ライフサイエンスコーパス: terfenadine

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1 d be observed only at high concentrations of terfenadine.

2 se of ("overlapping use") a prescription for terfenadine.

3 ocytes to compare the sensitivity of each to terfenadine.

4 In this study, we found that terfenadine (1) increased both the fast and slow time co

5 Na(+)- and K(+)-free solutions; exposure to terfenadine (10(-9) to 5 x 10(-6) mol/L) resulted in a c

6 ine 118, sertraline 124, suloctidil 125, and terfenadine 127.

7 Terfenadine (5 micromol/L) induced phase 2 reentry in 6

8 The antihistamine terfenadine and a gastrointestinal prokinetic drug, cisa

9 Concurrent use of terfenadine and contraindicated drugs declined over the

10 anges in product labeling, concurrent use of terfenadine and contraindicated macrolide antibiotics an

11 e group affected channel block by cisapride, terfenadine, and MK-499.

12 Cytochrome P450 3A4 metabolizes terfenadine, astemizole, carbamazepine, alprazolam, tria

13 h tonic and use-dependent blocks of ICa,L by terfenadine at -40 mV were greater than that at -70 mV,

14 overall improvement in activity of the set, terfenadine-based analogues provide a novel structural c

15 ure-activity relationship studies yielded 84 terfenadine-based analogues with several modifications p

16 These results suggest that terfenadine binds to L-type Ca2+ channels in inactivated

17 values compare well with values reported for terfenadine block of IKr and IKur currents in human atri

18 RG was 10 times more sensitive than Kv1.5 to terfenadine block.

19 We tested terfenadine carboxylate (fexofenadine) and terfenadine,

20 Terfenadine carboxylate, the major metabolite of terfena

21 ity of the antihistamine, since the clinical terfenadine concentrations in human plasma may reach the

22 enadine carboxylate, the major metabolite of terfenadine, does not block either HERG or Kv1.5, which

23 ree chemically diverse ERG channel blockers (terfenadine, ErgToxin-1, and E-4031) abolished persisten

24 aloperidol, bufuralol, midazolam, clozapine, terfenadine, erlotinib, olanzapine, and moxifloxacin) in

25 We propose that the blocking of HERG by terfenadine explains the acquired long QT syndrome.

26 ere evaluated for organ-specific processing: terfenadine for pharmacokinetics (PK) and toxicity; trim

27 an average of 2.5 per 100 persons receiving terfenadine in 1990 to 0.4 per 100 persons during the fi

28 Among persons with paid claims for terfenadine in any given month, percentage with a prescr

29 The terfenadine-induced inhibition of ICa,L was not mediated

30 The terfenadine-induced tonic and use-dependent block and th

31 th the hypothesis that the buildup of parent terfenadine is the likely explanation for its cardiotoxi

32 ar wedge preparations with the use of either terfenadine or verapamil to inhibit INa and ICa or pinac

33 The histamine H1 receptor antagonist terfenadine prevented scratching and alloknesis evoked b

34 Terfenadine rescued the N470D mutation but blocked the c

35 Administration of the antihistamine terfenadine (Seldane) to patients may result in acquired

36 d terfenadine carboxylate (fexofenadine) and terfenadine, structurally similar drugs with markedly di

37 mechanisms underlying the cardiotoxicity of terfenadine, the effect of this antihistamine on L-type

38 roughput screen identified the antihistamine terfenadine to possess, previously unreported, antimicro

39 eactivating current was blocked by E-4031 or terfenadine (V(0.5,act) = -58.4 +/- 0.9 mV, V(0.5,inact)

40 Terfenadine, verapamil, and pinacidil each induced all-o

41 cin and cisapride, as well as cimetidine and terfenadine, were also reproduced.

42 The high-affinity interaction of terfenadine with the inactivated state of L-type Ca2+ ch

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