ライフサイエンスコーパス: telomeric repeat

1 lomere homology that is longer than the unit telomeric repeat.

2 ppress corresponding sequence changes in the telomeric repeat.

3 nucleotides of perfect homology to the 25-bp telomeric repeat.

4 a specific permutation of the guanosine-rich telomeric repeat.

5 referred termination points within the 25-bp telomeric repeat.

6 anslocation step after the synthesis of each telomeric repeat.

7 n being the central guanine residues in each telomeric repeat.

8 t lasted only 1-2 h from a DSB adjacent to a telomeric repeat.

9 ene family are located within 10 kb from the telomeric repeat.

10 s specifically with the G-rich strand of the telomeric repeat.

11 ruitment--binding and extension of the first telomeric repeat.

12 N-terminal OB domain of each monomer to each telomeric repeat.

13 red for a high affinity of YlTay1p to either telomeric repeat.

14 unit binds sequence specifically to multiple telomeric repeats.

15 than those seen in cells with only wild-type telomeric repeats.

16 odified base, J is located mainly within the telomeric repeats.

17 ted and typically capped by species-specific telomeric repeats.

18 omere, which contains degenerate and variant telomeric repeats.

19 wed by several kilobases of TTAGG or variant telomeric repeats.

20 has adapted mechanisms to maintain terminal telomeric repeats.

21 multiple 8-oxo-guanine lesions in the tandem telomeric repeats.

22 a Pot1 monomer is extended into two adjacent telomeric repeats.

23 lomere length and the sequence of newly made telomeric repeats.

24 t observed above background along the duplex telomeric repeats.

25 rm within guanine-rich DNA sequences such as telomeric repeats.

26 e alterations appearing in newly synthesized telomeric repeats.

27 constant to 24 bp sequences made up of four telomeric repeats.

28 l as the synthesis of aberrant, 5-nucleotide telomeric repeats.

29 ataxia telangiectasia, have short but stable telomeric repeats.

30 hrough its interactions with the most distal telomeric repeats.

31 oduct was then elongated to generate perfect telomeric repeats.

32 ntains at least three G-rich single-stranded telomeric repeats.

33 ming, which results in the rapid deletion of telomeric repeats.

34 s of eukaryotic chromosomes by adding tandem telomeric repeats.

35 ell lineages by restricting the reservoir of telomeric repeats.

36 on ablated RPA1 and RPA2 binding to the cell telomeric repeats.

37 cules bind an oligonucleotide containing two telomeric repeats.

38 b-like domains conferring specificity toward telomeric repeats.

39 of an RNA subunit as template to synthesize telomeric repeats.

40 erase RNA subunit templates the synthesis of telomeric repeats.

41 some ends by the addition of single-stranded telomeric repeats.

42 PA, Teb1 binds DNA with high specificity for telomeric repeats.

43 subunit to elongate chromosome ends with new telomeric repeats.

44 linking hinge, which bound to 12 bp in human telomeric repeats (5'-(TTAGGG)n-3') and could be used to

45 n the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcripti

46 ose that after formation of the DSB near the telomeric repeat, a mature telomere forms in 1-2 h, and

47 es composed of either of two types of mutant telomeric repeats, Acc and SnaB, that each alter the bin

48 r DNA also resembles the situation found for telomeric repeat addition to macronuclear-destined seque

49 geneity could be observed in the position of telomeric repeat addition.

50 I), and the other possesses amplification of telomeric repeats alone (type II), similar to previously

51 The telomeric repeat amplification protocol (TRAP assay) has

52 We develop a real-time quantitative PCR telomeric repeat amplification protocol (TRAP) assay tha

53 Typical assay for telomerase activity is the telomeric repeat amplification protocol (TRAP) based on

54 The telomeric repeat amplification protocol (TRAP) is a two-

55 The sensitive telomeric repeat amplification protocol (TRAP) permits t

56 Telomerase activity was measured using the telomeric repeat amplification protocol (TRAP).

57 Additional evidence from Telomeric Repeat Amplification Protocol (TRAP-LIG) assay

58 nhibited telomerase activity, as measured by telomeric repeat amplification protocol assay and human

59 Telomerase activity was evaluated by a telomeric repeat amplification protocol assay based on e

60 and it can be regarded as an alternative to telomeric repeat amplification protocol assay, having th

61 Using the telomeric repeat amplification protocol assay, we found

62 uantitative real-time quantitative-PCR-based telomeric repeat amplification protocol assay, with telo

63 el of telomerase activity as measured by the telomeric repeat amplification protocol assay.

