ライフサイエンスコーパス: tensin

1 We also showed expression of tensin 1 during valve morphogenesis and describe enlarge

2 kdown of the ortholog of TNS1, which encodes tensin 1, a focal adhesion protein involved in cytoskele

3 und that MSI1 directly binds to the 3'UTR of Tensin 3 (TNS3) mRNA, a negative regulator of cell migra

4 Knockdown (KD) of tensin 4 (TNS4), a particularly highly upregulated gene,

5 Independently, Tensin-4 (TNS4) is emerging as a putative oncogene in ma

6 s ability to bind several ligands, including tensin and talin.

7 ts Rho-GAP activity, and its ability to bind tensin and talin.

8 mote rapid FA elongation and maturation into tensin-containing fibrillar FAs in the cell center.

9 hat p17 positively regulates phosphatase and tensin deleted on chromosome 10 (PTEN), AMP-activated pr

10 o Rho-GAP through DLC1 and suggests that the tensin-DLC1-RhoA signaling axis plays an important role

11 study therefore links dynamic regulation of tensin family members by EGF to Rho-GAP through DLC1 and

12 Su Hao Lo provides an introduction to the tensin family of focal adhesion proteins.

13 al adhesion molecule that is a member of the tensin family.

14 focal adhesion molecule and a member of the tensin family.

15 pecific conditional TSC1 and phosphatase and tensin homlog knock-out mice, both of which display aber

16 al cell-specific deletion of Phosphatase and tensin homolog (K14-CreER;Pten(fl/fl)) develops prostate

17 Furthermore, RA reduces phosphatase and tensin homolog (Pten) accumulation in migrating cells, w

18 ated protein 53 (Trp53), and phosphatase and tensin homolog (Pten) allowed the generation of 3 murine

19 Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT sig

20 and nuclear translocation of phosphatase and tensin homolog (PTEN) and FOXO 3a.

21 icted targets of miR-486 are phosphatase and tensin homolog (PTEN) and Foxo1a, which negatively affec

22 s contain a reduced level of phosphatase and tensin homolog (PTEN) and increased Akt1 activation coup

23 is model was validated using phosphatase and tensin homolog (PTEN) and its ceRNA VAMP (vesicle-associ

24 Phosphatase and tensin homolog (PTEN) and mothers against decapentaplegi

25 B cells express phosphatase and tensin homolog (PTEN) and multiple isoforms of class IA

26 However, the phosphatase and tensin homolog (Pten) and neurofibromatosis 1 (Nf1) gene

27 ack loop circuit mediated by phosphatase and tensin homolog (PTEN) and PDZ and LIM domain 2 (PDLIM2).

28 on with the up-regulation of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signali

29 Levels of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signali

30 SCRIB interacts with phosphatase and tensin homolog (PTEN) and the expression of P305L, but n

31 and Nedd4-2 may ubiquitinate phosphatase and tensin homolog (PTEN) and thereby regulate axonal growth

32 that tumors deficient of the phosphatase and tensin homolog (PTEN) are often dependent on the p110bet

33 We identified phosphatase and tensin homolog (PTEN) as a novel target of miR-132 and d

34 ated with phosphorylation of phosphatase and tensin homolog (PTEN) at residues Ser380/Thr382/383.

35 ys cross-talk through a Hes1-phosphatase and tensin homolog (PTEN) axis during normal T-cell developm

36 The phosphatase and tensin homolog (PTEN) can function as a dual specificity

37 vasive adenocarcinoma in the phosphatase and tensin homolog (Pten) conditional deletion model of pros

38 ary tumorigenesis induced by phosphatase and tensin homolog (Pten) deletion in mice.

39 is associated with increased phosphatase and tensin homolog (PTEN) expression, which inhibits Src, an

40 ell types, and cells lacking phosphatase and tensin homolog (PTEN) function were relatively resistant

41 g in mice by deletion of the phosphatase and tensin homolog (Pten) gene (which regulates the levels o

42 Mutations in the human phosphatase and tensin homolog (PTEN) gene cause PTEN hamartoma tumor sy

43 n which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated.

44 A reduction in phosphatase and tensin homolog (PTEN) has been shown to be involved in a

45 Germline mutations in phosphatase and tensin homolog (PTEN) have been recently reported in 23%

46 sion of the tumor suppressor phosphatase and tensin homolog (PTEN) in 248 primary DLBCL patient sampl

47 Deletion of phosphatase and tensin homolog (PTEN) in adult CNS neurons promotes rege

48 presses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle.

