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1 mediating the local unfolding of the Mad2 C-terminal region.
2 m the presence of an acidic residue at its N-terminal region.
3 state, with structure apparent only in the C-terminal region.
4 nding protein C (cMyBP-C), focusing on the N-terminal region.
5 reported functional regulation of the p53 C-terminal region.
6 ucture of a stable domain (CHD4-N) in this N-terminal region.
7 gion and residues 30-36 (AIIGLMV) from the C-terminal region.
8 tivity, and a functionally uncharacterized N-terminal region.
9 gions of Abeta: the central region and the C-terminal region.
10 gesting enhanced local cleavage of the CgA C-terminal region.
11 ease domain, but instead binds to the EsaD N-terminal region.
12 ion-permeation properties are conferred by C-terminal region.
13 against Plasmodium should include the CSP N-terminal region.
14 of the amino acid changes occurring in the C-terminal region.
15 nt segment (positions 61-67) in the FLIL33 N-terminal region.
16 ecifically at the chromatin via its carboxyl-terminal region.
17 or, CdiA delivers a toxin derived from its C-terminal region.
18 cb1 and Lhcb2 can be phosphorylated in the N-terminal region.
19 cting on different receptors within the same terminal region.
20 e domain at the C terminus and an extended N-terminal region.
21 n range, and are partly conferred by WRN's C-terminal region.
22 emely transient helices are present in the N-terminal region.
23 function for other amino acids within this C-terminal region.
24 -binding sequence (CBS) located within its C-terminal region.
25 conserved cysteine residues located in the C-terminal region.
26 mental evidence of O-linked glycans in the N-terminal region.
27 more prominent in the most distal axons and terminal regions.
28 was likely affected by its N-terminal and C-terminal regions.
29 nt dynamic interactions involving loop and C-terminal regions.
30 heterogeneity arises due to variation in the terminal regions.
31 ing a catalytic domain and extended N- and C-terminal regions.
32 th Titin truncations in the N-terminal and C-terminal regions.
33 domain (DUF583) that is flanked by variable terminal regions.
34 re involved in RAD51 interaction via their C-terminal regions.
35 e-binding domains were mapped within their N-terminal regions.
36 male mouse dopaminergic somatodendritic and terminal regions.
37 Among the basic amino acids in the PA-X C-terminal region, 3 residues, 195K, 198K, and 199R, were
39 ta8.1, 8.2(+) immune T cells recognize the N-terminal region (aa 41-152) of dense granule protein 6 (
40 present study, we identified a NiV-G stalk C-terminal region (amino acids 159 to 163) that is importa
41 ensor that detects RNA viruses through its C-terminal region and activates the production of antivira
42 of two monomers that each contain a folded N-terminal region and an intrinsically disordered C-termin
44 form higher-order oligomers through their N-terminal region and that the same AT-rich site is recogn
45 BP3 to chromatin depends on both its C and N terminal regions and is affected by the cell cycle and p
46 n constructed two deletion mutants lacking C-terminal regions and mutants with point mutations of two
47 tive groups of hnRNP proteins, through its N-terminal region, and directly regulates pre-mRNA splicin
48 hanges that affect the solvent exposure of N-terminal region, and hence the redox sensitivity of the
49 f PINK1, including the architecture of the C-terminal region, and reveals how the N lobe of PINK1 bin
50 to ECL2 established the importance of its C-terminal region, and site-directed mutagenesis of each n
51 olecular rationale for the function of the N-terminal region, and support the idea that Cerberus coul
52 ng truncated MeCP2 lacking both the N- and C-terminal regions (approximately half of the native prote
53 abolites (most likely depending on the amino-terminal region around the highly conserved cysteine res
54 mediated cleavage mechanism, featuring the N-terminal region as an anchor for at least one of the DNA
55 activation required not only the conserved N-terminal region but also permissive communication of the
56 protein that may be cleaved in vivo at the N-terminal region by neutrophil proteases including elasta
58 ed rates of MT polymerization, whereas the N-terminal region cannot bind to MT plus ends but can act
59 the presence of two conserved regions: an N-terminal region codifying for signal peptide and a C-ter
60 lographic structure of the Arabidopsis TPL N-terminal region comprising the LisH and CTLH (C-terminal
63 angiosperms and possess a highly conserved C-terminal region containing linear motifs (CKII-acidic, L
67 MBS (localized within and adjacent to the C-terminal region) contributing to the dimer-dimer interac
68 ed splice-site mutation that truncates the C-terminal region (CTR) domain of RELN protein and display
69 A new Reln mutant with a truncation of the C-terminal region (CTR) domain shows that Reln mutation ca
71 hibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occlude the cytoplasmic exit of
72 hermore, we found that deletion of the F1L N-terminal region does not impede F1L antiapoptotic activi
73 By contrast, a mutation in the whirlin C-terminal region eliminated all normal whirlin isoforms b
75 leucine-rich repeats (LRRs) and having an N-terminal region enriched in alternating lysine and gluta
78 n TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic rin
79 We demonstrate here that a yeast-specific C-terminal region from Pat1 interacts with several short m
81 clear localization of PA-X mediated by its C-terminal region has a significant impact on shutoff acti
82 ase and methyltransferase (MTase), and the C-terminal region has the polymerase (POL), all of which a
84 ith deletion of residues 338 to 347 in the C-terminal region, has been an enigma, because the basis f
85 opy assays indicated that the Rec10 N- and C-terminal regions have complex interactions with Rec25.
