ライフサイエンスコーパス: tempol

1 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL).

2 ydroxy-2,2,6,6-tetramethylpiperydine-1-oxyl (Tempol).

3 ydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL).

4 e than a less targeted antioxidant approach (Tempol).

5 t with the reactive oxygen species scavenger Tempol.

6 by pretreating animals with the antioxidant tempol.

7 it is rescued by infusion of the SOD mimetic tempol.

8 NMDA and kainate, and during treatment with tempol.

9 ng, which was abolished by the SOD1 mimetic, tempol.

10 ERK was abolished by treatment of rats with tempol.

11 pinephrine (NE) are normal and unaffected by tempol.

12 rsus -46 +/- 4%; P < 0.05) and normalized by tempol.

13 n of CGP-20,712A to NE but was normalized by tempol.

14 cessary for the chemopreventative effects of tempol.

15 of mice were coinfused with the antioxidant Tempol.

16 ated in SOD2+/-, and was acutely restored by Tempol.

17 arison with those on a KD diet alone without tempol.

18 e of p53 in the chemopreventative effects of tempol.

19 hypothermia, except perhaps the antioxidant tempol.

20 groups and was unaffected by the addition of tempol.

21 ers citrate buffer containing 0 mM or 100 mM TEMPOL.

22 nal FXR mediates the anti-obesity effects of tempol.

23 dministered the superoxide dismutase mimetic tempol.

24 or by exposure to the free radical scavenger Tempol.

25 In some pigs, superoxide dismutase mimetic TEMPOL (1 mM) or vehicle (saline) was injected intravitr

26 l injection into the hindlimb circulation of tempol (10 mg), a superoxide dismutase mimetic (DeltaMAP

27 ins compared with equimolar concentration of tempol (10 mM).

28 The superoxide dismutase mimetic tempol (10(-4) M) moderated the AngII responses of Aff f

29 during inhibition of oxidative stress using tempol (100 microM).

30 mpol before shock was induced (LTA/PepG plus tempol, 100 mg/kg i.v. bolus injection, 15 mins before L

31 5 mL/kg i.v., n = 6) or tempol (control plus tempol, 100 mg/kg i.v. bolus injection, followed by an i

32 Administration of Tempol (250 mg/kg, i.p.) 10 min prior to administration

33 tine diet (2 weeks prior to noise exposure), tempol (3 mM in drinking water 2 weeks prior to exposure

34 ed by the antioxidants ebselen (100 mum) and TEMPOL (3 mm).

35 droxy-2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPOL), 3-carboxy-proxyl, and 3-ethoxycarbonyl-proxyl,

36 ersus -34 +/- 3%; NS) and were unaffected by tempol (-32 +/- 4%; NS).

37 nd restored by coincubation of AA (37+/-2%), tempol (33+/-2%), losartan (34+/-2%), or apocynin (36+/-

38 gated to a triphenylphosphonium cation, Mito-Tempol (4) [Mito-T (4)].

39 ed hydroxytoluene, butylated hydroxyanisole, TEMPOL (4-hydroxy-2,2,6, 6-tetramethylpiperidine-N-oxyl)

40 addition of the superoxide scavenging agent tempol (4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl)

41 demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl)

42 er the well-described nitroxide antioxidant, tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl),

43 id is oxidized to dehydroascorbic acid using Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy) and

44 nger, 4-hydroxytetramethylpiperidine-1-oxyl (tempol; 5 mM), was used in some experiments.

45 toTEMPO (mitochondria-targeted antioxidant), TEMPOL (a general antioxidant), apocynin (nicotinamide a

46 Intrathecal Mito-tempol (a mitochondria-targeted O2(.-)scavenger) reduced

47 Chronic administration of Tempol (a potent antioxidant) attenuated both SERCA oxid

48 f cells with Trolox (a soluble vitamin E) or Tempol (a radical scavenger).

49 e pyroptosis could be partially inhibited by Tempol (a superoxide dismutase-mimetic agent) and by gly

50 ongruently, the addition of 4-hydroxy-TEMPO (TEMPOL), a superoxide dismutase mimic that reacts with s

51 a model of FA, we examined the potential of tempol, a nitroxide antioxidant and a superoxide dismuta

52 xygen species, whereas preincubation of mito-TEMPOL, a superoxide dismutase mimetic, abolished statin

53 Coadministration of tempol, a superoxide dismutase mimetic, ameliorated the

54 Finally, treatment with Tempol, a superoxide dismutase mimetic, and insulin, bot

55 protein (P < 0.05), which were inhibited by Tempol, a superoxide dismutase.