49 n levels of tumor suppressor phosphatase and tensin homolog (PTEN) in drug-induced gingival overgrowt

50 strated that genetic loss of phosphatase and tensin homolog (PTEN) in mammary fibroblasts induces an

51 ted that genetic deletion of phosphatase and tensin homolog (PTEN) in mouse corticospinal neurons rea

52 loss of the PI3K antagonist phosphatase and tensin homolog (PTEN) in myeloid cells renders APCs towa

53 tion of the tumor suppressor phosphatase and tensin homolog (Pten) in retinal ganglion cells (RGCs),

54 protein kinase 1 (Pdk1) and phosphatase and tensin homolog (Pten) in the male germ line, we found th

55 ditional genetic deletion of phosphatase and tensin homolog (PTEN) in the sensorimotor cortex of neon

56 cause the lipid phosphatase, phosphatase and tensin homolog (PTEN) inhibits Akt, we generated a mouse

57 t that UVB exposure triggers phosphatase and tensin homolog (PTEN) interaction with wild-type (WT), b

58 Phosphatase and tensin homolog (PTEN) is a critical negative regulator o

59 Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counter

60 The tumor suppressor phosphatase and tensin homolog (PTEN) is a key inhibitor of the protein

61 Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab

62 Phosphatase and tensin homolog (PTEN) is a major negative regulator of n

63 Phosphatase and tensin homolog (PTEN) is a negative regulator of the pho

64 Phosphatase and tensin homolog (PTEN) is a phosphoinositide lipid phosph

65 Phosphatase and tensin homolog (PTEN) is a tumor suppressor and a guardi

66 nd that the tumor suppressor phosphatase and tensin homolog (PTEN) is an important regulator of the h

67 en when the tumor suppressor phosphatase and tensin homolog (PTEN) is deleted to enhance intrinsic gr

68 vity of the tumor suppressor phosphatase and tensin homolog (PTEN) is enhanced by the presence of its

69 Phosphatase and tensin homolog (PTEN) is one of the molecular pathways i

70 Phosphatase and tensin homolog (PTEN) is one of the most frequently muta

71 Phosphatase and tensin homolog (PTEN) loss or activating mutations of ph

72 of chromosomal instability, phosphatase and tensin homolog (PTEN) loss, and E2F3 transcription facto

73 y on liver tumors induced by phosphatase and tensin homolog (Pten) loss.

74 ilizing the tumor-suppressor phosphatase and tensin homolog (PTEN) mRNA via a mechanism that is indep

75 oson mutagenesis screen in a phosphatase and tensin homolog (Pten) mutant mice and identified 12 cand

76 Germline phosphatase and tensin homolog (PTEN) mutations cause Cowden syndrome (C

77 Phosphatase and tensin homolog (PTEN) negatively regulates downstream pr

78 n a twofold reduction of the phosphatase and TENsin homolog (PTEN) phosphatase expression and modulat

79 he miR-17-92 cluster reduced phosphatase and tensin homolog (PTEN) proteins and elevated phosphorylat

80 We find here, using the phosphatase and tensin homolog (PTEN) pseudogene as a model system, that

81 bition of negative regulator phosphatase and tensin homolog (PTEN) resulted in increased pDC numbers

82 en the 5-HT(2C)R and protein phosphatase and tensin homolog (PTEN) serves as a regulatory mechanism t

83 though the lipid phosphatase phosphatase and tensin homolog (PTEN) suppresses Akt activity, the contr

84 from a point mutation in the phosphatase and tensin homolog (PTEN) tumor suppressor protein.

85 factor receptor, loss of the phosphatase and tensin homolog (PTEN) tumor suppressor, and KRAS mutatio

86 mice haplodeficient for the phosphatase and tensin homolog (Pten) tumor-suppressor gene.

87 Moreover, deletion of phosphatase and tensin homolog (Pten) upregulated mTORC2 activity and en

88 e phosphatase 1B (PTP1B) and phosphatase and tensin homolog (PTEN) were found in hepatocytes treated

89 and further inactivation of phosphatase and tensin homolog (PTEN) yields GBM.

