ライフサイエンスコーパス: teratogenic

1 bitor of the phosphoinositide pathway and is teratogenic.

2 t passive smoke exposure during pregnancy is teratogenic.

3 and are cytotoxic, genotoxic, mutagenic, and teratogenic.

4 ibute to a body of evidence that PAHs may be teratogenic.

5 leflunomide was found to be embryotoxic and teratogenic.

6 To assess whether some teratogenic actions of ethanol might occur via dysregula

7 ic effect, suggesting that the antitumor and teratogenic activities of thalidomide-like drugs are dis

8 Like other examples of strain-specific teratogenic activity, the underlying nature of the diffe

9 RAP mutant, demonstrating that rapamycin has teratogenic activity.

10 that the amino acid homocysteine may be the teratogenic agent, since serum homocysteine increases in

11 (including VEGF and VEGF receptors) and many teratogenic agents (including excess D-glucose) that giv

12 f brain also protects embryos from otherwise-teratogenic agents.

13 antisense morpholino oligonucleotides or the teratogenic alkaloid cyclopamine, in order to dissect th

14 nic effects in vertebrate embryos, while non-teratogenic analogues of valproic acid do not inhibit hi

15 ations reveal the mechanism of cyclopamine's teratogenic and antitumor activities and further suggest

16 The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ab

17 d that CRBN, a direct protein target for the teratogenic and antitumor activities of immunomodulatory

18 Aflatoxins are highly toxic, mutagenic, teratogenic and carcinogenic mycotoxins.

19 ts that sunitinib, sorafenib and TNP-470 are teratogenic and demonstrate that axitinib, pazopanib, va

20 In women, taking MPA is teratogenic and may also influence spermatogenesis.

21 amacogenetic component to sodium valproate's teratogenic and neurodevelopmental effects.

22 Methotrexate and leflunomide are teratogenic and should be avoided during pregnancy.

23 lex inheritance likely results from a mix of teratogenic and single gene disorders with variable expr

24 -2 signaling during embryonic development is teratogenic and suggest a possible association of COX-2

25 -dioxin (TCDD) causes a wide range of toxic, teratogenic, and carcinogenic effects.

26 ototype compound, elicit a variety of toxic, teratogenic, and carcinogenic responses in exposed anima

27 methimazole or carbimazole--are occasionally teratogenic; and the alternative--propylthiouracil--can

28 nal zone disorganization in this widely used teratogenic animal model.

29 s limits fetal growth and, if severe, causes teratogenic anomalies.

30 e of cell specificity, and has no detectable teratogenic, antiangiogenic or neurotoxic effects at pot

31 Phenylalanine, teratogenic anticonvulsants, and high concentrations of

32 not only confirmed that sodium valproate is teratogenic but also that it may be associated with neur

33 ants clearly understood that isotretinoin is teratogenic but had less understanding of contraceptive

34 we hypothesized that excess retinoic acid is teratogenic by inducing a longer lasting, local retinoic

35 Regarding teratogenic, carcinogenic, and immunotoxic nature of och

36 nd -independent pathways are involved in the teratogenic/carcinogenic syndrome that follows developme

37 Unintended exposure to teratogenic compounds can lead to various birth defects;

38 ic of embryogenesis, to identify potentially teratogenic compounds.

39 ored over methimazole (MMI) due to potential teratogenic concerns with MMI.

40 servations are very important in considering teratogenic consequences of drugs aimed at inhibiting FA

41 y allow a more complete understanding of the teratogenic consequences of exposure in utero to vitamin

42 and is perturbed in a number of genetic and teratogenic contexts.

43 Zika virus congenital syndrome is a new teratogenic disease.

44 f embryos treated with 50 microliters of the teratogenic dose (200 mM D,L-homocysteine or 100 mM L-ho

45 To determine the effect of the teratogenic dose on the process of heart septation, embr

46 The teratogenic dose was shown to raise serum homocysteine t

47 s inspired a second wave of research on this teratogenic drug.

48 ystematically identify and avoid exposure to teratogenic drugs.

49 PTU is teratogenic during late blastula, gastrulation, and neur

50 This demonstrated that thalidomide had a teratogenic effect between approximately 20 to 36 days a

51 The teratogenic effect of alcohol may depend on the genetic

52 Numerous studies have confirmed the teratogenic effect of hyperglycemia on the developing em

53 ovel mechanism whereby retinoids can exert a teratogenic effect on craniofacial morphogenesis indepen

54 approximately 45 nmol/ml, and prevented the teratogenic effect.

55 poor inhibitory activity in vivo have little teratogenic effect.

56 omain protein suggests a mechanism for viral teratogenic effects and for the tissue-specific manifest

57 The mechanisms behind these teratogenic effects are unknown, although epidemiologica

58 er unmeasured familial factors before causal teratogenic effects can be suggested.

59 The only possible teratogenic effects detected included hypoplastic nails

60 Penicillamine and trientine have teratogenic effects in animals, and penicillamine has kn

61 ects in animals, and penicillamine has known teratogenic effects in humans.

62 d and trichostatin A have remarkably similar teratogenic effects in vertebrate embryos, while non-ter

63 Thus, RA- and T3 receptor-mediated teratogenic effects in Xenopus embryos occur through dis

64 rior to becoming pregnant to avoid potential teratogenic effects of antithyroid drugs during pregnanc

65 , that mediates many of the carcinogenic and teratogenic effects of certain environmental pollutants.

