ライフサイエンスコーパス: telomere maintenance

1 o finely tune specific mechanisms underlying telomere maintenance.

2 tion, immunoglobulin diversity, meiosis, and telomere maintenance.

3 bination can provide an alternative means of telomere maintenance.

4 n which the principal pathology is defective telomere maintenance.

5 ete loss of repeat addition processivity for telomere maintenance.

6 luding in heterochromatic gene silencing and telomere maintenance.

7 , restart of collapsed replication forks and telomere maintenance.

8 These data implicate RECQL4 in telomere maintenance.

9 rocesses such as DNA replication, repair and telomere maintenance.

10 However, only TER1 is required for telomere maintenance.

11 g that BLM and WRN function independently in telomere maintenance.

12 replication, DNA repair, recombination, and telomere maintenance.

13 gy-directed repair, checkpoint signaling and telomere maintenance.

14 viously undescribed EWSR1 gene fusions), and telomere maintenance.

15 lure syndrome disorder because of defects in telomere maintenance.

16 '-C-overhangs in the HR-dependent pathway of telomere maintenance.

17 marrow failure syndrome caused by defects in telomere maintenance.

18 e mature hTR accumulation and thereby reduce telomere maintenance.

19 PinX1-TRF1 interaction in the regulation of telomere maintenance.

20 DC genes identified to date are important in telomere maintenance.

21 within hTR can stimulate telomerase-mediated telomere maintenance.

22 replication, double-strand break repair and telomere maintenance.

23 ndle checkpoint, postreplication repair, and telomere maintenance.

24 a new player in the telomere interactome for telomere maintenance.

25 , not in NHEJ or V(D)J recombination, but in telomere maintenance.

26 ruplex secondary structures which may affect telomere maintenance.

27 Okazaki fragment processing, DNA repair, and telomere maintenance.

28 n, which regulates genome activities such as telomere maintenance.

29 athways, have been shown to also function in telomere maintenance.

30 ng protein POT1 are thought to play roles in telomere maintenance.

31 ersity)joining [V(D)J] recombination, and/or telomere maintenance.

32 ential functions for SNL1 in development and telomere maintenance.

33 Telomerase function is critical for telomere maintenance.

34 in the response to DNA damage and regulates telomere maintenance.

35 n nevus to malignant melanoma do not support telomere maintenance.

36 us recombination, checkpoint activation, and telomere maintenance.

37 cularly and pathophysiologically by abnormal telomere maintenance.

38 -mediated dimerization of SLX4 in genome and telomere maintenance.

39 ement of NOP10 in the telomerase complex and telomere maintenance.

40 athways to form the telomere interactome for telomere maintenance.

41 RN-Tel1 and Rap1 promote recombination-based telomere maintenance.

42 that DC is primarily a disease of defective telomere maintenance.

43 ation of telomeric proteins is important for telomere maintenance.

44 lizes to telomere repeats and contributes to telomere maintenance.

45 gth, suggesting an important role of CIRP in telomere maintenance.

46 patient prognosis as compared with a lack of telomere maintenance.

47 ing the regulation of telomerase-independent telomere maintenance.

48 and spatial control of telomeric proteins in telomere maintenance.

49 etic requirements for telomerase-independent telomere maintenance.

50 n, TOP1, and RAD27 have overlapping roles in telomere maintenance.

51 or DNA ligation but has no known function in telomere maintenance.

52 latory properties independent of its role in telomere maintenance.

53 e biogenesis, premessenger RNA splicing, and telomere maintenance.

54 a RAD52-dependent recombinational pathway of telomere maintenance.

55 of its subunits, and, ultimately, regulated telomere maintenance.

56 elomerase enzyme that is required for normal telomere maintenance.

57 eric DNA sequences, a function important for telomere maintenance.

58 transcription, replication, translation and telomere maintenance.

59 tumor progression in addition to its role in telomere maintenance.