86 ement of RNA-binding sites, although these N-terminal regions have only limited sequence conservation
87 se R, whereas the Walker B motif is in its N-terminal region implying that the two parts of the prote
88 regulate DNA-damage responses through its N-terminal region in a poly(ADP-ribose) polymerase-depende
89 monstrate that the established role of the N-terminal region in dimerization is not conserved; instea
94 kinase-mediated phosphorylation within the C-terminal region is inhibitory and regulates catalytic ac
95 zation, it has also been reported that the C-terminal region is involved in p130Cas FA targeting.
97 onserved membrane-proximal amino-terminal (N-terminal) region, is distinct from other lipid-activated
99 imers linked to DNA-PKcs via flexible Ku80 C-terminal regions (Ku80CTR) in a complex stabilized throu
100 best-scoring receptor structures have the N-terminal region lid region bound in a helical conformati
101 hannel that otherwise binds ppGpp, and its N-terminal region, like the coiled-coil tip of DksA, engag
102 against hydrogen/deuterium exchange in the C-terminal region near the N-glycan sites, suggesting this
103 of an auto-regulatory motif, AutoN, in the N-terminal region (NTR) of ISWI, indicating that AutoN doe
104 netic techniques to show that the myosin-I N-terminal region (NTR) plays a critical role in tuning my
105 e shows the stalk region and the essential N-terminal region (NTR) previously unseen in our DNA unbou
106 vealed that PA2588 has a novel fold at the N-terminal region (NTR), and its C-terminal HTH (helix-tur
109 (NoLS) localization signals near the carboxy-terminal region of AAP2 (amino acid positions 144 to 184
110 serine 8 causes structural changes in the N-terminal region of Abeta aggregates in favor of less com
112 beta and residues 30-36 (AIIGLMV) from the C-terminal region of Abeta assemble to form homotetramers
113 deling revealed that two residues near the N-terminal region of alpha-helix 1 in GPPrP might mediate
117 ns to refine structure and topology of the N-terminal region of alphaS bound to the surface of synapt
119 ate the interaction between the disordered C-terminal region of Artemis and the DNA binding domain of
121 ATXN7L3B shares 74% identity with the N-terminal region of ATXN7L3, but the functions of ATXN7L3
122 structural pocket proximal to S184 in the C-terminal region of Bax, directly activating its proapopt
125 es identified phosphorylation sites in the C-terminal region of BRM at SnRK2 target sites that are ev
127 ing question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), whic
128 y binding of the Hsp90 middle domain to an N-terminal region of Caenorhabditis elegans Cdc37 (CeCdc37
133 ed and conserved Sufu-binding motif in the C-terminal region of Ci/Gli and provides mechanistic insig
135 a structural description of the Fn binding N-terminal region of CshA, derived from a combination of X
136 ional analysis predicted that the extended N-terminal region of CYP144A1-FLV is largely unstructured.