64 se activity was determined using a PCR-based telomeric repeat amplification protocol coupled with ELI

65 invasive breast cancers by the quantitative telomeric repeat amplification protocol method.

66 erase activity at 24 h as detected using the telomeric repeat amplification protocol, and this inhibi

67 ive telomerase, as assessed according to the Telomeric Repeat Amplification Protocol.

68 Telomeric-repeat amplification protocol assays and telom

69 which rules out quadruplex formation by the telomeric repeat and confirms an ordered secondary struc

70 e hairpin conformation of the Oxytricha nova telomeric repeat and consider its possible roles in mech

71 We designed TALEs for the human telomeric repeat and fused them with any of numerous flu

72 ese complexes also fold much faster than the telomeric repeat and there is little or no hysteresis be

73 ions many kilobases internal to the terminal telomeric repeats and correlates strongly with the previ

74 TRF2 binds to DNA substrates containing telomeric repeats and facilitates their degradation spec

75 l senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telo

76 its RNA subunit as a template to synthesize telomeric repeats and maintain telomere tracts on chromo

77 Telomerase catalyzes conservation of telomeric repeats and may promote cell immortality and h

78 lencing is initiated by Rap1p binding to the telomeric repeats and subsequent recruitment of the Sir

79 The bridges required telomeric repeats and were dependent on meiotic recombin

80 ogeneous spacers that occur between S. pombe telomeric repeats, and it also has implications for telo

81 Telomeric repeats are lost rapidly (at a rate of >1 kilo

82 The telomeric repeats are maintained by telomerase, which so

83 We further discovered that telomeric repeats are refractory to heterochromatin spre

84 ase levels--and extension of as few as three telomeric repeats are sufficient to maintain functional

85 Telomeric repeats are synthesized and maintained by a sp

86 of the 3' telomeric overhang into the duplex telomeric repeat array.

87 TRF1 formed filamentous structures on longer telomeric repeat arrays (>/=27 repeats) consistent with

88 nity in vitro correlates with the ability of telomeric repeat arrays to regulate telomere length in v

89 Rye telomeric repeat arrays were shortest, ranging from 8 kb

90 The shortening of telomeric repeats as a cell replicates has long been imp

91 Mammalian POT1 binds two telomeric repeats as a monomer in a sequence-specific ma

92 ble as part of a holoenzyme that synthesizes telomeric repeats at chromosome ends.

93 RNA, which can explain the heterogeneity of telomeric repeats at de novo and native telomeres in S.

94 them also carry several shorter stretches of telomeric repeats at or near their 3' ends, which could

95 chromosomal segmental duplications capped by telomeric repeats at the ends of chromosomes.

96 ase recognizes, and compensates for, partial telomeric repeats at the ends of fragmentation intermedi

97 The total number of telomeric repeats at the terminal end of a chromosome de

98 8-oxoG in telomeric repeats attenuates the binding of the telomere

99 hand, when hPOT1 is bound at a position one telomeric repeat before the 3'-end, leaving an 8-nucleot

100 ADP-ribosylate TRF1 and to down-regulate the telomeric repeat binding activity of TRF1, resulting in

101 interacts with the telomere-binding protein telomeric repeat binding factor (TRF)2 and localizes to

102 Here we report the identification of telomeric repeat binding factor 1 (Tbf1), a second TRF1/

103 Telomeric repeat binding factor 1 (TRF1) is a component

104 Telomeric repeat binding factor 1 (TRF1) is essential to

105 igh-mobility group AT-hook 1 (HMGA1), HMGB1, telomeric repeat binding factor 1 (TRF1), xeroderma pigm

106 nd in telomerase and the shelterin component telomeric repeat binding factor 1 (TRF1)-interacting nuc

107 re maintained by three DNA-binding proteins (telomeric repeat binding factor 1 [TRF1], TRF2, and prot

