ライフサイエンスコーパス: tendon

1 nd/or calcifications greater than 30% of the tendon.

2 content than did the flexor digitorum longus tendon.

3 ifications of viscoelastic anisotropy in the tendon.

4 d servo-motor coupled to a biological muscle-tendon.

5 ne function of the calf muscles and Achilles tendon.

6 superficially embedded within the quadriceps tendon.

7 ransducer focused at the level of the flexor tendon.

8 to objectively assess a diseased or healing tendon.

9 in a transected rabbit model of the Achilles tendon.

10 increased injury risk in aged energy storing tendons.

11 and old equine energy storing and positional tendons.

12 in ECM properties favors lipid accretion in tendons.

13 zed and nonmineralized regions of turkey leg tendons.

14 tly decreases in healthy-aged mouse Achilles tendons.

15 y, interdigital nerves, or underlying flexor tendons.

16 dynamic tissues such as the heart, lungs and tendons.

17 pletes guided elongation to reach its target tendons.

18 nt with ageing, especially in energy storing tendons.

19 +/- 6.7) in xanthoma tendons than in control tendons (24.5% 6 5.8; P < .001).

20 lowing: tendinosis of the long head of bicep tendon (48.9%), inferior shoulder subluxation (44.4%), c

21 opsies from the healing area of the Achilles tendon 6 weeks after treatment with PRP or placebo contr

22 n, with different combinations of muscle and tendon action providing the same net joint torque.

23 ts, there is only a limited understanding of tendon adaptation in vivo.

24 Adjustable bilateral superior oblique tendon advancement allows independent control of torsion

25 erwent adjustable bilateral superior oblique tendon advancements for bilateral fourth nerve palsy: 11

26 ct a decrease of GAG content in the Achilles tendon after ciprofloxacin intake.

27 thoma tendons compared with those in control tendons (all P < .05).

28 ema detection, metal artifact reduction, and tendon analysis, with potential in arthrography, bone de

29 In many animals, the bonding of tendon and cartilage to bone is extremely tough (for exa

30 r responsiveness to Ihh, from the developing tendon and enthesis altered the differentiation of enthe

31 with Scleraxis-Cre mice to create a targeted tendon and ligament Col5a1-null mouse model, Col5a1(Delt

32 provides a framework for future analyses of tendon and musculoskeletal phenotypes.

33 ies of the intrinsic healing capacity of the tendon and offers an effective therapeutic possibility f

34 n, due to the large distance between the FHL tendon and the medial and lateral plantar nerves.

35 ndinous xanthomatosis or nodule formation in tendons and brain (preferentially in the cerebellum) ric

36 ecursors of vertebrae and associated muscle, tendons and dorsal dermis.

37 These features were then measured in whole tendons and identified in regions of tendon which are de

38 We define the function of collagen V in tendons and ligaments, as well as the role of alteration

39 llagen is the predominant collagen in mature tendons and ligaments, where it gives them their load-be

40 hallenging movements, the internal skeleton, tendons and muscles involved were reconstructed in 3-D f

41 st widely studied areas include the muscles, tendons and rheumatic diseases.

42 vitro and animal studies in bone, cartilage, tendon, and muscle.

43 prevalent in energy storing than positional tendons, and is mainly localised to the IFM.

44 ko adhesion coevolves with modified muscles, tendons, and reflexes.

45 re, we report cellular-level preservation of tendon- and cartilage-like tissues from the lower hindli

46 initial attachment of their respective wrist tendon anlage to multiple muscles.

47 al domain cross-linking sites in skin, bone, tendon, aorta, and cornea.

48 In summary, we propose that Sparc levels in tendons are critical for proper collagen fibril maturati

49 Here, we show that mouse limb tendons are formed in modular units that combine to form

50 ollagen fibrillogenesis defects and Sparc-/- tendons are less able to withstand force in comparison w

51 Energy storing tendons are more elastic and extensible than positional

52 inopathies remain clinically challenging and tendons are predisposed to degeneration or injury with a

53 that cycle large amounts of energy in series tendon as a source of elastic limb behavior.

