ライフサイエンスコーパス: tenase

1 finity and the potency of LMWH for intrinsic tenase.

2 ccharide was sufficient to inhibit intrinsic tenase.

3 2302 showed partial inhibition of intrinsic tenase activity (to approximately 35% of control) at cli

4 affinity, and accelerated decay of intrinsic tenase activity.

5 the PTT by selectively inhibiting intrinsic tenase activity.

6 d endothelial cells can support formation of tenase and prothrombinase and may be a source of activat

7 cs of zymogen activation when both extrinsic tenase and prothrombinase are assembled on an appropriat

8 telets provide a surface for assembly of the tenase and prothrombinase complexes required for thrombi

9 y the membrane-bound procoagulant complexes, tenase and prothrombinase.

10 its ability to inhibit wild-type IXa in the tenase assay and from the changes in dansyl fluorescence

11 m, tissue factor activity using an enzymatic Tenase assay, the level of target protein expression by

12 ted from its ability to inhibit IXaWT in the Tenase assay.

13 ional computer simulation model of intrinsic tenase based on these data.

14 Thus, LMWH inhibits intrinsic tenase by interacting with the heparin-binding exosite i

15 ts factor X (FX) activation by the extrinsic tenase complex (ETC) and thus named as exactin.

16 Heparin inhibits the intrinsic tenase complex (factor IXa-factor VIIIa) via interaction

17 nhibits factor X activation by the intrinsic tenase complex (factor IXa-factor VIIIa).

18 e for PE in the assembly and activity of the tenase complex and further extend the understanding of t

19 m) and k(cat) for factor X activation by the tenase complex are independent of PE in the presence of

20 an increase of the activity of the intrinsic tenase complex by 25% to 60%.

21 ite-inactivated factor IXas in the intrinsic tenase complex confirm that the defect in the variant pr

22 l region is neither directly involved in the tenase complex formation required for factor X activatio

23 nhances factor Xa generation by facilitating tenase complex formation; PE lowers the K(d(app)) of fac

24 entrations selectively inhibit the intrinsic tenase complex in an antithrombin-independent manner.

25 The effect of PE on the k(cat) of the tenase complex is mediated through factor VIIIa.

26 hway directly yielding FVIIIa-FIXa intrinsic tenase complex may be prohemostatic before further coagu

27 The formation of the tenase complex requires delivery of factor VIII (FVIII)

28 ete for physical assembly into the intrinsic tenase complex was enhanced by EGR-chloromethylketone bo

29 resence of activated factor VIIIa (intrinsic tenase complex), the normal augmentation of the cleavage

30 ential design of inhibitors of the intrinsic tenase complex, a novel target for anticoagulation.

31 PE) during the activation of factor X by the tenase complex, an enzymatic complex composed of the ser

32 so accelerated decay of the intact intrinsic tenase complex.

33 dulating catalytic activity of the intrinsic tenase complex.

34 tion of factor X activation by the intrinsic tenase complex.

35 factor IXa to factor VIIIa in the intrinsic tenase complex.

36 factor, or other components of the intrinsic tenase complex.

37 t of these mutations with purified intrinsic tenase components, and establish the factor IXa heparin-

38 e in human plasma by inhibition of intrinsic tenase (factor IXa-factor VIIIa) activity.

39 esting inhibition was dependent on intrinsic tenase (factor IXa-factor VIIIa) components.

40 hibition of factor X activation by intrinsic tenase (factor IXa-factor VIIIa) was investigated.

41 propagated through the assembly of intrinsic tenase (factor VIIIa/factor IXa), prothrombinase (factor

42 Kinetic analysis of intrinsic tenase inhibition demonstrated that relative affinity fo

43 Glycosaminoglycan-mediated intrinsic tenase inhibition is a novel antithrombotic mechanism wi

44 mechanism and molecular target for intrinsic tenase inhibition were determined and compared with inhi

45 Analysis of intrinsic tenase inhibition, employing factor IXa with mutations i

46 one, suggesting that inhibition of intrinsic tenase is a general property of this class of oligonucle

47 in isolation by surface-localized extrinsic tenase, it exhibits characteristics of diffusion-mediate

48 than on the "balloon." Assembly of intrinsic tenase on liposomes with various PS densities while keep

49 g in the activation of factor X by extrinsic tenase under flow conditions, we demonstrate that bovine