108 CSNK2A2 phosphorylates telomeric repeat binding factor 1 and plays an important

109 teraction proteins, we have identified TRF1 (telomeric repeat binding factor 1) as a potential Plk1 t

110 teins suppressed the ADP-ribosylation of the telomeric repeat binding factor 1, another tankyrase 1-i

111 Human telomeric repeat binding factor 2 (hTRF2) is a protein t

112 of either or both of the shelterin proteins telomeric repeat binding factor 2 (TRF2) and protection

113 (SSRP1), a subunit of the FACT complex, and telomeric repeat binding factor 2 (TRF2) formed complexe

114 t cells lacking MRN do not activate ATM when telomeric repeat binding factor 2 (TRF2) is removed from

115 TRF2 (telomeric repeat binding factor 2) is an essential compo

116 c.752-2A>C) and another shelterin component, telomeric repeat binding factor 2, interacting protein (

117 ctional interactions between WRN and TRF2, a telomeric repeat binding factor essential for proper tel

118 In mammalian cells, abrogation of telomeric repeat binding factor TRF2 or DNA-dependent pr

119 xpression of a dominant negative form of the telomeric repeat binding factor, TRF2(DN).

120 eas mammalian cells harbor two double strand telomeric repeat binding factors, TRF1 and TRF2, the fis

121 t this suppression of apoptosis involves the telomeric-repeat binding factor 2 (TRF2).

122 ion of shelterin complex, competing with the telomeric-repeat binding factors TRF1 and TRF2.

123 We demonstrated that NS could interact with telomeric repeat-binding factor 1 (TRF1) and enhance the

124 Here we establish that telomeric repeat-binding factor 1 (TRF1), a core compone

125 Repressor activator protein 1 (RAP1) and telomeric repeat-binding factor 2 (TRF2) are two subunit

126 To examine the role of telomeric repeat-binding factor 2 (TRF2) in epithelial t

127 ditional deletion of the shelterin component telomeric repeat-binding factor 2, cells survived but re

128 SIRT1 but abolished its association with the telomeric repeat-binding factor 2-interacting protein 1.

129 d reduced expression and telomere binding of telomeric repeat-binding factor-2 (TRF2), associated wit

130 plex array of telomeric repeats bound to the telomeric repeat-binding factors TRF1 and TRF2.

131 ammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric repeat-binding

132 g from DNA breaks up to 0.6 kb away from the telomeric repeat but not from a DSB present on a separat

133 contains a template for the synthesis of the telomeric repeats by the telomerase reverse transcriptas

134 Rif1 function is weaker at short telomeric repeats compared with Rif2 function and is par

135 eatment and hybridization with a Cy3-labeled telomeric repeat complementing (CCCTAA)3 peptide nucleic

136 The literature seems to agree that the human telomeric repeat containing four stretches of three guan

137 Telomeric repeat-containing RNA (TERRA) has been identif

138 RPA displacing activity is inhibited by the telomeric repeat-containing RNA (TERRA) in early S phase

139 Telomeric repeat-containing RNA (TERRA) is important for

140 Functions of the telomeric repeat-containing RNA (TERRA), the long noncod

141 monstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA).

142 cised) plus a template sequence encoding the telomeric repeat d(GGT TAG).

143 ith G-quadruplex DNA (G4DNA) formed by human telomeric repeat d[(G(3)T(2)A)(3)G(3)].

144 been reported for Q-quadruplexes formed from telomeric repeats depending on DNA length and ion soluti

145 ng studies that a single deoxythymidine in a telomeric repeat dictates the DNA versus RNA discriminat

146 Pin2 directly bound the human telomeric repeat DNA in vitro, and was localized to all

147 t suppress the accumulation of DNA damage at telomeric repeat DNA.

148 and the structural basis and significance of telomeric-repeat DNA recognition by Teb1, we solved crys

149 elease of all of the subunits, including the telomeric-repeat DNA-binding subunit Teb1.

150 e, including an increase in extrachromosomal telomeric repeat DNAs, putative recombinational byproduc

151 omerase, as well as disperse and amplify sub-telomeric repeat elements.

