214 The use of currently available telomere-length measurement techniques is often restrict

215 ocol provides comparative cell-type-specific telomere-length measurements in relatively small human c

216 ric lagging strands leading to heterogeneous telomere lengths observed in most ALT cancers.

217 Recently, the influence of telomere length on chromatin organization prior to senes

218 Our objective was to evaluate the impact of telomere length on duration of post-therapy neutropenia

219 te these associations, no study has assessed telomere length or its relation with HPA-axis activity i

220 there was a significantly greater decline in telomere length over the year of 35 bp (P<0.05).

221 % confidence interval [CI] = 1.29-1.37]) and telomere length (p = 2.84 x 10(-14), odds ratio 0.85 [95

222 significantly impacted the association with telomere length (P<0.0001 and P=0.0025, respectively).

223 increases Est1 abundance but suppresses the telomere length phenotype of the single mutant.

224 In this group, telomere length positively correlated with TP53 and RB1

225 whole, the assessment of cell-type-specific telomere length provides valuable information on individ

226 iated beta-galactosidase activity, preserved telomere length, reduced expression of p16 and p53, and

227 no significant association with age-adjusted telomere length reduction was documented.

228 the shelterin complex and are essential for telomere length regulation and maintenance.

229 Studies of the contributions of Rap1 to telomere length regulation and transcriptional repressio

230 ntire Rap1 and Poz1 proteins does not impair telomere length regulation as long as a static bridge is

231 sis of these results, we propose a model for telomere length regulation in mammalian cells: The reduc

232 elineation of human cis elements involved in telomere length regulation.

233 ing evidence of a role of DNA replication in telomere length regulation.

234 fine key elements of shelterin important for telomere length regulation.

235 bromodomain-containing protein 4 (BRD4) as a telomere length regulator.

236 ssessed using the quantitative PCR method of telomere length relative to standard reference DNA.

237 cular lean mass (ALM) and relative leukocyte telomere length (rLTL) in 1398 participants of the Berli

238 Telomere length, RTEL1 and TERT expression may serve as

239 We studied the association between relative telomere length (RTL) and CKD progression and tested whe

240 reduced telomerase activities and shortened telomere length, suggesting an important role of CIRP in

241 loss of proliferation without any change in telomere length, suggesting that the effects of TERT cou

242 f apical (dividing) cells was quantified and telomere length, telomerase expression and activity were

243 itative FISH (Q-FISH) protocol for measuring telomere length that bypasses the previous limitations b

244 We studied the longitudinal relation between telomere length, the change in telomere length, and circ

245 dx(4cv)/mTR(G2) mouse model with "humanized" telomere lengths, the devastating dilated cardiomyopathy

246 telomerase action on itself that replenishes telomere length, thereby stabilizing the telomere.

247 Telomere length (TL) analysis represents a promising mol

248 re, we investigated the relationship between telomere length (TL) and aortic stiffness in well-charac

249 Shorter childhood telomere length (TL) and more rapid TL attrition are wid

250 e reported inconsistent associations between telomere length (TL) and risk for various cancers.

251 Leukocytes with longer telomere length (TL) are more responsive to inflammatory

252 nconsistent associations between smoking and telomere length (TL) have been reported in epidemiologic

253 Telomere length (TL) in early life has been found to be

254 RATIONALE: Short telomere length (TL) in leukocytes is associated with at

255 Telomere length (TL) is a marker of biological aging, an

256 Telomere length (TL) is a marker of cellular aging, with

257 with longer lifespan, but no information on telomere length (TL) is available.

258 sk for major cancers, thus creating a cancer-telomere length (TL) paradox.

259 Although telomere length (TL) reflects the replicative history of

260 ational studies have found shorter leukocyte telomere length (TL) to be a risk factor for coronary he

261 Telomere length (TL) trajectories in somatic tissues dur

262 Dietary factors can affect telomere length (TL), a biomarker of aging, through oxid

263 s to measure the shortest (not just average) telomere lengths (TLs) are needed.

264 der adults who have relatively short or long telomere lengths to compare their antibody response agai

265 myces cerevisiae These include regulation of telomere length, transcriptional repression of both telo

266 sity by a computer assisted method and blood telomere length using a validated PCR method.

267 We assessed proliferative capacity and telomere length using flow-fluorescence in situ hybridiz

268 Telomere length varied markedly among cohorts.

269 Telomere length was also shorter in relatives (regardles

270 Telomere length was assessed by high-throughput quantita

271 Telomere length was assessed using the quantitative PCR

272 Longer donor leukocyte telomere length was associated with higher survival prob

273 Longer donor leukocyte telomere length was associated with increased 5-year sur

274 Median telomere length was determined in peripheral blood leuko

275 In the 342 women examined telomere length was negatively correlated with age, was

276 Telomere length was not associated with percent mammogra

277 Patient leukocyte telomere length was not associated with survival.

278 In the entire sample, telomere length was positively associated with left and

279 Telomere length was positively associated with temporal

280 Telomere length was shorter in psychiatrically well rela

281 A 1-SD decrease in leukocyte telomere length was significantly associated with stroke

282 udinal changes in individuals' body mass and telomere length, we demonstrated that the fitness costs

283 Immune phenotyping, thymic output, and telomere length were assessed in 94 HIV-infected individ

284 ed lag models, both cord blood and placental telomere length were associated with average weekly expo

285 ower levels of MDA, mammographic density and telomere length were inversely associated; while at high

286 ns, cord blood and placental tissue relative telomere length were measured.

287 Peripheral blood mononuclear cell and AEC telomere length were shorter in at-risk individuals than

288 In 641 newborns, cord blood and placental telomere length were significantly and inversely associa

289 Early adversity and telomere length were significantly associated (Cohen's d

290 hemical, and anthropometric measurements and telomere lengths were compared between iciHHV-6+ and ici

291 Telomere lengths were determined by qPCR.

292 h full data on both cord blood and placental telomere lengths were included, resulting in a final stu

293 Telomere lengths were normal in patient fibroblasts and

294 a = -0.108, p = 0.002), and no alteration of telomere length when compared with healthy controls.

295 isorder (MDD) are characterized by shortened telomere length, which has been posited to underlie the

296 the relationship between early adversity and telomere length while exploring factors affecting the as

297 ral blood leukocytes was used to measure the telomere length with a quantitative polymerase chain rea

298 ociations between MUC5B rs35705950 and short telomere length with extent of fibrosis, histopathologic

299 sistent with earlier studies relating longer telomere length with increased NHL risk.

300 hematological malignancy, smoking behavior, telomere length, Y-chromosome loss, and other phenotypic