60 ced replisome orchestrates homology-directed telomere maintenance.

61 rase biogenesis and trafficking pathways for telomere maintenance.

62 restart of collapsed replication forks, and telomere maintenance.

63 a specialized replisome, which underlies ALT telomere maintenance.

64 ding of the diverse contributions of TPP1 in telomere maintenance.

65 iating redox reactions, DNA replication, and telomere maintenance.

66 also contains a STE, which is essential for telomere maintenance.

67 a role in other cellular processes including telomere maintenance.

68 ence and a switch to recombination-dependent telomere maintenance.

69 proteins, ensures unhindered, but regulated telomere maintenance.

70 ring defects in both DNA damage response and telomere maintenance.

71 meres, suggesting that this variant perturbs telomere maintenance.

72 e fragility, indicating a role for RECQL1 in telomere maintenance.

73 helicase but functionally least studied, in telomere maintenance.

74 mpacting the expression of genes involved in telomere maintenance.

75 with exquisitely high affinity to coordinate telomere maintenance.

76 Q helicase family involved in DNA repair and telomere maintenance.

77 llular processes such as gene regulation and telomere maintenance.

78 ssociates with two other cochaperones, TEL2 (Telomere maintenance 2) and TTI1 (Tel2-interacting prote

79 plexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, an

80 or example, Ku70:Ku86 possesses an essential telomere maintenance activity.

81 d that this function in turn is critical for telomere maintenance after DNA ICL damage.

82 nstrate that alphaIISp is also important for telomere maintenance after ICL damage.

83 a complete holoenzyme that is functional for telomere maintenance, albeit at shortened telomere lengt

84 e and recombination-mediated lengthening for telomere maintenance (ALT).

85 6, and link chromatin regulation by SIRT6 to telomere maintenance and a human premature ageing syndro

86 n decreased expression of genes required for telomere maintenance and an aberrant DNA damage response

87 regulators of telomerase that could disrupt telomere maintenance and cancer cell proliferation are n

88 ions, possibly due to their critical role in telomere maintenance and chromosomal stability.

89 omplex has been implicated in transcription, telomere maintenance and chromosome segregation, but its

90 of seven telomerase proteins is required for telomere maintenance and copurifies active RNP.

91 y, these results identify a role for PARN in telomere maintenance and demonstrate that it is a diseas

92 ring complex encloses DNA ends to facilitate telomere maintenance and DNA break repair.

93 Telomere maintenance and DNA repair are important proces

94 rotein kinase (DNA-PK), which is involved in telomere maintenance and DNA repair by nonhomologous end

95 ty mutants can lead to a profound failure of telomere maintenance and early-onset multisystem disease

96 <0.02) gene sets related to DNA replication, telomere maintenance and elongation, cell cycle progress

97 The role of mRtel1 in telomere maintenance and genome stability is poorly unde

98 for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase

99 EIL DNA glycosylases may be involved in both telomere maintenance and in gene regulation.

100 -oligo model helps define the role of WRN in telomere maintenance and initiation of DNA damage respon

101 Here we show that Zscan4 is involved in telomere maintenance and long-term genomic stability in

102 thways including nucleotide excision repair, telomere maintenance and non-homologous end-joining.

103 Telomerase is required for long-term telomere maintenance and protection.

104 omology searching mechanism in ALT-dependent telomere maintenance and provide a molecular basis under

105 in RTEL1, encoding a helicase essential for telomere maintenance and regulation of homologous recomb

106 Genetic defects in telomere maintenance and repair cause bone marrow failur

107 ethylation at repeated sequences, linking to telomere maintenance and self-renewal of ES cells.

108 erase RNA component (TERC) levels to restore telomere maintenance and self-renewal.

