ライフサイエンスコーパス: temper

1 hings', 'I'm a good friend', 'I have a quick temper').

2 ing diseases in which mTOR activity is to be tempered.

3 ther sampling techniques, including parallel tempering.

4 er failure during liver regeneration through tempering a strong innate inflammatory response mediated

5 oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who t

6 suggest that VHR is a target for ZAP-70 and tempers activation of the Erk2 pathway in a ZAP-70-contr

7 Chronic inhibition of this protease may temper amyloid production and cure or prevent AD.

8 A new approach for non-isothermal tempering analysis utilizing dilatometry is proposed and

9 showing that specific criteria for explosive temper and mood lability identify disruptive youth who i

10 ex is an efficacious treatment for explosive temper and mood lability in disruptive children and adol

11 der) met the specific criteria for explosive temper and mood lability.

12 ation of the field of transplantation can be tempered and controlled.

13 l reports of donor deaths, interest has been tempered and more diligent evaluation of the ethics and

14 pace is sampled by a combination of parallel tempering and equi-energy Monte Carlo, we find that the

15 ilk allergens was differentially affected by tempering and extractant.

16 was sampled by replica exchange with solute tempering, and the free energy landscape was explored by

17 ular interactions within epithelial clusters temper anisotropic cell-substratum forces, resulting in

18 onment of hepatocellular carcinoma (HCC) and temper anticancer immune responses.

19 Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during ba

20 ers were generated using a Bayesian parallel tempering approach to produce model fits that could recr

21 growth condition were transient and largely tempered as B31 adapted to the mammalian host, suggestin

22 the formation of transition carbides by auto-tempering as well as the presence of retained austenite

23 and compared with experimental melting point temper-atures to explain the structural basis to improve

24 wever, several regulatory T cell subsets can temper autoaggressive T cells, although it remains undet

25 Dietary cyclocreatine tempered autophagy, restored microglial clustering aroun

26 Cryab plays a critical role in tempering AxD pathology and should be investigated as a

27 Npas4 tempers beta-cell function through a direct inhibitory i

28 To this end, we have used well-tempered bias exchange metadynamics simulations to deter

29 cal for full anabolism in cortical bone, but tempers bone gain in cancellous bone.

30 atment of respiratory and cardiac failure is tempered by a need for evidence to support many current

31 This disappointment is tempered by a potentially important observation suggesti

32 r particular lesions of the neuraxis must be tempered by a working knowledge of false and nonlocalizi

33 its impact on treatment resistance could be tempered by altering the dosing schedule of systemic che

34 Nevertheless, this finding is tempered by an inability to prolong survival, a limitati

35 in ApoE(-/-) mice, anti-col(V) immunity was tempered by an interleukin (IL)-10-dependent mechanism.

36 inhibit hepatitis C virus replication can be tempered by baseline mutations that confer resistance.

37 s and feelings; however, such effects can be tempered by broader social network resources.

38 ension) and anatomical considerations and be tempered by careful assessment of surgical risk.

39 Editing was tempered by coexpression of HLA-DO, suggesting that DM:D

40 , the extent of complement activation may be tempered by complement inhibiting regulatory proteins th

41 however, efforts to increase production are tempered by concern over induced earthquakes.

42 e use of stents in smaller patients has been tempered by concerns about the potential for stent expan

43 nthusiasm for their use in patients has been tempered by concerns of a possible profibrotic role of e

44 However, enthusiasm for this approach is tempered by concerns that the therapeutic synergy of a c

45 Nevertheless, early enthusiasm was tempered by controlled studies showing that antibiotics

46 Because LC activation is tempered by endogenous opioid release during stress, the

47 r disorders, and vascular lesion severity is tempered by enhanced endothelial repair.

48 ishment for advancing public health has been tempered by ethical concerns about the protection of hum

49 iPSCs) in cell replacement therapy have been tempered by evidence that undifferentiated, syngeneic mo

50 ews media and on the Internet, with optimism tempered by evidence to support the ethical translation

51 ogical impact of these observations might be tempered by extensive recombination of co-ingested strai

52 the authors' confidence in these results is tempered by factors related to study design that may hav

53 vation, advanced by thrombin generation, and tempered by fibrinolysis.