56 Treatment with Tempol, a superoxide scavenger, attenuates the augmented

57 Chronic administration of tempol, a superoxide scavenger, reduced intraretinal oxi

58 ydroxy-2,2,6,6-tetramethylpiperidine-n-oxyl (TEMPOL,a superoxide dismutase-mimetic), N-omega-nitro-L-

59 cynin, or superoxide dismutase (SOD) mimetic tempol abolished O2- and restored BH4 levels.

60 mice with antioxidants (mitoTEMPO, apocynin, Tempol) abrogates the hypertensive, prothrombotic phenot

61 Thus, tempol acts as a novel chemopreventative agent in this m

62 ron spin resonance spectroscopy suggest that Tempol acts in this system by reacting directly with bot

63 icacy of 6OHDA, we have used the antioxidant Tempol adjunctively with 6OHDA.

64 on of 14 drugs in dogs, only the antioxidant tempol administered at the start of prolonged cardiac ar

65 Tempol administered continuously via the diet after wean

66 Finally, Tempol administration markedly attenuated impaired endot

67 ay 10 was equally attenuated by creatine and tempol alone or in combination.

68 OL for almost 5 h, whereas administration of TEMPOL alone results in clearance of blood redox activit

69 Tempol alone significantly reduced ABR threshold shifts

70 mor weights from mice administered saline or Tempol alone were 3.6 +/- 1.9 and 2.9 +/- 0.7 g, respect

71 enal superoxide levels more effectively than tempol alone.

72 TEMPOL also abrogated the inhibitory effect of 15-A2-Iso

73 Tempol also attenuated the RSNA response to 1 min interm

74 Tempol also normalized NF-kappaB translocation, PKC acti

75 Tempol also significantly decreased the AP-1-DNA binding

76 A broad antioxidant, Tempol, also reduced oxidant stress yet did not recouple

77 Here we show that tempol alters the gut microbiome by preferentially reduc

78 The decay of Tempol and 3CP in tumor tissue was significantly faster

79 Tempol and Apocynin reversed the increased expression of

80 weeks prior to exposure), and creatine plus tempol and exposed to 120 dB SPL one-octave band noise c

81 Tempol and tempo are stable free radical nitroxides that

82 bsence of an environmental oxidative stress, tempol and tempo elicit distinct cellular signaling path

83 Both TEMPOL and TEMPOL/PNA give rise to prevention of apoptos

84 ith phentolamine, antioxidant treatment with Tempol and thromboxane receptor antagonism with SQ-29548

85 roxy-2,2,6,6,-tetramethyl-1-piperidynyloxyl (Tempol) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1

86 e restored in the presence of ascorbic acid, tempol, and apocynin, which inhibits NADPH oxidase assem

87 revented by the antioxidant agents Desferal, Tempol, and dimethylsulfoxide.

88 holine responses were improved (P<0.05) with Tempol, and histochemistry revealed oxidative stress in

89 a diet supplemented with a stable nitroxide, Tempol, and showed that the progression of neuromuscular

90 PNA enhances the therapeutic index of TEMPOL, and the recycling antioxidant that results from

91 apocynin, and the nonspecific ROS scavenger, tempol, are shown to reduce oxidative stress and improve

92 These results encourage further study of Tempol as a chemopreventive, to reduce the incidence of

93 ormed two types of adducts (LT and OLT) with TEMPOL as characterised by HPLC.

94 and reactive oxygen species (ROS) scavenger tempol, as well as mitochondrial NCX (mNCX) blocker CGP-

95 racellular application of the ROS scavenger, Tempol, attenuated the Ang II-induced increase in neuron

96 Pretreatment of rats with tempol augmented the hypotension but attenuated the rena

97 Another group of rats was pretreated with tempol before shock was induced (LTA/PepG plus tempol, 1

98 , polarity or partitioning of the spin probe TEMPOL-benzoate (TB), as proved by EPR measurements and

99 er (xestospongin C), or ROS scavengers (PBN, tempol), but not by an mGluR1 antagonist (LY367385) or N

100 The free radical scavenger Tempol, but not other classes of antioxidants, reduced o

101 tor of cAMP; -56 +/- 4%); were normalized by tempol; but were unaffected by ICI-118,551 (selective be

102 Agents such as the nitroxide Tempol can facilitate the oxidation of the semiquinone t

103 These results show that tempol can significantly delay tumor formation in Fancd2

104 Interestingly, however, only tempol caused increased extracellular signal-regulated k

105 ng and the reactive oxygen species inhibitor Tempol completely reversed the decline in Ser(P)(473)-AK

106 is inhibited by the antioxidants ebselen and TEMPOL, consistent with the concept that it requires an

107 metry of the adduct formation is two mole of TEMPOL consumed for one mole of LH and one mole of LOOH.

