ライフサイエンスコーパス: telomere-binding protein

1 at EV71 3C directly interacted with PinX1, a telomere binding protein.

2 cilitate structural characterization of this telomere binding protein.

3 ed it was predicted to be another structural telomere-binding protein.

4 telomeric silencing and mislocalize Rap1p, a telomere-binding protein.

5 has been shown to modify itself and TRF1, a telomere-binding protein.

6 the idea that hPot1 is a bona fide mammalian telomere-binding protein.

7 instead, is complexed with a heterodimeric, telomere-binding protein.

8 , Sir4p, and Cdc13p were found to be in vivo telomere binding proteins.

9 viously to bind telomeres in vivo are indeed telomere binding proteins.

10 ation about the evolution of single-stranded telomere binding proteins.

11 at is distinct from monitoring the number of telomere binding proteins.

12 haracteristics as the Euplotes and Oxytricha telomere-binding proteins.

13 aining a Myb-like motif similar to two human telomere-binding proteins.

14 ene, and/or the activity and distribution of telomere-binding proteins.

15 uited to telomeres through interactions with telomere-binding proteins.

16 shortening or disruptions in the function of telomere-binding proteins.

17 The interaction with telomere-binding protein 1 was found to be mediated thro

18 In particular, mutations of the telomere binding proteins alpha thalassemia/mental retar

19 uence similarity to the first OB fold of the telomere-binding protein alpha subunit of Oxytricha nova

20 We describe a one-hybrid assay for telomere binding proteins and use it to establish that s

21 ain homologous to the second OB-fold of POT1 telomere-binding proteins and a C-terminal SNM1 family n

22 tability requires the coordinated actions of telomere-binding proteins and the DNA replication and re

23 The known viral replication proteins, a telomere binding protein, and a protein kinase were asso

24 vely studied in many species: actin I, alpha-telomere binding protein, and DNA polymerase alpha.

25 promoted apoptosis through cleaving PinX1, a telomere binding protein, and that this cleavage facilit

26 function of telomerase and its regulation by telomere-binding proteins, and these strains will serve

27 We conclude that rTP and the telomere-binding proteins are members of a class of prot

28 ue to telomerase deficiency or by removal of telomere-binding proteins are recognized as DSBs.

29 YS EARLY proteins AtALY2 and AtALY3, and two telomere binding proteins AtTBP1 and AtTRP2/TRFL1 as SNL

30 uclear gene encoding the beta-subunit of the telomere-binding protein (beta-TP) are not conserved in

31 by multiple independent mechanisms involving telomere binding protein Ccq1 cooperating with Taz1 and

32 In Saccharomyces cerevisiae, the telomere binding protein Cdc13 mediates telomere replica

33 Inactivation of the budding yeast telomere binding protein Cdc13 results in abnormal telom

34 biochemical interaction between Est1 and the telomere binding protein Cdc13 that recapitulates the pr

35 between the Est1 telomerase subunit and the telomere-binding protein Cdc13 is essential for telomera

36 The essential budding yeast telomere-binding protein Cdc13 is required for telomere

37 een the catalytic core of telomerase and the telomere-binding protein Cdc13.

38 interacted with the putative single-stranded telomere-binding protein Cdc13p.

39 lytic subunit of telomerase and the nematode telomere-binding protein CeOB2.

40 A telomere-binding protein complex from human sperm (hSTBP

41 lot3-uv3 carries a mutation in Taz1, a telomere-binding protein containing a Myb-like motif sim

42 bility through loss-of-function mutations in telomere binding proteins contributes to genomic instabi

43 to ssDNA at unprotected telomeres (in Cdc13 telomere-binding protein defective strains).

44 Although telomere binding proteins from evolutionarily distant sp

45 Gbp1p is a putative telomere-binding protein from Chlamydomonas reinhardtii

46 Protection of telomere 1 (POT1), a telomere binding protein, has an OB domain like single-s

47 lpha and beta subunits of the Oxytricha nova telomere binding protein have been investigated by Raman

48 Telomere-binding proteins have crucial roles in controll

49 The human telomere binding protein hPot1 binds to the most distal

50 e second and first OB folds of the mammalian telomere binding protein hPOT1, respectively.

51 ng different mutations in this domain to the telomere binding protein hTRF2 redirected the mutated hT

52 It is generally assumed that telomere-binding proteins impede replication fork progre

53 uggesting that there could be other abundant telomere binding proteins in fission yeast.

54 or instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of m

55 The protein hPot1 shares homology with telomere-binding proteins in lower eukaryotes and associ

56 ic DNA in vitro as well as colocalizing with telomere-binding proteins in vivo.

57 omere maintenance is governed by a number of telomere binding proteins, including the newly identifie

58 eraction with specific DNA-damage sensors or telomere-binding proteins, including RPA, MRE11-RAD50-NB

59 riments with mutants defective in the Cdc13p telomere-binding protein indicate that ssDNA formation i

60 Telomere binding proteins interact with numerous protein

61 Interaction with telomere binding proteins is not sufficient to prevent a

62 tudies which demonstrate that when Cdc13p, a telomere-binding protein, is disabled, loci close to the

63 We hypothesize that these telomere binding proteins may play a role in the initiat

64 he identification of the first mitochondrial telomere-binding protein (mtTBP) that specifically binds

65 Work on the RAP1 telomere-binding protein now indicates that silencing sp

66 During the examination of ceramide-regulated telomere-binding proteins, nuclear glyceraldehyde-3-phos

67 A and the alpha subunit of the heterodimeric telomere binding protein of Oxytricha nova have been pro

68 distinct from candidate genes encoding known telomere-binding proteins or telomerase components.