54 also reveal that immature GC excitability is tempered by functional synaptic inhibition and reduced e

55 stic criteria, although this effect could be tempered by future adaptation of diagnostic practices an

56 on stimulated by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mech

57 e human disease, the knockdown phenotype was tempered by genetic-modifier loci.

58 aroscopic adjustable banding (LAGB) has been tempered by high reoperation rates.

59 favorable route of Cr(VI) formation which is tempered by humic matter.

60 e reactivity of the key radical precursor is tempered by hybridization effects.

61 primarily due to water temperature increases tempered by increased nutrient levels resulting from cha

62 that the face validity of the system may be tempered by insufficient specificity in the indexing ter

63 the diagnosis of extracapsular extension is tempered by its low sensitivity.

64 spread use of adjuvant IFN alpha-2b has been tempered by its significant toxicity.

65 sm for vanguard biologic therapies should be tempered by judicious monitoring for adverse events.

66 However, this possibility is tempered by limitations in interpreting the functional c

67 locus analysis, and the results were further tempered by multiple test effects.

68 Success has been tempered by new challenges.

69 benefit for the organ transplant recipient, tempered by patient informed awareness of limited organ

70 lthough its predictive value is likely to be tempered by phylogenetic distance and genome duplication

71 n (LMWH) in anti-angiogenic therapy has been tempered by poor in vivo delivery to the tumor cell and

72 Activation of the Lmd protein is also tempered by posttranslational modifications of the prote

73 Although tempered by power considerations, there is no evidence i

74 n) and APOBEC3G (retrovirus restriction) are tempered by probable contributions to carcinogenesis.

75 regenerative medicine in the heart has been tempered by realizations that reparative processes in th

76 initial enthusiasm for these agents has been tempered by recognition that JAK2 V617F may represent on

77 inotropic agents for heart failure has been tempered by reports of impaired relaxation.

78 otentiating influence of the Girk1 P-loop is tempered by residue F162 in the second membrane-spanning

79 However, this is tempered by results from several recent studies that sho

80 ion and exercise capacity but its benefit is tempered by significant morbidity.

81 omise of high rates of hematologic responses tempered by studies showing the inability to overcome po

82 are tempered by study heterogeneity and methodologic limitat

83 Although these findings are tempered by the absence of information concerning the ty

84 oncogenic activity of the mutant receptor is tempered by the activation of premature cellular senesce

85 quisition and how these negative effects are tempered by the AM colonization.

86 ased importance of capturing those elements, tempered by the challenges to collect them.

87 utic potential of endogenous neurogenesis is tempered by the demonstration that traumatic brain injur

88 haematopoietic stem-cell transplantation are tempered by the depletion of T-cells accompanying this p

89 This interest is tempered by the discovery of SMO mutations mediating res

90 y period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resi

91 ncer with small molecule inhibitors has been tempered by the emergence of drug-resistant kinase domai

92 of the strength of that relationship must be tempered by the fact that some of the converting patient

93 This enthusiasm should be tempered by the fact that the probability for life to or

94 The new genetics must be tempered by the findings that many epigenetic phenomena

95 ral complication rates, long-term outcome is tempered by the frequent need for repeat revascularizati

96 Early optimism, however, was soon tempered by the hard realities of these new materials: b

97 appropriateness of the patients admitted are tempered by the high cost of providing this service.

98 ced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond S

99 compromising physicochemical properties was tempered by the judicial use of ligand efficiency indice

100 SUD treatment via Medicaid expansion may be tempered by the local availability of facilities to prov

101 effects of tracheal gas insufflation may be tempered by the long-term effects of altering distal air

102 pretation of the BACH Survey results must be tempered by the low enrollment rate (less than 25% of el

103 However, this conclusion is tempered by the nonadherence rate.

104 This enthusiasm has been tempered by the observations that the transition from da

105 Preliminary evidence of efficacy is tempered by the open-label uncontrolled design of the st

106 This extraordinary achievement is tempered by the persistence of cognitive delays and cere

107 which this hypothesis can be held has to be tempered by the poor reproducibility between studies in