108 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) consumption by using ESR allows to follow the an

109 by an infusion of 1.5 mL/kg i.v., n = 6) or tempol (control plus tempol, 100 mg/kg i.v. bolus inject

110 However, tempol decreased basal production of superoxide anion in

111 In BSO-treated rats' supplementation of tempol decreased oxidative stress, normalized BP, and re

112 Tempol decreased the level of Ang II-induced aortic supe

113 More strikingly, tempol delayed the onset of epithelial tumors and increa

114 he animals that had first been injected with TEMPOL developed only stage 2 to stage 4 cataracts (the

115 Tempol did not affect the increase in nitrite/nitrate ca

116 ikewise, the antioxidants dithiothreitol and tempol did not reverse permeabilization.

117 Notably, delaying administration of the Tempol diet one month after TBI could also enhance survi

118 , and forebrain of animals maintained on the Tempol diet, IRP1 was converted from a cytosolic aconita

119 Oxypurinol and Tempol diminished the leak in NOS1(-/-) cardiomyocytes.

120 Here we show for the first time that tempol dramatically reduced STAT1 and 3 phosphorylation.

121 ted with the STAT1 activator, IFN-gamma, and tempol during I/R injury.

122 The antioxidants tempol, ebselen, and deferoxamine inhibited CO-induced O

123 Mice treated with antibiotics or tempol exhibited altered bile acid composition, with a n

124 In contrast, except for one antioxidant (Tempol), explorations of 14 different drugs added to the

125 olate-antioxidant conjugate 4-hydroxy-Tempo (tempol)-folate to target folate receptors, which are hig

126 nce revealed the successful targeting of the tempol-folate conjugate to the kidney and other tissues

127 Administration of tempol-folate protected the renal function of mice after

128 model of renal ischemia-reperfusion injury, tempol-folate reduced renal superoxide levels more effec

129 In contrast, mice administered Tempol followed by 6OHDA had an average tumor weight of

130 ine (BSO), an oxidant, with and without 1 mM tempol for 2 wk.

131 t of animals on a K-deficient (KD) diet with tempol for 7 days significantly decreased the production

132 L/PNA maintains redox-active blood levels of TEMPOL for almost 5 h, whereas administration of TEMPOL

133 oss (NIHL), we measured the effectiveness of tempol (free radical scavenger) and creatine (enhances c

134 ,6,6-tetramethylpiperidine hydrochloride), a TEMPOL-H (OT-674) derivative, is a new catalytic antioxi

135 oxy-2,2,6,6-tetramethyl-1-hydroxypiperidine (TEMPOL-H) as a probe in conjunction with superoxide dism

136 Oxidized but not reduced TEMPOL (TEMPOL-H) was an effective radioprotector in cultured ra

137 In the control rats, tempol had no effect on these responses.

138 aled oxidative stress in KW animals, whereas Tempol had no impact and reactive oxygen species stainin

139 TEMPOL/PNA is also less toxic than TEMPOL in mice, allowing administration of higher doses

140 The level of total TEMPOL in the aqueous humor of rabbits at 15 minutes aft

141 t chronic supplementation of the antioxidant Tempol in the diet of mice can reduce body weight withou

142 y 6-OHDA than the non-recycling antioxidant, TEMPOL, in a murine model of catecholaminergic oxidative

143 Dietary tempol increased the mean tumor-free survival time of Fa

144 Both SOD and TEMPOL increased the signal intensity of the .OH adduct

145 Tempol inhibited the effects of IP(3) but not those of a

146 suggest that the chemopreventative effect of tempol is not solely due to the reduction of oxidative s

147 The free radical scavenger, tempol, is known to have cardioprotective properties, al

148 manner that was inhibited by bradykinin, AA, tempol, losartan, or apocynin.

149 ter incubation with the superoxide scavenger TEMPOL, maximal EDD improved by approximately 65% in Eln

150 Tempol may also find applications to reduce the risk of

151 l, suggesting that the protective effects of tempol may partly operate by decreasing the phosphorylat

152 suggested that SMG-1 was responsible for the tempol-mediated enhancement of p53 serine 18 phosphoryla

153 y in p53-deficient mice and the finding that tempol-mediated resistance to oxidative insult was p53-d

154 Administration of the superoxide scavenger TEMPOL, NAD(P)H oxidase inhibitor (apocynin), or anti-TN

155 ts, and administration of the O2*- scavenger TEMPOL, NAD(P)H oxidase inhibitor (apocynin), or anti-TN

