ライフサイエンスコーパス: termini

1 d for binding blunt, but not 3' overhanging, termini.

2 ns as well as very well defined non-reducing termini.

3 late stage functionalization of spiroligomer termini.

4 in a 2',3'-cyclic phosphate (cP) at their 3' termini.

5 ted at the confluence of cytoplasmic N and C termini.

6 d this enzyme to isolate acylated Vi antigen termini.

7 y depends on the substitution at the C and N termini.

8 Orb2 has two isoforms that differ in their N-termini.

9 s are frequently associated with presynaptic termini.

10 easing lengths and functionalizable N- and C-termini.

11 hrough their third intracellular loops and C-termini.

12 r substrates with intrinsically disordered N termini.

13 architecture with the ladder broken in both termini.

14 plication reinitiation events at the genomic termini.

15 ntiparallel beta-sheet with flexible N and C termini.

16 coordination between pre- and post-synaptic termini.

17 ble binding event involving both the N and C termini.

18 eated to expose the underlying sensory nerve termini.

19 lical structure in LPS with extended N and C termini.

20 nus, N-terminus, or simultaneously from both termini.

21 orms a tight dimer through swapping of the N termini.

22 nd locations of unreliable/flexible loops or termini.

23 H3.1-containing nucleosomes with wrapped DNA termini.

24 reciprocal translocations at the chromosome termini.

25 (Abeta(1-40)) but can have variable C and N termini.

26 -133) due to the intertwining of its N and C termini.

27 igomers dictated by features of the N- and C-termini.

28 ia the rapid reuptake of DA into presynaptic termini.

29 -nucleotide small RNAs with 5'-polyphosphate termini.

30 ed by transversal filaments by their N and C termini.

31 exible and charged segments of the peptide N termini.

32 ith Fc-C identical withC-Fc (Fc, ferrocenyl) termini.

33 ghly conserved Rab-binding domain at their C termini.

34 cytosol have four residues, EEVD, at their C-termini.

35 yrin repeat (AR) domain at their cytosolic N termini.

36 e optimal with BLT termini compared to 3'ovr termini.

37 ts to basic sequence motifs near the N and C termini.

38 ing NAD(+) caps can be added to 5'-processed termini.

39 packing interactions with extended N- and C-termini.

40 trally to enable contact between the N and C termini.

41 identifying RNAs with 2',3'-cyclic phosphate termini.

42 dmDcr-2 binds 3' overhanging, but not blunt, termini.

43 ecting functional regulation through their N termini.

44 uced the loss of striatal DA neuronal axonal termini.

45 d in DAT chimeras encoding both SERT N and C termini.

46 fold with degraded kinase motifs at their C termini.

47 rands and shorter more labile strands at the termini.

48 virus 1 (HSV-1) to enter neurons via axonal termini.

49 nabling enzymatic modification of the glycan termini.

50 nyl and methyl groups at their free N- and C-termini.

51 te the effect of modulating the C- and the N-termini.

52 er-2 distinguishes dsRNA substrates by their termini.

53 nly to the hydrophobic residues near peptide termini.

54 arged domains (Pro-Arg-Gly) at both N- and C-termini.

55 r DAT, because replacing the SERT N and/or C termini affected neither substrate nor inhibitor affinit

56 Finally, RtcB is enriched at axon termini after nerve injury.

57 ise to two protein isoforms with different N termini: AKR1B15.1 is a 316-amino acid protein with 91%

58 Fused Hisn -tags at the protein termini allow rapid bioconjugation and consequent purifi

59 ave mapped proteolysis sites at the N- and C-termini and at a limited internal segment, while other p

60 , and tissues by removing cleavable N- and C-termini and by shielding components from metabolic enzym

61 his method enables specific capture of 5'-OH termini and complements existing methods for identifying

62 eate a hydrophilic core made of zwitterionic termini and expose hydrophobic aromatic side chains to t

63 systems, our findings indicate that free DNA termini and PAMs are conserved features important for CR

64 beta-sheets, flanked by disordered N- and C-termini and Ser13 phosphorylation creates a network of s

65 the ends of protein helices stabilize helix termini and shape the geometry of the adjacent loops, ma

66 inase/phosphatase that processes damaged DNA termini and that, if mutated, results in ataxia with ocu

67 oval of the intrinsically disordered N and C termini and the hook region of beta1a prevented oligomer

68 s of amino acid position relative to peptide termini and the influence of peptide secondary structure

69 n which the long-range contacts between both termini and the microtubule binding region that characte

70 ps allow independent modification of the two termini and the side chains.

