ライフサイエンスコーパス: termination

1 echanism underlying eukaryotic transcription termination.

2 escribes loading, initiation, elongation and termination.

3 and uncover a critical function for eIF5A in termination.

4 athy in other fedratinib trials led to study termination.

5 isassembly during vertebrate DNA replication termination.

6 he onset of the T-OAE and peaking during its termination.

7 es stalled at the level of elongation and/or termination.

8 olerability, withdrawal of consent, or study termination.

9 collapse and act as hotspots for replication termination.

10 d by additional effects, including DNA chain termination.

11 SRO/BTO top interfaces with uniform SrO-TiO2 termination.

12 to facilitate growth cone collapse and axon termination.

13 ng poly(A) sites and affecting transcription termination.

14 s in almost all cases limited to a monolayer termination.

15 hinery used for transcription elongation and termination.

16 t transcriptional pausing, backtracking, and termination.

17 ion, followed by Rho-dependent transcription termination.

18 ntrols two subsequent steps of Rho-dependent termination.

19 oximal sites, reflecting early transcription termination.

20 causes a frame shift resulting in premature termination.

21 dpoints to indicate the need for early trial termination.

22 closure of the chloride channel and response termination.

23 tion mechanism on STO with different surface termination.

24 and competes with UGA-directed translational termination.

25 o; these findings are limited by early trial termination.

26 d persisted for up to 19 days after stressor termination.

27 eby contributing to gradient maintenance and termination.

28 nsition depending on the Fe- or Rh-interface termination.

29 lly linked and occur only during replication termination.

30 her molecular weight copolymers with minimal termination.

31 cleavage mechanism acts to induce premature termination.

32 ng any unexcitable boundary, did not lead to termination.

33 nd serum 25-hydroxyvitamin D levels at study termination.

34 articles due to a dysfunction in translation termination.

35 can best be explained by a rapid decrease in termination.

36 insulating film thickness for the different terminations.

37 ice buildup and delayed, but rapid, glacial terminations.

38 exhibits a mixture of RuO2 -BaO and SrO-TiO2 terminations.

39 rbon nitride containing photocatalytic chain terminations.

40 In contrast to Termination 1 (T1), which was interrupted by the Bolling

41 he next safest operative maneuver upon video termination (10 s), and reported decision confidence.

42 y 20 p.p.m.v. overshoot in CO2 at the end of Termination 2 (T2) approximately 129 ka was associated w

43 Here we describe euryarchaeal termination activity (Eta), the first archaeal terminati

44 the release factors, (ii) delays translation termination and (iii) dissociates post-termination ribos

45 ith weight and glycemic outcomes both at LCD termination and 6 mo after the LCD.Using RNA sequencing

46 This revealed intertwining at replication termination and cohesin-binding sites, where intertwines

47 on with the substrate, due to very fast self-termination and cross-termination of the oxidative chain

48 Dual-assignment of codons as termination and elongation codons is used to expand the

49 ding to both premature DNA damage checkpoint termination and inhibition of DNA repair.

50 cleavage occurs only late after gp160 chain termination and is dependent on folding of the soluble s

51 ORFs (sORFs) by quantitation of translation termination and peptidic analysis identified lncRNAs tha

52 ional neural mass model of epileptic seizure termination and postictal recovery was developed.

53 e show that a combination of transcriptional termination and ribosome binding site sequestration incr

54 tion on ZnO, and are governed by the surface termination and the extent of surface hydroxylation.

55 neuronal network dynamics underlying seizure termination and the postictal generalized EEG suppressio

56 ends on the anatase titanium dioxide surface termination and the vanadium oxide layer thickness, sugg

57 techniques, including armchair-type surface terminations and coherent interfaces between assembled c

58 een annealed to achieve alternating chemical terminations and thus enable selective epitaxy during th

59 requirements for Eta-mediated transcription termination, and describe a role for Eta in transcriptio

60 c p97 complex, other potential regulators of termination, and many replisome components.

61 xpression, such as transcription elongation, termination, and polyadenylation, must also be considere

62 enes: essentiality, expression, orientation, termination, and presence of duplicates.

63 were the spatial distribution, the synaptic termination, and the glutamatergic transporter profiles

64 Data from mapping, acute terminations, and outcomes strongly support the mechanis

65 be the NMD proteins for interaction with the termination apparatus.

66 r myocyte model, we show that initiation and termination are inherently random events.

67 he contributions of RNA and DNA sequences to termination are largely understood, the roles of conform

68 in FeSe films grown on different STO surface terminations are likely enhanced by a common mechanism.

