ライフサイエンスコーパス: telomeric

1 crucial role in maintaining newly replicated telomeric 3' overhangs and facilitating the switch from

2 c approach provides a detailed snapshot of a telomeric 3' quadruplex-duplex junction: a junction that

3 newly replicated telomeres and prevention of telomeric aberrations.

4 Telomeric abnormalities caused by loss of function of th

5 e shelterin protein TIN2 is required for the telomeric accumulation of TPP1/POT1 heterodimers and for

6 We speculate that telomeric aggregates and ongoing breakage-bridge-fusion

7 multinucleated cells, nuclear volume, and 3D telomeric aggregates when compared with the LMP1-suppres

8 d yeast strains, each containing a different telomeric amplicon (Tamp), ranging in size from 0.4 to 1

9 Our genome-wide Tamp screen confirmed that telomeric amplifications identified in laboratory-evolve

10 ealed that the fitness landscape explored by telomeric amplifications is much broader than that explo

11 enome-wide screen for the fitness effects of telomeric amplifications to address the relationship bet

12 case may contribute to its functions at both telomeric and nontelomeric sites.

13 ounds were investigated employing both human telomeric and oncogene promoter G-quadruplexes with diff

14 th an increase in the number of colocalizing telomeric and RNA polymerase I foci in the nucleus.

15 mosomal interactions between the cell lines; telomeric and sub-telomeric regions in the MCF-10A cells

16 two enantiomers binds specifically to human telomeric antiparallel G-quadruplex.

17 (TPP1), mutations of which lead to decreased telomeric association of telomerase, similar to the phos

18 We observed extra-telomeric binding of the telomere repeat binding factor

19 was also defective in the maintenance of the telomeric C strand, causing extended 3' overhangs and st

20 Consistent with shortening of the telomeric C strand, metaphase chromosomes showed loss of

21 Based on experiments with high telomeric C-rich strand production efficiencies, we conc

22 y that can explain the incremental nature of telomeric C-strand synthesis following telomerase action

23 lterin subunits TRF1, TRF2, and TIN2 mediate telomeric chromatin compaction, which was proposed to mi

24 investigated the structural organization of telomeric chromatin in human cells using super-resolutio

25 strate that shelterin-mediated compaction of telomeric chromatin provides robust protection of chromo

26 Recompaction of telomeric chromatin using an orthogonal method displaces

27 is in close proximity to NUP-1, the NPCs and telomeric chromosomal regions.

28 In vivo, in the presence of functional BLM, telomeric circle formation and telomere sister chromatid

29 The ANK domain of TNKS1 is essential for the telomeric damage response and TRF1 interaction.

30 1/2 inhibitor only has such an effect at non-telomeric damage sites.

31 WRN responds to site-specific telomeric damage via its RQC domain, interacting at Lysi

32 and-break repair nuclease MRE11A, leading to telomeric damage, juxtacentromeric heterochromatin unrav

33 on, WRN depleted cells are also sensitive to telomeric damage.

34 ere dysfunction induces the transcription of telomeric DDRNAs (tDDRNAs) and their longer precursors f

35 iciently unwind G-quadruplex rescues all the telomeric defects of the D223Y cells.

36 Here, we measured loss of telomeric DNA and accumulation of replication errors in

37 telomerase activity results in shortening of telomeric DNA and eventually a specific G2/M cell-cycle

38 he ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity.

39 exes between these small molecules and human telomeric DNA and RNA quadruplexes.

40 (Tg), regulate the structural properties of telomeric DNA and telomerase extension activity.

41 Phe, AtPOT1bOB1 gained the capacity to bind telomeric DNA and to stimulate telomerase repeat additio

42 Increases in telomeric DNA are suppressed by loss of BLM but not RAD5

43 b paralogs are atypical: they do not exhibit telomeric DNA binding, and they have opposing roles in r

44 Telomeric DNA can form duplex regions or single-stranded

45 Telomeric DNA consists of tandem repeats of the sequence

46 Telomere shortening is associated with telomeric DNA damage response and apoptosis in stem cell

47 Telomerase was able to resolve existing telomeric DNA damage response foci and suppressed format

48 Telomeric DNA damage shortens the average length of telo

49 This leads to accumulation of RPA and telomeric DNA damage signaling.

50 oci, and augmented cell death upon oxidative telomeric DNA damage.