71 NHEJ relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enz

72 been ascribed to the receptor cytoplasmic C-termini and to AMPAR-associated auxiliary subunits, both

73 of peptides, including those with expanded N termini and unfitting anchor residues.

74 h siloxy or alkoxy functional groups at both termini, and can also be applied to polymeric vinyl- and

75 uctural similarities between TssA1 and gp6 C-termini, and propose that TssA1 could be a baseplate com

76 pairs Tdp2 mediated NHEJ of tyrosine blocked termini, and renders cells sensitive to the anticancer a

77 ed transcriptome, identify 40,000 novel 3' termini, and reveal that two-thirds of Drosophila genes

78 gradual accumulation of tubular ER in axonal termini, and such abnormal tubular ER inclusion is found

79 te processive cleavage, while 3' overhanging termini are cleaved distributively.

80 ycosylases from diverse sources, where the C termini are disordered and do not form comparable intram

81 ched vs. mismatched base pairs at duplex DNA termini are far too low to explain pol accuracy.

82 le, the core is highly structured, and the C-termini are flexible but restrained by their contact wit

83 e survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core i

84 In contrast, the sequences of the C-termini are highly conserved, consistent with them encom

85 The two termini are in close proximity to each other via aromati

86 RNA-Seq analyses revealed that these termini are ligated together to generate circular SRP RN

87 nged such that, on average, two of the seven termini are localized inside the lumen of the proteasome

88 The peptide C termini are located close to the main fibril axis, where

89 We also found that NIP4;1 and NIP4;2 C termini are phosphorylated by a pollen-specific CPK that

90 Protein amino (N) termini are prone to modifications and are major determi

91 mophore exposing 2,6-di(acetylamino)pyridine termini are reported.

92 Notably, Ub E2 N termini are serine/threonine rich in many other Ub E2s,

93 ed ryanodine receptor, the cytosolic carboxy termini are uniquely arranged in a left-handed alpha-hel

94 RNA-seq protocols that focus on transcript termini are well suited for applications in which templa

95 th had different and unique conserved genome termini, as in separate bunyavirus genera.

96 e if application of rAAV to peripheral nerve termini at the epithelial surface would allow rAAV to tr

97 r spokes radiate, placing the Sas-6 carboxyl termini at the outer edge of the approximately 60 nm rad

98 The termini bind to each other to facilitate linear extensio

99 rm initiation complexes and sequester primer termini but not elongate, we investigated the possibilit

100 ains activity of PPAD against arginines at C-termini but not within peptides.

101 F are isoforms that are identical in their N termini but unique in their C termini due to a -1 riboso

102 We discovered that it was not the N termini, but the loop2 regions connecting TM2 and TM3 of

103 mic Rho1 activity that retracts s-LNv axonal termini by increasing myosin phosphorylation and simulta

104 cted this loss of sequencing coverage at the termini by introducing modified primers during the targe

105 ese peptides are protected at their N- and C-termini by macrocyclization.

106 regarding the repeating units, lengths, and termini can be obtained directly from the surface sample

107 sults indicate that modulations of the Abeta termini can determine the fate of a salt bridge far away

108 RE ) for proteins with fluorescently labeled termini, can be estimated using single-molecule Forster

109 absolute sense of conrotation of the dienone termini ("clockwise" or "counterclockwise") in the liter

110 age, and ATP hydrolysis are optimal with BLT termini compared to 3'ovr termini.

111 ore compact and rigid sites at their N and C termini compared with WT alpha-Syn that may facilitate t

112 e guest occupying a polar region and the two termini competing for occupancy of the other pole), or a

113 ule which we show is sensitive to poly(A) 3'-termini, consistent with protection from deadenylation.

