ライフサイエンスコーパス: terminally differentiated

1 t majority of symbionts has been regarded as terminally differentiated.

2 rapidly than adult cells and quickly became terminally differentiated.

3 sts, withdraw from the cell cycle and become terminally differentiated.

4 state, in contrast to CCR9(+) pDCs which are terminally differentiated.

5 7(+) NK cells are highly mature and might be terminally differentiated.

6 nounced effector phenotype, and appear to be terminally differentiated.

7 tinued proliferation and clonal expansion of terminally differentiated acinar cells in all major sali

8 mia efficiently stimulates the conversion of terminally differentiated acinar cells to beta-like cell

9 demonstrate that binuclear acinar cells are terminally differentiated acinar cells.

10 s of unique transcriptional states to become terminally differentiated acinar, ductal and myoepitheli

11 Conversion of mesenchymal stem cells into terminally differentiated adipocytes progresses sequenti

12 Here, we identified a subset of lincRNAs in terminally differentiated adult human retinal neurons ba

13 ficantly elevated frequencies of circulating terminally differentiated alpha-NAC-specific CD8(+) T ce

14 hils, a leukocyte subset generally viewed as terminally differentiated and catabolic.

15 e mainly naive and CD26(high) T cells appear terminally differentiated and exhausted.

16 had a higher level of TCR signaling and were terminally differentiated and exhausted.

17 3 (-)2B4(+) cells; in turn, these cells were terminally differentiated and highly susceptible to cell

18 tes are, except under unusual circumstances, terminally differentiated and incapable of re-entering t

19 chynomene spp. and that these bacteroids are terminally differentiated and polyploid, similar to bact

20 osphohydrolase, down-regulates dNTP pools in terminally differentiated and quiescent cells, thereby i

21 monstrating that this tolerized state is not terminally differentiated and that tolerized DCs can rec

22 In vivo, type I cells are thought to be terminally differentiated and their ability to give rise

23 at mammalian adult cardiomyocytes (ACMs) are terminally-differentiated and are unable to proliferate.

24 t neuronal populations that are postmitotic, terminally differentiated, and non-regenerating, depend

25 or the T-box transcription factor T-bet lack terminally differentiated antitumor CD27(low)KLRG1(+) NK

26 The hepatic NKG2C+ population was terminally differentiated, as in the circulation, but de

27 Glioblastoma can originate from terminally differentiated astrocytes and neurons, which

28 tudied multiple myeloma (MM) as a model of a terminally differentiated B cell malignancy that selecti

29 lts from clonal expansion of an Ig-secreting terminally differentiated B cell.

30 Ig secretion by terminally differentiated B cells is an important compon

31 (MM) is a neoplasm of post-germinal center, terminally differentiated B cells.

32 marrow are heterogeneous, consisting of (a) terminally differentiated B-1-derived plasma cells expre

33 erials, which is difficult for unculturable, terminally differentiated bacteroids.

34 In contrast, ablation of Foxo1 in terminally differentiated beta-cells did not increase be

35 ossible to deliver safely stem cell-derived, terminally differentiated, biologically and genetically

36 transition from hematopoietic stem cells to terminally differentiated blood cells.

37 at coordinate the final mitotic divisions of terminally differentiated bone marrow (BM) erythroid cel

38 in infarcted hearts and emerged de novo into terminally differentiated cardiac myocytes, smooth muscl

39 ch has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardia

40 stage, resulting in the complete absence of terminally differentiated CD11b(hi)CD27(low) NK cells.

41 Mainly the terminally differentiated CD16(+) NK cells demonstrate l

42 production--are specifically associated with terminally differentiated (CD27(-)) allergen-specific CD

43 s thematuration of NK cells from CD27high to terminally differentiated CD27low NK cells, we used Rag-

44 trophoblast stem cells and distinct types of terminally differentiated CD4(+) T cells.

