ライフサイエンスコーパス: telomere repeat

1 ustered in two loci within the 23-bp Candida telomere repeat.

2 independent of its activity in synthesizing telomere repeats.

3 r promoting degradation of dsDNA in and near telomere repeats.

4 in its intrinsic RNA component to synthesize telomere repeats.

5 riction fragment length and in the number of telomere repeats.

6 rays, a selectable marker and terminal human telomere repeats.

7 ence RGGG, a sequence found in a majority of telomere repeats.

8 - geneous alphoid DNA retrofitted with human telomere repeats.

9 iggered apoptosis followed by degradation of telomere repeats.

10 ns its own RNA template for the synthesis of telomere repeats.

11 tion independently of the orientation of the telomere repeats.

12 to the C-rich strands of the subtelomere and telomere repeats.

13 ment (GGATGT) that is shared by many Candida telomere repeats.

14 Retrotransposons or MoTeRs) inserted in the telomere repeats.

15 ted by release of Sir3 specifically from the telomere repeats.

16 tromere, 45S ribosomal DNA (rDNA), knob, and telomere repeats.

17 ome and are associated with intrachromosomal telomere repeats.

18 c residues to interact with species-specific telomere repeats.

19 e of Cdk1 completely blocked the addition of telomere repeats.

20 position, but also the rate of synthesis, of telomere repeats.

21 tation-specific manner adjacent to a perfect telomere repeat (5'-TTAGGG-3').

22 Telomere repeat addition onto non-telomeric 3' ends was

23 cleotides from a primer 3' terminus prior to telomere repeat addition.

24 crease the rate or alter the processivity of telomere repeat addition.

25 eature that plays a critical role in de novo telomere repeat addition.

26 in hybridization (FISH) and primer extension telomere repeat amplification (PETRA).

27 Using a modified version of the telomere repeat amplification protocol (TRAP) assay, we

28 nzymatic activity is assayed by means of the telomere repeat amplification protocol (TRAP) assay.

29 The telomere repeat amplification protocol (TRAP) for the hu

30 low detectable activity, as analyzed by the telomere repeat amplification protocol assay.

31 e assessed by using quantitative PCR and the telomere repeat amplification protocol from PBMCs and en

32 cies by using a modification of the one-tube telomere repeat amplification protocol, although better

33 were subsequently achieved with the two-tube telomere repeat amplification protocol.

34 Primer extension telomere repeat amplification relies on the presence of

35 circle and a DNA polymerase gives a positive telomere-repeat amplification protocol assay result for

36 PCR method and telomerase activity by TRAP (Telomere-Repeats Amplification Protocol) assay in periph

37 ensions of chromatin function-the vertebrate telomere repeat and the promoter regions of many Schizos

38 We now show that ORC localizes to telomere repeats and contributes to telomere maintenance

39 ual role at telomeres, maintaining tracts of telomere repeats and forming telomeres de novo on broken

40 The first possesses telomere repeats and the Y' subtelomeric element amplifi

41 possessed chromosome ends lacking detectable telomere repeats, aneuploidy, and chromosomal abnormalit

42 DNTF can be instigated by the insertion of a telomere repeat array (TRA) into the host genome, which

43 Age-adjusted telomere repeat array (TRA) reduction was found to signi

44 screte point (fusion point) with a different telomere repeat array.

45 lengthening of telomeres (ALT), to maintain telomere repeat arrays.

46 The molecular identity of this telomere repeat-associated anticheckpoint activity is un

47 or the catalytic hTERT protein to synthesize telomere repeats at chromosome ends.