54 s that govern the force-length curve of each tendon as well as the strength and optimal fiber length

55 erials during injections for joint spine and tendon, aspiration biopsies and dermal fillers (DF).

56 7-T MR imaging examinations of the Achilles tendon at baseline and 10 days and 5 months after ciprof

57 when compared with the contralateral, intact tendon based on LYVE1+ tubules (10.9% vs 0.8%, P < 0.05)

58 resistant, potentially explaining why older tendons become more injury-prone.

59 more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM

60 rations of NaBu may contribute to healing of tendon-bone injury in part at least through promotion of

61 Here we identify that the Achilles tendon-bone insertion is characterized by an interface r

62 lagen V-null ACL and flexor digitorum longus tendon both had significant alterations in mechanical pr

63 ter is an important component of collagen in tendons, but its role for the function of this load-carr

64 ined from 20 patients with ruptured Achilles tendon by means of ultrasound-guided needle biopsies fro

65 geometric equilibrium state of the Achilles tendon can coincide with minimization of the total metab

66 evel adaptations to a mechanical lesion in a tendon caused by pathology.

67 of mTORC1 signaling by removal of Raptor in tendons caused severe tendon defects postnatally, includ

68 ion factor that controls glia, hemocyte, and tendon cell differentiation in Drosophila.

69 ion of mTORC1 signaling in tendons increased tendon cell numbers and proliferation.

70 ual myofibers must form stable contacts with tendon cells and then assemble sarcomeres.

71 Specialized tendon cells, resembling tendon cells at myotendinous junctions, form at the ends

72 g the phenotypic plasticity of cartilage and tendon cells has not been considered systematically.

73 First, we identified a rare fraction of tendon cells that was positive for the known tendon stem

74 Human tendon cells were derived from hamstring tendon obtained

75 tro, IL-10 expression was detected only when tendon cells were stimulated with IL-1beta, and CTGF and

76 Incubation of IL-1beta stimulated healthy tendon cells with 15-epi-LXA4 or MaR1 down-regulated PGE

77 during monolayer expansion of cartilage and tendon cells, and the expression of key developmental ma

78 biosynthesis in diseased compared to healthy tendon cells, and up regulated the formation of several

79 Specialized tendon cells, resembling tendon cells at myotendinous ju

80 In diseased tendon cells, we also found increased 15-Prostaglandin D

81 ing that myofibers induce differentiation of tendon cells, which reciprocally regulate myofiber lengt

82 higher in CD146(+) TSCs compared to CD146(-) tendon cells.

83 differentiation transitions in cartilage and tendon cells.

84 cantly higher in CD146(+) TSCs than CD146(-) tendon cells.

85 Using the well-established rat tail tendon collagen as a benchmark, we apply our novel kanga

86 benchmark, we apply our novel kangaroo tail tendon collagen as an alternative collagen source for ou

87 Loss of Sparc results in tendon collagen fibrillogenesis defects and Sparc-/- ten

88 ing-based parameters were higher in xanthoma tendons compared with those in control tendons (all P <

89 e important insights into how differences in tendon composition and turnover contribute to tendon str

90 In mammals, the tendon connective tissue experiences and resists physica

91 The enthesis for many tendons consists of a mineralized graded fibrocartilage

92 that mechanical damage and tenocyte-mediated tendon damage and repair processes modify the distributi

93 astography may enable clinicians to diagnose tendon damage and track healing, which should improve bo

94 itro tenocyte cultures and in vivo models of tendon damage, we demonstrate that such IL-33 expression

95 y removal of Raptor in tendons caused severe tendon defects postnatally, including decreased tendon t

96 ent study aimed to investigate the effect of tendon degeneration on its mechanical properties, the ne

97 Subsequent individuation of these tendons depends on muscle activity.

98 cellular level, Sparc-null and healthy-aged tendon-derived cells exhibited a more contracted phenoty

99 ed bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donor

100 e of limb cartilage the zeugopod segments of tendons develop despite the absence of tendons in the au

101 contiguous structure; in muscle-less limbs, tendons develop in the autopod but do not extend into th

102 mTORC1 signaling is essential for postnatal tendon development and maturation.