45 rated a greater fall in the concentration of terminally differentiated CD8 effector memory T cells (T

46 Although terminally differentiated CD8 T cells became the predomi

47 ion leads to acute loss of antigen-specific, terminally differentiated CD8 T cells, possibly through

48 multivariate analysis, only the frequency of terminally differentiated CD8 Temra cells (per percent,

49 at is associated with a relative increase of terminally differentiated CD8 Temra cells protects again

50 vere disease stage had a higher frequency of terminally differentiated CD8(+) T cells than patients a

51 d that an increased proportion of senescent, terminally differentiated CD8(+) T cells would identify

52 s to the accumulation of more cytotoxic, but terminally differentiated, CD8(+) TEX cells.

53 These results indicate that a terminally differentiated cell type derived from HSCs co

54 Conversion of one terminally differentiated cell type into another (or tra

55 Osteocytes are the terminally differentiated cell type of the osteoblastic

56 -mediated reprogramming can endow a defined, terminally differentiated cell type with a developmental

57 nd mouse genomes in embryonic stem cells and terminally differentiated cell types at unprecedented re

58 results have challenged this by showing that terminally differentiated cell types can be reprogrammed

59 Progress has also been made in converting terminally differentiated cell types into beta-cells usi

60 mmalian gene expression are established in a terminally differentiated cell.

61 sor effector cells; MPEC) and those that are terminally differentiated cells (short-lived effector ce

62 mechanisms of protection, poor protection by terminally differentiated cells and the importance of T

63 of replicating muscle progenitor cells into terminally differentiated cells and to develop new strat

64 Moreover, terminally differentiated cells can be experimentally pr

65 As apparently terminally differentiated cells embedded in a mineralize

66 development of a population of precursor and terminally differentiated cells exposed to sublethal dos

67 method of generating iMS cells from primary terminally differentiated cells has significant scope fo

68 Terminally differentiated cells in Drosophila melanogast

69 ition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of n

70 the long-held belief that DNA methylation of terminally differentiated cells is permanent and essenti

71 n proliferating stem or progenitor cells and terminally differentiated cells is unclear.

72 Plasma cells (PCs) are terminally differentiated cells of the B-cell lineage th

73 Podocytes are terminally differentiated cells of the kidney glomerulus

74 ifferentiating precursors or self-renewal of terminally differentiated cells or relies heavily on cel

75 ell subsets are more appropriately viewed as terminally differentiated cells or works in progress.

76 Terminally differentiated cells release proteins (e.g.,

77 Glomerular podocytes are highly specialized terminally differentiated cells that act as a filtration

78 Platelets are classified as terminally differentiated cells that are incapable of ce

79 However, neutrophils are terminally differentiated cells that are short lived and

80 Heterocysts are terminally differentiated cells that fix nitrogen in fil

81 Kidney podocytes are highly specialized terminally differentiated cells that form the final barr

82 Cardiomyocytes in adult mammalian hearts are terminally differentiated cells that have exited from th

83 Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regene

84 An alternate approach is to induce terminally differentiated cells to dedifferentiate into

85 eostasis of multicellular organisms requires terminally differentiated cells to preserve their lineag

86 Re-expression of p44/wdr77 caused terminally differentiated cells to re-enter the cell cyc

87 The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has

88 iated repression continue to be expressed in terminally differentiated cells where further changes in

89 d transfusion products (TPs) are composed of terminally differentiated cells with a finite life span.

90 ically considered a homogenous population of terminally differentiated cells with a well-defined and

91 H3 from centromeres is a general property of terminally differentiated cells, and the persistence of

92 Although expressed mainly in terminally differentiated cells, ARC is markedly upregul

93 In terminally differentiated cells, common KDM5A and E2F4 g

94 immune system, were previously thought to be terminally differentiated cells, incapable of altering t

95 s were prominent in G1/S arrested as well as terminally differentiated cells, indicating that they di

96 to acquire KIRs when maturing from naive to terminally differentiated cells, little information is a

97 te PPARgamma cistrome and show that, even in terminally differentiated cells, PU.1 can remodel the ci

98 gulation led to an increase in the number of terminally differentiated cells, resulting in a drastica

99 en give rise to transit-amplifying cells and terminally differentiated cells, similar to what happens

100 Corneal endothelial cells (CECs) are terminally differentiated cells, specialized in regulati

101 Unlike terminally differentiated cells, the impact of epigeneti

102 Since not all TAFs are required in terminally differentiated cells, we examined the essenti

103 their differentiated derivatives, as well as terminally differentiated cells, we report the coexisten

104 Parasites completely renovate the terminally differentiated cells, which lack most of the

105 ression loss also resulted in the decline of terminally differentiated cells, which was supplanted by

106 all Hydra stem/progenitor cells, but not in terminally differentiated cells.