114 cal membrane domains and large cytoplasmic C-termini containing two cystathionine-beta-synthase domai

115 They depend on their fatty-acylated N-termini, containing N-myristate and either a polybasic c

116 e the highly divergent intracellular N and C termini contribute to these processes.

117 roteins to test whether DAT and SERT N and C termini contribute to transporter substrate and inhibito

118 tryptophans exists, with residues at the WR termini contributing more to Nanog function, particularl

119 There is also increasing evidence that N-termini could act as important protein stability determi

120 rotein where the intersection of two helix N-termini creates a region with a strong, localized positi

121 ilA proteins with diverse and/or truncated C termini decreased native pilA transcription, suggesting

122 Quantitative mapping of N-termini demonstrated perturbation of protease action dur

123 r-2's partner protein, Loquacious-PD, alters termini dependence, enabling dmDcr-2 to cleave substrate

124 ferentially and enantioselectively protected termini display moderate screw-sense preferences.

125 One mouse truncated all C termini downstream of Oprm1 exon 3 (mE3M mice), while th

126 cal in their N termini but unique in their C termini due to a -1 ribosomal frameshift during translat

127 racellular loops with the amino and carboxyl termini facing the cytoplasm.

128 o equally active isoforms with alternative C-termini, Fes1L and Fes1S.

129 an oligonucleotide linker to RNAs with 5'-OH termini, followed by steps for library construction and

130 cleotidyltransferases, enzymes modifying RNA-termini for ligation (phosphatases and kinases) or prote

131 d chromatin that protects natural chromosome termini from being recognized as DNA double-strand break

132 Spontaneous DNA opening at the nucleosome termini has long been hypothesized to enable gene access

133 n which the V1, V2, and V3 loops and N and C termini have been truncated) have indicated that a hallm

134 d for subclasses having homologous F(ab')2 C termini (IgG1/3/4).

135 rated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/6J (B6) and

136 lysis to investigate the role of the N and C termini in ATP hydrolysis and auto-inhibition of the yea

137 transcription products and their precise 3'-termini in HIV-1 infected T cells.

138 lipid bilayer, implicating both the N and C termini in membrane binding.

139 hese mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting the

140 wing degradation of neuronal cell bodies and termini in MPTP-intoxicated mice.

141 Our approach reveals that DNA termini in the nucleosome open and close repeatedly at 0

142 th all kinds of seeds implying that extended termini interfere with the ability of monomers to nuclea

143 Formation of the Drosophila embryonic termini is controlled by the localized activation of the

144 ates maturation of corresponding presynaptic termini is unknown.

145 tion to canonical LTR-RTs with 5'-TG...CA-3' termini, LTR_retriever also identifies noncanonical LTR-

146 o the human 43-mer inhibitory tract (N and C termini, mAbinhibit, and mAb4C11) and the neoepitope gen

147 e side chain-to-side chain and side chain-to-termini macrocyclization of peptides, thus enabling not

148 lectron microscopy, we show that the GroEL C-termini make physical contact with the PepQ folding inte

149 netically ductile when pulled from their two termini, making them resistant to force spikes.

150 stable proteoforms with undocumented N- or C-termini, meaning these proteoforms are stable functional

151 AA and ARF proteins share highly conserved C-termini mediating homotypic and heterotypic interactions

152 To understand how the distinct C termini might affect transporter trafficking and surface

153 ion of a linearized plasmid with 3-P-blocked termini, mimicking those at X-ray-induced strand breaks,

154 dipeptide containing azide and alkyne at its termini (N3-Ala-Val-NHCH2C identical withCH, 1) was synt

155 lator decorated with azide and alkyne at its termini, N3-Ala-Val-NHCH2-C identical withCH, which is d

156 rmining step is bond formation at the alkyne termini nearest the tether, which involves a transition-

157 relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants.

