ライフサイエンスコーパス: telomeric sequence

1 1 419 bp (plus about 2000 bp of undetermined telomeric sequences).

2 e-stranded DNA as well as internal tracts of telomeric sequence.

3 nteractions and DNA repair within the GGTTAC telomeric sequence.

4 les stabilize the G4DNA derived from a human telomeric sequence.

5 brid G-quadruplex structures formed by human telomeric sequence.

6 fic manner, and discriminates against RNA of telomeric sequence.

7 er extent than the quadruplex DNA of a human telomeric sequence.

8 the interface between the duplex and the 3' telomeric sequence.

9 n]pyrrole, the more strongly it binds to the telomeric sequence.

10 ely without polymerase-mediated extension of telomeric sequence.

11 specificity to the hairpin form of the viral telomeric sequence.

12 Sessea (family Solanaceae) lack known plant telomeric sequences.

13 elomerase templating region in vivo with non-telomeric sequences.

14 a variety of DNA structures without or with telomeric sequences.

15 forms of several oligonucleotides containing telomeric sequences.

16 ity of telomerase to elongate completely non-telomeric sequences.

17 e non-replicative DNA rings containing yeast telomeric sequences.

18 of labile mRNAs, 5'- and 3'-splice sites and telomeric sequences.

19 d DNA damage foci and loss or duplication of telomeric sequences.

20 r Y. lipolytica telomeres but also for human telomeric sequences.

21 lytica (GGGTTAGTCA)(n) and human (TTAGGG)(n) telomeric sequences.

22 ion nor in vitro DNA replication through non-telomeric sequences.

23 rity of known naturally occurring eukaryotic telomeric sequences.

24 bility by repressing recombination involving telomeric sequences.

25 enome against recombination events involving telomeric sequences.

26 tion fork progression through the repetitive telomeric sequences.

27 ation events between different DNAs at their telomeric sequences.

28 a cells that lack telomerase or have altered telomeric sequences.

29 s), ultimately leading to stochastic loss of telomeric sequences.

30 recombination events and accelerated loss of telomeric sequences.

31 exchanges between often imperfectly matched telomeric sequences.

32 ramolecular G-quadruplex formed by the human telomeric sequence 5'-(GGTTAG)(5)-3', and that inhibits

33 quence was removed on addition of Sch. pombe telomeric sequence, a process similar to that described

34 genomic stability in addition to maintaining telomeric sequences above a critical length.

35 In both structures, the telomeric sequence adopts an intramolecular quadruplex s

36 uplex formed by the 22-mer four-repeat human telomeric sequence AG3(TTAG3)3 and (ii) the intermolecul

37 ic effect on its affinity toward the cognate telomeric sequence, alleviating the need for homodimeriz

38 How these proteins find telomeric sequences among a genome of billions of base p

39 s that result in an increase in HR between a telomeric sequence and a more internal sequence, which n

40 uctures, including those formed in the human telomeric sequence and in the promoter regions of bcl-2

41 ormation with effective packing in the human telomeric sequence and provide important implications fo

42 replication fork pause was specific to yeast telomeric sequence and was independent of the Sir and Ri

43 MECs emerge from senescence, exhibit eroding telomeric sequences and ultimately enter telomere-based

44 mpassing long tracts of alpha satellite DNA, telomeric sequences, and the human hypoxanthine phosphor

45 rom degradation in a CDC13-dependent manner, telomeric sequences are added efficiently, and addition

46 major conformations in K(+) solution, human telomeric sequences are always in equilibrium between Hy

47 have implications for current models of how telomeric sequences are lost in normal somatic cells and

48 Repetitive telomeric sequences are maintained by telomerase, a ribo

49 Short, repetitive, G-rich telomeric sequences are synthesized by telomerase, a rib

50 x known as shelterin prevents recognition of telomeric sequences as sites of DNA damage.