69 ify a role for phospho-Thr4 in transcription termination at noncoding small nucleolar RNA (snoRNA) ge

70 pho-Thr4 marks and facilitates transcription termination at protein-coding genes.

71 Typically, Rho promotes termination at the end of coding sequences, but it can a

72 lyadenylate tail, and triggers transcription termination, but it is unclear how its various enzymes a

73 shown to potentially ensure transcriptional termination by dephosphorylation of Ser2 on the CTD.

74 cleotide addition, also is proposed to drive termination by folding into the trigger helices and cont

75 Furthermore, we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (

76 n E. coli riboswitches control transcription termination by using the Rho transcription factor.

77 iciency by altering the time window in which termination can occur.

78 They introduce a premature termination codon (PTC) and prevent the formation of ful

79 ents with RDEB harbor at least one premature termination codon (PTC) mutation in COL7A1, and previous

80 with a mutation that introduces a premature termination codon (PTC) that prevents synthesis of the f

81 trate that its inclusion creates a premature termination codon (PTC), that leads to a 65kDa truncated

82 s of both endogenous and exogenous Premature Termination Codon (PTC)-containing mRNA isoforms and its

83 s-of-function mutations creating a premature termination codon and the degradation of the mutated mes

84 transcript that bears the unusual premature termination codon besides the canonically spliced OsPCS2

85 es, but a child homozygous for the premature termination codon displayed symptoms consistent with MMI

86 lts in a frameshift and subsequent premature termination codon in each.

87 olated family was found to carry a premature termination codon in Leiomodin1 (LMOD1), a gene preferen

88 A premature termination codon in the human histidine decarboxylase (

89 ein-altering variants, including a premature termination codon, in CRKL.

90 f, resulting in a frameshift and a premature termination codon.

91 erate and present epitopes downstream of the termination codon.

92 in read through of the normal translational termination codon.

93 In-frame premature termination codons (PTCs) account for approximately 11%

94 mRNAs containing premature termination codons (PTCs) are rapidly degraded through n

95 recognizes and degrades mRNAs with premature termination codons (PTCs).

96 be highly conserved and introduced premature termination codons into coding regions.

97 (NMD) eliminates transcripts with premature termination codons.

98 ome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (

99 We determined the structure of an anti-termination complex in which TEFM is bound to transcribi

100 adenosine monophosphate (cAMP) complex (the termination complex).

101 veal a general role of ARS2 in transcription termination-coupled RNA turnover at short transcription

102 lobal optima, (ii) no clear optimization run termination criteria and (iii) no criteria to detect sta

103 on of the self-renewal network and a lack of termination cytokines that normally restore haematopoiet

104 ts to a different gene induces transcription termination, demonstrating that such elements are modula

105 cripts are also attenuated through premature termination directed by the NNS complex.

106 , and 19% (LPeAF) of patients, with 15 of 67 terminations due to right atrial ablation.

107 leotide addition rate that indirectly affect termination efficiency by altering the time window in wh

108 TL sequence insertion (SI3) increase overall termination efficiency by stimulating pausing, which inc

109 ition metal oxides and controlled by surface-termination engineering.

110 Their termination-enhancing antioxidant chemistry might be rel

111 In human mitochondria, transcription termination events at a G-quadruplex region near the rep

112 Transcription termination events in bacteria often require the RNA hel

113 ngly, ARS2 is also involved in transcription termination events within first introns of pc genes.

114 latory proteins, such as TTF2 (transcription termination factor 2), TFIIS, and RPB9.

115 rmination activity (Eta), the first archaeal termination factor capable of disrupting the transcripti

116 and self-propagating form of the translation termination factor eRF3 (Sup35), can be cured of its inf

117 inase 1alpha (CK1alpha), and the translation termination factor GSPT1] whose ubiquitylation is induce

118 is devoid of the mitochondrial transcription termination factor MOC1 and aberrantly expresses the mit

119 -binding dynamics of the yeast transcription termination factor Nab3 in response to glucose starvatio

120 t prion [PSI (+)], formed by the translation termination factor Sup35.

121 sult of aggregation of the Sup35 translation termination factor, which increases stop codon read-thro

122 3, a 3'-end RNA-processing and transcription termination factor.

123 racterized in each domain, but transcription termination factors have been identified only in bacteri

124 tify many core spliceosome and transcription termination factors that control the RNA outputs of repo

125 n Tyr1 and both transcription initiation and termination factors.

126 Ca store depletion level required for spark termination for each cluster size.

127 interlayer coupling formed by MXene surface termination groups.