158 ted the five Cys residues in the identical N termini of 6K and TF, the four additional Cys residues i

159 s (or in proteins with amide linkages), when termini of a protein backbone pierce through an auxiliar

160 NatA co-translationally acetylates the N termini of a wide variety of nascent polypeptides.

161 Recombinant C-termini of ADAMTS10 and ADAMTS6, both of which induce fo

162 The N and C termini of adjacent BAFF or APRIL monomers are spatially

163 The C-termini of all isoforms localize to the active zone.

164 ribe the cP-RNA-seq protocol in which the 3' termini of all RNAs, except those containing a cP, are c

165 ar interactions play a role in capping the C-termini of alpha-helices and 310-helices.

166 particle (CP) is blocked by the convergent N termini of alpha-subunits.

167 us, proteolytic modifications of the N and C termini of alpha2AP constitute major regulatory mechanis

168 In this study we establish that N-termini of amino acid transporters can also determine su

169 L-terminase protomers projecting from the C-termini of an S-terminase ring.

170 -5 nm, revealing that the amino and carboxyl termini of Ana2 are located in the outer cartwheel regio

171 NRBF2 interacts primarily with the N termini of ATG14 and BECN1.

172 Thus, the hydrophobic regions in the C termini of BH3-only members associated in distinct ways

173 on structures of the ANK repeat-containing C termini of both kidney-type glutaminase (KGA) and GLS2 i

174 The noncore C termini of both RAG1 and RAG2 are also required for ATM'

175 he absence of nucleotides, the RNAP-bound 3' termini of both vRNA and cRNA exist in two conformations

176 The N termini of CC chemokines are shown to be involved in rec

177 well-separated protein interfaces at the two termini of CRY2.

178 with direct binding mediated by the carboxy termini of Dam1p and Duo1p.

179 of RNA Ends to specifically identify the 5' termini of decay intermediates whose production is depen

180 es with homotypic interactions between the N termini of different HttEx1Qn molecules that trigger the

181 sely determined the locations of the N and C termini of DRC3 and the C terminus of DRC4 within the th

182 The C-termini of E2 [amino acids (aa) 890-1053] and MEK2 (aa 2

183 n resides in short acidic regions near the C termini of each subunit.

184 eres are the protective end-complexes at the termini of eukaryotic chromosomes.

185 he 'alpha3/alpha5' interface, in which the C-termini of helices alpha3 and alpha5 are in close proxim

186 constitutively bound to IQ domains of the C termini of human Kv7 (hKv7, KCNQ) channels to mediate Ca

187 onstrate following proteolysis that N- and C-termini of IP3 R1 remain associated, presumably through

188 We have documented new detached pits at the termini of linear gullies on Martian dunes.

189 ependent conformational variation near the C termini of molecules within PrP(Sc) multimers.

190 ature (TRIM) elements were identified at the termini of most chromosomes.

191 e elimination of saccharides attached to the termini of N-glycans.

192 The amino termini of nine Sas-6 dimers form a central hub of appro

193 We find that B9D1, AHI1, and the N termini of NPHP4 and NPHP5 interact with the transmembra

194 ave features that discriminate them from the termini of organellar amino acid transporters.

195 bind to negatively charged residues at the C-termini of P-proteins.

196 pendently monitor the environment of the two termini of pHLIP.

197 results indicate that the amino and carboxyl termini of PHO1 are both oriented toward the cytosol and

198 s of mRNA sequences that correspond to the C-termini of protein domains, suggesting ribosome protecti

199 UBE2W ubiquitinates N termini of proteins rather than internal lysine residues

200 a strategy specifically designed to enrich N termini of proteins, we demonstrate that many human prot

201 xin 2 (Stx2A1) interact with the conserved C termini of ribosomal-stalk P-proteins to remove a specif

202 psis and rice, we found a predominance of 5' termini of RNA degradation intermediates that were separ

203 The N termini of several needle proteins were truncated and te

204 N-termini of several proteases were downregulated in prt6,

205 transcriptional activation domains in the C termini of several tail module subunits of Saccharomyces

206 s (ERret) are incorporated into the N- or C- termini of Shaker monomers or within sodium channels two

207 nds between the 5'-phosphate and 3'-hydroxyl termini of single-stranded RNAs.