69 tered by mutation, by changing the levels of telomere binding proteins, or by increasing the amount o

70 ne-rich hexameric DNA together with specific telomere-binding proteins, play essential roles in prote

71 to complementary single stranded DNA and to telomere binding protein POT1.

72 RecQ helicases WRN and BLM and telomere-binding protein POT1 are thought to play roles

73 Alterations in the single-stranded telomere-binding protein POT1 have recently been identif

74 re, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production

75 s, such as the beta-subunit of the Oxytricha telomere-binding protein, promote the formation of G-qua

76 Deficiency for the POT-2 telomere binding protein promoted ALT in telomerase muta

77 Telomere binding proteins protect chromosome ends from d

78 of the homeodomain-like motifs of the yeast telomere binding protein RAP1.

79 that with critical telomere shortening, the telomere-binding protein Rap1 (repressor activator prote

80 ut affecting plasmid colocalization with the telomere-binding protein Rap1.

81 e function and alter the localization of the telomere binding protein Rap1p.

82 cerevisiae, the RAP1 gene encodes the major telomere binding protein Rap1p.

83 ent evidence suggests that the silencer- and telomere-binding protein Rap1p initiates silencing by re

84 The yeast telomere-binding protein Rap1p negatively regulates telo

85 s eliminated in cells that overexpressed the telomere-binding protein Rap1p, a condition that also in

86 rough its association with the silencer- and telomere-binding protein Rap1p.

87 omeric repeats attenuates the binding of the telomere binding protein, Rap1p, to telomeric DNA in vit

88 Rap1p, the major yeast telomere binding protein, recognizes a 13 bp duplex site

89 east and humans that encodes a single-strand telomere binding protein required for chromosome end pro

90 Therefore, Cdc13p is a telomere-binding protein required to protect the telomer

91 the solution conformations of the Oxytricha telomere binding protein subunits and serve as the basis

92 rticle are also capable of colocalizing with telomere binding proteins, suggesting that the C protein

93 caused by the absence of the double-stranded telomere-binding protein Taz1 demonstrates that the circ

94 In contrast, when the telomere-binding protein Taz1 is also deleted, taz1Delta

95 In the absence of the telomere-binding protein Taz1, fission yeast undergo let

96 d17, Rad26, Hus1, Crb2, Chk1, Cds1), Tel1, a telomere-binding protein (Taz1), and DNA repair proteins

97 nfluence telomere length regulation, such as telomere binding proteins, telomere capping proteins, te

98 ments revealed that cRap1 interacts with the telomere-binding protein telomeric repeat binding factor

99 n genes encoding components of telomerase or telomere-binding protein (TERT, TERC, DKC1, NOP10, or TI

100 y demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and

101 tection of telomeres 1) is a single-stranded telomere binding protein that is essential for chromosom

102 omeres 1 (POT1) protein is a single-stranded telomere binding protein that is essential for proper ma

103 The biological implications of a telomere-binding protein that is regulated by dimerizati

104 CDC13 encodes a telomere-binding protein that prevents degradation of te

105 When tethered away from telomeres and other telomere-binding proteins, the TPP1 OB-fold domain is su

106 Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to tel

107 The telomere binding proteins TRF1 and TRF2 limit digestion

108 the telobox that is also found in the human telomere binding proteins TRF1 and TRF2, and Tbf1p, a pr

109 ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere len

110 compared with the bulk genome in cells, and telomere-binding protein TRF1 significantly reduces phot

111 nteraction with the resident double-stranded telomere-binding protein TRF1.

112 In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial rol

113 Instead, this role is replaced by SA1 and telomere binding proteins (TRF1 and TIN2).

114 d52 along with replication factors (RPA) and telomere binding proteins (TRF1 and TRF2), are associate

115 ve recently been revealed: these involve the telomere-binding protein TRF2 and the ubiquitin E3 ligas

116 be localized to telomeres via binding to the telomere-binding protein TRF2.

117 ere via interaction with the double-stranded telomere-binding protein TRF2.

118 Rap1 and were additive with knockdown of the telomere-binding protein TRF2.

119 mage was suppressed by overexpression of the telomere-binding protein TRF2.

120 o interact with the Werner protein (WRN) and telomere-binding protein (TRF2) were required for FEN1 a

121 current model for telomere protection by the telomere-binding protein, TRF2, involves the formation o

122 ns of a myb/SANT DNA-binding domain from the telomere-binding protein, TRF2, with reconstituted telom

123 ayed marked upregulation (10-15 fold) of the telomere-binding protein, TRF2.

124 n fall within the DNA-binding domains of the telomere-binding proteins, when rTP was first identified

125 mining regions and sequences from Myb family telomere binding proteins, which are hypothesized to con

126 These repeats are bound by telomere binding proteins, which are thought to interact

127 ct physical interactions between Blm and two telomere-binding proteins, which may thus recruit or reg

128 ns of the beta subunit of the Oxytricha nova telomere binding protein with the telomeric DNA sequence

129 In the absence of the DSB and telomere-binding protein yKu70, the bleomycin sensitivit

130 Recently we identified a novel type of telomere-binding protein YlTay1p from the yeast Yarrowia