156 In the presence of superoxide scavenger TEMPOL, NAD(P)H oxidase inhibitor apocynin, p38 kinase i

157 Tempol normalized basal VO2 and VCO2 and improved the wo

158 We also examined the effect of ICV Tempol on the RVLM of CHF rabbits.

159 s of a membrane-permeable radical scavenger (tempol) on the circulatory failure and MODS (kidney, liv

160 pyrroline N-oxide) or the O(2)(*-) scavenger Tempol or an SOD mimic (AEOL10113) resulted in a decreas

161 ations were inhibited by treatment with mito-tempol or apocynin or by inhibiting EGFR expression or a

162 ta with either superoxide dismutase (SOD) or tempol or apocynin significantly improved acetylcholine-

163 pletely restored by coincubation with tiron, tempol or apocynin.

164 ic arteries, which is rescued by SOD mimetic tempol or gene transfer of SOD3.

165 Treatment with the antioxidant TEMPOL or lung-specific overexpression of ecSOD prevente

166 tetramethylpiperidine1-oxyl (tempol) or Mito-tempol or MitoQ in the presence or absence of PEG-catala

167 Treatment with the superoxide scavenger tempol or the isoketal scavenger 2-hydroxybenzylamine (2

168 Administration of the SOD mimetic mito-tempol or the NADPH oxidase inhibitor apocynin attenuate

169 RPM2+/+ mice with the free radical scavenger Tempol or the PARP1 inhibitor 3-aminobenzamide attenuate

170 ion of L-arginine or a superoxide scavenger, tempol or tiron, attenuated sympathetic vasoconstriction

171 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL or TPL) in the ischemic isolated rat heart, allow

172 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) or mice overexpressing lung-specific extracellul

173 ydroxyl-2,2,6,6-tetramethylpiperidine1-oxyl (tempol) or Mito-tempol or MitoQ in the presence or absen

174 blocked by the antioxidant 4-hydroxy-TEMPO (TEMPOL) or the mitochondrial uncoupler carbonyl cyanide

175 reduced by intracerebroventricular losartan, tempol, or apocynin in CHF rabbits but not in sham rabbi

176 restored by coincubation with ascorbic acid, Tempol, or apocynin.

177 olished by intracerebroventricular losartan, tempol, or apocynin.

178 ed by treatment of the superoxide scavenger, TEMPOL, or by overexpression of manganese superoxide dis

179 prevented by losartan, superoxide scavenger TEMPOL, or NADPH oxidase inhibitor apocynin.

180 of ceramide levels in the ileum and serum in tempol- or antibiotic-treated mice fed a HFD resulted in

181 Tempol, oxypurinol, or SB203850 decreased O2- in all gro

182 by preincubation with Tiron, ascorbic acid, Tempol, oxypurinol, or SB203850, an inhibitor of p38 kin

183 73 arbitrary units (a.u.); before vs. after tempol; P < 0.05).

184 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL) partially recovered impaired endothelial functio

185 Both TEMPOL and TEMPOL/PNA give rise to prevention of apoptosis and to t

186 TEMPOL/PNA is also less toxic than TEMPOL in mice, allow

187 TEMPOL/PNA is more effective against depression of activ

188 PC12 cells treated with 6-OHDA, but in vivo, TEMPOL/PNA maintains redox-active blood levels of TEMPOL

189 eridine-1-oxyl and polynitroxylated albumin (TEMPOL/PNA), an antioxidant complex that facilitates rec

190 On the other hand, tempo, but not tempol, potently activated stress-activated protein kina

191 t with the reactive oxygen species scavenger Tempol prevented FRD-induced apoptosis in WT mice.

192 We suggest that Tempol protected IRP2(-/-) mice by disassembling the cyt

193 Treatment with L-NAME or TEMPOL protected retinal neurons and confirmed the invol

194 in modulating the cardioprotective effect of tempol, rats were injected with the STAT1 activator, IFN

195 O(2)(-) scavenging with Tempol reduced flow-induced vasodilatation from all grou

196 Tempol reduced oxidative stress and thereby restored D1

197 The permeant superoxide dismutase mimetic tempol reduced the effects of AngII400 on the SBP (-1.7

198 Tempol reduced the incidence of hematopoietic neoplasms

199 When combined with caspase inhibition, tempol reduced the production of ROS and provided an add

200 IKKbeta(-/-) cells, BCL10 silencing, but not Tempol, reduced the CGN-induced increases in KC, phospho

201 The antioxidant tempol reduces obesity in mice.

202 atment of the cerebral microcirculation with tempol restored impaired nNOS-dependent vasodilatation i