90 Phosphatase and tensin homolog (PTEN)(shRNA) negatively regulated PAX2 e

91 ther enhanced by deletion of phosphatase and tensin homolog (PTEN), a mechanistic target of rapamycin

92 brain and mTORC1, along with Phosphatase and tensin homolog (Pten), a negative regulator of PI3K.

93 Phosphatase and tensin homolog (PTEN), a negative regulator of the mamma

94 ccurs is by silencing of the phosphatase and tensin homolog (PTEN), a tumor suppressor and major anta

95 represses the expression of phosphatase and tensin homolog (PTEN), a tumor suppressor gene, by recru

96 Phosphatase and tensin homolog (PTEN), a tumor suppressor that antagoniz

97 Somatic loss of phosphatase and tensin homolog (PTEN), a tumor suppressor that counterac

98 horylation, higher levels of phosphatase and tensin homolog (PTEN), and diminished Akt phosphorylatio

99 n phosphatase 2A (PP2A), and phosphatase and tensin homolog (PTEN), are commonly inactivated in prost

100 vels of the tumor suppressor phosphatase and tensin homolog (PTEN), both directly and indirectly by d

101 g the tumor-suppressor genes phosphatase and tensin homolog (PTEN), cyclin dependent kinase inhibitor

102 me that dephosphorylates it, phosphatase and tensin homolog (PTEN), is an important tumor suppressor.

103 Three other (phosphatase and tensin homolog (PTEN), myristoylated alanine-rich protei

104 f the tumor suppressor gene, phosphatase and tensin homolog (PTEN), occurs in 10% of melanoma specime

105 1 transcriptionally silences phosphatase and tensin homolog (PTEN), resulting in AKT activation, whic

106 xidation and deactivation of phosphatase and tensin homolog (PTEN), resulting in upregulation of PtdI

107 oma tumor suppressor protein phosphatase and tensin homolog (PTEN), suggesting that STAT3 regulates i

108 by directly down-regulating phosphatase and tensin homolog (PTEN), thereby promoting phosphorylation

109 (2+)-mediated degradation of phosphatase and tensin homolog (PTEN), which impaired intercellular junc

110 lated AKT, and downregulates phosphatase and tensin homolog (PTEN), which is involved in suppressing

111 Phosphatase and tensin homolog (PTEN), which negatively regulates tumori

112 regulate the activity of the phosphatase and tensin homolog (PTEN), which plays a critical role in ne

113 astoma, promotes invasion in phosphatase and tensin homolog (PTEN)-competent and PTEN-deficient gliob

114 oorapoikayil et al have used phosphatase and tensin homolog (Pten)-deficient zebrafish to uncover pro

115 Phosphatase and tensin homolog (PTEN)-inactivating mutations and/or dele

116 ners of MARK2, we identified phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1), which is

117 ltiple PD models have linked Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)

118 mitochondrial damage induces Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)

119 ion of cells lacking CnrN, a phosphatase and tensin homolog (PTEN)-like phosphatase, is not inhibited

120 g our previously established phosphatase and tensin homolog (Pten)-null acute T-lymphoblastic leukemi

121 nd localization, we define a phosphatase and tensin homolog (PTEN)-regulated checkpoint that retains

122 otein and activity levels of phosphatase and tensin homolog (PTEN).

123 loss of the tumor suppressor phosphatase and tensin homolog (PTEN).

124 domain containing 2 (SETD2), phosphatase and tensin homolog (PTEN).

125 croRNAs that repress mRNA of phosphatase and tensin homolog (PTEN).

126 loss of the PI3K antagonist phosphatase and tensin homolog (PTEN).

127 Subsequently, phosphatase and tensin homolog (which suppresses PI3K activity) is inact

128 rate the inhibitory role of phosphatase with tensin homolog and Forkhead Box class O factors on megak

129 ta in the neuron inactivates phosphatase and tensin homolog and induces its transfer into the astrocy

130 d cell proliferation through phosphatase and tensin homolog and phosphoinositide 3-kinase/Akt signali

131 translational degradation of phosphatase and tensin homolog and the activation of the PI3K signaling

132 ificity phosphatases such as phosphatase and tensin homolog and vaccinia H1-related phosphatase.

133 negatively regulated by the phosphatase and tensin homolog DAF-18/PTEN.

134 ma in vivo in the context of phosphatase and tensin homolog deficiency.