51 1 complex, which affects its ability to bind telomeric DNA efficiently.

52 At telomeres, TERRA competes with telomeric DNA for ATRX binding, suppresses ATRX localiza

53 he most abundant sequence motif in irregular telomeric DNA from Saccharomyces cerevisiae (yeast), is

54 e rational design of ligands targeting human telomeric DNA G-quadruplexes is a complex problem due to

55 ridostatin) induce conformational changes of telomeric DNA G-quadruplexes to an antiparallel structur

56 ed space on the property of individual human telomeric DNA G-quadruplexes.

57 otein enzyme that catalyzes the extension of telomeric DNA in eukaryotes.

58 stone gamma-H2AX foci and a striking loss of telomeric DNA in mus81 send1 further support this interp

59 ort that SSB1 binds specifically to G-strand telomeric DNA in vitro and associates with telomeres in

60 Interestingly, we estimated higher levels of telomeric DNA methylation in studies that produced C-ric

61 We found that the levels of estimated telomeric DNA methylation varied among studies.

62 nteractions of the gold complex with various telomeric DNA models have been analyzed by a combined ES

63 result of conventional DNA replication, new telomeric DNA must be added onto the chromosome end.

64 pies its internal RNA template to synthesize telomeric DNA repeats at chromosome ends in balance with

65 lterin complex, and its interaction with the telomeric DNA repeats.

66 indicate that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcripti

67 We propose that normally occurring telomeric DNA replication stress is resolved by telomera

68 Telomeric DNA represents a novel target for the developm

69 e structure of TRF1 and its interaction with telomeric DNA sequence.

70 nfold G-quadruplex (G4) structures formed by telomeric DNA sequences, a function important for telome

71 ral motif of G-quadruplexes formed by, e.g., telomeric DNA sequences, but are also interesting target

72 In contrast to 8oxoG which disrupts the telomeric DNA structure, Tg exhibits substantially reduc

73 Our results reveal telomeric DNA substrates bound to telomerase exhibit a d

74 d POT1 has the strongest binding affinity to telomeric DNA substrates comprised of double-stranded DN

75 lizes the association between telomerase and telomeric DNA substrates, providing a molecular explanat

76 Sequence analogs of human telomeric DNA such as d[AGGG(TTAGGG)3] (Tel22) fold into

77 rase RNA (TR) that provides the template for telomeric DNA synthesis.

78 mosomes terminate in stretches of repetitive telomeric DNA that act as buffers to avoid loss of essen

79 The human shelterin proteins associate with telomeric DNA to confer telomere protection and length r

80 ALT relies on exchanges of telomeric DNA to maintain telomeres, a process that we s

81 eficient TRF2 mutant, named Top-less, alters telomeric DNA topology, decreases the number of terminal

82 esides their ability to bind specifically to telomeric DNA using their N-terminally positioned myb-li

83 s chromosome ends, recognizing single-strand telomeric DNA via two oligonucleotide/oligosaccharide bi

84 terins but rather on the unique character of telomeric DNA when it is opened for transcription.

85 r resolution of stalled replication forks in telomeric DNA while BLM facilitates their resection and

86 Although TRF1 binds telomeric DNA with similar affinity, it has minimal effe

87 Irradiation of G-quadruplex forming human telomeric DNA with ultraviolet B (UVB) light results in

88 With the exception of the single-stranded telomeric DNA, all genomic G-rich sequences will always

89 interactions between shelterin subunits and telomeric DNA, but not by DNA methylation, histone deace

90 irect connection between oxidative damage to telomeric DNA, comprising <1% of the genome, and telomer

91 lude that a distinctive topological state of telomeric DNA, controlled by the TRF2-dependent DNA wrap

92 POT1 OB-fold fail to bind to single-stranded telomeric DNA, eliciting a DNA damage response at telome

93 embly of proteins that binds to and protects telomeric DNA, which composes the ends of all linear chr

94 vity of SLX1-SLX4 is negatively regulated by telomeric DNA-binding proteins TRF1 and TRF2 and is supp

95 array of bound Rap1 molecules that mimics a telomeric DNA-protein assembly.

96 Here we found that SmedOB1 is required for telomeric DNA-protein complex formation and it associate

97 but not POT1b, has an intrinsic affinity for telomeric DNA.

