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1 MLL1 catalytic activity, and erythroid cell terminal differentiation.
2 al nervous system rely on Brg1 (Smarca4) for terminal differentiation.
3 verstimulation, excessive proliferation, and terminal differentiation.
4 tivator 4 (NCOA4) as a critical regulator of terminal differentiation.
5 ishing the effector program and forestalling terminal differentiation.
6 hocytic leukemia (CLL) cells fail to undergo terminal differentiation.
7 pocytes and decreasing PKCdeltaI accelerated terminal differentiation.
8 ntiated, suprabasal layers, and it regulates terminal differentiation.
9 , suggesting impaired cell-cycle exit during terminal differentiation.
10 tition between these factors controls B cell terminal differentiation.
11 l mediator of brown adipocyte commitment and terminal differentiation.
12 f blood cell development but cannot complete terminal differentiation.
13 pathway, and coincided with progress toward terminal differentiation.
14 in RUNX1-translocated leukemia cells induced terminal differentiation.
15 romoting cell cycle exit in cells undergoing terminal differentiation.
16 and the importance of Mbnl1 during erythroid terminal differentiation.
17 equally to genes that are not required until terminal differentiation.
18 new virions occurs in infected cells during terminal differentiation.
19 e cells that proliferate before the onset of terminal differentiation.
20 etermine the proper initiation and timing of terminal differentiation.
21 roliferation, loss of E-cadherin, and failed terminal differentiation.
22 e I transglutaminase to enhance keratinocyte terminal differentiation.
23 r development, from initial specification to terminal differentiation.
24 nodules in which bacterial symbionts undergo terminal differentiation.
25 anscription factor KLF4 and are committed to terminal differentiation.
26 ensable for their proliferative activity and terminal differentiation.
27 well as the subsequent commitment to proper terminal differentiation.
28 proerythroblasts that undergo apoptosis upon terminal differentiation.
29 tibodies unless stimulated by LPS to undergo terminal differentiation.
30 ion of which is crucial for proper spermatid terminal differentiation.
31 drocytes in the growth plate as they undergo terminal differentiation.
32 sfolded proteins that are synthesized during terminal differentiation.
33 not known whether it has other functions in terminal differentiation.
34 ng from specification of the early embryo to terminal differentiation.
35 the lens epithelium in which cells commit to terminal differentiation.
36 cell commitment, after activation but before terminal differentiation.
37 s IL-27 leads to suppression of keratinocyte terminal differentiation.
38 loop-helix protein MyoD but fails to undergo terminal differentiation.
39 ential during the intermediate stages before terminal differentiation.
40 Stem cells generate progeny that undergo terminal differentiation.
41 cell cycle progression, DNA replication, and terminal differentiation.
42 re able to stratify and undergo a program of terminal differentiation.
43 /-) keratinocytes did not express markers of terminal differentiation.
44 able to profound defects in sensory receptor terminal differentiation.
45 ipotent pancreatic progenitor cells prior to terminal differentiation.
46 cell (HSC) self-renewal, proliferation, and terminal differentiation.
47 during myogenesis being sustained throughout terminal differentiation.
48 ad, undergo unperturbed ductal outgrowth and terminal differentiation.
49 associated with transcripts abundant during terminal differentiation.
50 epidermis and cSCC, and downregulated during terminal differentiation.
51 tor ZEB1 to repress Notch3, thereby limiting terminal differentiation.
52 ycle genes and down-regulation of markers of terminal differentiation.
53 progenitor cells and is further remodeled in terminal differentiation.
54 memory CD8(+) T cell maintenance and T cell terminal differentiation.
55 poietin-dependent cell growth while favoring terminal differentiation.
56 d a stably maintained primed state, prior to terminal differentiation.
57 Most radiated tumor cells underwent terminal differentiation.
58 were cocultured with B cells to induce their terminal differentiation.
59 -erythroid transition, but without affecting terminal differentiation.
60 CR-driven induction of genes associated with terminal differentiation.
61 icrobial systems and in many fate choices in terminal differentiation.
62 chromatin-remodeling mechanisms that enforce terminal differentiation.
63 o not undergo NCR-induced and bacA-dependent terminal differentiation.
64 s on a balance between stem cell renewal and terminal differentiation.
65 astic epidermis and disruption in late stage terminal differentiation.
66 tion that is initiated in the early stage of terminal differentiation.
67 forced transition from a neoplastic state to terminal differentiation.
68 shed role in repressing neuronal genes until terminal differentiation.