137 es showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) wh
138 mAb designated 2E8 does not recognize the C-terminal region of DENV NS1 in which host-cross-reactive
139 otentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding regio
142 nd structural approaches, we find that the C-terminal region of DRC2 is critical for the coassembly o
143 n at Y102 disrupts the helical fold of the N-terminal region of E2 and its interaction with key cellu
145 In this study, we discovered that the N-terminal region of Efb (Efb-N) promotes platelet binding
146 non-synonymous substitution (A120G) in the N-terminal region of eIF2Bbeta was responsible for the TuM
148 played by a stretch of 17 residues in the N-terminal region of EZH2, we call the activation loop, in
149 Lsm11, in addition to interacting with the N-terminal region of FLASH, also contacts the C-terminal S
151 ich efficiently competes with ZipA for the C-terminal region of FtsZ, a central hub for multiple inte
152 sugar modifications and revealed that the C-terminal region of FUS is sufficient to retain ASOs in c
154 characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into th
156 n E3 ubiquitin ligase, interacted with the C-terminal region of HSPA5 and mediated HSPA5 ubiquitinati
157 Here, we present the structure of the N-terminal region of human BCAP and show that it possesses
158 gical missense variants cluster in the amino-terminal region of human BCL11A, and we demonstrate that
159 in the endoplasmic reticulum (ER) via the N-terminal region of human invariant chain p33, with or wi
160 be important for biological activity: the N-terminal region of human neuropeptide Y (NPY1-9, Tyr(1)-
163 ulated in a strain lacking only the unique C-terminal region of MceG, suggesting an important functio
164 ctors (eIF) 2, 3, 1 and 1A, attach to the 5'-terminal region of messenger RNA and scan along it to th
165 ds via its substrate-binding domain to the C-terminal region of MRTF-A and that CCTepsilon is able to
168 ure of MtTOP1 by first predicting that the C-terminal region of MtTOP1 contains four repeated domains
169 harp contrast, recombinant proteins of the N-terminal region of MUC5B (D1-D2-D'-D3 domains, NT5B), C-
170 gion of MUC5B (D1-D2-D'-D3 domains, NT5B), C-terminal region of MUC5B (D4-B-C-CK domains, CT5B) and t
172 oteolytic product p22-FLIP all require the C-terminal region of NEMO/IKKgamma (amino acids 272-419) a
173 allow pocket adjacent to the groove in the N-terminal region of NHR trimer as a new drug target, and
174 dicates that dramatic rearrangement of the C-terminal region of Nop15 in the pre-ribosome exposes the
176 nded alpha-helix from the disordered carboxy-terminal region of nucleoprotein-core links nucleoprotei
178 ll-length p17 demonstrating that the final C-terminal region of p17 is irrelevant for the protein's b
180 cleaved eight amino acid residues from the N-terminal region of Prx1 inside the matrix, without inter
181 binding to polar residues in the conserved N-terminal region of PulG, we propose that PulM acts as ch
183 he central part of M-Tha, and the specific C-terminal region of RelAp43 are required for this interac
185 ngly, the Walker A motif is located in the C-terminal region of RNase R, whereas the Walker B motif i
189 hat links the activity of SidJ and the amino-terminal region of SidE, which is required to modulate t
190 We demonstrated that the glycine-rich N-terminal region of SPS is crucial for the SelA-tRNA(Sec)
195 d versions of SS4 and a fusion between the N-terminal region of SS4 and GS in the Arabidopsis ss4 mut
198 re-function analysis demonstrates that the C-terminal region of TACC2 is both necessary and sufficien
199 n mutants, we further demonstrate that the N-terminal region of TALEs is required for the initial non
204 ed in eukaryotic cells, the TMH-containing N-terminal region of the CbuD1884 protein trafficked to th
205 observed that HCV1, a bNAb recognizing the N-terminal region of the CD81bs, bound a soluble E2 core c
207 s proposed to be its active state, but the C-terminal region of the enzyme adopts a distinct conforma
208 rinogen induced a structural change in the C-terminal region of the fibrinogen beta-chain (beta384-39
210 f six SN-HPCs for mutations within the amino-terminal region of the gene CTNNB1 (cadherin-associated
211 we identified a distinct domain within the N-terminal region of the HSP-16.48 protein that specified
218 ng the parasite's hepatic replication, the C-terminal region of the parasitic PV membrane protein exp
221 the presence of distinct insertions at the C-terminal region of the protein responsible for a structu
