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1 e modification of OsFIE1 were observed to be temperature sensitive.
2 aeruginosa chronic infection isolate 2192 is temperature sensitive.
3 morphic alleles, and another two mutants are temperature sensitive.
4 other key biochemical processes appear more temperature sensitive.
5 g315Leu, indicating that these mutations are temperature sensitive.
6 development rate, and vector competence are temperature sensitive.
7 renders yeast cells rapamycin resistant and temperature sensitive.
8 pathogenic Cx31 mutants are un/misfolded and temperature sensitive.
9 136 kJ mol(-1), HMF formation being the most temperature sensitive.
10 The mutant phenotype is also temperature-sensitive.
11 We allowed all five steps in the cycle to be temperature-sensitive.
12 dization processes, which are expected to be temperature-sensitive.
13 ed (CPD) versions of RSV were attenuated and temperature-sensitive.
16 ase A (ACA) with SQ22536 and incubation of a temperature-sensitive ACA mutant at the restrictive temp
20 lement the growth of Escherichia coli with a temperature-sensitive AK identified functional proteins
22 in S. pombe We show that the lethality of a temperature-sensitive allele of eso1 (eso1-H17) is due t
25 d a robust system that serves the purpose of temperature-sensitive alleles in other model organisms,
27 P417L or P417S as the only copy of Ssa were temperature sensitive and exhibited defects in Ssa1-depe
28 stabilized vaccine candidate was moderately temperature sensitive and had a level of restriction in
29 g evidence that mutations at these sites are temperature sensitive and highlighting the importance of
30 tures at low temperature, as inactivation of temperature-sensitive and cold-sensitive ded1 mutants ga
35 nuclear migration in unc-84 null animals is temperature sensitive; at 25 degrees migration fails in
36 function of inner hair cell ribbon synapses (temperature-sensitive auditory neuropathy) or auditory n
37 A mutant screen with an Arabidopsis thaliana temperature-sensitive autoimmune mutant bonzai1 revealed
38 of TRPC5 in 129S1/SvImJ mice resulted in no temperature-sensitive behavioral changes, TRPM8 and/or o
39 omyces cerevisiae that allowed a recovery of temperature-sensitive but respiratory competent zim17 mu
40 1 neurons) were artificially activated via a temperature-sensitive cation channel (dTRPA1), males fol
41 lation of the DPM neurons by activation of a temperature-sensitive cation channel between acquisition
44 anilloid 1 and 4 genes (trpv1, trpv4) encode temperature-sensitive cation channels hypothesized to me
48 utants were viable at 32 degrees C, showed a temperature-sensitive cell entry defect, and, after prot
50 By generating clones of cells that carry a temperature-sensitive cell-lethal mutation, we condition
52 formed temperature-insensitive isoforms into temperature-sensitive channels and significantly perturb
53 olecular basis of the thermal sensitivity of temperature-sensitive channels appears to arise from a s
56 the Fe-S cluster domain, which renders cells temperature sensitive, closely mimics the global defects
57 he six internal protein gene segments of the temperature sensitive, cold-adapted (ca) A/Ann Arbor/60
58 es low surfactant emulsion formulations with temperature-sensitive compounds, is scalable to industri
62 Here we investigated the critical period for temperature-sensitive courtship rate plasticity in the b
65 ydomonas reinhardtii mutant (dhc1b-3) with a temperature-sensitive defect in DHC1b, enabling inducibl
68 d against deattenuation, specifically, a non-temperature-sensitive deletion mutation involving 6 nucl
69 two orders of magnitude, owing to the highly temperature-sensitive diffusion between aggregated DNA-c
70 ell extravasation within tumors treated with temperature-sensitive doxorubicin and ultrasound hyperth
