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1 tylase (Nt-acetylase) and therefore cannot N-terminally acetylate a majority of normally N-terminally
6 erminally acetylate a majority of normally N-terminally acetylated proteins, including Hsp90 and most
8 PilD and (iii) that pilin subunits with a C-terminally appended hexa-histidine (6His) tag are still
9 binding of the viral haemagglutinin (HA) to terminally attached alpha2,3 or alpha2,6 sialic acids on
11 cyclononane-based pentadentate ligand, and a terminally bound azide ligand has been prepared and spec
14 ntify a heretofore unknown modification-an N-terminally bound glyoxylyl group-in the poorly character
15 the alkali metal with cryptand provides the terminally bound nitride as a discrete salt [K(2,2,2-Kry
17 as a useful entry point to rare examples of terminally-bound Fe(CNH) and Fe(CNH2 ) species that, in
19 Patch-clamp experiments indicated that the C-terminally cleaved CaValpha2delta1 proteins up-regulate
20 FTLD-TDP brains, TDP-43 is phosphorylated, C-terminally cleaved, lost from the nucleus and accumulate
23 cyanobacterium Anabaena sp. strain PCC 7120 terminally commits approximately 10% of its cells to bec
24 t the impaired RNA synthesis associated with terminally deleted viruses could be due to destabilizati
25 position, and in polyubiquitin chains, the N-terminally derived fragments from each constituent monom
28 tinued proliferation and clonal expansion of terminally differentiated acinar cells in all major sali
30 s of unique transcriptional states to become terminally differentiated acinar, ductal and myoepitheli
31 ficantly elevated frequencies of circulating terminally differentiated alpha-NAC-specific CD8(+) T ce
34 3 (-)2B4(+) cells; in turn, these cells were terminally differentiated and highly susceptible to cell
35 chynomene spp. and that these bacteroids are terminally differentiated and polyploid, similar to bact
38 tudied multiple myeloma (MM) as a model of a terminally differentiated B cell malignancy that selecti
40 marrow are heterogeneous, consisting of (a) terminally differentiated B-1-derived plasma cells expre
43 in infarcted hearts and emerged de novo into terminally differentiated cardiac myocytes, smooth muscl
44 s thematuration of NK cells from CD27high to terminally differentiated CD27low NK cells, we used Rag-
45 rated a greater fall in the concentration of terminally differentiated CD8 effector memory T cells (T
46 vere disease stage had a higher frequency of terminally differentiated CD8(+) T cells than patients a
47 d that an increased proportion of senescent, terminally differentiated CD8(+) T cells would identify
51 method of generating iMS cells from primary terminally differentiated cells has significant scope fo
52 Glomerular podocytes are highly specialized terminally differentiated cells that act as a filtration
53 Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regene
55 The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has
56 ically considered a homogenous population of terminally differentiated cells with a well-defined and
60 alpha5 localizes to the lateral membrane of terminally differentiated colonocytes and that integrin
61 nity while other effector cells develop into terminally differentiated effector (TE) cells with limit
62 fection, an activated CD4(+) T cell produces terminally differentiated effector cells and renews itse
63 ld, which were proliferative and exhibited a terminally differentiated effector memory phenotype.
64 daughter cells with a propensity towards the terminally differentiated effector or self-renewing memo
65 nce, most CMV-specific CD8(+) T cells become terminally differentiated effector phenotype CD8(+) T ce
66 l memory T cell, effector memory T cell, and terminally differentiated effector T cell populations to
67 n the generation of more cytolyticly potent, terminally differentiated effectors that possess limited
69 confined within the effector memory (EM) or terminally differentiated EM CD45RA(+) cell subsets expr
71 the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendo
74 eted beta cells revealed the collapse of the terminally differentiated gene program, indicated by a l
75 cell-derived hepatocyte-like cells to their terminally differentiated human counterparts using defin
76 nvasion, which is crucial for replacement of terminally differentiated hypertrophic chondrocytes by b
77 ymocytes maintained high PLZF expression and terminally differentiated into interleukin 4 (IL-4)-prod
78 as established memory CD8(+) T cells toward terminally differentiated KLRG-1(hi)IL-7Ralpha(lo)GzmB(h
81 tein LL (hnRNPLL) is specifically induced in terminally differentiated lymphocytes, including effecto
82 sion of cell cycle-associated proteins, with terminally differentiated macrophages becoming highly su
83 how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restri
84 hyltransferase Dnmt3a has high expression in terminally differentiated macrophages; however, its role
85 , CD8CD28, CD4CD57PD1, and CD8CD28 end-stage terminally differentiated memory T cells were measured p
86 on of CD8(+)CD28(-) T cells, a population of terminally differentiated memory T cells, is one of the
87 with greater than 35 cells CD8CD28 end-stage terminally differentiated memory T cells/muL rejected, m
88 view, until now based on in vitro data, that terminally differentiated myeloid cells in vivo are site