128 imal Pol II pause release, and transcription termination; however, mechanisms regulating transcriptio

129 d to regulate ligand-dependent transcription termination in Escherichia coli.

130 icacy of optogenetic atrial tachycardia (AT) termination in human hearts using a strategy that target

131 in the 3' UTR, suggesting a global defect in termination in the absence of eIF5A.

132 ow growth cone collapse occurs prior to axon termination in vivo Using the mechanosensory neurons of

133 rowth cone collapse is regulated during axon termination in vivo, and suggest that RPM-1 signaling de

134 and describe a role for Eta in transcription termination in vivo.

135 solution to show that grain-boundary surface terminations in gold electrodes are more active than gra

136 n is a separate brain state and that seizure termination is a plastic and autonomous process, reflect

137 n a defluoroalkylation process where radical termination is accomplished by a polarity reversal catal

138 owever, the mechanism by which transcription termination is achieved is not understood.

139 Intrinsic termination is caused by the formation of a nascent RNA

140 simulations that the structure of the (1102) termination is dynamically stabilized by picosecond wate

141 Eta-mediated transcription termination is energy-dependent, requires upstream DNA s

142 Axon termination is essential for efficient and accurate nerv

143 Growth cone collapse prior to termination is facilitated by the signaling hub RPM-1.

144 We conclude that transcription termination is followed by TRAMP-mediated RNA decay.

145 al several important findings about how axon termination is orchestrated: (1) RPM-1 functions in para

146 C. elegans, we found collapse prior to axon termination is protracted, with the growth cone transiti

147 A key event during eukaryotic replication termination is the removal of the CMG helicase from chro

148 ch, we find that Rho-dependent transcription termination is triggered as a consequence of translation

149 vices with symmetric and uniform interfacial termination, it is demonstrated for the first time that

150 ns in various response attributes, including termination kinetics and adaption properties, OSNs in ei

151 Little is known, however, about the termination kinetics of the intrinsic melanopsin-based p

152 the ipRGC response will be determined by the termination kinetics of the rod/cone circuits.

153 The late termination (ltm) tomato (Solanum lycopersicum) mutant s

154 onal compartment immediately proximal to its termination may affect strategies targeting pain of peri

155 Thus, the multi-step nature of Rho-dependent termination may facilitate regulation of a given coding

156 relatively slow and, therefore, replication termination may frequently occur by an active fork conve

157 Our results show that ribosome premature termination may lead to non-intuitive ribosome density p

158 at the alpha-chain end but, depending on the termination mechanism and the occurrence of transfer of

159 confined in time and space by an unexplained termination mechanism.

160 ciers to climate variability during the last termination more significant than implied by previous st

161 mic mRNAs, which revealed that transcription termination occurs upstream of a 5'-GCCAGCC-3' motif pre

162 Our data indicate that mtDNA replication termination occurs via a hemicatenane formed at the orig

163 controls the location at which Rho-dependent termination occurs, despite having no effect on initial

164 udoalteromonadaceae might be crucial for the termination of a dinoflagellate bloom.

165 tisense transcription termination, premature termination of a proportion of sense transcripts and ini

166 mboembolic events on dabigatran led to early termination of a randomized controlled trial of dabigatr

167 rise in atmospheric oxygen (pO2) leading to termination of an OAE after approximately 1 Myr.

168 ia to explore the feasibility of optogenetic termination of atrial tachycardia (AT), comparing two di

169 compute the probabilities of initiation and termination of bursts of triggered activity that are mai

170 upport the proposed role of calsequestrin in termination of calcium release by conformationally induc

171 e in one STS (AtTPS19) resulted in premature termination of carbocation intermediates and accumulatio

172 Cardiac arrest is defined as the termination of cardiac activity associated with loss of

173 ncides with the reduction in growth rate and termination of cell division of the underlying epidermal

174 tion in CERKL cDNA that caused the premature termination of CERKL.

175 sed in the early Eocene, consistent with the termination of conditions required by thermophilic linea

176 ions may represent the early steps linked to termination of diapause programming.

177 tional accidents and a 2-fold higher risk of termination of employment compared with the employed gen

178 The 2-year risk of termination of employment was 31.3% (95% CI, 30.4%-32.3%

179 Factors associated with termination of employment were age <40 years (incidence

180 s of syncope with occupational accidents and termination of employment.

181 The reduction of FCO2 upon termination of enrichment ( 35%) cannot be explained by

182 tivated during and immediately following the termination of every odorant.

183 However, how CTLs regulate the termination of granule secretion remains unclear.

184 eated hearts, significantly more spontaneous termination of initial long-duration VF was observed (66

185 Finally, we discovered that the termination of integrin tension is coupled with the expo

186 h visual information in the mind's eye after termination of its retinal input.