51 uadruplex structures formed within the human telomeric sequence, as well as the effects of sequence a

52 ric DNA primers that carried one repeat of a telomeric sequence at various positions upstream of a no

53 overhangs, blunt ends or 3' termini with non-telomeric sequences at the junction are deficient in loo

54 ded DNA (ssDNA) containing the Chlamydomonas telomeric sequence but not the RNA containing the cognat

55 enzymes, efficiently extended completely non-telomeric sequences by positioning the 3' terminus at a

56 We show that a three-repeat human telomeric sequence can also associate with a single-repe

57 Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomeras

58 ll dividing cells are subject to the loss of telomeric sequences, cells with long proliferative lifes

59 ential lies in overcoming the steady loss of telomeric sequence commonly referred to as the 'end-repl

60 exhibited a strong preference for Tg in the telomeric sequence context.

61 d enhanced glycosylase activity on Gh in the telomeric sequence context.

62 ic G-quadruplex formed by the Oxytricha nova telomeric sequence d(G(4)T(4)G(4)) with a peptide nuclei

63 demonstrate by NMR that the two-repeat human telomeric sequence d(TAGGGTTAGGGT) can form both paralle

64 mplate consisting of 10 repeats of the human telomeric sequence d(TTAGGG) and deoxy- and ribonucleosi

65 The human telomeric sequence d[T(2)AG(3)](4) has been demonstrated

66 in particular, that produced from the human telomeric sequence d[T(2)AG(3)](4).

67 of a misfolded G-quadruplex in a particular telomeric sequence decreases with an increase in the loo

68 didates, we have targeted a 24-nt G4-forming telomeric sequence employing a receptor-based virtual sc

69 short region of the immediately adjacent non-telomeric sequence, exist in two distinct types of chrom

70 al changes are also observed with the duplex telomeric sequence from the Oxytricha species.

71 mobilization; mutant Rap1p binding sites and telomeric sequences from other organisms were not suffic

72 art because the perfect repetitive nature of telomeric sequence hampers in situ detection of telomere

73 ilization of DNA G-quadruplexes in the human telomeric sequence have been shown to inhibit the activi

74 Telomeric sequences have been translocated to the centro

75 The guanine-rich telomeric sequences have the ability to form G-quadruple

76 his suggests that as hTRF2 recruits hRap1 to telomeric sequences, hRap1 alters the affinity of hTRF2

77 ring was diminished by addition of competing telomeric sequences, implicating a role for an as yet un

78 adruplex structure formed by a variant human telomeric sequence in K(+) solution.

79 uplex formed in a native, non-modified human telomeric sequence in K(+) solution.

80 we report the folding structure of the human telomeric sequence in K+ solution determined by NMR.

81 rate constant was 2-fold lower for the same telomeric sequence in the duplex form ((3.0 +/- 1.3) x 1

82 stimulation is dependent on the presence of telomeric sequence in the duplex regions of the substrat

83 d serve to hold the genomic subtelomeric and telomeric sequences in a partially single-stranded confi

84 g that t-loops can also form at interstitial telomeric sequences in a TRF2-dependent manner, forming

85 een confounded by the underrepresentation of telomeric sequences in standard libraries.

86 erase adds telomeric repeats directly to non-telomeric sequences in Tetrahymena, forming de novo telo

87 retention of G.G pairing is specific to the telomeric sequence incorporating the 5' leading sequence

88 when it was adjacent to an internal tract of telomeric sequence, indicating that Cdc13p binding was t

89 nvolved in mismatch repair (MMR), suppresses telomeric sequence insertion (TSI) at intra-chromosomal

90 an also associate with a single-repeat human telomeric sequence into a structure with the same topolo

91 An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strong

92 ecombination hotspot created by insertion of telomeric sequences into the region upstream of HIS4.

93 Telomeric sequences investigated include the Oxytricha 3

94 ng of HJs with a telomeric center or lacking telomeric sequence is unaffected.