108 But the convenience of using xenografts is tempered by the possibility of disease transmission from

109 However, these inferences must be tempered by the potential for epistatic interactions bet

110 e, the benefit of carotid stenting should be tempered by the potential for increased perioperative ev

111 That optimism has been tempered by the potential risks of these therapies, such

112 l Endoscopic Surgery (NOTES) has been partly tempered by the reality that a NOTES procedure without l

113 Enthusiasm for tolerance induction has been tempered by the realization that it is more difficult to

114 the benefit of prospective clinical trials, tempered by the recognition of all of the possible medic

115 itial therapy, even for advanced disease, is tempered by the recognition of some important limitation

116 , and very-late-onset subtypes now should be tempered by the recognition that comorbid medical and ne

117 This realization is tempered by the relatively mild SMA phenotype in our mod

118 This is tempered by the reports of younger patients developing h

119 ne-reactivation strategies, however, will be tempered by the stability that epsilon-globin mRNA exhib

120 randomized phase-I clinical trials, was then tempered by the subsequent disappointing results of rand

121 expression is abated in a wak2-null, but is tempered by the WAK-dominant allele that induces elevate

122 ition in treating neurological conditions is tempered by their toxicity toward a host of CNS cell typ

123 Although tempered by transmission risk factors, such as donor vir

124 the enthusiasm for these therapies has been tempered by tumor resistance and the paucity of informat

125 ess of orthopedic implants has been recently tempered by unexpected pathologies and early failures of

126 Unfortunately, this success has been tempered by unintended and often devastating cardiac com

127 study were: (1) to determine whether thermal tempering by air blasting reduces the length of cracks i

128 nergy surface that we obtain from a parallel tempering calculation.

129 n the eye to promote inflammation while also tempering cell responses to PGN akin to what has been re

130 iR-146a regulates cholesterol metabolism and tempers chronic inflammatory responses to atherogenic di

131 ckling in" a swarm of individual small tasks tempers competition for CPU time in the shared HPC envir

132 surgeon opinion and patient attitudes should temper concerns about the quality of treatment for women

133 ssor of cytokine signaling 3, a protein that tempers cytokine receptor signaling, they also suggest t

134 by which adaptive immunity, once triggered, tempers DC activation and prevents overreactive immune r

135 Tempering decreased antibody binding regardless of extra

136 hanced sampling approaches, such as Parallel Tempering, do not improve the situation, as the entropic

137 us, as with FGF and EGF receptors, Spry2-GFP tempers downstream Met signaling in addition to its pron

138 The tempered dynamics contrast sharply with the dynamics of

139 he peptide conformational space by simulated tempering dynamics with the simplified, knowledge-based

140 genous LO-generated effectors that assist in tempering EAE.

141 (BTLA) coinhibitory signaling is required to temper early inflammation.

142 othesized that such feedback can potentially temper effects of delayed relaxation and/or volume loadi

143 e first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent infl

144 ferent approaches: a combination of the well-tempered ensemble (WTE) and parallel tempering (PT) sche

145 that publication of this viewpoint will help temper enthusiasm for overzealous conversion of guidelin

146 es due to the infused cells themselves, have tempered enthusiasm.

147 It localizes to acidic organelles, tempers evoked Ca(2+) signals, and regulates cell-matrix

148 AAT2 modulates cardiorespiratory control and tempers excitatory cardiorespiratory responses to activa

149 gy perturbation with replica exchange solute tempering (FEP/REST).

150 after gastrulation in the forelimb field to temper Fgf8a signaling in the cardiac field, thus coordi

151 ied: 1) aggressive phenomena (e.g., kicking, temper fits, argumentativeness), 2) purely motor and pho

152 sis requires intrinsic sensing mechanisms to temper function in the face of prolonged activity.