103 he molecular mechanisms regulating postnatal tendon development are not well understood.

104 ll-regulated collagen fibril assembly during tendon development in which MMP14 cleaves a molecular br

105 In this study, we show that tendon development is arrested in Scleraxis-Cre::Mmp14 l

106 sults establish an integrated model for limb tendon development that provides a framework for future

107 ne the role of mTORC1 signaling in postnatal tendon development using mouse genetic approaches.

108 Scleraxis (Scx) is a known regulator of tendon development, and recent work has identified the r

109 ating that mTORC1 is necessary for postnatal tendon development.

110 ion of the muscle patterning and compromised tendon development.

111 developmental programs, we re-examined early tendon development.

112 Tissue-engineered tendons differentiated from bone marrow derived mesenchy

113 Despite the high prevalence of tendon disease in the elderly, our current understanding

114 Quervain syndrome and extensor carpi ulnaris tendon disorders being the most common among them; howev

115 therapeutic approaches in the management of tendon disorders.

116 ve therapeutic possibility for patients with tendon disunion.

117 nimally invasive incision to harvest the FHL tendon, due to the large distance between the FHL tendon

118 use stock parameters when simulating muscle-tendon dynamics tend to significantly overestimate metab

119 in the method used, clinical translation of tendon elastography may enable clinicians to diagnose te

120 The tendon enthesis originates from a specific pool of hedge

121 Torn supraspinatus tendon (established pathology) and matched intact subsca

122 readmill exercise, whereas in Mkx(-/-) mice, tendons failed to respond to the same mechanical stimula

123 collagen in mechanically stretched rat tail tendon fascicle.

124 As relative tendon fat content decreased with treatment, relative wa

125 eter, followed by tendon volume and relative tendon fat content.

126 those of stem/progenitor cells isolated from tendon fibers.

127 Here we compared chick tendon fibroblasts (CTFs) at three stages of embryonic d

128 Recent work has shown how tendon fibroblasts (tenocytes) interact with muscles via

129 ping murine enthesis that were distinct from tendon fibroblasts and epiphyseal chondrocytes.

130 Linear combinations of whole muscle-tendon force and the first time derivative of force (dF/

131 ry contraction isometric torque and patellar tendon force were significantly lower; (ii) muscle fibre

132 e an overview of the functions of the ECM in tendon formation and maturation that attempts to integra

133 significantly decreased by 25% in the whole tendon (from baseline to 10 days after ciprofloxacin int

134 nderlying the age-dependent deterioration of tendon function remains very limited.

135 NA knockdown to evaluate factors involved in tendon generation, we demonstrated that the FAK/ERK1/2 s

136 Notably, the tendons grow to normal size and collagen fibril release

137 Whereas the biomechanical properties of tendons have been studied extensively, the molecular mec

138 Damaged tendons heal poorly and frequently undergo unpredictable

139 the cell and molecular mechanisms regulating tendon healing are poorly understood.

140 fectively corrected the insufficiency of the tendon healing capacity.

141 e significantly improves functional Achilles tendon healing in a rabbit model, resulting in increased

142 em/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling.

143 PRP samples, which indicates improved early tendon healing.

144 SCs that are likely associated with improved tendon healing.

145 underlying regenerative vs non-regenerative tendon healing.

146 s significantly attenuated in CTGF-delivered tendon healing.

147 so linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration.

148 periment to microarray and RNA-seq data from tendon identified gender specific gene expression change

149 anical and histologic changes of the healing tendon in a transected rabbit model of the Achilles tend

150 years +/- 9) were compared with 20 Achilles tendons in 10 control subjects without FH (two men, eigh

151 his strategy for the regeneration of injured tendons in a rat model.

152 ate, sesamoids are thought to develop inside tendons in response to mechanical signals from the attac

153 ts of tendons develop despite the absence of tendons in the autopod.