75 TEs of >600 mRNAs, whereas inactivation of a temperature-sensitive eIF4A variant encoded by tif1-A79V
78 acid changes is able to rescue growth of the temperature-sensitive Escherichia coli glnS strain UT172
80 , the observation of striking differences in temperature-sensitive expressions, testicular physiology
81 tional mutation in the cdkg1 gene leads to a temperature-sensitive failure of meiosis in late Zygoten
83 we screened for extragenic suppressors of a temperature-sensitive fission yeast strain mutated in th
84 ne conductance regulator (CFTR) results in a temperature-sensitive folding defect that impairs protei
85 on human CFTR, the F508del mutation caused a temperature-sensitive folding defect, which disrupted ov
86 molecular analyses identified p.R3277C as a temperature-sensitive folding/trafficking mutant, and le
90 rprisingly, the recombinant CPD viruses were temperature-sensitive for replication in vitro (level of
91 BSI: 5 have been previously described in non-temperature-sensitive forms of congenital ichthyosis (Ar
93 ow an elongated cell division phenotype in a temperature-sensitive FtsA background, demonstrating the
94 rA and DrrB proteins expressed together in a temperature-sensitive ftsH mutant strain of Escherichia
95 Here, we combined the Gal4/UAS system and a temperature-sensitive Gal80 molecule to induce RNAi-medi
96 The physicochemical underpinnings of this temperature-sensitive gating have proven difficult to pa
98 10, Saccharomyces cerevisiae cells exhibit a temperature-sensitive growth defect under oxidative grow
102 hosphomimetic cse4-4SD mutant suppresses the temperature-sensitive growth of ipl1-2 and Ipl1 substrat
104 rms based on their ability to complement the temperature-sensitive growth phenotype of Escherichia co
105 BI in the context of a bcmd-RGFlu carrying a temperature-sensitive H1N1 virus resulted in protection
106 , we report the generation of a recombinant, temperature-sensitive H3N8 CIV as a live-attenuated infl
107 10-bp gene that codes for a homologue of the temperature-sensitive hemagglutinin (Tsh) autotransporte
108 ers of photo-crosslinkable copolymers with a temperature-sensitive hydrogel as the middle layer.
110 le copy, including constructs expressing the temperature-sensitive inactivator of neuronal function S
111 arge peptide pool, subsequently refined by a temperature-sensitive induced-fit mechanism to retain th
112 n of Escherichia coli, which is dependent on temperature-sensitive interdomain unfolding and cis-tran
113 or 555-conjugated human transferrin revealed temperature-sensitive internalisation indicating the BBB
121 here the isolation and characterization of a temperature-sensitive lethal mutation, bamAE373K, which
124 duced levels of Mitf activity using an mitfa temperature-sensitive line results in a dramatic increas
125 diated nanoparticles were quantified using a temperature sensitive lipid-based assay and compared to
126 oteridol was enhanced in tumors treated with temperature-sensitive liposomal doxorubicin and ultrasou
128 Clinical-grade doxorubicin encapsulated low temperature sensitive liposomes (LTSLs) were combined wi
130 ted whether enhanced therapeutic activity of temperature sensitive liposomes (TSL) could be obtained
131 (Free-DOX), Stealth liposomes (Stealth-DOX), temperature sensitive liposomes (TSL) with intra-vascula
134 design principles around the construction of temperature-sensitive liposomes (TSL) and their use in c
135 n, hyperthermia-triggered drug delivery from temperature-sensitive liposomes (TSLs), and combinations
139 behavior, and clinical potential of various temperature-sensitive liposomes, as well as the various
141 ne expression on virus pathogenesis, using a temperature-sensitive, live-attenuated 2009 pandemic H1N
