ライフサイエンスコーパス: tens of thousands of

1 The lack of cumulative damages even from tens of thousands of 12-ns stimuli and the similarities

2 5 meters of slackwater sedimentation, behind tens of thousands of 17th- to 19th-century milldams, bur

3 regression models, to survey the dynamics of tens of thousands of 3' UTR sequences during early zebra

4 tributed computing implementation to produce tens of thousands of 5-20-ns trajectories (700 micros) t

5 Tens of thousands of A-to-I editing events are defined i

6 erations reside in a cancer genome alongside tens of thousands of additional mutations termed passeng

7 atomic structure of a protein was revealed, tens of thousands of additional structures have been sol

8 ividualized approach can potentially prevent tens of thousands of adverse cardiovascular events in th

9 ic cDNA libraries cloned into pCAST produced tens of thousands of ampicillin-resistant clones, 80% of

10 teins, and yet their neutralization requires tens of thousands of antibodies per virion, leading us t

11 We have decoded tens of thousands of arrays, each with 1520 sequences re

12 or drug discovery and evaluation by allowing tens of thousands of assays to be completed in 1 day.

13 clustering analysis with cross-validation on tens of thousands of atom volumes and attempt to compile

14 so often large, containing thousands or even tens of thousands of atoms, the computational difficulty

15 rentiated into neurons and glia and extended tens of thousands of axons from the lesion site over vir

16 t the regulatory sequences of a gene are, as tens of thousands of base pairs flanking the gene of int

17 ained for both short (a few bases) and long (tens of thousands of base pairs) DNA fragments.

18 e contains sizeable regions (stretching over tens of thousands of base pairs) that have intrinsically

19 ingle PKA molecule extending over 10 min and tens of thousands of binding events, we determine the fu

20 Tens of thousands of biomedical journals exist, and the

21 Recent monitoring has shown that tens of thousands of birds land on ponds containing this

22 This technique has been used to characterize tens of thousands of C. difficile isolates from cases of

23 By measuring tens of thousands of capturing events, we build the dist

24 gene-centric genotyping studies that involve tens of thousands of cases and controls have now mapped

25 nternational collaborative efforts involving tens of thousands of cases and controls, more than 100 a

26 sive unwinding of a DNA molecule, comprising tens of thousands of catalytic steps, each of which is m

27 ted three different ECS geometries involving tens of thousands of cells and performed Monte Carlo sim

28 us xanthus requires the ordered migration of tens of thousands of cells by using a form of surface mo

29 ed rate: in a single experiment, potentially tens of thousands of cells can be stimulated for high st

30 When they sense starvation, tens of thousands of cells change their movement pattern

31 When starved, tens of thousands of cells change their movement pattern

32 pe were able to form tumors in mice, whereas tens of thousands of cells with alternate phenotypes fai

33 f confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail inacc

34 ry small samples, on a scale of thousands or tens of thousands of cells.

35 The mammalian genome contains tens of thousands of CG and TG repeat sequences that hav

36 To cope with the tens of thousands of chemical lesions introduced into th

37 n a rapid and efficient manner the more than tens of thousands of chemicals in current use.

38 Of the tens of thousands of chemicals in use, only a small frac

39 t at home and at work, humans are exposed to tens of thousands of chemicals, many of which have not b

40 l to avert several million malaria cases and tens of thousands of childhood deaths each year if succe

41 methods that (1) enable easy maintenance of tens of thousands of Chlamydomonas strains by propagatio

42 ual screening of ligand libraries containing tens of thousands of compounds.

43 id ranking of large ensemble data comprising tens of thousands of conformations.

44 al metazoan transcriptome containing several tens of thousands of contigs can be annotated in a few m

45 We demonstrate our approach using tens of thousands of control subjects from studies of Cr

46 present evidence that Epulopiscium contains tens of thousands of copies of its genome.

47 on (NCBI), HMMER, and MUSCLE; scaled them to tens of thousands of cores on high-performance computing

48 Structural information over volumes of tens of thousands of cubic micrometers is possible, reve

49 cRNAs reveals 233 constrained lncRNAs out of tens of thousands of currently annotated transcripts, wh

50 trodes is demonstrated by performing several tens of thousands of cycles of device operation.

51 r mechanical components, and can operate for tens of thousands of cycles without failure.

52 ly hazardous pesticides is likely to prevent tens of thousands of deaths every year.

53 bosis is a common disease process leading to tens of thousands of deaths per year.

54 nology capable of simultaneously quantifying tens of thousands of defined mRNA species in a miniaturi

55 suring the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP.