98 vation of telomerase, an enzyme that extends telomeric DNA.

99 e (F65) that in human POT1 directly contacts telomeric DNA.

100 d conformational alterations and dynamics in telomeric DNA.

101 has been designed that targets G-quadruplex telomeric DNA.

102 on by aiding fork progression through G-rich telomeric DNA.

103 urn stabilizes the interaction with specific telomeric DNA.

104 s and aggregates containing TRF1 protein and telomeric DNA.

105 l effects on WRN-mediated strand exchange of telomeric DNA.

106 nalysis together with experimentally induced telomeric double-stranded DNA breaks.

107 intenance leads to gradual shortening of the telomeric dsDNA, similar to that observed in cells lacki

108 CST first aids in duplication of the telomeric dsDNA.

109 -forming scaffolds linked at the 3' end to a telomeric duplex sequence and annealed to a complementar

110 lomeric hybrids that, in turn, can result in telomeric dysfunction.

111 g the activation of a DNA damage response at telomeric ends.

112 phate (IP) pathway controls transcription of telomeric ESs and VSG antigenic switching in Trypanosoma

113 variation by switching transcription between telomeric ESs or by recombination of the VSG gene expres

114 The derepression is specific to telomeric ESs, and it coincides with an increase in the

115 he active VSG gene is in a Pol I-transcribed telomeric expression site (ES).

116 ly one VSG gene at a time from 1 of about 20 telomeric expression sites (ESs).

117 meres using CAPTURE identifies known and new telomeric factors.

118 nificantly reduces photoproduct formation in telomeric fragments in vitro.

119 TPP1 loss induced increased telomeric fusion events in bone marrow progenitors.

120 ole chromosomes containing massive arrays of telomeric fusions indicative of multiple breakage-fusion

121 whereas Tg retains limited accessibility, of telomeric G-quadruplex DNA to complementary single stran

122 ies show that Delta1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplex

123 induce conformational switching of the human telomeric G-quadruplexes to an antiparallel structure an

124 Also contrasting with telomeric G-quadruplexes, the parallel-stranded Pu24-myc

125 ral G-quadruplexes with respect to the human telomeric G-quadruplexes.

126 nate human telomeric G-quadruplex from other telomeric G-quadruplexes.

127 ates DNA polymerase delta progression across telomeric G-rich repeats, only WRN promotes sequential s

128 e anticancer alkaloid berberine to the human telomeric G4 (d[AG3(T2AG3)3]), computing also the bindin

129 date the mechanism through which RPA unfolds telomeric G4s, we studied its interaction with oligonucl

130 -rich region that is also located within the telomeric gene desert but has no impact on Hoxd8 transcr

131 osely located sequences and the most distant telomeric gene desert.

132 s and alleviates repression of some polycomb telomeric genes.

133 Even a segment of only 10 telomeric (GGGTTA) repeats was modified in the plasmid.

134 s on different GQ constructs including human telomeric GQ (with different overhangs and polarities) a

135 ic studies on Bloom (BLM) helicase and human telomeric GQ interactions using single-molecule Forster

136 e telomere lengths linked to distinguishable telomeric haplotypes; this single-telomere genotyping me

137 he presence of K(+) ions and hemin, into the telomeric hemin/G-quadruplex structure, exhibiting horse

138 We find that telomeric heterochromatin is dynamic and remodelled upon

139 oth arising out of nucleolytic processing of telomeric homologous recombination intermediates, are su

140 tion, can enantioselectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telom

141 omers with contrasting selectivity for human telomeric hybrid G-quadruplex.

142 Telomeric hybrids are associated with high levels of DNA

143 vels in ICF syndrome lead to accumulation of telomeric hybrids that, in turn, can result in telomeric

144 Third, inter-telomeric interactions significantly increase in quiesce

145 Here we demonstrate that a non-telomeric isoform of telomere repeat-binding factor 2 (T

146 the SLX1-SLX4 complex processes a variety of telomeric joint molecules in vitro.

147 Both centromeric and telomeric KIR B genes contribute to the effect, but the

148 By contrast, telomeric KIR B genes protect Europeans against pre-ecla

149 as significant interaction between HLA-B and telomeric KIR B haplotype (containing the activating gen

150 hat the ALT pathway preferentially occurs at telomeric lagging strands leading to heterogeneous telom

151 lls exhibited preferential elongation of the telomeric lagging strands, whereas telomerase positive c

152 The RCT-TIN2-L247E fusion showed improved telomeric localization and was fully functional in terms

153 ization abrogates nuclear foci formation and telomeric localization of not only SLX4 but also of its

154 2 also binds to TRF1 and TRF2, improving the telomeric localization of TRF2 and its function.