187 licing and poly(A) signal-independent Pol II termination of lincRNAs as compared to pre-mRNAs.

188 The chain termination of living ROAMP with substituted ethynylpyrr

189 In addition, we show that Mmi1-mediated termination of lncRNA transcription also takes place at

190 dings reveal an important role for selective termination of lncRNA transcription in both euchromatic

191 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses.

192 Termination of mRNAs is coupled to cleavage and polyaden

193 ne histology) in the OM, at 2 or 20 hr after termination of NA exposure, in humanized mice.

194 of small clusters and nanoparticles and thus termination of NPF.

195 rimer-primase complexes triggering the early termination of Okazaki fragment synthesis has distinct a

196 Opiates are essential for treating pain, but termination of opiate therapy can cause a debilitating w

197 ses parallel optimization runs for automatic termination of optimization tasks in case of consensus a

198 ure in the periplasm that persists until the termination of passenger-domain translocation.

199 ic function describing the beginning and the termination of plant growing season; actually, in many r

200 ent was obtained after she opted for medical termination of pregnancy.

201 ent was obtained after she opted for medical termination of pregnancy.

202 ortant sequelae, intrauterine mortality, and termination of pregnancy; and late onset sequelae.

203 ge, multidomain DEBS1, substantial premature termination of protein translation was observed.

204 sion yeast CID-protein Seb1 is essential for termination of protein-coding and non-coding genes throu

205 at regulate and fine-tune the initiation and termination of release are reviewed.

206 Termination of RNA polymerase II (Pol II) transcription

207 Clp1 plays a general role in poly(A)-coupled termination of RNAPII transcription and in enhancing pro

208 ng the role of glutamate in the duration and termination of SD caused by K+ perfusion and oxygen-gluc

209 equently, IKur block produces dose-dependent termination of simulated atrial fibrillation (AF) in the

210 provides an efficient solution to the sudden termination of spot machines as a result of a sudden pri

211 nitive changes that persisted long after the termination of stress.

212 We also find that the onset and termination of the calling activity of users follows a y

213 e same time-zone, we show that the onset and termination of the calling activity synchronizes with th

214 A mutation in tsv causes premature termination of the gene product.

215 ion signal causing premature transcriptional termination of the Lepr gene were crossed with AgRP-Cre

216 r domain of the riboswitch induces premature termination of the mRNA synthesis of ligand-associated g

217 me (ORF) were needed to ensure the efficient termination of the N mRNA and were required for recombin

218 due to very fast self-termination and cross-termination of the oxidative chain.

219 of a bicyclic lactone arising from oxidative termination of the photoredox-catalyzed radical cyclizat

220 The termination of the proliferation of Drosophila neural st

221 Strong flowering signals can result in termination of the SAM, usually by its differentiation i

222 ion with a trailing ribosome causes abortive termination of the stalled ribosome.

223 nglia neurons excised from NC/Nga mice after termination of the studies.

224 logic characteristics of the brain after the termination of the treatment and did not induce glial re

225 %], P<0.001), and this result prompted early termination of the trial.

226 ing frame within the leader sequence and the termination of this potential protein in TPL3.

227 he 3' end processing of mRNA and the coupled termination of transcription by RNAPII requires the CF I

228 The poly(A)-independent termination of transcription of snoRNAs, however, remain

229 y suggest a role for Clp1 in poly(A)-coupled termination of transcription.

230 least in part by nonadherence and premature termination of treatment.

231 was achieved by mapping the transcriptional termination of two S-segment-derived subgenomic mRNAs, w

232 ed temporally with resolution of viremia and termination of virus shedding in oropharynges and feces.

233 P<0.0001), intrauterine deaths (P=0.01), and terminations of pregnancy (P<0.0001) in Group I compared

234 mportant role in controlling the interfacial terminations of SrRuO3 /BaTiO3 /SrRuO3 (SRO/BTO/SRO) fer

235 atmospheric CO2 were associated with glacial terminations of the Late Pleistocene.

236 The size, density and surface terminations of the nanostructures were leveraged toward

237 nd safety monitoring board recommended study termination on September 26, 2016.

238 t and timing of the last glacial advance and termination on sub-Antarctic South Georgia in particular

239 They exert indentation, segmentation, and termination on the viscous sublayer streaks, and they co

240 itive techniques to characterize the surface termination (one aspect of surface reconstruction) of Sr

241 ported on connectional grounds, and that CEA termination over the PBP and RRF neuronal populations ca

242 1), intrauterine demise (P=0.036), and early termination (P<0.0001) were identified compared with fet

243 ng, which increases the flux of ECs into the termination pathway.