90 the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how thi
93 ts suggest that telomeres are dispensable in terminally differentiated neurons and provide mechanisti
94 taining the survival and normal functions of terminally differentiated neurons is also crucial for li
100 e effects reduced the number and function of terminally differentiated NKT and gammadelta T cells in
102 ifferent stages of erythropoiesis, including terminally differentiated nucleated RBCs that we term "j
103 Although their phenotype resembles that of terminally differentiated or exhausted T cells, lack of
108 not revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute
109 d a high number of activated CD8(+) T cells, terminally differentiated plasma cells, and activated ep
110 versial, and has gained interest because the terminally differentiated pollen vegetative nurse cell s
111 thymus TPA(lo)MHCII(lo) pre-Aire rather than terminally differentiated post-Aire TPA(hi)MHCII(lo) mTE
117 monstrate plasticity in the reprogramming of terminally differentiated sperm nuclei and suggest that
120 ed a requirement for LDB1 in maintaining the terminally differentiated status of pancreatic beta cell
121 d, the specific accumulation of oocytes, the terminally differentiated stem cell progeny, triggers a
122 ell response deficiency, a high frequency of terminally differentiated T cells, the presence of monof
125 nfirmed an acute and persistent depletion of terminally differentiated TEMRA and cytomegalovirus-spec
126 otection to Mtb rechallenge when compared to terminally differentiated Th1 cells that reside preferen
127 subset of RD-histone genes are expressed in terminally differentiated tissues as polyadenylated mRNA
129 ossible to deliver safely stem cell-derived, terminally differentiated, biologically and genetically
132 tal Cell, Amulic et al. (2017) show that the terminally differentiated, non-cycling neutrophils repur
134 not only during differentiation but also in terminally differentiated-macrophages and immature dendr
136 at mammalian adult cardiomyocytes (ACMs) are terminally-differentiated and are unable to proliferate.
137 PA:LFn-GAL4:ASO transfection of non- or terminally-differentiated THP-1 cells and Vero cells res
143 ythroleukaemic K562 cell line, expanding and terminally differentiating primary erythroblasts and mat
145 oding of specific mRNAs that are depleted in terminally differentiating/enucleating cells with decrea
146 scription factors; restored functionality in terminally diseased hepatocytes isolated from CCl4-treat
147 n with a target organism was discharged were terminally disinfected with one of four strategies: refe
149 ates with exhaustion severity and identifies terminally exhausted CD8(+) T cells both in mice and hum
150 lf-renewal and also differentiating into the terminally exhausted CD8(+) T cells that were present in
152 , coinciding with the strong accumulation of terminally exhausted programmed cell death-1 (PD-1)(high
153 ic (R/K)XX(R/K) CendR element that must be C-terminally exposed to trigger neuropilin-1 (NRP-1) bindi
158 RAP1 and ERAP2 heterodimers (ERAP1/2), and N-terminally extended model and natural peptides in their
161 (-1 PRF) to synthesize the NS1' protein, a C terminally extended version of its non-structural protei
163 gion of F1L spanning residues 1-50 located N-terminally from the Bcl-2 fold is an intrinsically unstr
164 for DNA contacts to the residues extending C-terminally from the globular core, which are lacking in
165 New stilbenoid and thiophenic compounds terminally functionalized with donor-donor, acceptor-acc
168 developed premature signs of ALS and became terminally ill after approximately 100 days, which is 20
172 le of 28 nurses who have been taking care of terminally ill patients in a cancer hospital in Tianjin,
177 igh sequence identity with those localized c-terminally in c5 and CcoP and all three domains were sho
178 Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estro
180 iant of an evolved sortase A (SrtA 7M) was N-terminally labeled with lithocholic acid (LA)-an inexpen
183 alpha-l-arabinofuranosidase, removing single terminally-linked arabinose residues, decreased the exte
184 beta-strands, whereas in mammalian cells, C-terminally located alpha-helical domains are sufficient
186 g A1 domain of VWF is connected to the VWF N-terminally located D'D3 domain through a relatively unst
187 nal deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following rec
189 ructure of cryogenically cooled protonated C-terminally methyl esterified leucine enkephalin [YGGFL-O
190 culum (ER) quality control mechanisms target terminally misfolded proteins for ER-associated degradat
191 n (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pat
192 adation (ERAD) machinery efficiently targets terminally misfolded proteins while avoiding the misiden
193 ncers and so increases clearance not only of terminally misfolded substrates, but also of wild-type g
197 Membrane targeting is mediated by the N-terminally myristoylated matrix (MA) domain of Gag and i
199 ions of the peptide backbone (either N- or C-terminally, or both) with organometallic moieties will b
201 ylated (18)F-FBA-A20FMDV2 (1), it was the bi-terminally PEGylated 5 that displayed the more favorable
202 Finally, we demonstrate that linker and C-terminally phosphorylated Mad can be regulated by one of
203 pon keratinocyte differentiation, Fra-2 is C-terminally phosphorylated on Ser320 and Thr322 by ERK1/2