152 on of several kilobase pairs compared to the telomeric repeat, even though both silencers recruited s

153 stablish a convenient way to make long human telomeric repeats for in vitro study of their folding an

154 cially constructed circles of DNA containing telomeric repeats form long tandem arrays at telomeres w

155 TRF1 and TRF2, which preferentially bind the telomeric repeat found at chromosome ends, effectively b

156 chromosomes separating the relatively stable telomeric repeats from the recombinationaly active regio

157 De novo telomeric repeats from transformants indicate that the p

158 Telomeric repeats >>1000 nt in length could be synthesiz

159 he 5' thymidine tail preceding the Oxytricha telomeric repeat has no apparent effect on the hairpin s

160 adruplex d(TTAGGGT)(4), containing the human telomeric repeat, has been determined in solution in com

161 ng of the DNA quadruplex formed by the human telomeric repeat have been investigated using real-time

162 -stranded nucleic acids, including the human telomeric repeat (hTR) d(TTAGGG)n.

163 ochromatin that silences pericentromeric and telomeric repeats in a cell cycle- and differentiation-i

164 e useful for probing structures of Oxytricha telomeric repeats in complexes with telomere end-binding

165 WRN helicase strand displacement of HJs with telomeric repeats in duplex arms, but unwinding of HJs w

166 DNA telomeric repeats in mammalian cells are transcribed to

167 ining a duplex region at the 5' end and four telomeric repeats in the 3' overhang.

168 ide probe confirmed its effective binding to telomeric repeats in the complex chromatinized genome.

169 non-coding bases immediately internal to the telomeric repeats in the two 5' ends of macronuclear DNA

170 ADP-ribosylation inhibits binding of TRF1 to telomeric repeats in vitro [5], suggesting that tankyras

171 ce in normal human cells, demonstrating that telomeric repeats indeed are hypersensitive to DNA repli

172 ity of telomerase to processively synthesize telomeric repeats, indicating a role for the T motif in

173 ld observe the direct folding of long, human telomeric repeats induced by the small analyte potassium

174 We found that an internal tract of telomeric repeats inhibited DNA damage checkpoint signal

175 lication efficiency of guanine-rich (G-rich) telomeric repeats is decreased significantly in cells la

176 g that exogenous DNA exclusively composed of telomeric repeats is recognized by shelterin components.

177 Instead, a tandem array of 12 telomeric repeats is sufficient to impede illegitimate r

178 DNA repair intermediates when the number of telomeric repeats is too small to completely inhibit DNA

179 Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon

180 The observation of spacer DNAs with telomeric repeats makes it unlikely that differential te

181 The replication of long tracts of telomeric repeats may require specific factors to avoid

182 he human genome, this study has examined the telomeric repeat, necessary for the protection of chromo

183 f the IGH gene is located within 8 kb of the telomeric repeats of 14q.

184 ptase that directs RNA-templated addition of telomeric repeats on to chromosomal termini.

185 Telomerase adds telomeric repeats onto chromosome ends and is almost uni

186 its integral RNA as a template to synthesize telomeric repeats onto chromosome ends.

187 s an RNA subunit to template the addition of telomeric repeats onto chromosome ends.

188 Incorporation of incorrect telomeric repeats onto the ends of chromosomes has been

189 scriptase (RT) and catalyses the addition of telomeric repeats onto the ends of chromosomes using the

190 emplate, acting processively to add multiple telomeric repeats onto the same substrate.

191 ining the capacity to add short stretches of telomeric repeats onto the shortest telomeres, sole expr

192 telomerase reconstitution in vivo and direct telomeric-repeat primer extension activity assays to com

193 affects telomerase activity and synthesis of telomeric repeat products.

194 1B, achieve high affinity and selectivity of telomeric-repeat recognition by principles similar to th

195 ins that retained the ability to localize to telomeric repeats revealed that FEN1's nuclease activity

196 In contrast, the human telomeric repeat sequence and a complex containing two h

197 alian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in turn are bound by TIN2,

198 plex C3 was highly specific for the G-strand telomeric repeat sequence and shares biochemical charact

199 n vivo, de novo synthesis of one strand of a telomeric repeat sequence by telomerase balances the seq

200 The interactions of the Tetrahymena telomeric repeat sequence d(TG4T) and the polyguanylic a

201 The Tetrahymena telomeric repeat sequence d(TG4T) contains only guanine

202 y for both single-stranded RNA and the human telomeric repeat sequence d(TTAGGG)(n).