109 ate that Tel1p has two separate functions in telomere maintenance and that the Xrs2p-dependent recrui

110 F2 has come to the limelight for its role in telomere maintenance and tumorigenesis.

111 (FA)/BRCA DNA repair pathway, (2) defects in telomere maintenance, and (3) abnormal ribosome biogenes

112 We excluded Fanconi anemia, mutations of telomere maintenance, and a family history of BM failure

113 es cell growth through pathways unrelated to telomere maintenance, and a subset of tumors elongate te

114 r the preservation of replication forks, for telomere maintenance, and chromosome segregation in meio

115 plays roles in DNA replication, DNA repair, telomere maintenance, and homologous recombination and t

116 he telomerase pathway and link proteostasis, telomere maintenance, and human disease.

117 er cells divide necessitates a mechanism for telomere maintenance, and in approximately 90% of all ca

118 EL1 is important in Saccharomyces cerevisiae telomere maintenance, and its kinase activity is require

119 lar functions including DNA damage response, telomere maintenance, and Notch signaling (mediated thro

120 DNA replication, double strand break repair, telomere maintenance, and p53 activation.

121 maturation, long-patch base excision repair, telomere maintenance, and stalled replication fork rescu

122 dings highlight the critical role of TPP1 in telomere maintenance, and support a yin-yang model in wh

123 ins that influence nuclear transcription and telomere maintenance, and that associate with nucleoids

124 ss genes involved in DNA repair pathways and telomere maintenance, and the L3 layers express transcri

125 netheless dispensable, whereas Ku70:Ku86 and telomere maintenance are essential.

126 ed that both types of telomerase-independent telomere maintenance are inherited as a non-Mendelian tr

127 Mutations in genes responsible for telomere maintenance are linked to a number of human dis

128 Individuals with deficiencies in telomere maintenance are susceptible to enhanced telomer

129 echanistic details of how they contribute to telomere maintenance are unclear.

130 ation, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood.

131 erevisiae, the Ku heterodimer contributes to telomere maintenance as a component of telomeric chromat

132 novel combinatorial approaches to targeting telomere maintenance as a strategy for cancer therapy.

133 uman patients, suggesting a common defect in telomere maintenance because of the loss of MRN integrit

134 hTERT, are necessary but not sufficient for telomere maintenance because stabilized mTERT mutants ca

135 e has established the centrality of Pot1 for telomere maintenance but prohibited elucidation of the i

136 of telomeres are thought to be critical for telomere maintenance, but how they are generated has bee

137 T (alternative lengthening of telomeres) for telomere maintenance, but its function in telomere recom

138 these mutations have significant defects in telomere maintenance, but not in homologous recombinatio

139 can efficiently inhibit recombination-based telomere maintenance, but the inhibition requires both E

140 lex, the complex may promote recombinational telomere maintenance by altering chromatin structure.

141 xpression of a minimal TPP1 OB-fold inhibits telomere maintenance by blocking access of telomerase to

142 Telomerase promotes telomere maintenance by copying a template within its in

143 Telomere maintenance by minimized telomerase was unaffec

144 determine if Mre11p, Tel1p, or Mec1p affects telomere maintenance by promoting recruitment of telomer

145 Telomere maintenance by telomerase is critical for the u

146 Telomere maintenance by telomerase is impaired in the st

147 cts of the DNA damage response and regulates telomere maintenance by telomerase.

148 ny indication of dominant-negative impact on telomere maintenance by the coexpressed wild-type RNA.

149 Insufficient telomere maintenance can cause stem cell and tissue fail

150 ncrease telomerase activity and consequently telomere maintenance capacity in human immune-system cel

151 with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs302723

152 NA)-binding protein Pot1, a component of the telomere maintenance complex shelterin, which is present

153 form a soluble complex that may be the core telomere maintenance complex.