69 tic transit amplifying (TA) divisions before terminal differentiation, allowing production of many di
71 yoblasts lacking LAP1 demonstrated defective terminal differentiation and altered expression of muscl
73 ved in later developmental events, including terminal differentiation and axon morphogenesis, are les
75 r CD8(+) T cells, but it also promoted their terminal differentiation and contraction; thus, fewer me
76 rophages, which require GM-CSF signaling for terminal differentiation and effective degradation of al
77 e epidermis revealed defects in keratinocyte terminal differentiation and epidermal barrier formation
78 epidermal cells display profound defects in terminal differentiation and express a subset of markers
80 to regulate its involvement in keratinocyte terminal differentiation and incorporation into the corn
81 odel system that recapitulates physiological terminal differentiation and its reversal upon oncogene
82 olerable in vivo and that K9 is required for terminal differentiation and maintaining the mechanical
83 livered at relatively late time points drive terminal differentiation and marked Bim-mediated contrac
84 res of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes.
85 ge by preventing articular chondrocytes from terminal differentiation and may have implications in jo
87 velope-1 (Lce1) family involved in epidermal terminal differentiation and of anticancer genes such as
88 Loss of trophoblast c-Met also disrupted terminal differentiation and polarization of syncytiotro
89 ory axis during CD8 T cell activation limits terminal differentiation and preserves memory CD8 T cell
90 during B cell activation is known to inhibit terminal differentiation and promote memory generation.
91 gulation in spermatocytes affected spermatid terminal differentiation and resulted in increased male
94 , whose structure is markedly changed during terminal differentiation and transition of the genome fr
95 egions revealed hyperproliferation, impaired terminal differentiation, and abnormal expression of ker
96 to activate enzymes involved in keratinocyte terminal differentiation, and at the centrosome to inhib
98 a result of impaired proliferation, delayed terminal differentiation, and ectopic death of chondrocy
99 vated B cells that precedes the induction of terminal differentiation, and Hrd1 feeds into this pathw
102 lecular determinants that drive cells toward terminal differentiation are also genetically targeted i
103 new light on the way iterative divisions and terminal differentiation are coordinately regulated in a
105 Remarkably, these alterations and defective terminal differentiation are reversed upon depletion of
106 ed from newborn AnxA6-/- mice showed delayed terminal differentiation as indicated by reduced termina
108 een shown to have phenotypes associated with terminal differentiation, as well as both cytokine and p
109 ere seen in the repressed expression of late/terminal differentiation-associated uroplakin 3a gene ex
110 ion together to halt root growth and promote terminal differentiation at least in part in a transcrip
111 e a previously undescribed block during late terminal differentiation at the orthochromatic erythrobl
113 genome become open for transcription during terminal differentiation, blocking the action of a promi
114 widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby cau
115 ilar to RA, these uncoupled retinoids elicit terminal differentiation, but unexpectedly fail to impai
116 es TG activity in keratinocytes committed to terminal differentiation by direct induction of TG1 expr
117 ceptor neuron subtypes, which complete their terminal differentiation by expressing light-sensing Rho
118 ate to promote DNA replication and erythroid terminal differentiation by preventing E2F2-mediated abe
119 imuli trigger a common outcome-initiation of terminal differentiation-by activating different signali
122 1 (special AT-rich binding protein) promotes terminal differentiation, connectivity, and survival in
123 rons, the intrinsic factors required for the terminal differentiation, connectivity, and survival of
125 tional glia-specific deletion in mice led to terminal differentiation defects that were highly remini
126 t EPB defects including altered keratinocyte terminal differentiation, delayed skin barrier developme
128 transition from retinoblast proliferation to terminal differentiation during vertebrate retinogenesis
129 ssed by immunohistochemistry and RT-qPCR for terminal differentiation (E-cadherin, high molecular wei
130 (2) There is little control over the cells' terminal differentiation, e.g., a graft intended to repl
131 lsion by orthochromatic erythoblasts late in terminal differentiation (enucleation), but the mechanis
133 umber of intermediate progenitors and limits terminal differentiation, except for a late induction of
134 e most potent and broad immune response, but terminal differentiation, exhaustion, and apoptosis in t
135 till generated and express a subset of their terminal differentiation features in ham-3 null mutants,
136 atinocytes showed a significant reduction in terminal differentiation gene and protein expression, si
137 ifferentiated and up-regulate both early and terminal differentiation genes associated with HCs, incl
138 onal properties of a neuron are specified by terminal differentiation genes, which are controlled by
140 thropoiesis is well studied, its role during terminal differentiation has been difficult to functiona
142 genetic mechanism that may control timing of terminal differentiation in developing photoreceptors.