66 t also provide a potential mechanism for the teratogenic effects of DES on the developing reproductiv

67 es in the absence of mouse Cyp1a2 gene), the teratogenic effects of dioxin reverted to the wild-type

68 mediate many of the toxic, carcinogenic, and teratogenic effects of environmental contaminants such a

69 s that micro-RNAs (miRNAs) could mediate the teratogenic effects of ethanol in a fetal mouse cerebral

70 , rodent systems have been used to study the teratogenic effects of ethanol on vertebrate embryonic d

71 Although controversy over the teratogenic effects of lithium remains, our studies sugg

72 contribute to a better understanding of the teratogenic effects of maternal diabetes and improved co

73 en together, these results indicate that the teratogenic effects of RA exposure result, in part, from

74 findings, together with previously reported teratogenic effects of selective BCR-ABL inhibitors in h

75 bryogenesis, we first screened the potential teratogenic effects of TDCPP, TCEP, TCPP, and V6 using a

76 orosis, and at least partially underlies the teratogenic effects of thalidomide on limb development.

77 lation of caspase activity is central to the teratogenic effects of thalidomide.

78 t comprehensive analysis on the toxicity and teratogenic effects of the bisphenols BPA, BPS, BPF, and

79 Together, the results demonstrate that the teratogenic effects of VPA are very likely mediated spec

80 n implicated in cardiac morphogenesis by its teratogenic effects on the heart, although its role in n

81 Finally, when these ligands were tested for teratogenic effects on zebra fish and Xenopus embryos, w

82 whether this association results from causal teratogenic effects or from confounding influences share

83 compounds were responsible for fetal cardiac teratogenic effects seen when TCE or DCE is consumed by

84 Retinoic acid, which induces teratogenic effects similarly to ethanol, also caused up

85 In addition to its well known sedative and teratogenic effects, thalidomide also possesses potent i

86 d offer a possible explanation for lithium's teratogenic effects.

87 hich the retinoids exert some of their known teratogenic effects.

88 d studies on the mechanism of their presumed teratogenic effects.

89 erapy, but cereblon binding can also mediate teratogenic effects.

90 sess for developmental defects and potential teratogenic effects.

91 nly prescribed antiepileptic drug with known teratogenic effects.

92 ) and 9.4 mug Se L(-1)) were in the range of teratogenic effects.

93 t toxicity, reduced fertility, or subsequent teratogenic effects.

94 e is most effective in attenuating ethanol's teratogenic effects.

95 ating the cellular or developmental basis of teratogenic exposures in experimental animals is an impo

96 Heterotaxy may be caused by teratogenic exposures, especially maternal diabetes.

97 me abnormalities, single gene disorders, and teratogenic exposures.

98 ologies have been linked to both genetic and teratogenic factors and to date, a definitive, commonly

99 13-cis-retinoic acid (RA), and it is highly teratogenic for the developing central nervous system.

100 nitroso compounds that have been found to be teratogenic in animal models.

101 c exposure increases risk for cancers and is teratogenic in animal models.

102 ed to acetaldehyde, is both carcinogenic and teratogenic in humans.

103 women because marginal biotin deficiency is teratogenic in mammals.

104 Biotin deficiency is teratogenic in several mammalian species.

105 Chemotherapy is teratogenic in the early stages, but seems to be safe in

106 ith low doses of retinoic acid following the teratogenic insult rescued metanephric kidney developmen

107 ave evolved principally as a defense against teratogenic insult that permits plasticity of developmen

108 the nervous system's homeostatic response to teratogenic insult: an attempt to maintain stability des

109 s a significant overlap with those caused by teratogenic levels of retinoic acid, strongly suggesting

110 confounded by concomitant use of potentially teratogenic medications and severe underlying disease.

111 Prescriptions for potentially teratogenic medications are frequently filled by women o

112 Identification of teratogenic metabolites would allow more accurate assess

113 Valproic acid (VPA) is among the most teratogenic of commonly prescribed anticonvulsants, incr

114 genital anomaly syndromes, have Mendelian or teratogenic origins; the non-syndromic forms of orofacia

115 ly to the Hedgehog antagonist cyclopamine, a teratogenic plant alkaloid, which had been previously sh

116 ng an in vivo model, we have tested the anti-teratogenic potential of a potent synthetic superoxide d

117 This study was to determine the teratogenic potential of MMI and PTU using a validated X

118 oped to quantify and classify the compounds' teratogenic potential.

119 The teratogenic process is poorly understood, and vulnerable

120 It is presently unclear whether the teratogenic properties of thalidomide are connected in a

121 intercalators, but presents carcinogenic and teratogenic properties.

122 ding strategy that allowed us to compare the teratogenic response in embryos from Ahr(-/-) (null) and

123 n-associated risks and understanding of ways teratogenic risks can be avoided.

124 than it helps women feel protected from the teratogenic risks of isotretinoin.

125 Moreover, this increased teratogenic sensitivity extends beyond dioxin, because e

126 Cyclopamine is a teratogenic steroidal alkaloid that causes cyclopia by b

127 Human epidemiologic studies and previous teratogenic studies using chick embryos and fetal rats h

128 gated the role of cereblon (CRBN), a primary teratogenic target of thalidomide, in the antimyeloma ac

129 ncy suggest that this medication may be less teratogenic than previously thought.

130 ases in which the exposure time was known, a teratogenic timetable was constructed relating affected

131 Versatile synthesis of the teratogenic, TNFalpha-modulatory, and antiangiogenic tha

132 Ethanol is teratogenic to many vertebrates.

133 at RXR-specific agonists may possess reduced teratogenic toxicity compared to RAR-specific agonists s

134 ors, regardless of the molecular target, are teratogenic when exposed to chicken embryos.