144 eal of work has been dedicated to developing temperature sensitive macromolecules that can be crafted
146 n-coding gene segments from the cold-adapted temperature-sensitive master donor virus A/Ann Arbor/6/1
147 Thermal stability of channel function and temperature-sensitive maturation of the mutant protein a
148 Mathematical modeling further supports a temperature-sensitive mechanism to protect a subset of t
149 ser beam at-a-distance was found to activate temperature-sensitive membrane receptors, resulting in a
150 We then validated and narrowed our list of temperature-sensitive microbes by comparing the results
152 rticular, the Northern Hemisphere network of temperature-sensitive millennial tree-ring chronologies,
153 eveloped plasmid constructs that overexpress temperature sensitive miRNAs: miR-34a, miR-451, and miR-
155 pen reading frames (ORFs) (C(Delta170)) or a temperature-sensitive missense mutation in the L ORF (L(
157 Selection drove complete replacement of the temperature-sensitive mitochondrial genome by a wild-typ
158 may serve as the basis for developing other temperature-sensitive models for the study of recessive
160 edimentation of mitochondrial ribosomes from temperature-sensitive mtg3 mutants grown at the permissi
162 spatial and temporal control of Filamenting temperature sensitive mutant Z (FtsZ) Z-ring formation i
163 ees C with those in the widely used pat1-114 temperature-sensitive mutant at 34 degrees C, a temperat
166 tivity on the functional conformation of the temperature-sensitive mutant cystic fibrosis channel (F5
167 Genetic analysis of the outer core in a temperature-sensitive mutant demonstrated this core func
169 ROS is not observed in cells infected with a temperature-sensitive mutant of Ad2, ts1, which is defec
170 ream region of highly transcribed genes in a temperature-sensitive mutant of Clp1 at elevated tempera
173 e characterized the growth of a B1-deficient temperature-sensitive mutant virus (Cts2 virus) in U2OS
176 eukaryotic tubulin and bacterial filamenting temperature-sensitive mutant Z protein (FtsZ) polymers.
177 thesized Gp0.4 binds to purified filamenting temperature-sensitive mutant Z protein and directly inhi
182 In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cel
186 ased temperature imposed selection against a temperature-sensitive mutation affecting cytochrome oxid
188 the flagella of fla10-1 cells, which carry a temperature-sensitive mutation in the anterograde motor
191 ypomorphic mutations that behave as apparent temperature-sensitive mutations due to the additive effe
192 f the UTRs together with the introduction of temperature-sensitive mutations in both the nucleocapsid
193 subgenic M polypeptides, by incorporation of temperature-sensitive mutations in the N and L genes, an
194 hing suit ichthyosis is caused by recessive, temperature-sensitive mutations in the transglutaminase-
195 onditional loss-of-function reagents such as temperature-sensitive mutations is that the resulting ph
196 encoding the NSs protein and introduction of temperature-sensitive mutations, in the design of attenu
200 lobal transcriptome analysis reveals a major temperature-sensitive node of SA signalling, impacting
203 tion mutant of stO1, we demonstrate that the temperature-sensitive O-antigen production defect in 219
206 varian tumor cells expressed a heterozygous, temperature-sensitive p53(V172F) mutation, which reduced
207 ecreased life span, locomotor abnormalities, temperature-sensitive paralysis, and defects of neuromus
208 e find that the drug-metal complex formed in temperature-sensitive particles can be internalized by c
209 der to design protocols for the use of these temperature-sensitive particles in cancer treatment, the
210 is required to inactivate the commonly used temperature-sensitive Pat1 kinase mutant (pat1-114).