155 l machinery, in addition to its preferential telomeric localization.

156 ced from a gene 60 kb upstream of its normal telomeric location.

157 cloche gene has been challenging due to its telomeric location.

158 nd hinders chromosomal translocations at non-telomeric loci.

159 The telomeric long noncoding RNA TERRA has been implicated i

160 Here we examine WRN's role in telomeric maintenance, by comparing its action on a vari

161 s at telomeres, leading to the engagement of telomeric MiDAS (spontaneous mitotic telomere synthesis)

162 Telomeric MiDAS is a conservative DNA synthesis process,

163 N complex suppresses telomere clustering and telomeric MiDAS, whereas the SMC5/6 complex promotes the

164 this model, initial damage to DNA (genomic, telomeric, mitochondrial and epigenetic changes) results

165 rrence of an unusual eukaryote (TTTTTTAGGG)n telomeric motif in C. elegans represents a switch in mot

166 ent types of large structural mosaic events: telomeric neutral events and interstitial losses.

167 oss compromises cell-cycle regulation of the telomeric noncoding RNA TERRA and leads to persistent as

168 ne-rich oligonucleotide homologous to the 3'-telomeric overhang of telomeres, elicits potent DNA-dama

169 disrupt the interaction between POT1 and the telomeric overhang.

170 rved that ALT cells possess excessively long telomeric overhangs derived from telomere elongation pro

171 ile SNM1B/Apollo is required for maintaining telomeric overhangs.

172 RA increases telomerase activity and induces telomeric pathologies, including formation of telomere-i

173 t for XPA protein indicates the mechanism of telomeric photoproduct removal is NER.

174 Negative regulation by VEX1 also affected telomeric pol-I-transcribed reporter constructs, but onl

175 ture of the interacting portion of the human telomeric POT1-TPP1 complex and suggest how several of t

176 Naturally occurring mutations of the telomeric POT1-TPP1 complex are implicated in familial g

177 Typical nematode telomeres and telomeric protection-encoding genes are lacking.

178 tion of the telomerase protein TERT with the telomeric protein TPP1.

179 interactions with telomerase RNA (TLC1) and telomeric proteins Sir4 and Cdc13, respectively.

180 ting proteins, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX.

181 while the stoichiometry was more complex for telomeric quadruplex DNA and a double-stranded DNA contr

182 EIL1, NEIL2 and NEIL3 remove hydantoins from telomeric quadruplexes formed by five TTAGGG repeats muc

183 the thermostability and alter the folding of telomeric quadruplexes in a location-dependent manner.

184 n in selected positions in Na(+)-coordinated telomeric quadruplexes.

185 observed in co-crystal structures with human telomeric quadruplexes.

186 cluding OGG1, are able to remove 8-oxoG from telomeric quadruplexes.

187 nd strongly suggests a physiological role in telomeric recombination processes, including T-loop dyna

188 a major malting QTL, QTL2, located near the telomeric region that accounts, respectively, for 28.9%

189 s their human counterparts also populate the telomeric region.

190 atin is associated with the rDNA locus while telomeric regions are assembled into a weak heterochroma

191 Telomeric regions contain prominent sites of heterochrom

192 ns between the cell lines; telomeric and sub-telomeric regions in the MCF-10A cells display more freq

193 U2OS and IMR90 cells, when DNA damage at non-telomeric regions is undetectable.

194 ed efficiently compared to DNA damage in non-telomeric regions of the same length in heterochromatin.

195 TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with.

196 ed TERRA levels, are enriched for hybrids at telomeric regions throughout the cell cycle.

197 5hmU is enriched in strand switch regions, telomeric regions, and intergenic regions.

198 methylation, including centromeric repeats, telomeric regions, and the mating-type locus, consistent

199 c DNA binding and subdiffusive dynamics over telomeric regions.

200 recognition through subdiffusive sliding at telomeric regions.

201 ell as acetylated H4K16 both globally and at telomeric regions.