95 hRap1 are in a complex, its affinity for ds telomeric sequences is 2-fold higher than TRF2 alone and

96 rate that TRF2 association with interstitial telomeric sequences is stabilized by co-localization wit

97 cated reverse transcriptase that synthesizes telomeric sequences, is strongly associated with cancer,

98 telomere becomes dysfunctional, the terminal telomeric sequence itself determines the fate of that te

99 Interstitial telomeric sequences (ITSs) are present in many eukaryoti

100 Aberrant formation of interstitial telomeric sequences (ITSs) promotes genome instabilities

101 ide, which base-pairs near the 5' end of the telomeric sequence, leaving a telomerase-extendable 3' t

102 ic chromosomes that may arise as a result of telomeric sequence loss.

103 Hence, telomeric sequences may have evolved to facilitate their

104 inum drug cisplatin, which targets the human telomeric sequence nonspecifically, the platinum-interca

105 of conventional DNA synthesis, a net loss of telomeric sequences occurs at each cell division.

106 me integrity through synthesis of repetitive telomeric sequences on the ends of eukaryotic chromosome

107 e budding yeast Cdc13p binds single-stranded telomeric sequences, prevents lethal degradation of chro

108 G-rich telomeric sequences readily form structures stabilized b

109 The telomeric sequence repeats at the ends of eukaryotic chr

110 yme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends.

111 yme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends.

112 rase is a ribonucleoprotein enzyme that adds telomeric sequence repeats to the ends of linear chromos

113 ized DNA and plasmids containing Histoplasma telomeric sequences showed the greatest transformation e

114 The telomeric sequence shows intrinsic structure polymorphis

115 erin, fission yeast shelterin is composed of telomeric sequence-specific double- and single-stranded

116 ted reduced activity on a more physiological telomeric-sequence substrate.

117 Longer telomeric sequences, such as TTAGGGTT, TTAGGGTTA, and TA

118 Sgs1p efficiently unwinds G-G paired telomeric sequences, suggesting that one function of Sgs

119 single-stranded representative of the yeast telomeric sequence [Tel11, d(GTGTGGGTGTG)] with a 3 pM a

120 dominant conformation for the extended 26 nt telomeric sequence Tel26 in the presence of K+, regardle

121 cancer cells causes incorporation of mutant telomeric sequences, telomere uncapping, and initiation

122 While all mutant telomeric sequences tested induced heterodicentric chrom

123 The pause at telomeric sequence TG(1-3) repeats was stronger at the t

124 h unprecedented transition dynamics in human telomeric sequences that contain four to eight TTAGGG re

125 tory sequences show striking similarities to telomeric sequences that form diverse G-quartet structur

126 te folds back and hybridizes with downstream telomeric sequence to form a t loop that is stable in th

127 Telomerase adds a hexonucleotide telomeric sequence to the chromosomal ends during replic

128 Addition of non-telomeric sequences to the distal portion of a 3' overha

129 cer cells to evade cell senescence by adding telomeric sequences to the ends of chromosomes.

130 r containing two tandem repeats of the human telomeric sequence (TTAGGG) into di- and tetrameric G-qu

131 in the GGG triplet found in the G-rich human telomeric sequence (TTAGGG), making telomeres highly sus

132 nce for the presence of the Arabidopsis-type telomeric sequence (TTTAGGG)n at the chromosome termini

133 mposed of a heterogeneous mixture of GT-rich telomeric sequence, unlike in higher eukaryotes which ha

134 of a peptide nucleic acid probe specific for telomeric sequence was evaluated.

135 Much of the human telomeric sequence was removed on addition of Sch. pombe

136 Direct repeats of Arabidopsis telomeric sequence were constructed to test telomere-med

137 trast, chromosomal end fusions that retained telomeric sequence were observed in nontransformed DNA-P

138 Two constructs with 2.6 kb of telomeric sequence were used to transform maize immature

139 A fragments composed solely of mitochondrial telomeric sequences were detected and their properties w

140 The loss of telomeric sequences with each cell division eventually i

141 mportantly, WRN's specificity for the G-rich telomeric sequence within this precise structural contex

142 s improved 500-fold by the addition of yeast telomeric sequences within the T-DNA sequence.

143 ly be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, ou

144 ng and both factors bind along their cognate telomeric sequences without showing strong cooperative i