204 specifically to telomeric DNA using their N-terminally positioned myb-like domain of the same type a
205 zoite invasion, we show that native CSP is N-terminally processed in the mosquito host and undergoes
206 etic resonance experiments that a similar, C-terminally retracted (Ub-CR) conformation also exists at
208 is a human-adapted pathogen that encounters terminally sialylated glycoconjugates and free sialic ac
209 n ligase ZNF598 is required for ribosomes to terminally stall during translation of poly(A) sequences
214 additionally use CRISPR/Cas9 technology to N-terminally tag Rab8, which is then used to address endog
215 eting constructs, we could not truncate or C-terminally tag the SERA5 gene, or replace Ser596 with a
217 agged AIF and NADH-binding site mutants of N-terminally tagged AIF and AMID failed to show both NADH:
218 isingly found that the redox activities of N-terminally tagged AIF and AMID were sensitive to rotenon
220 gT was N-terminally tagged with 3xFLAG and C-terminally tagged with 18xHis, we isolated SigT-interact
222 Whereas almost stable helices are formed C terminally to the oligomerization domain, extremely tran
223 s between basic (Arg/Lys) residues located N-terminally to the phosphorylated Ser/Thr residues in the
231 Thus, we compared the accumulation of N-terminally truncated amyloid-beta and full-length amyloi
232 ross disease stages and brain areas, while N-terminally truncated amyloid-beta40 and full-length amyl
234 y APOE) were more strongly correlated with N-terminally truncated amyloid-beta42 accumulation than th
237 inical records showed that accumulation of N-terminally truncated amyloid-beta42 in cortical areas wa
239 spectrometry analysis showed that several N-terminally truncated amyloid-beta42 species, represented
242 ty of tau released from healthy neurons is C-terminally truncated and lacks the microtubule-binding r
243 ptides, including full-length p19(Arf) and N-terminally truncated and unstable p15(smArf) ("small mit
244 bination and in vitro nuclease assays with C-terminally truncated ARTEMIS showing DNA-PKcs-independen
245 we determined x-ray crystal structures of C-terminally truncated Aspergillus nidulans and Coccidioid
246 lex between the full-length protein and an N-terminally truncated C-terminal cell wall binding domain
248 We solved the 2.0 A crystal structure of N-terminally truncated CofB, revealing a pilin-like protei
249 tural leukocyte- and fibroblast-derived COOH-terminally truncated CXCL9 forms missing up to 30 amino
253 on results in expression of full-length or N-terminally truncated ERG protein in prostate epithelia.
255 econstituted human P-protein complexes and C-terminally truncated forms with ricin A chain (RTA), whi
257 The mutations result in the expression of C-terminally truncated G-CSFRs that promote strong cell pr
258 vant signals in GADA RBAs and suggest that N-terminally truncated GAD labels will enable more specifi
259 l-length GAD, suggesting that assays using N-terminally truncated GAD should be used to select partic
260 y study were reassayed with full-length or N-terminally truncated GAD using the National Institute of
261 This finding prompted development of an N-terminally truncated GAD65 radiolabel, (35)S-GAD65(96-58
262 both full-length/glycosylated beta1ARs and N-terminally truncated glycosylation-defective beta1ARs co
263 rosophila models, we provide evidence that C-terminally truncated Hay/XPB alleles enhance overgrowth
265 e complex comprises one subunit each of an N-terminally truncated Ino80, actin, Arp4, Arp5, Arp8, Ies
266 of p73 and reduced levels of the oncogenic N-terminally truncated isoform DeltaNp73 in Aldefluor(+) c
269 lation is posttranslational and identify a C-terminally truncated MRE11, which is formed after HDAC i
270 Pan-neuronal expression of full-length or N-terminally truncated mutHtt recapitulates sleep phenotyp
272 pression of full-length P protein (P1) and N-terminally truncated P proteins (tPs), designated P2, P3
274 arnered no information on the import of an N-terminally truncated PEX5 (PEX5C) receptor construct or
277 ally inactive SpoIVFB was coexpressed with C-terminally truncated Pro-sigma(K)(1-126) (which can be c
278 n translation re-start and production of a N-terminally truncated protein (p.M1_E165del) that is unst
280 ed decay (NMD), and most likely generate a C-terminally truncated protein with a distinct -1 reading-
281 ways degraded efficiently and can generate C-terminally truncated proteins which might have residual
283 position both in vitro and in vivo Because N-terminally truncated pyroglutamate (pE)-modified Abeta s
285 ant mouse PrP [denoted recPrP(23-230)] and N-terminally truncated recPrP(89-230), as well as their co
287 importance of full-length CaV1.3L and two C-terminally truncated splice variants (CaV1.342A and CaV1
288 es containing a series of N-terminally and C-terminally truncated Swr1 subunits reveal further detail
290 ptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8 variant (TRPM8-Delta801) are
294 of Gag that is missing the MA domain and a C-terminally truncated version that is missing the NC doma
295 he great majority of AD plaque consists of N-terminally truncated versions of Abeta(1-40/1-42), with
297 the Galpha portion, but not Gsalpha or an N-terminally truncated XLalphas mutant unable to interact
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