135 on of beta-catenin inhibited phosphatase and tensin homolog delete on chromosome 10 (PTEN) and promot

136 ositol (3,4,5)-trisphosphate phosphatase and tensin homolog deleted from chromosome 10], a phosphatas

137 the tumor suppressor protein phosphatase and tensin homolog deleted in chromosome 10 (PTEN) contribut

138 Tumor-suppressor genes phosphatase and tensin homolog deleted on chromosome 10 (Pten) and andro

139 in the tumor-suppressor gene phosphatase and tensin homolog deleted on chromosome 10 (Pten) are assoc

140 Mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are impli

141 The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI

142 lines, we show that loss of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) confers s

143 tion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) elicits a

144 zygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experienc

145 lerosis complex 2 (TSC2) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) function

146 The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is o

147 ed that the loss of LKB1 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) induces a

148 te signaling with a specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor

149 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipi

150 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an imp

151 tion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is strong

152 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negativel

153 tem cells, we found that the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) overexpre

154 s express significantly more phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein w

155 The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates

156 The Phosphatase And Tensin Homolog Deleted On Chromosome 10 (PTEN) regulates

157 sion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) through i

158 Here we demonstrate that the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor sup

159 phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor sup

160 Down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was obser

161 Levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a phosph

162 report that the activity of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a phosph

163 ion of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), alters t

164 eads to decreased colon cell phosphatase and tensin homolog deleted on chromosome 10 (PTEN), increase

165 ve regulator of the pathway, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is prima

166 The tumor-suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), was iden

167 PINK1 (phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced k

168 -regulated in the absence of phosphatase and tensin homolog deleted on chromosome 10 (PTEN).

169 s not apparently affected by phosphatase and tensin homolog deleted on chromosome 10 functional statu

170 lipid phosphatase known as "phosphatase and tensin homolog deleted on chromosome 10" (PTEN), a key r

171 germline mutations in PTEN (phosphatase and tensin homolog deleted on chromosome 10) are found in sp

172 vestigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) during neurite

173 Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlyi

174 f the tumor suppressor Pten (phosphatase and tensin homolog deleted on chromosome 10) is thought to m

175 tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) plays important

176 the ASD candidate gene PTEN (phosphatase and tensin homolog deleted on chromosome 10).

177 Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a dir

178 Phosphatase and tensin homolog deleted on chromosome ten (PTEN) regulate

179 on in association with PTEN (phosphatase and tensin homolog deleted on chromosome ten) accumulation,

180 clear translocation of PTEN (phosphatase and tensin homolog deleted on chromosome TEN) is a delayed s

181 lial cells exhibited reduced phosphatase and tensin homolog expression and a constitutive rise in the

182 because of relatively higher phosphatase and tensin homolog expression in the former.

183 Loss of phosphatase and tensin homolog expression was found in 16% (22/138) of c

184 The phosphatase and tensin homolog gene (PTEN) on chromosome 10 controls the

185 Mutation of the phosphatase and tensin homolog gene in this pool of adult precursors lea

186 ion of the tumour-suppressor phosphatase and tensin homolog in schwannoma cells leading to increased

187 ctor receptor activation and Phosphatase and Tensin homolog inactivation are thought to promote the m

188 d NFATc1 activation, reduced phosphatase and tensin homolog levels, and increased Akt activation.

189 antagomir (Ant-21) increased phosphatase and tensin homolog levels.

190 The importance of PTEN (phosphatase and tensin homolog located on chromosome 10) in cancer has s

191 by germ-line mutation of the phosphatase and tensin homolog mutated on chromosome 10 (PTEN) tumor-sup

192 ns in the lipid phosphatase, phosphatase and tensin homolog on chromosome 10 (Pten).

193 Moreover, phosphate tensin homolog on chromosome 10 depletion in human kidne

194 Thus, phosphate tensin homolog on chromosome 10 is an upstream regulator

195 Conversely, PTEN (phosphatase and tensin homolog on chromosome 10) dephosphorylates PtdIns

196 Cells lacking PTEN (phosphatase and tensin homolog on chromosome 10) function were relativel

197 Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppr

198 De novo phosphatase and tensin homolog on chromosome ten (PTEN) mutations are a

199 owing to inappropriately low phosphatase and tensin homolog phosphatase activity.

200 ssociated with increased Akt/phosphatase and tensin homolog proliferation/survival signals in FL-fibr

201 Low expression of phosphatase and tensin homolog showed a modest association with lower re

202 ssociated with inactivation of phosphate and tensin homolog through its protein phosphatase activity

203 ression of the miR-21 target phosphatase and tensin homolog was reduced.