48 Canonical telomere repeats at chromosome termini can be maintained

49 ced by the 'capture' or de novo synthesis of telomere repeats at double-stranded breaks and by the ca

50 is the length, purity, or orientation of the telomere repeats at these potentially destabilizing inte

51 one such folding competent substrate, human telomere repeat binding factor (hTRF1), which is bound t

52 e we use NMR spectroscopy to study the human telomere repeat binding factor 1 (hTRF1) in complex with

53 This interaction is blocked by the telomere repeat binding factor 1, but not by a dominant

54 By fusing the KillerRed chromophore with the telomere repeat binding factor 1, TRF1, we developed a n

55 re we demonstrate that PARP1 associates with telomere repeat binding factor 2 (TRF2) and is capable o

56 a screen for potential interactions between telomere repeat binding factor 2 (TRF2) and proteins inv

57 ia deubiquitination and stabilization of the telomere repeat binding factor TRF1.

58 We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the promoter

59 omosomal localization of the Chinese hamster telomere repeat binding factor, chTRF1.

60 nal region of NBS1 interacts directly with a telomere repeat binding factor, TRF1, by both yeast two-

61 whether these alterations are due to lack of telomere repeat binding factor/s.

62 Two proteins in this complex, telomere repeat binding factors (TRF1 and TRF2), specifi

63 Telomere repeat binding factors 1 and 2 (TRF1 and TRF2)

64 that has been implicated along with several telomere repeat binding factors in the regulation of Eps

65 Two enhancing mutations were mapped to TELOMERE REPEAT BINDING PROTEIN1 (TRB1) and its paralog

66 Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which ar

67 ain to bind diverse proteins, including TRF (telomere-repeat binding factor)-1, IRAP (insulin-respons

68 pecifically with defective expression of the telomere repeat- binding factor TRF2, telomere shortenin

69 In contrast, telomere repeat-binding factor 2 (TRF2) expression is un

70 insertion of the 3' overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric D

71 Telomere repeat-binding factor 2 (TRF2) is critical for

72 demonstrate that a non-telomeric isoform of telomere repeat-binding factor 2 (TRF2-S) is a novel RBP

73 1 physically and functionally interacts with telomere repeat-binding factor 2 that in turn regulates

74 re elongation is negatively regulated by the telomere repeat-binding protein Rap1p, such that a narro

75 Chromosome ends are maintained by telomere-repeat-binding factors (TRFs) that coordinate D

76 TbOrc1 associates with telomere repeats but appears to do so independently of t

77 e that replication can initiate within human telomere repeats but was most frequently accomplished by

78 -transcribe through selected barriers in the telomere repeat by acting as an allosteric activator and

79 transcriptase that extends one strand of the telomere repeat by using a template embedded in an RNA s

80 gth is maintained by the de novo addition of telomere repeats by telomerase, yet recombination can el

81 Transcription of telomere repeats can initiate at subtelomeric CTCF-bindi

82 ed ends of broken chromosomes, which contain telomere repeats, can enter the bouquet; (b) ring chromo

83 ly, suggesting that maintenance of taz1Delta telomere repeats cannot be sustained through semi-conser

84 at are entirely composed of the C-rich human telomere repeat, (CCCTAA)n.

85 Without telomerase's ability to synthesize telomere repeats, chromosome ends shorten progressively,

86 ts in elevated subtelomeric RNA levels while telomere-repeat containing transcript levels remain repr

87 or rap1(+) leads to increased levels of both telomere repeat-containing and subtelomeric transcripts.

88 Often, six new Bal-31-resistant, telomere repeat-containing bands appeared, and we infer

89 While telomere repeat-containing non-coding RNA has been ident

90 ccumulation of telomere-associated noncoding telomere repeat-containing RNA (TERRA) is required for t

91 ation of subtelomeric transcripts, including telomere repeat-containing RNA (TERRA).

92 replication and preventing the generation of telomere-repeat-containing circles.

93 res, including telomere-signal-free ends and telomere-repeat-containing double minutes.

94 We also find a wide range of rDNA and telomere repeat copy number in both sets.

95 on between average relative telomere length, telomere repeat copy number to single gene copy number (

96 mean natural logarithm-transformed ratio of telomere repeat copy number to single gene copy number 0

97 ative PCR method for T/S ratio (the ratio of telomere repeat copy numbers to single-copy gene numbers

98 nsisting of two conserved hexameric S. pombe telomere repeats, d(GGTTACGGTTAC), with an affinity appr

99 of nucleotides to the 3'-end of the TTTTGGGG telomere repeat decreases the level of alpha binding by

100 aintain telomeres by processive synthesis of telomere repeat DNA at their 3'-ends, using an integral

101 o-end chromosome fusions and greater loss of telomere repeat DNA compared with Terc mutants.