107 ding the transposon regulatory gene piwi, in terminally differentiated cells.

108 ecific T cells were CD45RO(-)CCR7(-)CD127(-) terminally differentiated cells.

109 intestinal epithelium comprised of villi and terminally differentiated cells.

110 as suggested by the decreased percentage of terminally differentiated cells.

111 cific progenitor cells to differentiate into terminally differentiated cells.

112 ir system, is specifically down-regulated in terminally differentiated cells.

113 o tissue outgrowths composed of dividing but terminally differentiated cells.

114 t histone for damaged histones in long-lived terminally differentiated cells.

115 span from early cell morphogenetic events to terminally differentiated cellular functions.

116 alpha5 localizes to the lateral membrane of terminally differentiated colonocytes and that integrin

117 ogram that converts precursor cells to their terminally differentiated counterparts is critically dep

118 ping immature mast cells compared with their terminally differentiated counterparts.

119 lanted nucleus (ES cell, fetal fibroblast or terminally differentiated cumulus cell) and the recipien

120 h) CD57(+) CD8(high) T cells are a subset of terminally differentiated cytotoxic T(EM) cells, which c

121 e units composed of "dividing" LCs and their terminally differentiated daughter cells.

122 nity while other effector cells develop into terminally differentiated effector (TE) cells with limit

123 pressed by the effector memory compared with terminally differentiated effector CD8 T cells; and 5) f

124 fection, an activated CD4(+) T cell produces terminally differentiated effector cells and renews itse

125 on give rise to cellular progeny that become terminally differentiated effector cells and self-renewi

126 s, the Vbeta5(+) subset expressed markers of terminally differentiated effector cells, and their expa

127 etected and associated with the expansion of terminally differentiated effector memory (TEMRA; CD45RA

128 ustion-/suppression-associated PD1, CD57 and terminally differentiated effector memory cells, with mo

129 cts long-term memory CD8(+) T cells toward a terminally differentiated effector memory phenotype with

130 ld, which were proliferative and exhibited a terminally differentiated effector memory phenotype.

131 amma9Vdelta2 T cells and effector memory and terminally differentiated effector memory subpopulations

132 to the expansion of the effector memory and terminally differentiated effector memory subsets.

133 we show that human ALPS DNT have features of terminally differentiated effector memory T cells reexpr

134 daughter cells with a propensity towards the terminally differentiated effector or self-renewing memo

135 ve mTORC1 activation, these cells retained a terminally differentiated effector phenotype and were in

136 nce, most CMV-specific CD8(+) T cells become terminally differentiated effector phenotype CD8(+) T ce

137 CD8(+) T cells in COPD do not belong to the terminally differentiated effector populations associate

138 l memory T cell, effector memory T cell, and terminally differentiated effector T cell populations to

139 n the generation of more cytolyticly potent, terminally differentiated effectors that possess limited

140 profiles in naive, effector memory (EM), and terminally differentiated EM (TEMRA) cells.

141 confined within the effector memory (EM) or terminally differentiated EM CD45RA(+) cell subsets expr

142 Many terminally differentiated endocrine cell types, however,

143 within the mouse pancreas do not represent a terminally differentiated endocrine population.

144 l, suggesting plasticity in the ability of a terminally differentiated endothelial cell to take on a

145 the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendo

146 em-cell population, but rather indicate that terminally differentiated epithelia reexpress apparent s

147 Podocytes are terminally differentiated epithelial cells in the kidney

148 Podocytes are terminally differentiated epithelial cells that reside a

149 nvolucrin expression, the latter a marker of terminally differentiated epithelium including Hassall's

150 roid (BFU-E), and increase the production of terminally differentiated erythroid cells.

151 eted beta cells revealed the collapse of the terminally differentiated gene program, indicated by a l

152 xA6) is highly expressed in hypertrophic and terminally differentiated growth plate chondrocytes.