203 Consistent with their roles at telomeres, telomeric repeat sequence DNA also stimulated binding an

204 d to an oligonucleotide containing the human telomeric repeat sequence folded in the G-quadruplex con

205 the TER sequence, we used the unusually long telomeric repeat sequence of Aspergillus oryzae together

206 elomerase that adds a well-tolerated variant telomeric repeat sequence to telomere ends.

207 plex DNA sequence constructed from the human telomeric repeat sequence TTAGGG.

208 ins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role

209 ics as native cytosine residues in the human telomeric repeat sequence, where it causes little or no

210 without added potassium, in contrast to the telomeric repeat sequence.

211 glycol, replacing the TTA loops in the human telomeric repeat sequence.

212 t, possibly concomitant with a change in the telomeric repeat sequence.

213 NA, and another DHBV integrant occurred in a telomeric repeat sequence.

214 ease results in terminal deletions involving telomeric repeat sequences added directly onto the end o

215 ns revealed one deletion to be stabilized by telomeric repeat sequences and two to have terminal dele

216 Analysis of J and telomeric repeat sequences by J immunoblots and Southern

217 ations were tested for the ability to detect telomeric repeat sequences in FISH assays.

218 scriptase responsible for the maintenance of telomeric repeat sequences in most species that have bee

219 were found that could effectively stain the telomeric repeat sequences of either cytidine- or guanos

220 Telomerase adds telomeric repeat sequences to chromosome ends using a sh

221 A gradual loss of telomeric repeat sequences with aging previously has bee

222 somes at metaphase showed frequent losses of telomeric repeat sequences, enhanced frequencies of chro

223 , reveals approximately 25% of J outside the telomeric repeat sequences.

224 contain short regions of complementarity to telomeric repeat sequences.

225 otein complex that binds specifically to the telomeric-repeat sequences, regulates telomere length, a

226 ures of quadruplexes with two and four human telomeric repeats show an all-parallel-stranded topology

227 and eight additional proteins, including the telomeric repeat single-stranded DNA-binding protein Teb

228 l components: an RNA molecule that templates telomeric repeat synthesis and a catalytic protein compo

229 t eukaryotes, telomere maintenance relies on telomeric repeat synthesis by a reverse transcriptase na

230 other species, the predominant pause during telomeric repeat synthesis by P. tetraurelia telomerase

231 Eukaryotic chromosome maintenance requires telomeric repeat synthesis by telomerase.

232 The template for telomeric repeat synthesis is carried within the RNA com

233 d of the template prior to a second round of telomeric repeat synthesis.

234 P catalytic activity, or loss in fidelity of telomeric repeat synthesis.

235 RNA molecule that provides the template for telomeric repeat synthesis.

236 RNA molecule that provides the template for telomeric repeat synthesis.

237 se of adjacent 5' residues as a template for telomeric repeat synthesis.

238 nent of telomerase provides the template for telomeric repeat synthesis.

239 function to these interactions in processive telomeric repeat synthesis.

240 y short primer-template hybrid necessary for telomeric-repeat synthesis.

241 mechanisms of telomerase specialization for telomeric-repeat synthesis.

242 Duplex DNA containing either human telomeric repeats (T(2)AG(3))(4) or the Tetrahymena telo

243 ic repeats (T(2)AG(3))(4) or the Tetrahymena telomeric repeats (T(2)G(4))(4) are readily photooxidize

244 /PK) which includes the template, for adding telomeric repeats, template boundary element (TBE), and

245 Telomerase replenishes the telomeric repeats that cap eukaryotic chromosome ends.

246 e DNA structures, forked duplexes containing telomeric repeats, that are substrates for the simultane

247 romyces lactis cells containing two types of telomeric repeats, that recombinational telomere elongat

248 To synthesize telomeric repeats, the catalytic subunit telomerase reve

249 of four hairpin moieties, targeting 24 bp in telomeric repeats, the longest reported binding site for

250 ssion of mutant telomerases that add mutated telomeric repeats, thereby compromising shelterin bindin

251 ly, a small minority survives by maintaining telomeric repeats through recombination among telomeres.