202 NA:RNA hybrids form at many subtelomeric and telomeric regions.

203 Telomerase activity was evaluated by a telomeric repeat amplification protocol assay based on e

204 and it can be regarded as an alternative to telomeric repeat amplification protocol assay, having th

205 Telomeric repeat binding factor 1 (TRF1) is essential to

206 c.752-2A>C) and another shelterin component, telomeric repeat binding factor 2, interacting protein (

207 eatment and hybridization with a Cy3-labeled telomeric repeat complementing (CCCTAA)3 peptide nucleic

208 t suppress the accumulation of DNA damage at telomeric repeat DNA.

209 e, including an increase in extrachromosomal telomeric repeat DNAs, putative recombinational byproduc

210 TRF1 and TRF2, which preferentially bind the telomeric repeat found at chromosome ends, effectively b

211 The interactions of the Tetrahymena telomeric repeat sequence d(TG4T) and the polyguanylic a

212 Consistent with their roles at telomeres, telomeric repeat sequence DNA also stimulated binding an

213 plex DNA sequence constructed from the human telomeric repeat sequence TTAGGG.

214 ics as native cytosine residues in the human telomeric repeat sequence, where it causes little or no

215 and eight additional proteins, including the telomeric repeat single-stranded DNA-binding protein Teb

216 t eukaryotes, telomere maintenance relies on telomeric repeat synthesis by a reverse transcriptase na

217 on results in replication stalling in duplex telomeric repeat tracts and the subsequent formation of

218 Repressor activator protein 1 (RAP1) and telomeric repeat-binding factor 2 (TRF2) are two subunit

219 ditional deletion of the shelterin component telomeric repeat-binding factor 2, cells survived but re

220 d reduced expression and telomere binding of telomeric repeat-binding factor-2 (TRF2), associated wit

221 Telomeric repeat-containing RNA (TERRA) has been identif

222 Functions of the telomeric repeat-containing RNA (TERRA), the long noncod

223 monstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA).

224 ruitment--binding and extension of the first telomeric repeat.

225 ion of shelterin complex, competing with the telomeric-repeat binding factors TRF1 and TRF2.

226 y short primer-template hybrid necessary for telomeric-repeat synthesis.

227 linking hinge, which bound to 12 bp in human telomeric repeats (5'-(TTAGGG)n-3') and could be used to

228 n the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcripti

229 l senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telo

230 We further discovered that telomeric repeats are refractory to heterochromatin spre

231 been reported for Q-quadruplexes formed from telomeric repeats depending on DNA length and ion soluti

232 ide probe confirmed its effective binding to telomeric repeats in the complex chromatinized genome.

233 lication efficiency of guanine-rich (G-rich) telomeric repeats is decreased significantly in cells la

234 Telomerase adds telomeric repeats onto chromosome ends and is almost uni

235 this terminal sequence loss by synthesizing telomeric repeats through repeated cycles of reverse tra

236 The telomerase is responsible for adding telomeric repeats to chromosomal ends and consists of th

237 The reverse transcriptase telomerase adds telomeric repeats to chromosome ends.

238 mosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks.

239 lterin components, which allows CLRC to skip telomeric repeats to internal regions.

240 istinct activities of telomerase, which adds telomeric repeats to solve the end replication problem,

241 Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase rev

242 /PK) which includes the template, for adding telomeric repeats, template boundary element (TBE), and

243 To synthesize telomeric repeats, the catalytic subunit telomerase reve

244 of four hairpin moieties, targeting 24 bp in telomeric repeats, the longest reported binding site for

245 constant to 24 bp sequences made up of four telomeric repeats.

246 ntains at least three G-rich single-stranded telomeric repeats.

247 ming, which results in the rapid deletion of telomeric repeats.

248 ALT cells, BRCA1 and BLM help to resolve the telomeric replication stress by stimulating DNA end rese

249 g the binding interactions between the human telomeric RNA (TERRA) G-quadruplex (GQ) and its ligands,

250 P1-regulated appropriate levels of TERRA and telomeric RNA:DNA hybrid are fundamental to subtelomere/

251 Depletion of TbRAP1 also results in more telomeric RNA:DNA hybrids and more double strand breaks

252 he RNA strand of the RNA:DNA hybrid, brought telomeric RNA:DNA hybrids, telomeric/subtelomeric DSBs a

253 RNAs, including ribosomal, spliceosomal and telomeric RNAs, cisplatin binding sites in most RNA mole

254 of reactive oxygen species, suggesting a non-telomeric role for Pot1a in HSC maintenance.