153 n contrast, lower affinity interactions show tempered GCs, producing B(mem) and affinity-matured, lon

154 sin plastic, heat-tempered glass, chemically tempered glass, and polycarbonate, all with 3.0-mm cente

155 sin plastic, heat tempered glass, chemically tempered glass, and polycarbonate, and with center thick

156 igh-index plastic, allyl resin plastic, heat tempered glass, chemically tempered glass, and polycarbo

157 al safety eyewear (allyl resin plastic, heat-tempered glass, chemically tempered glass, and polycarbo

158 monstrated to have a significant capacity to temper glycolytic acidification in vitro in the presence

159 Oral supplementation with Gln was shown to temper H. suis induced gastritis and epithelial (hyper)p

160 of FLD, we show that synthetic YLGA peptide tempers hepatocyte apoptosis and liver damage and theref

161 e has cast doubt on both these associations, tempering hopes of the feasibility of developing a vacci

162 otential neuroprotective therapeutic must be tempered, however, by the knowledge it also enlarges cir

163 ntitled "SSRIs, Adolescents, and Aggression: Tempering Human Implications Regarding SSRI-Induced Aggr

164 This reliance is tempered if adaptation is polygenic-does not depend on o

165 (CD25) on virus-specific CD4 T cells, which tempered IL-2 signaling and STAT5 and mammalian target o

166 critical function for Mvarphi HIF-1alpha in tempering IL-10 production following infection.

167 rucial role in tumor immune pathogenesis and temper immune therapeutic efficacy.

168 lular metabolism can beneficially enhance or temper immunity.

169 Immune responses are tempered in immunologically privileged sites including t

170 that sheds light on how its self-cleavage is tempered in the absence of RecA, as well as a framework

171 owth and how its predatory activities may be tempered in the wild, as well as suggestions for future

172 immunity is controlled by cDCs and actively tempered in vivo by migDCs.

173 on (AMI), enthusiasm for glucose lowering is tempered, in part, by concerns of inducing hypoglycemia.

174 culations by use of the model confirmed that tempering induces large residual compressive stresses in

175 eterogeneity and imprecision of some results temper inferences from this literature.

176 phagy accompanies inflammasome activation to temper inflammation by eliminating active inflammasomes.

177 T (Treg) cells inhibit immune responses and temper inflammation.

178 e data expand the roles of T-regs to include tempering inflammation during acute infection in additio

179 ting that C5a may play a significant role in tempering inflammation in Th2-driven diseases such as as

180 own pathway that allows the immune system to temper inflammatory responses.

181 potential limitations of disclosure somewhat tempered interest.

182 e-dependent increases in adverse events have tempered its utility.

183 their ability to preserve phosphatases that temper kinase signaling and proinflammatory cytokine pro

184 protein 3B [ARID3B]) that we show is able to temper lytic reactivation.

185 atalase restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2+) signaling and li

186 eted immune modulation should be possible to temper maladaptive factors, enabling beneficial immune r

187 s Coarse-Grained molecular dynamics and well-tempered MetaDynamics (CG-MetaD), we characterize the la

188 onal metadynamics, and multiple-walkers well-tempered metadynamics calculations.

189 Simulations were performed using well-tempered metadynamics combined with a path collective va

190 re are explored using microsecond-scale well-tempered metadynamics simulations.

191 ere we use atomistic level modeling and well-tempered metadynamics to calculate the configurational f

192 uated with advanced simulation methods (well-tempered metadynamics) allowing a microscopic understand

193 Taking advantage of well-tempered metadynamics, we compute the free-energy change

194 iltonian replica exchange combined with well-tempered metadynamics.

195 dynamics simulations together with parallel tempering, metadynamics, and one of the best force-field

196 we adapted the replica exchange with solute tempering method to sample the conformations of the beta

197 Using a single-trajectory-based tempering method with a high-temperature dihedral bias,

198 An innovative replica exchange (parallel tempering) method called replica exchange with solute te

199 We introduce a replica exchange (parallel tempering) method in which attempted configuration swaps

200 s, Gal1-glycan interactions are essential in tempering microglial activation, brain inflammation, and

201 We use parallel tempering molecular dynamics simulations on the microsec

202 We have performed simulated tempering molecular dynamics simulations to study the th

203 ced phase-space sampling algorithm, parallel-tempering molecular dynamics, we have explored the energ

204 A parallel tempering Monte Carlo algorithm with tempering over the

205 rly role in reducing CR cell neurogenesis by tempering Neurog2's proneural activity.