56 A typical mammalian cell contains tens of thousands of different gene products.

57 magnitude as that of proteins: cells express tens of thousands of different lipids and hundreds of pr

58 The system can print tens of thousands of different solutions at high speed,

59 reviously thought and some genes may produce tens of thousands of different transcripts.

60 n avoids sample loss: Samples are split into tens of thousands of discrete volumes with close to 100%

61 We detected tens of thousands of disease-causing mutations, includin

62 as produced gene expression measurements for tens of thousands of distinct cell perturbations using a

63 Although DCs express tens of thousands of distinct MHC-II, very small amounts

64 Tens of thousands of distinct molecular species are iden

65 le ubiquitin experiment for the detection of tens of thousands of distinct ubiquitination sites from

66 hysiological setting, a typical APC presents tens of thousands of diverse endogenous self-derived pep

67 h is a pathway responsible for the repair of tens of thousands of DNA lesions per cell per day.

68 DNA microarrays are used to quantify tens of thousands of DNA or RNA sequences in a single as

69 n multiple traits, thousands of families and tens of thousands of DNA sequences.

70 tmosphere, which may render a bottle costing tens of thousands of dollars worthless for later resale

71 ent screens yielded DNA-binding profiles for tens of thousands of domains and led to the successful d

72 This process produced tens of thousands of electrochemical measurements at dif

73 Recent surveys suggest tens of thousands of elephants are being poached annuall

74 We mapped tens of thousands of endogenous RNA-RNA interactions fro

75 of the first plant species was revealed, the tens of thousands of endogenous small RNA species as we

76 , e.g. 20-50 bases, from a large database of tens of thousands of ESTs: (i) selection of oligos each

77 ally sophisticated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites.

78 of thousands of excess hospitalizations, and tens of thousands of excess deaths.

79 e observed contractions of clouds containing tens of thousands of excitons within areas as small as (

80 Tens of thousands of exons were found to be polymorphica

81 solution from weeks to hours, for processing tens of thousands of experimental spectra.

82 polymerase replication errors could generate tens of thousands of false-positive calls per genome.

83 e thrust fault along the range front causing tens of thousands of fatalities and widespread damage, i

84 This provides tens of thousands of features for measuring background i

85 ed metabolomics, it is now routine to detect tens of thousands of features from biological samples.

86 It is built from tens of thousands of flagellin monomers in a self-assemb

87 within one week can organize a field of many tens of thousands of follicles, generating long-range or

88 Analysis of the tens of thousands of fragmentation spectra produced by a

89 of human DISC1 via solubility assessment of tens of thousands of fragments of recombinant DISC1.

90 functions, or do so in a manner scalable to tens of thousands of functions in the human catalog.

91 imaging have created new large datasets with tens of thousands of gene expression images.

92 ays is to discover genomic biomarkers, among tens of thousands of genes assayed, for disease classifi

93 e possible the assay of expression levels of tens of thousands of genes at a time; large databases of

94 icroarray technology, the mRNA expression of tens of thousands of genes can be measured simultaneousl

95 ulti-level mixed effects model that analyzes tens of thousands of genes efficiently.

96 ys, which determine the expression levels of tens of thousands of genes from a sample, are an importa

97 y experiments typically analyze thousands to tens of thousands of genes from small numbers of biologi

98 ences of several complex eukaryotic genomes, tens of thousands of genes have been predicted.

99 ed biologists to quantify gene expression of tens of thousands of genes in a single experiment.

100 ble of profiling gene expression patterns of tens of thousands of genes in a single experiment.

101 ign by providing expression measurements for tens of thousands of genes simultaneously via the abunda

102 experiments, which examine the expression of tens of thousands of genes simultaneously, the number of

103 ene expression (messenger RNA abundance) for tens of thousands of genes simultaneously.

104 apable of solving biclustering problems with tens of thousands of genes under up to thousands of cond

105 imultaneous measurement of the expression of tens of thousands of genes, has become an important tool

106 can provide information on the expression of tens of thousands of genes.

107 y scalable to the simultaneous monitoring of tens of thousands of genes.

108 WAS) have been used to successfully identify tens of thousands of genetic variants associated with co

109 e association studies (GWAS) have identified tens of thousands of genetic variants associated with hu

110 on Epulopiscium sp. type B, which maintains tens of thousands of genome copies throughout its life c

111 SEER is applicable to tens of thousands of genomes by counting variable-length

112 netics and comparative biology by delivering tens of thousands of genomes in the near future.