143 duction of apoptosis, cell-cycle arrest, and terminal differentiation in DNMT3A-mutant cell lines in
144 thyltransferase inhibitors (DNMTi) to induce terminal differentiation in fibroblasts was first noted
146 Further, we observed marked enhancement of terminal differentiation in HPV16(tg/+);Krt17(-/-)cervic
147 ation combined with induction of cancer cell terminal differentiation in human melanoma cells identif
148 inhibited myogenin expression and prevented terminal differentiation in murine satellite cells: the
149 ies identify CCND2 as a new key regulator of terminal differentiation in muscle progenitor cells and
150 P0 glycoprotein is an abundant product of terminal differentiation in myelinating Schwann cells.
151 eover, transient expression of TIG3 leads to terminal differentiation in normal keratinocytes and apo
152 ction is central to the triggering of B cell terminal differentiation in response to antigen stimulat
159 rction patients was associated with signs of terminal differentiation including an increase in killer
160 tercellular calcium and triggered aspects of terminal differentiation including decreased keratin-14
161 Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls
162 ht promote their maturation, activation, and terminal differentiation into effector cells that also e
163 e these defects, Rb deficiency did not block terminal differentiation into functional sperm; offsprin
164 ell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa.
165 regulated PLZF expression and directed their terminal differentiation into interferon-gamma (IFN-gamm
166 lag between myoblast activation by MyoD and terminal differentiation into myotubes directed by Mef2c
167 age 1-2, resulting in a dramatic decrease of terminal differentiation into stage 3 and severe reducti
168 ent, unbiased effector program that precedes terminal differentiation into T-bet(high) NK1.1(+) (NKT1
169 epresent a cell pool that might have escaped terminal differentiation into the olfactory circuitry.
170 nnective tissue and red blood cells; and (3) terminal differentiation is accompanied with loss of bot
177 forms provide a redundant silencing layer or terminal differentiation 'lock' at critical pluripotency
178 of Corti and the vestibular organ, impaired terminal differentiation manifests as immature stereocil
179 ment, including the expression of prestin, a terminal differentiation marker of outer hair cells, alt
180 escent rAM population did not upregulate the terminal differentiation marker sialic acid-binding immu
182 cally induces the expression of keratinocyte terminal differentiation markers in the duct luminal cel
183 hypertrophic, and has altered expression of terminal differentiation markers involucrin, loricrin, a
184 age homeostasis, chondrocyte maturation, and terminal differentiation markers were all up-regulated v
185 inal differentiation as indicated by reduced terminal differentiation markers, including alkaline pho
186 was associated with a profound repression of terminal differentiation markers, including filaggrin, a
188 ngth AnxA6 rescued the reduced expression of terminal differentiation markers, whereas transfection o
190 of genetic programs that drive cells toward terminal differentiation may also promote immature and h
192 cell) and early myogenic differentiation and terminal differentiation (myogenin and myosin heavy chai
194 ptors loosens PML/RARA DNA binding, inducing terminal differentiation of APL cells ex vivo or in vivo
197 hemokine that signals through CCR1, promotes terminal differentiation of CCR1-positive eosinophil pre
198 ta, but not PI3K-alpha or PI3K-beta, delayed terminal differentiation of CD8(+) T cells and maintaine
199 ves key features of mTECs: proliferation and terminal differentiation of CD80(lo), Aire(-) mTECs into
200 IRF8 and IRF4 act in pre-cDCs to direct the terminal differentiation of cDC1 and cDC2 subsets in the
201 es, variability of transgene expression, and terminal differentiation of cells at the end of culture.
202 3-KO mice indicates that Panx3 regulates the terminal differentiation of chondrocytes by promoting va
203 (TGFalpha), suggesting that ADAM17 regulates terminal differentiation of chondrocytes during endochon
204 ct cell type-specific levels is required for terminal differentiation of color- and motion-detecting
205 ISC proliferation and decreased capacity for terminal differentiation of daughter enteroblasts (EBs).
206 affect lymph node priming, but abrogated the terminal differentiation of effector TH2 cells and adapt
207 1 and Ovol2 results in expansion and blocked terminal differentiation of embryonic epidermal progenit
209 , potent FLT3 inhibition was shown to induce terminal differentiation of FLT3-mutant myeloblasts.
210 ion, EZH2 sustains AID function and prevents terminal differentiation of GC B cells, which allows ant
211 With one set of components, they inhibit terminal differentiation of germinal center B cells into
212 tion, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) ef
213 , and we suggest that dopamine regulates the terminal differentiation of histamine neurons via paracr
217 ling and inflammation through inhibiting the terminal differentiation of keratinocytes and inducing a
218 hlighted disturbed differentiation/premature terminal differentiation of keratinocytes and upregulati
219 LF4 has been shown to be required for normal terminal differentiation of keratinocytes, but the molec
221 in the developing hypothalamus promotes the terminal differentiation of melanocortinergic neurons an
222 y more T cells, more naive T cells, and less terminal differentiation of memory T cells compared with
223 tion of Muller-specific gene expression, and terminal differentiation of MG morphological features.