154 re we report the identification of conserved telomere maintenance component 1 (CTC1) in plants and ve

155 s from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammal

156 uced the more severe defect in both types of telomere maintenance, consistent with their more severe

157 that the lack of dominant-negative impact on telomere maintenance correlates with physiological assem

158 Telomere maintenance critically depends on the distinct

159 of the disease and that the magnitude of the telomere maintenance defect in iPSCs correlates with cli

160 /-) controls, establishing that the TIN2(DC) telomere maintenance defect was not solely due to dimini

161 esponse to DNA damage and conferred moderate telomere maintenance defect.

162 In human subjects telomere maintenance deficiency leads to dyskeratosis co

163 ation for the connection that exists between telomere maintenance deficiency states and diverse condi

164 roteins have been identified as critical for telomere maintenance, DNA repair, transcription and othe

165 However, genetically caused variations in telomere maintenance either raise or lower risks and pro

166 ction and expand mechanisms by which altered telomere maintenance engenders human disease.

167 mammary tumorigenesis, telomerase-dependent telomere maintenance facilitates the formation and metas

168 n and transcriptional regulators, as well as telomere maintenance factors.

169 These data suggest that an alternative telomere maintenance function may operate in human tumor

170 Finally, this telomere-maintenance function is not shared by ZRANB3 or

171 les can be used as a means of inhibiting the telomere maintenance functions of telomerase in human ca

172 tions sufficient for Tel1/ATM checkpoint and telomere maintenance functions.

173 of DNA repair molecules H2AX, BRCA1, and the telomere maintenance gene, hTERT.

174 a variety of biological processes including telomere maintenance, gene expression, epigenetic regula

175 h functions in nonhomologous end-joining and telomere maintenance, generates severe defects such as s

176 fferentiation and population structure of 37 telomere maintenance genes among 53 worldwide population

177 Mutations in telomere maintenance genes are associated with pathologi

178 was analyzed for germline mutations in four telomere maintenance genes associated with telomere biol

179 erase-independent survivors with alternative telomere maintenance have also been identified.

180 ends is a hallmark of cancer, telomeres and telomere maintenance have been prime drug targets.

181 pacts of different levels of processivity on telomere maintenance have not been examined.

182 for a number of cancers, but its effects on telomere maintenance have not been previously investigat

183 n and the key involvement of this protein in telomere maintenance have suggested directed inhibition

184 didate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progr

185 replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class swi

186 To examine the activation of telomere maintenance in a variety of sarcoma subtypes, a

187 emonstrate that dyskerin also contributes to telomere maintenance in Arabidopsis thaliana.

188 7, like AtTERT, is not haploinsufficient for telomere maintenance in Arabidopsis.

189 Limiting the potential for telomere maintenance in cancer cells has been long been

190 ith the RNA template of telomerase and halts telomere maintenance in cancer cells.

191 hese data indicate that CTC1 participates in telomere maintenance in diverse species and that a CST-l

192 man carboxy-terminal domain are critical for telomere maintenance in human fibroblasts.

193 ic integrity and could have implications for telomere maintenance in human telomerase-deficient cells

194 , providing direct evidence of their role in telomere maintenance in humans.

195 assess the role of telomerase activation and telomere maintenance in mammary carcinoma tumorigenesis,

196 In addition, we analyze telomere maintenance in mre11, rad50, nbs1, ku70 and lig

197 telomerase enzymatic activity and long-term telomere maintenance in normal human immune cells.

198 ad50 null strain with respect to meiosis and telomere maintenance in S. cerevisiae, correlating adeny

199 We used OndexView to investigate telomere maintenance in S. cerevisiae.

200 Telomere maintenance in STAG2 mutant tumor cells occurre

201 the possibility that t-circles contribute to telomere maintenance in stn1-M1 and ALT cells.

202 Surprisingly, Rap1 is also essential for telomere maintenance in taz1Delta trt1Delta cells, even

203 plex Rad32-Rad50-Nbs1 (MRN) are required for telomere maintenance in taz1Delta trt1Delta cells.