204 Cells lacking phosphatase and tensin homolog were as sensitive to the drug combination

205 nd validated by re-analyzing phosphatase and tensin homolog's cross-talk pattern from The Cancer Geno

206 ve kinase protein 1; PTEN is phosphatase and tensin homolog) and the cytosolic ubiquitin ligase Parki

207 ur, had a copy loss of PTEN (phosphatase and tensin homolog) and those lesions that became refractory

208 tumour suppressor gene PTEN (phosphatase and tensin homolog) are frequent events and are associated w

209 e inositol phosphatase PTEN (phosphatase and tensin homolog) as primarily responsible for defects in

210 tically, we identified Pten (phosphatase and tensin homolog) as the functionally important target of

211 17-92 cluster mediated PTEN (phosphatase and tensin homolog) expression, which is a predicted target

212 experiments show that PTEN (phosphatase and tensin homolog) is a target of the miR-17-92 cluster and

213 monstrate that loss of Pten (phosphatase and tensin homolog) protein at postnatal day 8 in mice harbo

214 arker the tumor-suppressor PTEN (phosphatase tensin homolog) that degrades PIP3.

215 rosine phosphatase-1B, PTEN (phosphatase and tensin homolog), and p85 phosphatidylinositol 3-kinase w

216 n of the gene encoding pten (phosphatase and tensin homolog), enables RGCs to regenerate axons the fu

217 Akt pathway inhibitor, PTEN (phosphatase and tensin homolog), which in turn facilitates pre-TCR-induc

218 acking the phosphatase Pten (phosphatase and tensin homolog), which negatively regulates phosphoinosi

219 ional mitochondria via PTEN (phosphatase and tensin homolog)-induced putative kinase 1 (PINK1) and ta

220 We identified phosphatase and tensin homolog, a tumor suppressor, as an miR-17-92 targ

221 ignal-regulated kinases 1/2, phosphatase and tensin homolog, adenosine monophosphate-activated protei

222 Similar changes in SIRT1, phosphatase and tensin homolog, and Akt were also noted in the aorta and

223 and 2, neurofibromatosis 1, phosphatase and tensin homolog, and potentially Rett syndrome.

224 v-ras) oncogene homolog, and phosphatase and tensin homolog, demonstrating PHIP activation in triple-

225 pressor genes including p21, phosphatase and tensin homolog, TGFbeta receptor II, and B-cell leukemia

226 ate tumor involution both in phosphatase and tensin homolog-deficient (PTEN-deficient) prostate cance

227 functions as a cofactor for phosphatase and tensin homolog.

228 and with high expression of phosphatase and tensin homolog.

229 nscription factor; and PTEN, phosphatase and tensin homolog.

230 hosphatidylinositol 3-kinase/phosphatase and tensin homolog/AKT, retinoblastoma/cyclin-dependent kina

231 such as a putative role for Phosphotase and tensin homolog/phosphoinositide 3-kinase (PTEN/PI3K) as

232 M) had reduced expression of phosphatase and tensin homolog; this reduction was also observed in a po

233 Phosphatase and tensin-homolog deleted on chromosome 10 (PTEN) is a tumo

234 ing or its downstream target phosphatase-and-tensin-homolog-deleted-on-chromosome-10 (PTEN).

235 loss of the tumor-suppressor phosphatase and tensin homologue (PTEN) and overexpression of prostate-s

236 The inositol phosphatases phosphatase and tensin homologue (PTEN) and Src homology 2 domain-contai

237 The phosphatase and tensin homologue (PTEN) gene is frequently mutated or lo

238 The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growt

239 dation and downregulation of phosphatase and tensin homologue (PTEN) in multiple cell lines.

240 Phosphatase and tensin homologue (PTEN) is an extensively studied tumour

241 The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via po

242 ay components, most commonly phosphatase and tensin homologue (PTEN) loss (by IHC) (30% of all patien

243 KT activation resulting from phosphatase and tensin homologue (PTEN) loss and EGFR-dependent PI3K act

244 Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the ph

245 Phosphatase and tensin homologue (PTEN) protein levels are critical for

246 actor receptor 3 (FGFR3) and phosphatase and tensin homologue (PTEN) signalling pathway components (f

247 he role for mutations in the phosphatase and tensin homologue (PTEN) tumor suppressor gene and unoppo

248 by a marked increase of the phosphatase and tensin homologue (PTEN) tumour suppressor protein.