154 response forms adhesions between the flexor tendons in the hand and surrounding tissues, resulting i

155 The tendons in the turkey leg have specific well-defined are

156 have been widely used to assess muscles and tendons in vitro since the early parts of the twentieth

157 contrast, activation of mTORC1 signaling in tendons increased tendon cell numbers and proliferation.

158 ovel therapeutic strategy to resolve chronic tendon inflammation.

159 Moreover, a subset of extensor tendons initially form as fused structures due to initia

160 Finally, finger lesions, including closed-tendon injuries (mallet and boutonniere injuries, jersey

161 Tendon injuries heal via scar tissue rather than regener

162 tion of inflammation during healing of acute tendon injuries.

163 Tendon injury during limb motion is common.

164 turnover which may contribute to age-related tendon injury.

165 ths (116 au +/- 10), as observed also at the tendon insertion (baseline, 10 days after ciprofloxacin

166 y used for the treatment of posterior tibial tendon insufficiency or chronic Achilles tendinopathy.

167 For tendon integrity, no significant difference in MTSWV was

168 SWV findings were compared with tendon integrity, tendon retraction (Patte classificatio

169 ical system (i.e., resonance tuning), muscle-tendon interactions resulting in spring-like behavior em

170 walking, running, hopping) identified muscle-tendon interactions that cycle large amounts of energy i

171 Tendon is a simple aligned fibre composite, consisting o

172 Tendon is composed of fascicles bound together by the in

173 support a model where the shape and size of tendon is determined by the number and position of embry

174 cis longus tendon or flexor digitorum longus tendon is frequently used for the treatment of posterior

175 the diaphragm muscle, the diaphragm central tendon is reduced in size, likely contributing to reduce

176 in vitro functional models of cartilage and tendon is retarding progress in this field.

177 and kinetic data are used to estimate muscle-tendon lengths, muscle moment arms, and joint moments wh

178 e, the OAF displays a deficiency of multiple tendon/ligament-related genes, a smaller OAF collagen fi

179 aminoproprionitrile (BAPN) to inhibit LOX in tendon-like constructs (prepared from human tenocytes),

180 a negative regulator of skeletal muscle and tendon mass.

181 harvesting the flexor hallucis longus (FHL) tendon may cause nerve injury.

182 ntrol allowed observation of emergent muscle-tendon mechanics resulting from dynamic interaction of n

183 e resulting changes in in vivo soleus muscle-tendon mechanics using ultrasonography.

184 ollagen fibers and neovascularization in the tendon midsubstance.

185 The proposed tendon model independently predicts rates of collagen fi

186 lytic fiber damage are incorporated into our tendon model.

187 As an alternative, we posit that the muscle-tendon morphology of the human leg has evolved to maximi

188 man tendon cells were derived from hamstring tendon obtained during ACL reconstruction.

189 gth and orientation, form within the central tendon of Abl2(+/-) mice.

190 gnal and the GAG CEST effect in the Achilles tendon of healthy volunteers.

191 ally, then attached to the fabella or to the tendon of the lateral head of the gastrocnemius and blen

192 ene expression patterns were similar between tendons of both genotypes.

193 es the structure and function of muscles and tendons of larger animals.

194 phy with histologic results in common flexor tendons of the elbow in human cadavers.

195 The long tendons of the limb extend from muscles that reside in t

196 le macaques at age 1 month by sectioning the tendons of the medial recti.

197 e in living collagen-based materials such as tendon or bone.

198 The transfer of the flexor hallucis longus tendon or flexor digitorum longus tendon is frequently u

199 nd/or calcifications in less than 30% of the tendon; or grade 3, hypoechoic areas and/or calcificatio

200 eptors innervating muscle spindles and Golgi tendon organs in mice.

201 t anatomy, such as the bone surface anatomy, tendon orientation, nerves, and vessels, is crucial for

202 FGF or VEGF from weeks 4 to 6 in the treated tendons (p < 0.05 or p < 0.01), (2) significantly promot

203 The associated optimal muscle-tendon parameter sets allow us to estimate the forces an

204 end on the dynamic properties of muscles and tendons, particularly their force-length relations.