208 ve previously demonstrated that the C- and N-termini of SK2 channels interact with the actin-binding

209 mportantly, our studies highlight that the N termini of SLN and PLB influence their respective unique

210 In this study, we demonstrated that the N termini of some needle proteins, particularly the N term

211 minopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in sec

212 f nNOS binds with very low affinity to the C termini of target proteins, and a necessary simultaneous

213 ction with the proline-rich sequence and the termini of tau.

214 ially located 27.5 A apart at the 3'- and 5'-termini of the 27-base mini TAR DNA relocated to opposit

215 d intermediates in which substituents on the termini of the allenes had rotated away from the vinyl m

216 n distances of neighboring residues at the C-termini of the alpha1 and alpha2 helices are consistent

217 es Tyr(240) and Tyr(274) binding the C and N termini of the B and C helices of IFN-beta, respectively

218 icosahedrally related His residues in the N termini of the C subunit at the quasi-6-fold axes.

219 otting can only be identified by closing the termini of the chain somehow.

220 The termini of the channels protrude into the cytosol.

221 e modification of numerous residues in the C termini of the D1 and D2 proteins on the donor side of t

222 om degrading and allows two structure-free N termini of the dimerized ORF57 to work coordinately for

223 ly modulated by small regions in the N and C termini of the Gle2 binding domain sequence, suggesting

224 raction with Manalpha1-2Man on two different termini of the glycan, with the reducing-end mannose res

225 in domains to N-terminus, C-terminus or both termini of the knotted proteins clearly demonstrate that

226 Interestingly, genomic termini of the large (L) and small (S) components were d

227 The termini of the meso oligomers are enantiotopic, and desy

228 vidual saccharide units from the nonreducing termini of the multiantennary structures.

229 We find that the nucleoporin Nup62 and the C termini of the nephronophthisis (NPHP) proteins NPHP4 an

230 considerably if the stereochemistry at both termini of the new bond could be controlled effectively.

231 cation, is coupled with the rotation of the termini of the pentadienyl cation, favoring a particular

232 Mcl-1 deletion mutants from both the N and C termini of the protein, including one that contained a d

233 munodominant antigenic sites in the N- and C-termini of the RSV-G protein, that were boosted >10-fold

234 juxtaposition of 3 hydroxyl and 5 phosphate termini of the strand breaks for catalysis.

235 atus, and has a preference for acetylating N termini of the transmembrane proteins.

236 sphatase BL (PDZ2) interacts and binds the C-termini of the tumour suppressor protein APC and of the

237 system, we identified regions in the N and C termini of the V protein that inhibit viral RNA synthesi

238 e Wnt/beta-catenin signaling to polarize the termini of their anteroposterior axis, but little is kno

239 While the C termini of these orthologs are not conserved in amino ac

240 omains, and recently it was shown that the N termini of these proteins form a tubulin-binding module

241 g of their progenitor mRNAs joined the amino termini of these proteins to the NP1 open reading frame,

242 We demonstrate that modifying the termini of these siRNAs with a terminal G-U wobble pair

243 r wires connecting the positive and negative termini of this reaction centre is capable of conducting

244 The 5'- and 3'-termini of this SRP RNA are located close to a functiona

245 sitive varphi-values occurs at the cytosolic termini of transmembrane helices 1 and 2, which we ident

246 alphao interacts with both the N- and the C- termini of TRPM1, Gbetagamma interacts only with the N-t

247 attaching isotopic tags to both the N- and C-termini of tryptic peptides, and second, a search engine

248 reaction between the carboxyl and the amine termini of two fragments.

249 The C termini of various cellular proteins insert within the b

250 ymerases include promoter RNA (the 5' and 3' termini of viral genome segments), showing FluPol in tra

251 ed among different Cxs, whereas the carboxyl termini, often called the cytoplasmic tails, are highly

252 , which generates the Ler-type extra ccmB 5' termini only after the introduction of the RPF4 allele f

253 rtions, which arose by expansion of flexible termini or internal loops, show greater variation in str

254 brane domains (TMDs), with both the N- and C-termini orientated toward the lumen of the ER.