249 Although deletion of either phosphatase and tensin homologue (PTEN), a negative regulator of mammali

250 s of function of the protein phosphatase and tensin homologue (PTEN), a phosphatase critically involv

251 Phosphatase and tensin homologue (PTEN), an established NEDD4 target, wa

252 target of rapamycin pathway, phosphatase and tensin homologue (PTEN), and PHLPP.

253 rmal growth factor 2 (HER2), phosphatase and tensin homologue (PTEN), and PI3K catalytic subunit (PIK

254 of the negative regulators, phosphatase and tensin homologue (PTEN), and tuberous sclerosis 1 promot

255 the PI3K pathway regulator, phosphatase and tensin homologue (Pten), which has been reported to occu

256 t the immunologic synapse by phosphatase and tensin homologue (PTEN), which increased nuclear localiz

257 int due in part to defective phosphatase and tensin homologue (PTEN).

258 expression, which inhibited phosphatase and tensin homologue and enhanced AKT signaling, thus endowi

259 Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encod

260 of c-Abl kinase and loss of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) activit

261 n and migration, whereas the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has inh

262 role of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) in the

263 enesis without affecting the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) loss re

264 at miR-21 not only regulates phosphatase and tensin homologue deleted on chromosome 10 (PTEN), but al

265 inhibited the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leadin

266 llular pathways regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN; eg, pho

267 eam of apo(a) attenuation of phosphatase and tensin homologue deleted on chromosome 10 activity.

268 f phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumo

269 PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the major

270 l line derivative (VC8), and phosphatase and tensin homologue deleted on chromosome ten- (PTEN-) defi

271 Mutations in the phosphatase and tensin homologue gene are frequently detected in EMC.

272 miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner.

273 ephalic tissue from dopamine phosphatase and tensin homologue knock-out or control animals was then t

274 d by altered IRS-1 and PTEN (phosphatase and tensin homologue on chromosome 10) activities.

275 sed suppression of PTEN (the phosphatase and tensin homologue protein) and inhibited tumor formation

276 wn downstream targets of the phosphatase and tensin homologue protein, and their activities are up-re

277 neous manifestation of PTEN (phosphatase and tensin homologue) hamartoma-tumor syndrome.

278 we show a function of Pten (phosphatase and tensin homologue) in quiescent SCs.

279 oinositide phosphatase PTEN (phosphatase and tensin homologue) promotes axon regrowth after injury.

280 Phosphatase and tensin homologue, deleted on chromosome 10 (PTEN), the m

281 s in decreased expression of phosphatase and tensin homologue.

282 argets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kina

283 ompanied by silencing of the phosphatase and tensin homology (PTEN) tumor suppressor.

284 represses the expression of Phosphatase and Tensin Homology (PTEN), thereby augmenting the PI3K-AKT-

285 Using an inhibitor of the Phosphatase with TENsin homology deleted in chromosome 10 (PTEN) phosphat

286 Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linke

287 tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden a

288 linositol-3 kinase regulator phosphatase and tensin homology, promotes a marked pro-survival effect.

289 Transient expression of tensins increases beta1-integrin activity, whereas tensi

290 C-terminal tensin-like (CTEN; TNS4) is a focal adhesion molecule th

291 cancer 1 (DLC1) by tensin3 and COOH-terminal tensin-like protein (cten) controls EGF-driven cell migr

292 s downstream migration regulators C-terminal tensin-like protein and matrix metalloproteinase 2.

293 hosphate-activated protein kinase influences tensin production to regulate alpha5beta1-integrin and f

294 e class II formin N-terminal phosphatase and tensin (PTEN) domain binds phosphoinositide-3,5-bisphosp

295 Akt-1 through repression of phosphatase and tensin (PTEN) homolog expression and induction of the in

296 centrally located active beta1-integrin- and tensin-rich mature fibrillar adhesions, and cell spreadi

297 Taken together, these studies suggest that tensin serves as a common cytoskeletal link for integrin

298 Accordingly, tensin silencing in AMPK-depleted fibroblasts impedes en

299 s increases beta1-integrin activity, whereas tensin silencing reduces integrin activity in fibroblast

300 , we show that the loss of AMPK up-regulates tensins, which bind beta1-integrins, supporting their ac