222 atic interaction of the positively charged C-terminal region of the protein with a negatively charged
223 O homooligomerization, mediated by the amino-terminal region of the protein, and carboxyl-terminal ta
224 on affecting structural aspects of the amino-terminal region of the protein, and support the concept
230 dy, we found that a 197-aa deletion in the N-terminal region of the S protein did not alter virus (TC
231 s enhanced by the presence of the unfolded N-terminal region of the sequence and by destabilization o
232 .0015, and 0.0023, respectively), in the Ch5 terminal region of the thalamus (P = 0.0003), and in the
233 gG that targets amino acid residues in the C-terminal region of the V3 loop crown, suggesting the imp
240 erved catalytic site was identified in the C-terminal region of TRP120, and TRP120 autoubiquitination
242 cyclin F-specific amino acid motif in the C-terminal region of Vif indicated rescue of the protein f
246 These studies show that the central and C-terminal regions of Abeta can preferentially segregate w
248 rmolecular interactions between the N- and C-terminal regions of alpha-syn play critical roles in med
249 amolecular interactions between the N- and C-terminal regions of alpha-Syn, resulting in the protein
250 (2+) binding allosterically destabilizes the terminal regions of C2alpha and thereby facilitates the
253 he FG/GLFG region of Nup98 binds to N- and C-terminal regions of DHX9 in an RNA facilitated manner.
256 ays showed that the 5' and YSS-containing 3' terminal regions of LCV RNA1 supported translation activ
259 estigated the specific roles of the N- and C-terminal regions of SS4 by expressing truncated versions
260 patients were significantly lower in the Ch4 terminal regions of the anterior cingulate cortex and th
261 y of peptides derived from the central and C-terminal regions of the beta-amyloid peptide (Abeta).
262 tudy the insertion capacity of hydrophobic C-terminal regions of the BH3-only proteins Bik, Bim, Noxa
263 ntified a Y-shaped structure (YSS) in the 3' terminal regions of the bipartite genome of Lettuce chlo
266 e of the JCI, Xu et al. show that specific C-terminal regions of the MOR can modulate side effects wi
270 Although the extended transmembrane Orai N-terminal region (Orai1 amino acids 73-91; Orai3 amino ac
271 NuMA localization to minus-ends involves a C-terminal region outside NuMA's canonical microtubule-bin
273 t the first 15 residues of the PA-X unique C-terminal region play a critical role in shutoff activity
274 e results confirm the influential roles of N-terminal region (positions 7 and 8) and the loop 40-60 (
276 g CyRPA and RIPR, and contains a conserved N-terminal region (RH5Nt) of unknown function that is clea
277 because it did not seem to contain a RecQ C-terminal region (RQC) found in the other RecQ paralogues
278 has a highly disordered conformation, its N-terminal region shows resonance broadening consistent wi
279 ine A3 receptor (A3AR) having an identical N-terminal region shows similar biological profiles to TMI
280 studies showed the alpha-actinin-4 carboxyl-terminal region specifically interacted with the NHERF1
281 formation of an AcAS-Cu(I) complex at the N-terminal region stabilizes local conformations with alph
282 midbrain DA cells and promotes DA release in terminal regions such as the nucleus accumbens (NAc).
283 ut not isoform3 (i3) which shares a common C-terminal region, suppresses these malignant properties.
284 CH1 to bind actin aided by an unstructured N-terminal region that becomes alpha-helical upon binding.
285 a stretch of hydrophobic residues from the C-terminal region that form a hydrophobic cleft, an adjace
286 CMV fusion factor has a Cys residue in the C-terminal region that is palmitoylated and mediates methy
289 nhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands.
291 GAP domain, induces strong binding of that N-terminal region to the RhoGAP domain, converting DLC1 fr
294 e in vivo and in vitro, whereas a separate C-terminal region was required for Sstn localization to fu
296 as RNA methyltransferase activities at its N-terminal region, which is responsible for capping the vi
297 s detected using mAbs against the head and C-terminal regions, which are widely separated in the tert
299 showed that replacement of the pre-TM1 amino-terminal region with the corresponding P2X2 receptor sec
300 mide shifts are localized mostly to N- and C-terminal regions within the rigid beta structure in the
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