153 ll samples, from early T cell progenitors to terminally differentiated helper T cell subsets.

154 Paneth cells (PCs) are terminally differentiated, highly specialized secretory

155 cell-derived hepatocyte-like cells to their terminally differentiated human counterparts using defin

156 draining lymph nodes became replenished with terminally differentiated human follicular Th cells, pla

157 nvasion, which is crucial for replacement of terminally differentiated hypertrophic chondrocytes by b

158 d that ventricular endocardial cells are not terminally differentiated; instead, they are angiogenic

159 ymocytes maintained high PLZF expression and terminally differentiated into interleukin 4 (IL-4)-prod

160 lls generated from somatic cells; (2) can be terminally differentiated into mature connective tissue

161 o critically dependent on normal shedding of terminally differentiated keratinocytes, a process terme

162 cells lacking Id2 did not generate a robust terminally differentiated killer cell lectin-like recept

163 as established memory CD8(+) T cells toward terminally differentiated KLRG-1(hi)IL-7Ralpha(lo)GzmB(h

164 tory cytokine IL-12 drives the generation of terminally differentiated KLRG1(+) effector CD8(+) T cel

165 er crystallins and genes highly expressed in terminally differentiated lens fibers.

166 allenging the classic view of neutrophils as terminally differentiated leukocytes destined to die or

167 Osteoclasts are terminally differentiated leukocytes that erode the mine

168 e myeloid cell lines are, by definition, not terminally differentiated like tissue macrophages.

169 ated genes, and promoted the appearance of a terminally differentiated-like phenotype.

170 er CD4(+) T cell subsets have been viewed as terminally differentiated lineages with limited flexibil

171 Although these subsets can act as terminally differentiated lineages, they have been incre

172 nitors and hence the extent of production of terminally differentiated lineages.

173 tein LL (hnRNPLL) is specifically induced in terminally differentiated lymphocytes, including effecto

174 idence that loss of CD28 cells is typical of terminally differentiated lymphocytes, the aim of this s

175 sion of cell cycle-associated proteins, with terminally differentiated macrophages becoming highly su

176 how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restri

177 pivotal for the proinflammatory response of terminally differentiated macrophages.

178 hyltransferase Dnmt3a has high expression in terminally differentiated macrophages; however, its role

179 not only during differentiation but also in terminally differentiated-macrophages and immature dendr

180 In terminally differentiated mammalian auditory hair cells,

181 expression is substantially downregulated in terminally differentiated mast cells as compared with th

182 The adult heart is composed primarily of terminally differentiated, mature cardiomyocytes that ex

183 , CD8CD28, CD4CD57PD1, and CD8CD28 end-stage terminally differentiated memory T cells were measured p

184 on of CD8(+)CD28(-) T cells, a population of terminally differentiated memory T cells, is one of the

185 with greater than 35 cells CD8CD28 end-stage terminally differentiated memory T cells/muL rejected, m

186 prisingly DNA replication takes place in the terminally differentiated mother cell as offspring grow.

187 f tissue-restricted genes, a key property of terminally differentiated mTECs.

188 le stem/progenitor cells, which give rise to terminally differentiated muscle, represent potential th

189 e is restricted to autoantigens expressed by terminally differentiated myelinating oligodendrocytes.

190 cycling neural progenitor cells but also in terminally differentiated, myelinating oligodendrocytes.

191 view, until now based on in vitro data, that terminally differentiated myeloid cells in vivo are site

192 in HCMV carriers routinely occurs from such terminally differentiated myeloid cells in vivo.

193 onal hematopoiesis and hyperproliferation of terminally differentiated myeloid cells.

194 derived suppressor cells into protumorigenic terminally differentiated myeloid mononuclear cells (TDM

195 of MUC1-C was associated with induction of a terminally differentiated myeloid phenotype in AML cell

196 nificant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adip

197 the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how thi

198 stemic RNAi approach targeting the nuclei of terminally differentiated myofibers.

199 transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an excepti

200 to complement-mediated injury owing to their terminally differentiated nature.