204 ed replication (BIR) as well as HR-dependent telomere maintenance in the absence of telomerase found

205 ase is believed to be the sole mechanism for telomere maintenance in the epidermis.

206 conserved shelterin complex is essential for telomere maintenance in the fission yeast Schizosaccharo

207 d mice, indicating a conserved dependence on telomere maintenance in this cell lineage.

208 The recombination-based telomere maintenance in trt1Delta cells is inhibited by

209 eres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been d

210 of several recombination/repair proteins to telomere maintenance in Ustilago maydis, a fungus that b

211 rase regulatory protein Est3 is required for telomere maintenance in vivo, and shares intriguing stru

212 human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.

213 1 in vitro yet is nevertheless essential for telomere maintenance in vivo.

214 d PPM1D, and repression of genes involved in telomere maintenance, including hPOT1 and PARP1.

215 skerin interacts with telomerase and affects telomere maintenance independently of telomere length.

216 ated with LPC expression of genes related to telomere maintenance, inflammation, and chemokine signal

217 Although the general concept of defective telomere maintenance initiating genomic instability has

218 Telomere maintenance is a highly coordinated process, an

219 These findings suggest that telomere maintenance is a noncanonical caretaker functio

220 Telomere maintenance is determined by genetic factors an

221 We show that somatic telomere maintenance is different in asexual and sexual

222 Telomere maintenance is essential for protecting chromos

223 upregulated in a number of human cancers as telomere maintenance is essential for tumorigenesis.

224 Mammalian telomere maintenance is governed by a number of telomere

225 further strengthens the model that defective telomere maintenance is the primary pathology in DC and

226 ALT telomere maintenance is therefore one mechanism by which

227 s congenita, but how PARN deficiency impairs telomere maintenance is unclear.

228 in addition to its long-term requirement for telomere maintenance, is also necessary for short-term i

229 group of disorders characterized by impaired telomere maintenance, known collectively as the telomero

230 s that rely on the alternative mechanism for telomere maintenance, LANA expression had minimal effect

231 n a model that shares many features with the telomere maintenance machinery of higher eukaryotes.

232 enetic diseases are caused by defects in the telomere maintenance machinery.

233 Activation of a telomere maintenance mechanism (TMM) is permissive for r

234 ing necessitates that tumor cells activate a telomere maintenance mechanism (TMM) to support immortal

235 , we use a liposarcoma model system to assay telomere maintenance mechanism (TMM)-specific genetic al

236 tive correlation between the activation of a telomere maintenance mechanism and tumor progression in

237 protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase

238 e characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative l

239 lomere lengths by the telomerase-independent telomere maintenance mechanism termed alternative length

240 telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset o

241 telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in approximat

242 esenchymal tumors have been interrogated for telomere maintenance mechanism, as well as characteristi

243 in human cells that had not yet activated a telomere maintenance mechanism, suggesting that abrogati

244 gthening of telomeres (ALT) pathway as their telomere maintenance mechanism.

245 be achieved, in part, by the activation of a telomere maintenance mechanism.

246 Deficiency in telomere maintenance mechanisms leads to the development

247 Cancer cells survive cellular crisis through telomere maintenance mechanisms.

248 l contribute greatly to better understanding telomere maintenance mechanisms.

249 anism linking cumulative childhood stress to telomere maintenance, observed already at a young age, w

250 This study emphasises the role of defective telomere maintenance on human disease.

251 telomeres constitute a robust mechanism for telomere maintenance, one which has persisted since befo

252 unit Trt1 (TERT) through recombination-based telomere maintenance or through chromosome circularizati

253 imary suspects are mutations that deregulate telomere maintenance, or mitosis, yet such mutations hav

254 in strains that had activated an alternative telomere maintenance pathway (ALT).