211 the incubation temperature during a critical temperature sensitive period (TSP) determines sexual fat
213 t in formation of noncytopathic viruses or a temperature sensitive phenotype cluster at the nsP2/nsP3
214 specifically to determine if the attenuating temperature-sensitive phenotype can revert and, if so, t
215 type mammalian PRDX4 into the ER rescued the temperature-sensitive phenotype of an ero1 yeast mutatio
216 n allele-specific manner, (b) suppresses the temperature-sensitive phenotype of both groES and groEL
218 ns and PVR-Tg21 transgenic mice, loss of the temperature-sensitive phenotype, and the capacity for su
219 ng the H3N2 NS1-V194I protein demonstrated a temperature-sensitive phenotype, further attenuating the
220 sequences partially suppresses the bdf1Delta temperature-sensitive phenotype, suggesting that maintai
224 sect pest, Drosophila suzukii, by creating a temperature-sensitive point mutation in the sex-determin
228 temperatures above 30 degrees C suggesting a temperature-sensitive process that slows impulse propaga
229 change is likely to increase the rate of the temperature-sensitive processes that decompose stored or
230 s can exploit degenerate relationships among temperature-sensitive processes to achieve robust functi
231 We show that R1108C and R1129C are both temperature-sensitive processing mutants that engage the
232 ccharide-based systems with inherent pH- and temperature-sensitive properties, as well as enzyme-clea
235 riple charged-to-alanine mutation produced a temperature-sensitive replication phenotype with no dete
239 ationale for understanding the phenotypes of temperature-sensitive Sgt1 mutants and for linking Skp1-
241 o alpine areas should not be based solely on temperature-sensitive, site-specific upper-treeline stud
242 emperature window, which correlates with the temperature-sensitive size transition of the molecular a
243 rate that the phosphoswitch is intrinsically temperature sensitive, slowing down PER2 degradation as
247 have implications for the interpretation of temperature-sensitive, speleothem climate proxies such a
248 Accordingly, we find that previously known temperature-sensitive splicing mutants become lethal in
251 DX3X complements the growth defect in a ded1 temperature-sensitive strain of Schizosaccharomyces pomb
252 Starting with a conditional strain (i.e., a temperature-sensitive strain), we describe how to effici
253 AF-C phosphorylation from wild-type and CKII temperature-sensitive strains (cka1Delta cka2-8) showed
254 d MDCK cells is defective, possibly due to a temperature-sensitive structural or functional property
256 ze the conserved GII.4 blockade epitope were temperature sensitive, suggesting that particle conforma
258 nt temperature window which coincides with a temperature-sensitive switch in seed dormancy state.
259 d-site mutation that enhances lethality of a temperature sensitive tbx-2 mutant and show that this mu
261 ge upstream of the second AAA+ domain in the temperature sensitive TgNoAP1 allele leads to conditiona
262 d that the rate of dissociation was far more temperature-sensitive than the rates of both association
263 ral of these TRP channels on macrophages are temperature sensitive, they may comprise the link for hy
264 monstrate that human alpha2C-AR has a unique temperature-sensitive traffic pattern within the G prote
266 ilic supramolecular assemblies with a unique temperature-sensitive transition have been investigated.
267 e systems are known to exhibit a macroscopic temperature-sensitive transition, where the assembly pha
268 dence of the coupling between gating and the temperature-sensitive transitions, as well as the DeltaH
269 tivity to drive channel activation, allowing temperature-sensitive TRP channels to function as polymo
271 tates are derived from a human virus that is temperature sensitive (ts), characterized by restricted
273 ive attenuated influenza vaccines (LAIVs) on temperature-sensitive (ts) backbones derived from animal
274 ising live-attenuated vaccine candidate is a temperature-sensitive (ts) cDNA-derived virus named rA2c
275 and yielded variants with wild-type (wt) or temperature-sensitive (ts) growth phenotypes or had a le
280 atitis virus (MHV) nsp5, we identified a new temperature-sensitive (ts) mutation in D2 of nsp5 (Ser13
282 have shown previously that incorporation of temperature-sensitive (ts) mutations into the PB1 and PB
283 is exquisitely bleach-sensitive, displays a temperature-sensitive (ts) phenotype during aerobic grow
284 ng the H3N2 NS1-V194I protein demonstrated a temperature-sensitive (ts) phenotype, providing a most l
285 hal mutants, bearing cold-sensitive (cs) and temperature-sensitive (ts) point mutations, were more am
286 n Mediator integrity is compromised in med17 temperature-sensitive (ts) yeast, demonstrating the modu
288 Alternatives to the widely used but highly temperature-sensitive uzu1.a allele of HvBRI1 represent
290 nents and the rationale behind the design of temperature-sensitive vesicle systems, as well as the cr
297 is specified by placement of the Filamentous temperature sensitive Z (FtsZ) ring, and the Min system
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