113 human preimplantation embryos and found that tens of thousands of genomic loci exhibited de novo DNA

114 lex shRNA libraries, parallel measurement of tens of thousands of GIs from a single double-shRNA expe

115 membrane of liposomes, which can accommodate tens of thousands of glucose molecules, the sensitivity

116 sure off-target cutting, we demonstrate with tens of thousands of guides both the nucleotide position

117 scopy, we are able to image distributions of tens of thousands of HA molecules with subdiffraction re

118 phasing of these deletions with the flanking tens of thousands of heterozygous SNPs and indels.

119 The analysis provided tens of thousands of high-confidence predictions of poly

120 Neurons receive tens of thousands of highly fluctuating inputs and gener

121 Here we statistically sample tens of thousands of homeostatic vesicle traffic network

122 Over a typical career piano tuners spend tens of thousands of hours exploring a specialized acous

123 s of somatic mutations will be generated for tens of thousands of human cancers.

124 In the past 15 years alone, RVFV caused tens of thousands of human cases, hundreds of human deat

125 structure, summarizing the design efforts of tens of thousands of human participants and three automa

126 First, multiplicity arises due to testing tens of thousands of hypotheses, rendering the standard

127 ppb on petroleum-based mixtures that contain tens of thousands of identified peaks.

128 olumes from single living cells encompassing tens of thousands of image frames.

129 We employed HTGTS to identify tens of thousands of independent translocation junctions

130 end out daily foraging columns consisting of tens of thousands of individual ants.

131 mental compositions in mixtures that contain tens of thousands of individual components (crude oil).

132 nt of high-precision micro-models containing tens of thousands of individual elements.

133 a large-sample exome-sequencing data set of tens of thousands of individuals assayed at a few hundre

134 me-wide association studies (GWAS) including tens of thousands of individuals have identified 26 vari

135 s that allow screening of dozens of genes in tens of thousands of individuals with high specificity a

136 CJD are rare, there is evidence there may be tens of thousands of infectious carriers in the United K

137 Experimental screens have identified tens of thousands of interactions, and structural biolog

138 d works in two and three dimensions, handles tens of thousands of interfaces and separate phases, and

139 spectrometer, the quantitative comparison of tens of thousands of ions emanating from identically pre

140 to whole-genome bacterial characterization, tens of thousands of isolates have been spoligotyped, gi

141 Migratory birds can navigate over tens of thousands of kilometers with an accuracy unobtai

142 ss, can propagate into the plasmasphere from tens of thousands of kilometres away, and evolve into hi

143 al circuit mapping is generating datasets of tens of thousands of labeled neurons.

144 nks, which are globally established to store tens of thousands of lines from healthy and diseased don

145 imated that the largest aggregates contained tens of thousands of Lipid II molecules.

146 Sierra Leone's decade-long conflict has cost tens of thousands of lives and all parties to the confli

147 Liberia's wars since 1989 have cost tens of thousands of lives and left many people mentally

148 ntify Pol IV/RDR2-dependent transcripts from tens of thousands of loci.

149 t become clear that mammalian genomes encode tens of thousands of long non-coding RNAs (lncRNAs).

150 regulatory RNAs, such as microRNAs, but also tens of thousands of long noncoding RNAs that are differ

151 complex network of transcripts that includes tens of thousands of long noncoding RNAs with little or

152 ng immunoprecipitation) to accurately locate tens of thousands of m(6)A residues in mammalian mRNA wi

153 roughtput technologies enable the testing of tens of thousands of measurements simultaneously.

154 nce-specialized components, with each having tens of thousands of members or elements.

155 fy very large and diverse superfamilies with tens of thousands of members, without the need for an in

156 ive waveguide, the rhabdomere, consisting of tens of thousands of microvilli.

157 hwann cell transplant protocols remyelinated tens of thousands of millimeters of axon length and remy

158 ene dosage, and resistance or sensitivity to tens of thousands of molecular compounds.

159 units and distributed computing to simulate tens of thousands of molecular dynamics trajectories eac

160 Tens of thousands of molecules were prescreened and a se

161 ntly, we have applied these tools to analyze tens of thousands of motifs derived from hundreds of mic

162 uencing), a tool for simultaneous mapping of tens of thousands of mutagenic insertion sites in the eu

163 Laboratories around the world have produced tens of thousands of mutant and transgenic zebrafish lin

164 usands of disease-associated genes and their tens of thousands of mutations, especially for those car

165 The sarcomere of muscle is composed of tens of thousands of myosin motors that self-assemble in

166 a sample digitization method that generates tens of thousands of nanoliter-sized droplets in a high-

167 synthases construct the carbon skeletons of tens of thousands of natural products.