102 Telomere repeat DNA forms a nucleo-protein structure tha

103 In the yeast Saccharomyces cerevisiae, telomere repeat DNA is assembled into a specialized hete

104 s, and a loss of histone H3 K9me3 and ORC at telomere repeat DNA.

105 inear chromosomes by successive additions of telomere repeat DNA.

106 t ORC subunits can be affinity purified with telomere-repeat DNA along with other components of the k

107 d OsRTBP1) recently shown to encode in vitro telomere-repeat DNA-binding activity.

108 pendence of the CD spectra of the vertebrate telomere repeat DNAs is distinctly different from that o

109 subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (TERRA), but the role of tr

110 Telomere-repeat-encoding RNA (referred to as TERRA) has

111 ovel exponential isothermal amplification of telomere repeat (EXPIATR) assay--a sensitive, simple, an

112 icant changes in overall enzyme activity and telomere repeat extension rate, but have little effect o

113 ERT) and an RNA that contains a template for telomere-repeat extension.

114 vitro inhibits ORC2 recruitment and remodels telomere repeat factor (TRF) binding at the dyad symmetr

115 h hyperacetylation of histone H3 and loss of telomere repeat factor 2 (TRF2) binding at the EBV origi

116 Telomere repeat factor 2 (TRF2) binds directly to OriP a

117 eral telomere-associated proteins, including telomere repeat factors 1 (TRF1) and 2 (TRF2), subunits

118 ORC subunits colocalized with telomere-repeat foci and coimmunoprecipitated with TRF2

119 s demonstrated to be TTAGGG, the most common telomere repeat found in organisms from the animal and f

120 d excellent agreement with the commonly used telomere repeat fragment-Southern blot method.

121 mere 29-base pair elements that separate the telomere repeats from their proximal telomere-associated

122 ucleoprotein enzyme complex that synthesizes telomere repeats, has been associated with acquisition o

123 locytic leukemia bodies and extrachromosomal telomere repeats; however, no alterations in the rate of

124 ization analysis showed that misrejoining of telomere repeats (i.e., chromosomes joined end to end at

125 y, and that the recent acquisition of TTAGGG telomere repeats in Asparagus appears to have co-evolved

126 Telomere repeats in the fission yeast Schizosaccharomyce

127 nucleoprotein (RNP) complex that synthesizes telomere repeats in tissue progenitor cells and cancer c

128 and act as templates for synthesis of human telomere repeats in vitro.

129 lly for the distribution of the interstitial telomere repeats (ITRs).

130 Furthermore, we found that neither telomere repeat length nor telomeric silencing correlate

131 h and support a model in which Rif1 measures telomere repeat length to ensure that telomere replicati

132 heir abilities to bind telomeric DNA, affect telomere repeat length, participate in telomeric DNA rep

133 In cells lacking telomerase, the rate of telomere-repeat loss appeared to be inversely proportion

134 revisiae, Cdc13 binds single-stranded G-rich telomere repeats, maintaining telomere integrity and len

135 sely flank the inverted arrays of degenerate telomere repeats marking the fusion site are duplicated

136 fragment length paralleled by a decrease of telomere repeat number.

137 NAs is distinctly different from that of the telomere repeats of Tetrahymena and Oxytricha as well as

138 The circular dichroism, CD, spectra of the telomere repeats of vertebrates, d(TTAGGG), indicate tha

139 TER1 results in the incorporation of mutant telomere repeats on chromosome ends.

140 hibits telomere elongation by its binding to telomere repeats, preventing access to telomerase.

141 s anchor site) that allows the enzyme to add telomere repeats processively.