203 Infusion of the ROS scavenger tempol restored sympatholysis in these rats.

204 Addition of the superoxide radical scavenger tempol restored the ability of bradykinin, enalaprilat,

205 Intracameral injection of TEMPOL resulted in a decrease of nearly 70% in the level

206 ical, 2,2,6, 6-tetramethyl-1-piperidinyloxy (TEMPOL), resulted in protection of plasma Fe-TF against

207 f AMPKalpha1(-/-) mice with the antioxidant, tempol, resulted in decreased reticulocyte counts and im

208 chromatography demonstrated that conjugated tempol retained its efficacy to scavenge superoxide in p

209 Addition of tempol reversed the defects in responsiveness to enalapr

210 of MG132 or a superoxide dismutase mimetic, tempol, reversed the diabetes mellitus-induced reduction

211 ng showed that Ang II elicited losartan- and TEMPOL-sensitive superoxide production in arterioles.

212 DHE staining showed that CRP produced TEMPOL-sensitive superoxide production in the arteriolar

213 eeks after x-ray, rabbits irradiated without TEMPOL showed either stage 5 (complete posterior subcaps

214 Compared to vehicle treated CHF rabbits, Tempol significantly decreased AT1R protein expression (

215 Finally, suppressing O(2)(-) production with tempol significantly increased renal K excretion measure

216 Both valsartan and tempol substantially attenuated mitochondrial lipid pero

217 FN-gamma abrogated the protective effects of tempol, suggesting that the protective effects of tempol

218 contractions to AngII that are normalized by tempol (superoxide dismutase mimetic), whereas contracti

219 Furthermore, addition of tempol (superoxide dismutase-mimetic) which is a superox

220 Oxidized but not reduced TEMPOL (TEMPOL-H) was an effective radioprotector in cul

221 ydroxyl-2,2,6,6-tetramethylpiperidin-1-oxyl (tempol) throughout exposure to intermittent hypoxia impr

222 tion in HF-SED was normalized by apocynin or TEMPOL to LF-SED and HF-RUN.

223 effect may be associated with the ability of TEMPOL to protect against radiation-produced peroxides b

224 Moreover, with the treatment of antioxidant tempol to suppress RNS, not only are DNA lesions signifi

225 elin-1 that was normalized by ifetroban plus tempol together.

226 Addition of catalase to Tempol-treated arterioles eliminated flow-induced vasodi

227 In Tempol-treated arterioles, flow-induced vasodilatation w

228 The reduction in oxidative DNA damage in tempol-treated FA fibroblasts and mice suggests that its

229 ue-Dawley, untreated Ren2, and valsartan- or tempol-treated Ren2 rats.

230 show lower diet-induced obesity, similar to tempol-treated wild-type mice.

231 arp apical ROMK staining was observed in the tempol-treated WT or gp91(-/-) mice.

232 Furthermore, tempol treatment did not adversely affect the repopulati

233 Further, tempol treatment does not decrease weight gain in Fxr(De

234 tribution in WT, gp91(-/-), and WT mice with tempol treatment in response to K restriction.

235 In contrast, tempol treatment in WT mice abolished whereas deletion o

236 Its increased levels during tempol treatment inhibit FXR signalling in the intestine

237 In contrast, the tempol treatment not only increased channel activity to

238 Tempol treatment of cancer-prone p53-deficient mice resu

239 Tempol treatment reduced ROS, restored mitochondrial mem

240 Surprisingly, tempol treatment specifically increased serine 18 phosph

241 m gp91(-/-) mice and completely abolished by tempol treatment.

242 conditions that were improved by apocynin or tempol treatment.

243 tan or superoxide dismutase/catalase mimetic tempol treatment.

244 rylated STAT1 and STAT3 and examined whether tempol was able to affect STAT activation after in vivo

245 TEMPOL was effective in protecting against lens epitheli

246 Consistent with these data, tempol was found to be noncytotoxic, whereas tempo induc

247 Tempol was given to each mouse for 7 days by an intraper

248 adioprotector in cultured rabbit lenses, and TEMPOL was nearly completely bioreduced in the plasma an

249 nsion, whereas a similar dose of nontargeted TEMPOL was not effective.

250 In vitro studies showed that TEMPOL was reduced rapidly by ascorbic acid but not by r

251 The latter process was inhibited by tempol, which recombines with the hSOD1-derived tryptoph

252 binding to Brca1 promoter by the antioxidant Tempol, which reduces NADH levels, relieved CtBP1-mediat

253 Furthermore, Tempol, which restored SERCA activity and decreased oxid