201 ls to be directly converted into individual, terminally differentiated neuron types and demonstrate t

202 However, terminally differentiated, neuronal SH-SY5Y cells releas

203 ts suggest that telomeres are dispensable in terminally differentiated neurons and provide mechanisti

204 yclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complex

205 Highly pure (>95%) terminally differentiated neurons derived from pluripote

206 rated acute murine knock-out models of Rb in terminally differentiated neurons in vitro and in vivo.

207 taining the survival and normal functions of terminally differentiated neurons is also crucial for li

208 These results suggest that terminally differentiated neurons require Rb for continu

209 Neural progenitors and terminally differentiated neurons show distinct redox pr

210 s surprisingly no detectable consequences on terminally differentiated neurons.

211 NB but independently of factors that act in terminally differentiated neurons.

212 igopotent common myeloid progenitor stage to terminally differentiated neutrophils.

213 NK cells, naive T cells, and accumulation of terminally differentiated NK and CD8(+) memory T cells.

214 A slightly increased percentage of terminally differentiated NK cells and functional respon

215 diating antibacterial effector function than terminally differentiated NK cells.

216 Terminally differentiated NKG2C+ cells show KIR expansio

217 In people, expansion of long-lived terminally differentiated NKG2C+ populations occur in th

218 rm (4-day) murine cytomegalovirus infection, terminally differentiated NKs accumulate in the livers o

219 e effects reduced the number and function of terminally differentiated NKT and gammadelta T cells in

220 es in alveolar maturation and can exit their terminally differentiated non-proliferative state.

221 tal Cell, Amulic et al. (2017) show that the terminally differentiated, non-cycling neutrophils repur

222 pools found in two HIV-1 target cell types: terminally differentiated/non-dividing macrophages and a

223 Terminally differentiated/non-dividing macrophages conta

224 e HBoV1 genome, and HBoV1 replicates only in terminally differentiated, nondividing cells.

225 Terminally differentiated/nondividing macrophages, which

226 rating de novo cardiomyocyte-like cells from terminally differentiated nonmyocytes in the heart in si

227 ifferent stages of erythropoiesis, including terminally differentiated nucleated RBCs that we term "j

228 biological functions of Olig2 suppressed in terminally differentiated oligodendrocytes?

229 Although their phenotype resembles that of terminally differentiated or exhausted T cells, lack of

230 Inflammation is, however, harmful to terminally differentiated organs, such as the heart and

231 Osteocytes are terminally differentiated osteoblasts embedded in minera

232 the differentiation of human macrophages to terminally differentiated osteoclasts are dependent on s

233 titative PCR for gene expression analysis in terminally differentiated osteoclasts.

234 ind also that miR-23a represses Runx2 in the terminally differentiated osteocyte, representing a feed

235 Terminally differentiated pancreatic acinar cells do not

236 activity and were a homogenous population of terminally differentiated Paneth cells.

237 cytoplasm of hES cells, hiPS cells, and the terminally differentiated parental human fibroblasts fro

238 Ig secretion from activated primary B cells, terminally differentiated PCs were not susceptible to in

239 Here we show that despite their terminally differentiated phenotype, human ALPS DNT cell

240 vector-elicited CD8(+) T cells are of a more terminally differentiated phenotype.

241 r of the transition from progenitor cells to terminally differentiated photoreceptors.

242 not revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute

243 d a high number of activated CD8(+) T cells, terminally differentiated plasma cells, and activated ep

244 Multiple myeloma (MM), a cancer of terminally differentiated plasma cells, is emblematic of

245 re, enforced expression of EBF1 and RUNX1 in terminally differentiated plasmacytoma cells activated m

246 versial, and has gained interest because the terminally differentiated pollen vegetative nurse cell s

247 thymus TPA(lo)MHCII(lo) pre-Aire rather than terminally differentiated post-Aire TPA(hi)MHCII(lo) mTE

248 Terminally differentiated post-mitotic cells are general

249 entury, the human heart has been viewed as a terminally differentiated postmitotic organ in which the

250 iminates total cellular miRNA populations in terminally differentiated primary cultures.

251 Vdelta2 T cells presented a terminally differentiated profile, expressed granzyme B

252 the needs for production of their immediate terminally differentiated progeny.

253 rs in the BM and alter the function of their terminally differentiated progeny.