255 in the GGG triplet found in the G-rich human telomeric sequence (TTAGGG), making telomeres highly sus

256 uplex formed by the 22-mer four-repeat human telomeric sequence AG3(TTAG3)3 and (ii) the intermolecul

257 nvolved in mismatch repair (MMR), suppresses telomeric sequence insertion (TSI) at intra-chromosomal

258 mportantly, WRN's specificity for the G-rich telomeric sequence within this precise structural contex

259 erin, fission yeast shelterin is composed of telomeric sequence-specific double- and single-stranded

260 Aberrant formation of interstitial telomeric sequences (ITSs) promotes genome instabilities

261 How these proteins find telomeric sequences among a genome of billions of base p

262 x known as shelterin prevents recognition of telomeric sequences as sites of DNA damage.

263 Hence, telomeric sequences may have evolved to facilitate their

264 ation events between different DNAs at their telomeric sequences.

265 s), ultimately leading to stochastic loss of telomeric sequences.

266 Sessea (family Solanaceae) lack known plant telomeric sequences.

267 a variety of DNA structures without or with telomeric sequences.

268 d DNA damage foci and loss or duplication of telomeric sequences.

269 In fission yeast, the conserved telomeric shelterin complex recruits the histone H3K9 me

270 og (ACD) (encoding TPP1), a component of the telomeric shelterin complex, in one family affected by H

271 ging upon telomere shortening or loss of the telomeric shelterin component TRF2.

272 gly, we demonstrate that deletion of Ccq1, a telomeric shelterin component, rescued cell death after

273 rapidly induces DNA damage at telomeres and telomeric shortening upon long-term chemical exposure in

274 ly conserved methyltransferase, disruptor of telomeric silencing (Dot1)-like (Dot1L).

275 ion program is dependent on the disruptor of telomeric silencing 1-like histone 3 lysine 79 (H3K79) m

276 residue is required for Gdh1's functions in telomeric silencing and H3 clipping.

277 ic variation and demonstrated a link between telomeric silencing and subtelomere/telomere integrity t

278 is observed in GDH1 mutants, consistent with telomeric silencing defects.

279 ssor/activator protein 1 (TbRAP1), and their telomeric silencing function is altered by TbPIP5K knock

280 nly a single methyltransferase, disruptor of telomeric silencing-1-like (DOT1L).

281 a key regulatory role for this metabolite in telomeric silencing.

282 ed Ku-binding protein that is a component of telomeric silent chromatin - is required for Ku-mediated

283 orylation promotes the RPA-to-POT1 switch on telomeric single-stranded 3' overhangs.

284 acts to repair DNA breaks, including in the telomeric site of VSG expression.

285 transcribed VSG expression site is the only telomeric site that is early replicating - a differentia

286 g, suppresses ATRX localization, and ensures telomeric stability.

287 methylation in studies that produced C-rich telomeric strands with lower efficiency.

288 block FANCJ from unwinding the forked duplex telomeric substrate.

289 A hybrid, brought telomeric RNA:DNA hybrids, telomeric/subtelomeric DSBs and VSG switching frequency

290 During limb development, the telomeric TAD controls the early transcription of Hoxd g

291 uncover a transition point in which 34 bp of telomeric (TG1-3)n repeat sequence renders a DNA end ins

292 Ts1Rhr mice harbor a duplication of the telomeric third of the Ts65Dn-duplicated sequence and de

293 imputed intronic SNP rs1830298 in ALS2CR12 (telomeric to CASP8), with per allele odds ratio and 95%

294 nd near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in EIF2AK4, near B

295 The telomeric transcript, TERRA, was detected in T. brucei p

296 ing RNAs, we investigate the function of the telomeric transcript, TERRA.

297 ealed previously unknown heterochromatic and telomeric transition sequences, and we assembled low-com

298 epeat tracts and the subsequent formation of telomeric ultrafine anaphase bridges (UFBs), ultimately

299 polymerase-I (pol-I) to transcribe just one telomeric variant surface glycoprotein (VSG) gene at a t

300 specific telomere-associated protein: TZAP (telomeric zinc finger-associated protein).