206 ow that the Serrate antagonist, fringe, must temper Notch activity to insure that the activation of t

207 ployed jagged-2 triggered Notch2/Hey1, while tempering Notch2/Hes1 signaling in HSPCs.

208 ate our planet's intermediate redox state by tempering O(2) production.

209 Slow cooling of such a melt or tempering of hP-Na2ZnSn5 (e.g., at 300 degrees C) leads

210 tingly, this occurs in resting MPhis through tempering of steady-state mitochondrial reactive oxygen

211 The findings offer cause for tempered optimism about the accuracy of strategic intell

212 results suggest that students' mindsets may temper or exacerbate the effects of economic disadvantag

213 The method, called catalytic tempering or CAT, is found to greatly improve the rate o

214 wide problem of antibiotic resistance should temper our approach.

215 which may be associated with the display of temper outbursts and repetitive questioning.

216 chronic nonepisodic irritability and severe temper outbursts.

217 arallel tempering Monte Carlo algorithm with tempering over the temperature domain is used to examine

218 nes, as a key circuit element that tunes and tempers P1 neuron activity.

219 as a treatment option has been appropriately tempered, particularly as the therapy is introduced beyo

220 development, survival, or homeostasis, while tempering peripheral NK cell activation.

221 Strategies that temper postprandial reductions in glucose levels might r

222 stem growth rate represent a mechanism that tempers progression of early commitment to the light env

223 In vascular smooth muscles, HDL tempers proinflammatory, promigratory, and degradative p

224 he well-tempered ensemble (WTE) and parallel tempering (PT) schemes and metadynamics (MetaD) to chara

225 s the use of activity-based probes that show tempered rates of reactivity with enzymes, such that com

226 ression is mediated by poverty and that heat tempers rather than fuels poverty-induced aggression.

227 To temper recombination, cells have employed DNA helicases

228 may deplete vesicle availability and thereby temper release strengthening.

229 ) method called replica exchange with solute tempering (REST) for the efficient sampling of aqueous p

230 dual compressive stresses induced by thermal tempering retarded the growth of surface cracks in bilay

231 used to investigate the polymorphic forms of tempered SHSs and CBEs in the long term.

232 s well as the observed growth inhibition, is tempered significantly by coexpression of the CfPV2 E6 a

233 Our computational studies exploit parallel tempering simulations of coarse-grained model proteins t

234 pluralism in both its homeland and colonies tempers some of archaeology's global assumptions about t

235 at controlling the chronic phase disease is tempered somewhat by the persistence of the LSC pool in

236 indicated that the mean crack lengths of air-tempered specimens were significantly smaller (p < or =

237 ults in the alleviation of heme toxicity and tempered staphylococcal virulence.

238 e as glass in as-quenched or low-temperature-tempered state.

239 had significantly more behavioral problems, temper tantrums, and learning, health, and sleep problem

240 haviors, teasing, silent bluff displays, and temper tantrums, and negatively with observational ratin

241 theta and thereby targeted to lipid rafts to temper TCR signaling.

242 Such genetic changes would temper the alkali sensitivity and Na(+) sensitivity that

243 sence of mitotic inhibitors normally used to temper the astrocyte population.

244 ide new molecular evidence that estrogen may temper the biological effects of hormones acting through

245 or 19 bp 5' to the transcription start site temper the effect of DNA supercoiling based on novobioci

246 properly folded proteins are secreted and to temper the effects of cellular stress, the ER can target

247 he release of glucocorticoids that, in turn, temper the ensuing immune/inflammatory response, and the

248 that one function of MeCP2 in neurons is to temper the expression of the longest genes in the genome

249 osis-competent VZV glycoprotein, was able to temper the fusogenicity of the gH endocytosis mutants by

250 n-induced D-type cyclin production serves to temper the mitogenic response to androgen.

251 reversibility of the intermediate steps, and temper the nature of the driving force of the reaction.