254 Thus, post-mitotic cells, though terminally differentiated, remain plastic to transdiffer

255 define paracellular transport properties of terminally differentiated renal proximal tubule epitheli

256 proliferative retinoblasts and an absence of terminally differentiated retinal neurons and glia.

257 These studies establish that the genomes of terminally differentiated rod cells can be efficiently e

258 er dissect the progression from stem cell to terminally differentiated secretory cell.

259 l properties after reinfection and may reach terminally differentiated, senescent states ("Hayflick l

260 specification of other identity aspects of a terminally differentiated sensory neuron.

261 We demonstrate that terminally differentiated SH-SY5Y cells have neuronal mo

262 These and other properties are analogous to terminally differentiated short-lived CD8(+) T effector

263 oliferation and activated stem cell genes in terminally differentiated somatic cells.

264 monstrate plasticity in the reprogramming of terminally differentiated sperm nuclei and suggest that

265 own about how gene batteries that define the terminally differentiated state of a neuron type are mai

266 Thus, LDB1 maintains the terminally differentiated state of beta cells and is a c

267 reveal a novel mechanism for maintaining the terminally differentiated state of Drosophila photorecep

268 The terminally differentiated state of individual types of m

269 specific monoamines) and thereby define the terminally differentiated state of monoaminergic neurons

270 glycolytic flux drives CD8+ T cells toward a terminally differentiated state, while its inhibition pr

271 eb2 mRNA, which then triggered CTLs to adopt terminally differentiated states.

272 ed a requirement for LDB1 in maintaining the terminally differentiated status of pancreatic beta cell

273 d, the specific accumulation of oocytes, the terminally differentiated stem cell progeny, triggers a

274 oid male gametophyte, the pollen grain, is a terminally differentiated structure whose function ends

275 arise from the memory precursor and not the terminally differentiated subset of effector CD8 T cells

276 In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1(+) NKT cells e

277 in the bladder whereas K20, a marker of the terminally differentiated superficial urothelial cells w

278 erative cytotrophoblast (CTB), precursors to terminally differentiated syncytiotrophoblast (STB) in c

279 eline naive T cells and lower percentages of terminally differentiated T cells, compared with nonresp

280 ell response deficiency, a high frequency of terminally differentiated T cells, the presence of monof

281 ancer efficacy compared with the infusion of terminally differentiated T cells.

282 sistant rejection (CoBRR) is associated with terminally differentiated T cells.

283 In developing and self-renewing tissues, terminally differentiated (TD) cell types are typically

284 nofunctional cells (p < 0.001) compared with terminally differentiated (TD; CD45RO(-)CD27(-)) HIV-spe

285 content and synthesis in MPEC compared with terminally differentiated Teff.

286 of CD4 effector memory T cells (TEM) and CD8 terminally differentiated TEM (TEMRA), with greater CD4

287 nfirmed an acute and persistent depletion of terminally differentiated TEMRA and cytomegalovirus-spec

288 otection to Mtb rechallenge when compared to terminally differentiated Th1 cells that reside preferen

289 PA:LFn-GAL4:ASO transfection of non- or terminally-differentiated THP-1 cells and Vero cells res

290 subset of RD-histone genes are expressed in terminally differentiated tissues as polyadenylated mRNA

291 ting for myelination studies, or they can be terminally differentiated to myelin basic protein-positi

292 udy, we show that Klrg1(+) Tregs represent a terminally differentiated Treg subset derived from Klrg1

293 vo progression from p63(+) CTB stem cells to terminally differentiated trophoblast subtypes.

294 ity is caused by an accumulation of the most terminally differentiated type of chondrocytes that prod

295 In galegoid plants, the endosymbionts are terminally differentiated, uncultivable polyploid cells,

296 In the bladder the luminal surface of terminally differentiated urothelial umbrella cells is a

297 some primate VNOs reflects a lower number of terminally differentiated VSNs compared to a diverse ran

298 Although initially viewed as terminally differentiated, we now recognize that Th cell

299 postnatal cochlea, the sensory epithelium is terminally differentiated, whereas tympanic border cells

300 n be similarly reprogrammed and subsequently terminally differentiated with abrogation of tumorigenic