168 Experimental results on tens of thousands of ncRNA sequences available from the

169 e cerebral cortex, local circuits consist of tens of thousands of neurons, each of which makes thousa

170 ce the results of simulations in networks of tens of thousands of neurons.

171 Tens of thousands of new lenses are expected to be disco

172 These trees are often large (containing tens of thousands of nodes and edges), and need a visual

173 Tens of thousands of noisy two-dimensional images of the

174 We also identify tens of thousands of novel splicing events beyond those

175 This results in extensive transcription for tens of thousands of nucleotides beyond poly(A) sites an

176 bility of RCA to produce single-stranded DNA tens of thousands of nucleotides in length from a single

177 or gene expression profiling using arrays of tens of thousands of oligonucleotides synthesized in sit

178 Tens of thousands of packing structures for the TTF- and

179 of national initiatives across the world and tens of thousands of papers have been published in the a

180 ain are lobed integration centers made up of tens of thousands of parallel-projecting axons of intrin

181 oproducts without interference from the many tens of thousands of parent compounds in the oil.

182 major problem in our society, accounting for tens of thousands of patient deaths and millions of doll

183 onia vaccines are slow and costly, requiring tens of thousands of patients.

184 S (5 to 15% case-fatality rate) and afflicts tens of thousands of people annually.

185 Genetic analyses of brain measures from tens of thousands of people are being extended to test g

186 Health care-acquired infections (HAIs) kill tens of thousands of people each year and add significan

187 ulmonary fibrosis, and cardiac fibrosis kill tens of thousands of people each year in the U.S. alone.

188 mptom of rabies encephalitis, is suffered by tens of thousands of people each year.

189 In these assemblies, tens of thousands of peptides align with their N- and C-

190 lity complex (MHC) class I molecules display tens of thousands of peptides on the cell surface, deriv

191 t highly variable signal-to-noise ratios for tens of thousands of peptides.

192 sitive, and reproducible quantitation across tens of thousands of phosphopeptides.

193 We printed tens of thousands of picoliter aqueous droplets that bec

194 Remarkably, tens of thousands of piRNAs arise from a minimal number

195 ere concordant between platforms, there were tens of thousands of platform-specific calls located in

196 otyping now permits simultaneous analysis of tens of thousands of polymorphisms, and this technology

197 enome sequencing has led to the discovery of tens of thousands of potential new genes.

198 oprecipitation and sequencing, we identified tens of thousands of potential regulatory regions that a

199 -commensurate specific energy, and (iii) the tens of thousands of power-demanding duty cycles require

200 ly 840 different fragment acquisitions, with tens of thousands of predicted gene fragments inside Hel

201 ted women(2,4,5), these results suggest that tens of thousands of pregnancies could be negatively imp

202 ndeveloped countries, they still account for tens of thousands of premature deaths every year.

203 idence-scoring method that can be applied to tens of thousands of protein interactions, we have devel

204 Toward the goal of assigning function to the tens of thousands of protein products encoded by eukaryo

205 yotes, transcription of the diverse array of tens of thousands of protein-coding genes is carried out

206 fer powerful means to simultaneously examine tens of thousands of proteins in various samples, and un

207 teracts with roughly 10 others, resulting in tens of thousands of proteins known or suspected to have

208 ta-sheet, now known to form the backbones of tens of thousands of proteins.

209 om genome sequencing projects that introduce tens of thousands of proteins.

210 he isolation of soil organic matter in 1786, tens of thousands of publications have searched for its

211 Exposing the network to tens of thousands of random combinations of inputs and a

212 Worldwide, tens of thousands of refugees and former refugees resett

213 approaches has led to the identification of tens of thousands of replication origins throughout mamm

214 cture-seq experiment provides information on tens of thousands of RNA structures in approximately 1 m

215 in that most of the simulated scenarios show tens of thousands of routers infected in as little as 2

216 SNPRelate can analyse tens of thousands of samples with millions of SNPs.

217 mewide association studies of common SNPs in tens of thousands of samples, array-based resequencing h

218 As tens of thousands of sequence searches are performed dai

219 the following features: (i) pools containing tens of thousands of sequences can be generated from the

220 dium-scale data sets and can process several tens of thousands of sequences within a few minutes, whi

221 Performance metrics show scalability into tens of thousands of sequences, with options for scaling

222 le of demarcating ecotypes in data sets with tens of thousands of sequences.

223 apidly process phylogenetic trees containing tens of thousands of sequences.