142 BLM co-localizes and complexes with the telomere repeat protein TRF2 in cells that employ the re

143 ERRA transcription acts in cis to facilitate telomere repeat replication and chromosome stability.

144 Point mutations in the telomere repeat residues reduced or abolished the bindin

145 Telomere repeat sequence (TRS) DNA is found at the termi

146 mid containing an 800 bp insert of the human telomere repeat sequence (TTAGGG)(n).

147 These studies define the telomere repeat sequence as a destabilizing element in t

148 n = 6, 7, and 8) was each added to the human telomere repeat sequence d(T(2)AG(3))(4) and examined wi

149 Although the human telomere repeat sequence d[G(3)(TTAG(3))(3)] folds into

150 The interstitial telomere repeat sequence in both orientations, however,

151 und in telomere proteins and binds the human telomere repeat sequence TTAGGG.

152 a strong preference for the canonical plant telomere repeat sequence TTTAGGG with no detectable bind

153 cted for a telomerase synthesizing the plant telomere repeat sequence TTTAGGG.

154 Telomere repeat sequences cap the ends of eucaryotic chr

155 addition to facilitating the maintenance of telomere repeat sequences via HR-dependent mechanisms, a

156 a ribonucleoprotein complex that synthesizes telomere repeat sequences, is linked to cell immortaliza

157 is process is dependent on the shortening of telomeres, repeated sequences at the ends of the chromos

158 n or hypomorphic cell lines caused a loss of telomere-repeat signal intensity and the appearance of d

159 ts measured for sequence permutations of the telomere repeat spanned the range of 55-1400 nM, with Ec

160 t when binding to the duplex subtelomere and telomere repeats, ST-2 may act as a protein bridge with

161 The TER includes a template for telomere repeat synthesis as well as other domains requi

162 elomerase RNA that provides the template for telomere repeat synthesis.

163 A:DNA hybrid register to prime each round of telomere repeat synthesis.

164 NA subunit (TER) functions as a template for telomere repeat synthesis.

165 Using linear constructs terminating in the telomere repeat, T2AG3, human telomere DNA was shown to

166 higher affinity to G4 DNA formed from yeast telomere repeats than to single-stranded DNA of the same

167 riptase (hTERT), and functions to synthesize telomere repeats that serve to protect the integrity of

168 ependent RNA polymerase, suggesting that the telomere repeats themselves serve as promoter sites; mul

169 A crude cell lysate which adds telomere repeats to a biotinylated DNA primer is the sou

170 ere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated

171 gral RNA subunit to template the addition of telomere repeats to chromosome ends.

172 hromosomal stability through the addition of telomere repeats to chromosome ends.

173 it ribonucleoprotein (RNP) complex that adds telomere repeats to the ends of chromosomes.

174 MAC vectors containing functionally defined telomere repeats together with candidate centromere and

175 p, such that a narrow length distribution of telomere repeat tracts is observed.

176 to the CTCF sites and extending towards the telomere repeat tracts.

177 with no detectable binding to hexanucleotide telomere repeat TTAGGG found in vertebrates and some pla

178 g-lived radical cations are detected for the telomere repeat TTAGGG in single-stranded configuration,

179 It binds specifically to the double-stranded telomere repeats (TTAGGG) and more tightly to the subtel

180 eposited 800 bp of the functional vertebrate telomere repeat, TTAGGG, in two orientations in the seco

181 east two internal tandem copies of the maize telomere repeat, TTTAGGG.

182 telomeres in vivo and recognizes the unusual telomere repeat unit with high affinity and sequence spe

183 detection of a chemically synthesized tetra-telomere repeat was about 10 attomoles.

184 The P. carinii telomere repeat was demonstrated to be TTAGGG, the most

185 Integration of the HHV-6 genome into TTAGGG telomere repeats was confirmed by additional methods and

186 Sequence adjacent to the telomere repeats was shown by Bal31 exonuclease digestio

187 54mer oligonucleotide composed of nine human telomere repeats, which was not possible to assemble by