244 d with motifs involved in the Nrd1-Nab3-Sen1 termination pathway.

245 gh selective nucleation of nanocomposites on termination patterned substrates.

246 The termination phase is initiated by PDEs actively targetin

247 AMP hydrolysis by phosphodiesterases (PDEs) (termination phase).

248 scription results in antisense transcription termination, premature termination of a proportion of se

249 tion elongation factor NusG facilitates this termination process by directly interacting with Rho.

250 is and trans factors, and the effects of the termination process on physiological processes in bacter

251 AF termination rate declines as patients progress to longst

252 We confirmed that the TL stimulates termination rate, but found that stabilizing either the

253 folded or unfolded TL conformation decreased termination rate.

254 AT termination rates for distributed illumination were low,

255 at eIF5A functions broadly in elongation and termination, rationalizing its high cellular abundance a

256 ion of peroxy radicals and their bimolecular termination reactions.

257 s of translation-initiation, elongation, and termination/reinitiation-determine protein synthesis rat

258 ect to debate because the mode of arrhythmia termination remains poorly understood, as dedicated mode

259 Rho-dependent termination requires initial recognition of a Rho utiliz

260 number of beats before initiation and before termination, respectively, which follow geometric distri

261 Termination reversal was not observed at higher temperat

262 ation termination and (iii) dissociates post-termination ribosomal complexes that are devoid of the n

263 in transcription initiation, elongation and termination, RNA processing and chromatin modification.

264 ithhold therapy, including strict VF episode termination rules, enhancements to minimize T-wave overs

265 start site of pol III genes extends past the termination sequences, resulting in nucleosome free gene

266 ng atomically sharp interfaces with designed termination sequences.

267 At study termination, serum 25-hydroxyvitamin D levels were 48.7

268 nally discovered and characterized as a molt termination signal in insects through its regulation of

269 is showed the polymerase reading through the termination signal in the downstream region of highly tr

270 In bacteria, intrinsic termination signals cause disassembly of the highly stab

271 tive promoters, enhancers, splice sites, and termination signals.

272 polymerase (RNAP) at a single Rho-dependent termination site over 100 nt downstream.

273 T cell epitopes downstream of the premature termination site that may render the subject tolerant to

274 scriptional start sites, 116 transcriptional termination sites and 80 splicing events.

275 These termination sites are consistent with both mono- and pol

276 regulated the transcriptional readthrough of termination sites located within two different antibioti

277 nknown mtDNA TIS, pausing, and transcription termination sites with unprecedented accuracy.

278 sis of foraging's transcription start sites, termination sites, and splicing patterns using rapid amp

279 re in the genome, including at transcription termination sites.

280 SIGNIFICANCE STATEMENT The elongation and/or termination steps of mRNA translation are emerging as im

281 st this hypothesis, we compared 3 CAR T-cell termination strategies: (1) transiently active anti-CD12

282 UDP-4-N3-GlcNAc served as a chain termination substrate for hyaluronan or heparosan syntha

283 ing the early and late phases of translation termination suggest that UPF3B is involved in the crosst

284 ucleotide insertions or deletions, premature termination, tandem repeat, nonstop, and missense mutati

285 ustainability of the effects after treatment termination, the cost-effectiveness of CAP over 12 month

286 ustainability of the effects after treatment termination, the cost-effectiveness of HAP over 12 month

287 s when an accumulation of evidence reaches a termination threshold, registered, subjectively, as an "

288 t is permissive for transcription initiation/termination, thus generating novel sense and antisense t

289 variability through the penultimate glacial termination (TII) and last interglacial, by applying the

290 y used in catalysis, tuning of their surface termination to control reaction selectivity has not been

291 At termination, under anaesthesia, transection of the vagi

292 Upon inhibiting RNA polymerase II termination via depletion of the cleavage/polyadenylatio

293 eline state (VISUAL-2) to the final or early termination visit was determined in each group and stati

294 Procedural AF termination was achieved in 70% of patients, but decreas

295 Median time to treatment termination was significantly shorter in dabigatran pati

296 f different carbon electrodes with different terminations was determined using cyclic voltammetry (CV

297 gate the contribution of the TL to intrinsic termination, we developed a kinetic assay that distingui

298 Upon CAR T-cell termination, we further demonstrated successful hematopo

299 nsight into the mechanism of DNA replication termination while at the same time raising important que

300 me collisions selectively stimulate abortive termination without fine-tuning of kinetic rate paramete