205 The digital flexor tendons passed through cartilages, cartilaginous cristae

206 strate the human body's capacity to adapt to tendon pathology and provide the physiological basis for

207 Overall, the muscle and tendon phenotype of myostatin-deficient rats was markedl

208 igate the molecular changes underlying these tendon phenotypes.

209 e qualitative and quantitative insights into tendon physiology and pathology.

210 hanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad)

211 eugopod and connect through short anlagen of tendon progenitors at the presumptive wrist to their res

212 To study adaptation of tendon properties to applied load, our model musculotend

213 astin localises to the IFM of energy storing tendons, reducing in quantity and becoming more disorgan

214 ithout weakness, muscle atrophy or increased tendon reflexes suggests a benign fasciculation syndrome

215 leptic encephalopathy, clubfoot, absent deep tendon reflexes, extrapyramidal symptoms, and persistent

216 , distal sensory loss, as well as diminished tendon reflexes.

217 these results establish an exciting model of tendon regeneration and uncover a novel cellular mechani

218 Here, we establish a novel model of tendon regeneration using neonatal mice and show that ne

219 r cells by CTGF delivery successfully led to tendon regeneration with densely aligned collagen fibers

220 nous stem/progenitor cells as a strategy for tendon regeneration without cell transplantation and sug

221 Here we develop a computational model of tendon remodeling based on the premise that mechanical d

222 oach to understanding the complex process of tendon remodeling in vivo, given these findings, it appe

223 e 3 collagen (Col3) synthesis and thus early tendon remodelling.

224 molecular functions of extrinsic tissues in tendon repair are not fully understood.

225 progenitor cell properties and contribute to tendon repair by activating Hedgehog signaling.

226 xtrinsic and intrinsic tissues contribute to tendon repair, but the origin and molecular functions of

227 Transplantation of sheath tissues improves tendon repair.

228 Hh signaling in extrinsic sheath tissues for tendon repair.

229 impaired gliding function in EP4cKO(S100a4) tendon repairs.

230 pathology) and matched intact subscapularis tendon (representing 'early pathology') along with contr

231 indings were compared with tendon integrity, tendon retraction (Patte classification), fatty muscle i

232 For tendon retraction, MTSWV varies significantly between pa

233 resumptive wrist to their respective autopod tendon segment, thereby initiating musculoskeletal integ

234 ms govern the growth of autopod and zeugopod tendon segments.

235 Here we show that tendon sheath cells harbor stem/progenitor cell properti

236 acromial-subdeltoid bursa/long head of bicep tendon sheath effusion (44.4%), and long head of bicep t

237 ath effusion (44.4%), and long head of bicep tendon sheath effusion only (40%).

238 Osteocalcin (Bglap) can be used as an adult tendon-sheath-specific marker in mice.

239 tor (CTGF) into full-transected rat patellar tendons significantly increased the number of CD146(+) T

240 stretch and tension experienced by muscles, tendons, skin and joints.

241 Tendon softening assessed by using SWE appeared to be hi

242 WE helped to confirm and quantify pathologic tendon softening in patients with tendonopathy in the mi

243 Tendon softening was a sign of tendonopathy in relaxed A

244 a 'neo-tendon' that differentiates along the tendon specific lineage with functional restoration of g

245 xperiences and resists physical forces, with tendon-specific mesenchymal cells called tenocytes orche

246 We show that Mohawk (Mkx), a tendon-specific transcription factor, is essential in me

247 We report that mohawk homeobox (Mkx), a tendon-specific transcription factor, regulates PDL home

248 tendon cells that was positive for the known tendon stem cell marker CD146 and exhibited clonogenic c

249 Tendon stem/progenitor cells (TSCs) have been found in d

250 Tendon stem/progenitor cells regulate inflammation in te

251 oliferation, and (3) significantly increased tendon strength by 68-91% from week 2 after AAV2-bFGF tr

252 tor and renal sympathetic nerve responses to tendon stretch, a purely mechanical stimulus, but had no

253 endon composition and turnover contribute to tendon structure-function relationships and the effects

254 However the IFM is poorly defined, therefore tendon structure-function relationships are incompletely

255 mpartment, which may act to maintain healthy tendon structure.