252 this terminal sequence loss by synthesizing telomeric repeats through repeated cycles of reverse tra

253 and HHV-6, among other herpesviruses, harbor telomeric repeats (TMRs) identical to host telomeres at

254 MDV, and several other herpesviruses harbors telomeric repeats (TMRs) that are identical to host telo

255 This allows a newly synthesized telomeric repeat to translocate back to the 3' end of th

256 The telomerase is responsible for adding telomeric repeats to chromosomal ends and consists of th

257 omerase is a reverse transcriptase that adds telomeric repeats to chromosomal ends.

258 Telomerase adds telomeric repeats to chromosome 3' ends, forestalling th

259 elomerase, a reverse transcriptase that adds telomeric repeats to chromosome ends [1,2].

260 The addition of telomeric repeats to chromosome ends by the enzyme telom

261 verse transcriptase, telomerase, adds tandem telomeric repeats to chromosome ends to promote genome s

262 Telomerase adds telomeric repeats to chromosome ends using an internal R

263 ase is a ribonucleoprotein complex that adds telomeric repeats to chromosome ends, using a sequence w

264 omerase, the reverse transcriptase that adds telomeric repeats to chromosome ends, was sufficient to

265 The reverse transcriptase telomerase adds telomeric repeats to chromosome ends.

266 mosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks.

267 lterin components, which allows CLRC to skip telomeric repeats to internal regions.

268 f telomerase, a specialized enzyme that adds telomeric repeats to pre-existing telomeres.

269 istinct activities of telomerase, which adds telomeric repeats to solve the end replication problem,

270 anscriptase, which catalyzes the addition of telomeric repeats to the 3' ends of linear chromosomes u

271 Telomerase activity, the ability to add telomeric repeats to the ends of chromosomes, has been d

272 The ribonucleoprotein enzyme telomerase adds telomeric repeats to the ends of linear chromosomes.

273 fully annotate the region extending from the telomeric repeats to the previously published tuberous s

274 ddition of only a few functionally wild-type telomeric repeats to their ends, after which the frequen

275 ties of two different silencers, HMR-E and a telomeric repeat, to promote silencing and found that th

276 t telomeres serves to maintain the length of telomeric repeats, to suppress recombination, and to aid

277 s a strong sequence preference for the human telomeric repeat tract and predict that POT1 can bind bo

278 begins approximately 100 bp upstream of the telomeric repeat tract sequence.

279 on results in replication stalling in duplex telomeric repeat tracts and the subsequent formation of

280 Stabilization of telomeric repeat tracts may also be achieved through a t

281 ls demonstrated that the outer halves of the telomeric repeat tracts turn over within a few hundred c

282 of telomeric RNA molecules containing G-rich telomeric repeats transcribed from the subtelomere to th

283 r fluorescent polyamide probes for the human telomeric repeat TTAGGG, and we examined the binding aff

284 s are bound to a significant fraction of the telomeric repeat (TTAGGG) (n).

285 ion directly affect the length of individual telomeric repeat units.

286 Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase rev

287 T-stumps contained arrangements of telomeric repeat variants and a minimal run of seven can

288 bind telomeric DNA directly but localizes to telomeric repeats via its interaction with TRF1.

289 Hybridization to a probe extended from telomeric repeats was used to anchor the ends of the map

290 a BclI restriction site in newly synthesized telomeric repeats, was indistinguishable from wild type

291 xpected from the presence of canonical TTAGG telomeric repeats, we identified a candidate telomerase

292 all genes telomeric to HIS1 were deleted and telomeric repeats were added to a 9 nt sequence within t

293 These telomeric repeats were incorporated into duplex/quadrupl

294 Nine complexes of UP1 bound to modified telomeric repeats were investigated using equilibrium fl

295 less TOTA photocleavage of these quadruplex telomeric repeats when compared to the duplex repeats.

296 They have 1-2 kb of TTAGGG telomeric repeats, which are preceded by a subtelomeric

297 Replacing the TTA loops of the human telomeric repeat with AAA causes a large decrease in qua

298 Human telomeres contain duplex telomeric repeats with 3' single-stranded G-overhangs, a

299 ere predicted to lead to synthesis of mutant telomeric repeats with disrupted binding of the telomeri

300 t chromosome ends through the interaction of telomeric repeats with shelterin, a protein complex that