252 t the analog 7-aza-Trp, which is expected to temper the nucleophilicity of C2 in Trp, is a very poor

253 endogenous functions of immune AT1 receptors temper the pathogenic actions of renal and vascular AT1

254 cess in using bidentate phosphine ligands to temper the reactivities of in situ-generated gold carben

255 of a large number of protecting groups that temper the reactivity of nitrogen; however, the use of p

256 DA neurons by SNr GABAergic neurons and also temper the release of glutamate in the dorsal striatum.

257 nd, differently to animal cells, it does not temper the ribonuclease activity of inositol-requiring e

258 late ligand bioavailability and consequently temper the signaling of canonical G protein-coupled rece

259 t declining C, called dematerialization, can temper the sustainability challenge of growth (P x A), a

260 These biases should temper the use of plots for extrapolations of forest dyn

261 aden, our understanding of complications has tempered the initial excitement.

262 Previous research has tempered the notion that sleepers are isolated from thei

263 Moreover, VLDLR deficiency tempered the synergistic inflammatory interactions betwe

264 decreases the action of the cag PAI T4SS via tempering the bacterium's interaction with alpha5beta1 i

265 n that is essential for efficient catalysis, tempering the consequence of the removal of any single i

266 More broadly, a case can be made for tempering the empirical enthusiasm here with a little mo

267 Tempering the enthusiasm for their use, however-particul

268 suggest that TLR2 plays an important role in tempering the host response to pneumonic tularemia.

269 of the sympathetic fight-or-flight response, tempering the rise in [Na](i) and cellular Ca loading an

270 in both cancerous and normal cells, however, tempers the broad spectrum of activity of currently used

271 suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to acti

272 tors by repressing the Ink4A-Ink4B locus and tempers the developmental rate of differentiation by pre

273 ork shows that transfection of GCS antisense tempers the expression of native GCS and restores cell s

274 ndamental mechanism by which the hippocampus tempers the forgetting of older memories as newer memori

275 uncovered an immune-regulatory pathway that tempers the intensity of the host response to influenza

276 eurons, mediated by GIRK channel activation, tempers the locomotor stimulatory effect of cocaine whil

277 uced miR-21, by silencing PTEN and GSK3beta, tempers the LPS-induced inflammatory response.

278 Myc, leading to the notion that organization tempers the sensitivity of individual cells to Myc activ

279 tting of primary immunodeficiencies but also temper their dysregulation in conditions of antibody-med

280 l responses to K(+) deprivation that seem to temper these negative effects.

281 e of scientists ( approximately 7,085), thus tempering these differences in propagule load.

282 a negative role of the morphogen TGF-beta in tempering these signals under physiological conditions,

283 Vertebrates temper this effect by catabolizing ATP to adenosine - a

284 lammatory cytokines and that the S-layer may temper this response to facilitate the survival of C. re

285 level of autophagy for survival, caspase-10 tempers this response to avoid cell death.

286 the strength of insulin-generated signals is tempered through interactions with the IGF-1R.

287 uited to the mucosa, where responses must be tempered to prevent excessive inflammation.

288 echniques, such as metadynamics and parallel tempering, to characterize the oligomerization landscape

289 gy perturbation/replica exchange with solute tempering, to two modifications of protein-ligand comple

290 This tempers triglyceride availabiity for very low density li

291 e American Thyroid Association guidelines of tempering TSH suppression in patients with low risk of c

292 Improving tumor perfusion, thus tempering tumor-associated hypoxia, is known to impair c

293 ilitates tracking of actions and outcomes to temper urges for riskier rewards as they become less pro

294 It would be prudent to temper widening the scope of practice of mid-level provi

295 epidemiologists have for population health, tempered with concerns for remaining true to epidemiolog

296 ers using solvophobic driving forces must be tempered with functionalities that promote solubility of

297 orts, but use of this new technology must be tempered with knowledge of its limitations as well as po

298 d interpret biomarkers with more confidence, tempered with necessary caution.

299 s on nontarget organisms, but theory must be tempered with pragmatism in the selection of volatiles a

300 The significance of these findings must be tempered with the limitations (possible underreporting)