224 energies of binding for several human TFs to tens of thousands of short DNA sequences with varying re

225 We have identified tens of thousands of short extrachromosomal circular DNA

226 istinguishing bona fide small genes from the tens of thousands of short ORFs is one of the most chall

227 s enabled identification of Cache domains in tens of thousands of signal transduction proteins includ

228 cell type or state by querying a database of tens of thousands of single cell profiles.

229 ased system that enables 3' mRNA counting of tens of thousands of single cells per sample.

230 ures of macromolecules to be determined from tens of thousands of single-particle cryo-EM images, rat

231 A large number (tens of thousands) of single molecular trajectories on a

232 For example, Myc binds to tens of thousands of sites in the human genome.

233 Doing this with tens of thousands of SNP markers, however, greatly incre

234 Tens of thousands of species are threatened with extinct

235 phylogenetic algorithms that can operate on tens of thousands of species in a reasonable amount of t

236 rategy that permits simultaneous analysis of tens of thousands of specimens.

237 o analyze atmospheric particles and generate tens of thousands of spectra from typical measurement ca

238 vered 25 years ago and has been the focus of tens of thousands of studies in diverse fields of biolog

239 nt of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans.

240 Tens of thousands of subjects may be required to obtain

241 ombine data from up to dozens of studies and tens of thousands of subjects.

242 k models powered from data sets representing tens of thousands of subjects.

243 ee classification of a large number of (e.g. tens of thousands) of subtomograms.

244 Although the rice genome contains tens of thousands of such elements, their actual role in

245 Tens of thousands of such microstates emerge even for th

246 Tens of thousands of such trait-associated SNPs have alr

247 escence, allowing high-throughput imaging of tens of thousands of synapses to assess synapse density

248 Pyramidal neurons receive tens of thousands of synaptic inputs on their dendrites.

249 ion to small, high-density arrays containing tens of thousands of synthetic oligonucleotides.

250 s spectrometers are now capable of producing tens of thousands of tandem mass (MS/MS) spectra per hou

251 xible and can be easily adapted to multiplex tens of thousands of target sequences in a single reacti

252 some of which enable estimates of trees with tens of thousands of taxa.

253 ible for phylogenetic datasets consisting of tens of thousands of taxa.

254 Tens of thousands of these events occur during the initi

255 rs there should be only a few large (several tens of thousands of times larger than those on the Sun)

256 or example, regulatory genes are transcribed tens of thousands of times per cell cycle.

257 Tens of thousands of tonnes of cyclic volatile methylsil

258 starting point for a future process in which tens of thousands of tonnes of wastewater could be treat

259 surface was estimated to be on the order of tens of thousands of tons, far less than expected.

260 tumor, and the Agilent microarrays carrying tens of thousands of total RNA samples in the MAQC proje

261 array experiments allow the interrogation of tens of thousands of transcripts simultaneously and thus

262 ultaneous monitoring of expression levels of tens of thousands of transcripts.

263 ufosinate have been used to generate several tens of thousands of transformed plants.

264 Tens of thousands of transfusion-dependent (eg, thalasse

265 Libraries of tens of thousands of transposon mutants generated from e

266 oinformatic analyses have recently uncovered tens of thousands of unique circular (circ)RNAs, but the

267 alton, three-dimensional nanostructures from tens of thousands of unique components, including a 0.5-

268 cient for high-dimensional data that include tens of thousands of variables for making inference.

269 lows for the global and unbiased analysis of tens of thousands of virus trajectories in live cells.

270 comprised of hundreds of players, operating tens of thousands of wells across 30 states.

271 It is only around 40,000 y ago, tens of thousands of years after anatomically modern hum

272 sulfate are available for the very first few tens of thousands of years after the onset of the meltdo

273 n in natural selection, a process that began tens of thousands of years ago.

274 me arc volcanic centers have been active for tens of thousands of years and show evidence for the con

275 was likely eruptible for periods of several tens of thousands of years or more with punctuated erupt

276 ulosis has succeeded as a human pathogen for tens of thousands of years thanks to its ability to resi

277 the reference human and personal genomes (in tens of thousands of years), and (iii) structurally alte

278 urishment of animals and humans for at least tens of thousands of years, are often absent from today'

279 Clicks may have persisted for tens of thousands of years, independently in multiple po

280 y have co-evolved with human populations for tens of thousands of years, or even with our primate anc

281 lutionary relations require a perspective of tens of thousands of years, whereas other changes are ob

282 obably had a minimum duration of hundreds to tens of thousands of years.

283 ology, growth rate, and survival outcomes of tens of thousands of yeast microcolonies simultaneously.

284 Every year, suicide claims the lives of tens of thousands of young people worldwide.