256 ble that the mechanical properties of muscle-tendon systems also affect its generation, amplification

257 e was 71% higher (42.0% +/- 6.7) in xanthoma tendons than in control tendons (24.5% 6 5.8; P < .001).

258 ent were significantly higher in PRP-treated tendons than in controls (p=0.01 and p<0.001, respective

259 re the hypothesis that regions of the turkey tendon that are associated with mineralization exhibit d

260 w that neonates heal via formation of a 'neo-tendon' that differentiates along the tendon specific li

261 merged with fibers from the semimembranosus tendon, the other originated from the posteromedial part

262 with homogeneous fibrillar pattern; grade 2, tendon thickening or hypoechoic areas and/or calcificati

263 don defects postnatally, including decreased tendon thickness, indicating that mTORC1 is necessary fo

264 Tendon tissue biopsy samples were obtained from 20 patie

265 ied PRP enhanced the maturity of the healing tendon tissues by promoting better collagen I deposition

266 Reattachment and healing of tendon to bone poses a persistent clinical challenge and

267 properties of the load-bearing connection of tendon to bone rely on an intricate interplay of its bio

268 We explain how these processes enable the tendon to geometrically adapt to its load conditions.

269 chemical response of ruptured human Achilles tendon to PRP.

270 one surgical repairs is direct attachment of tendon to smooth bone.

271 We performed RNA-seq analysis using Achilles tendons to investigate the molecular changes underlying

272 uences the development and maturation of the tendon-to-bone attachment (enthesis).

273 Results further suggested that the natural tendon-to-bone attachment presents roughness for which t

274 ause the mechanisms that imbue the uninjured tendon-to-bone attachment with toughness are not known.

275 s may serve to increase the toughness of the tendon-to-bone insertion site at the expense of its stre

276 One feature of typical tendon-to-bone surgical repairs is direct attachment of

277 Mice underwent hindlimb Achilles' tendon transection and dorsal burn injury (burn/tenotomy

278 issues was noted 2 weeks after injury at the tendon transection sites when compared with the contrala

279 Tendons transmit contractile forces between musculoskele

280 nvestigate the response of ruptured Achilles tendon treated with PRP.

281 The muscle-tendon unit on the tendinotic side exhibits a lowered te

282 When paired with tACS, muscle tendon vibration also induced elevations of CSE.

283 g treatment, only MR imaging measurements of tendon volume (P = .007), relative fat (P = .041), and r

284 as the most sensitive parameter, followed by tendon volume and relative tendon fat content.

285 Tendinosis of the long head of bicep tendon was commoner in hemiplegic shoulders with poor mo

286 teinase (MMP)-3 expression in CTGF-delivered tendon was organized along with the reorienting collagen

287 The mean GAG CEST value in the whole tendon was parallel to the sodium signal with a decrease

288 rease in lipid deposits in aged and Sparc-/- tendons was observed.

289 For depicting treatment change, relative tendon water content was the most sensitive parameter, f

290 amount of bFGF or VEGF intrinsically in the tendon, we effectively corrected the insufficiency of th

291 erials and Methods Twenty-five common flexor tendons were evaluated in 16 fresh, unembalmed cadavers

292 e, and fat-water separation) of the Achilles tendons were obtained at baseline and in patients with F

293 r at least 3 months with intact rotator cuff tendons, were eligible for arthroscopic surgery, and had

294 Achilles tendon, when degenerated, exhibits lower stiffness.

295 n whole tendons and identified in regions of tendon which are destined to become rapidly mineralized

296 We hypothesize that the degenerated tendon will lead to diminished tissue mechanical propert

297 S results were classified as grade 1, normal tendon with homogeneous fibrillar pattern; grade 2, tend

298 Materials and Methods Forty-eight Achilles tendons with clinically apparent xanthomas in 24 patient

299 nvestigate the fat-water content of Achilles tendon xanthomas at baseline and after treatment and to

300 nclusion Most of the enlargement of Achilles tendon xanthomas is due to an increase in water content