255 While the YopD amino and carboxy termini participate in pore formation, the role of the Y

256 reveals how conformational changes in CCL3 N termini profoundly alter its surface properties and dime

257 Blunt termini promote processive cleavage, while 3' overhangin

258 wth synthesis provides oligoPPEs with alkyne termini protected with the orthogonal groups trimethylsi

259 by addition of a different unimer to the arm termini, provided complementary characterization to tran

260 erized by a beta-turn structure near their C termini rather than the alpha-helical structure common t

261 Extension from DNA damage at primer termini remains poorly understood.

262 ends to generate the 3'-OH,2'-PO4 and 5'-PO4 termini required for sealing by an N-terminal ligase dom

263 s, we determined that the amino and carboxyl termini reside in the extracellular space and are initia

264 lacking 104 and 65 residues from its N and C termini, respectively.

265 rginine(R)-phenylalanine(F) motif at their C-termini (RFamide peptides).

266 The positively charged N-termini serve as a primary point of interaction.

267 s to juxtapose the amino (N) and carboxy (C) termini; several of these designed structures have been

268 Deep sequencing of TERC RNA 3' termini shows that PARN is required for removal of post-

269 nsport progression: cargoes pause at polymer termini, suggesting that switching MT tracks is rate lim

270 lling experimental evidence that DAT N and C termini synergistically contribute to substrate and inhi

271 nds to its cognate sites, called replication termini (Ter) or replication fork barriers (RFB), that a

272 , which generates 5-phosphate/3-hydroxyl DNA termini that are critical for ligation by the NHEJ DNA l

273 use Naa10 is reported to acetylate all amino termini that are devoid of methionine and Naa50 acetylat

274 ells can generate 5'-adenylated (5'-AMP) DNA termini that can be removed from DNA by aprataxin (APTX)

275 ains Gal-alpha(1-->4)-Gal-beta(1-->4)-GlcNAc termini that can bind SLT-1B selectively.

276 on, mapping, and quantification of protein N-termini to comprehensively characterize cleaved podocyte

277 oly(A)-binding proteins (PABPs) link mRNA 3' termini to translation initiation factors, but they also

278 h HSC/HSP70 binding scores and hydrophobic N-termini, two characteristics that were previously observ

279 ASIC subunits contain intracellular N and C termini, two transmembrane domains that constitute the p

280 ization of added unimers at the seed micelle termini under nonequilibrium self-assembly conditions ap

281 dered the only Dicer domains that bind dsRNA termini, unexpectedly, we found that the helicase domain

282 the transformations of macromolecular chain termini via high-resolution mass spectrometry and subseq

283 Using specific enrichment of protein amino termini, we analyzed the tic56-1 and plastid protein imp

284 ns accumulated with two or three different N termini; we evaluated the significance of these differen

285 LUC) or a repaired virus (30R) contained DNA termini, whereas cells infected with Delta30L, 30-IXAla,

286 endo conformation oriented toward the 3SCC C-termini, whereas the cysteines are predisposed for trigo

287 how the structural modifications of N-glycan termini, which are distal from the binding interface, co

288 inding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a univer

289 The introduced glycans carry mannose termini, which create potential novel binding sites for

290 ssesses multiple CaMBDs at cytosolic N and C termini, which is reminiscent of animal CNGCs and unlike

291 sterically bulky "protecting groups" at the termini, which shield the reactive carbon chain from unw

292 em dimer Tomato (tdTomato) were fused at NH2-termini with a palmitoylation signal (PalmGFP, PalmtdTom

293 und peptides, selectively labeled at their N-termini with a positive charge-bearing group, are subjec

294 confirm the exact orientation of its N and C termini with respect to the plasma membrane to get clues

295 cleotides that are labeled at their opposite termini with Tb and a fluorescent reporter dye.

296 Interaction of Galphas or Galphaq C termini with the GPCR increases signaling potency, sugge

297 We also found that swapping PLB N and C termini with those from SLN caused the resulting chimera

298 slowest steps in nucleosome assembly are DNA termini wrapping and tetramer positioning, both of which

299 ion, (H3-H4)2 tetramer incorporation and DNA termini wrapping are facilitated, whereas proper incorpo

300 B dimer binding, which is independent of DNA termini wrapping.