255 ely 10%-15% employ a recombination-dependent telomere maintenance pathway known as alternative length

256 ium conditions and reveal steps in the human telomere maintenance pathway that may provide additional

257 y genes (DKC1, TERC, and TERT) belong to the telomere maintenance pathway; patients with DC have very

258 results strongly suggest that both types of telomere maintenance pathways occur by recombination-dep

259 structure-function relationships underlying telomere maintenance pathways.

260 Alterations in chromatin-modifying genes and telomere-maintenance pathways were commonly observed, wh

261 y functions of InsPs and PP-InsPs (including telomere maintenance, phosphate sensing, cell migration,

262 al lines of evidence suggest that defects in telomere maintenance play a significant role in the init

263 ndrome, a disorder characterized by aberrant telomere maintenance, premature aging, chromosomal rearr

264 ells and tissues that further exacerbate the telomere maintenance problems in telomerase-positive ste

265 es an unusual homologous recombination-based telomere maintenance process.

266 We identified Mte1 (Mph1-associated telomere maintenance protein 1) as a multifunctional reg

267 ther supporting an evolutionary link between telomere maintenance proteins and DNA repair complexes.

268 sory complex that, in conjunction with other telomere maintenance proteins, ensures unhindered, but r

269 of cells lacking Ccq1 stem from its role in telomere maintenance rather than from a role in formatio

270 t necessary for this effect, indicating that telomere maintenance, rather than the presence of the en

271 , the FA pathway has a novel function in ALT telomere maintenance related to DNA repair.

272 In most eukaryotes, telomere maintenance relies on telomeric repeat synthesi

273 As proper telomere maintenance requires a multitude of DNA extensi

274 re crucial to pre-messenger RNA splicing and telomere maintenance, respectively.

275 An enhanced DNA repair and telomere maintenance response by the Mre11/Rad50/Nbs1 (M

276 tic organisms, such as membrane trafficking, telomere maintenance, ribosome biogenesis, and apoptosis

277 breaks in meiosis, homologous recombination, telomere maintenance, S-phase checkpoint, and genome sta

278 n but induces RAD51/HR, which contributes to telomere maintenance/stabilization and prevention of apo

279 lar processes, such as energetic metabolism, telomere maintenance, stress responses, and vesicle traf

280 tions in genes encoding factors required for telomere maintenance, such as telomerase reverse transcr

281 h dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer degeneration of multiple ti

282 wth advantage to cancer cells independent of telomere maintenance, suggesting that hTERT makes multip

283 ation by passaging cells lacking any form of telomere maintenance (telomerase and telomere recombinat

284 Given the role of the previous DC genes in telomere maintenance, telomere length was analysed in th

285 n replication stress and recombination-based telomere maintenance that may play a role in HPV-16 E7-m

286 propose that the BLM complex contributes to telomere maintenance through its activity in resolving L

287 ls usually engage the telomerase pathway for telomere maintenance to gain immortality.

288 i anemia protein SLX4 assembles a genome and telomere maintenance toolkit, consisting of the nuclease

289 we find that a protein known to function in telomere maintenance, TRF2, also plays a functional role

290 se to DNA interstrand crosslinking agent and telomere maintenance, underscoring the contribution of B

291 re amplifications, regardless of the mode of telomere maintenance used.

292 g that these proteins have opposing roles in telomere maintenance vs. establishment.

293 lving the POT1 and ATM genes responsible for telomere maintenance were detected and may contribute to

294 ), have important functions in physiological telomere maintenance, whereas DDR proteins that arrive l

295 HR is implicated in genomic instability and telomere maintenance, which are critical lifelines of ca

296 ve lengthening of telomeres (ALT) pathway of telomere maintenance, which relies on the homologous rec

297 Drosophila exhibit this variant mechanism of telomere maintenance, which was established before the s

298 alize the therapeutic potential of targeting telomere maintenance with a focus on telomerase are disc

299 subtypes, and to review the consequences of telomere maintenance with respect to genome stability an

300 ties of cells indirectly through its role in telomere maintenance, without altering growth stimulator