224 of the miR-183/96/182 cluster in driving the terminal differentiation of multiple sensory receptor ce
226 eral transcription factors are essential for terminal differentiation of myelinating glia, among them
227 We conclude that Sox10 functions during terminal differentiation of myelinating glia, at least i
228 anges in neuronal signaling and the possible terminal differentiation of neuronal and/or glial cells
229 er and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, wer
231 sa staining confirmed the dysfunction in the terminal differentiation of osteoblasts obtained from th
235 ional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TGCs and defines a linea
236 sox-2 and sox-3 have selective roles in the terminal differentiation of specific neuronal cell types
237 epithelial cells by two distinct mechanisms: terminal differentiation of suprabasal cells and a spati
238 1, and TNF-alpha, the cytokines required for terminal differentiation of Th cells, decreased in the C
240 ent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium lea
242 a potential role of vitamin A metabolism in terminal differentiation of the epidermis in humans.
244 EUO is a master regulator that prevents the terminal differentiation of the replicating form of chla
246 uired Brg1-dependent p63 expression, whereas terminal differentiation of the umbrella cells required
247 Despite changes in overall organization, terminal differentiation of the urothelium was not signi
248 l (DC) precursors occurs in bone marrow, the terminal differentiation of these cells takes place outs
249 latently infected B lymphocytes occurs upon terminal differentiation of these cells to plasma cells-
250 hrough inhibiting proliferation and inducing terminal differentiation of TPCs into myosin-expressing
252 yonic day 16.5, concurrent with the onset of terminal differentiation of type 1 and type 2 alveolar c
253 e of the basal cell population, guidance for terminal differentiation of urothelial cells, and proper
256 hat direct nuclear reprogramming can restore terminal differentiation potential to human-derived canc
257 e the proliferation of keratinocytes and the terminal differentiation process, resulting in an in viv
258 of Foxo1 in actively repressing effector or terminal differentiation processes to promote memory CD8
259 be maintained and secretory cells execute a terminal differentiation program and convert into ciliat
260 l cycle is essential for cells to initiate a terminal differentiation program during development, but
261 ich acts as a terminal selector to drive the terminal differentiation program of the cholinergic AIY
262 ptides, we show that ttx-3 also controls the terminal differentiation program of two additional, dist
264 fe cycle is tightly linked to the epithelial terminal differentiation program, with the virion-produc
267 as well as substantial reorganization of the terminal differentiation programs in hair follicle kerat
268 tion factors that drive neuron type-specific terminal differentiation programs in the developing nerv
269 insights into combinatorial codes that drive terminal differentiation programs in the nervous system
271 al and, later on, in selectively controlling terminal differentiation programs of specific neuron typ
272 severely impaired epidermal stratification, terminal differentiation protein expression, and stratum
273 ions with a striking increase in a subset of terminal differentiation proteins, specifically the cyto
274 rowth and early differentiation, rather than terminal differentiation, providing mechanistic insights
276 increases stem cell self-renewal and blocks terminal differentiation, resulting in epithelial hyperp
278 ssion of an essential mediator of neutrophil terminal differentiation, the ets transcription factor P
280 ons that erythroid precursors undergo during terminal differentiation, thereby controlling erythrocyt
281 ic pathway that forces commitment of CTLs to terminal differentiation, thereby restricting their memo
282 epidermis up to the granular layer where, on terminal differentiation, they progressively lose organe
283 e show that LINGO-1 inhibits oligodendrocyte terminal differentiation through intercellular interacti
284 ion of p63 and a strong inductive signal for terminal differentiation through its interaction with th
285 ed period of cortical neurogenesis, neuronal terminal differentiation to acquire mature electrophysio
287 maintaining the stem cell pool and fostering terminal differentiation to establish an epithelial stem
288 nal) CD20(-) plasmablasts lacking markers of terminal differentiation to plasma cell (CD138 and Blimp
289 present in progenitors and downregulated at terminal differentiation to promote acquisition of matur
293 obetasol) restored epidermal hyperplasia and terminal differentiation versus minimal changes with veh
294 Control of stem cell fate to either enter terminal differentiation versus returning to quiescence
297 cooperate with TRbeta during human erythroid terminal differentiation, we conducted RNA-seq in human
298 To explore the role of miRNAs in B-cell terminal differentiation, we use Aicda-Cre to specifical
299 rimitive hematopoietic cells rapidly undergo terminal differentiation when cultured away from their m
300 newly formed muscle fibers but delayed their terminal differentiation, whereas MS275 abolished the ea
301 els dropped further once NHBE cells achieved terminal differentiation, with mucociliary activity stro
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