ライフサイエンスコーパス: terminus

1 N-methylation of the mature (pseudo)pilin N terminus.

2 ylation of key serine residues in the IRF6 C-terminus.

3 de range of conditions and at either protein terminus.

4 wo conserved Trp(1)-Cys(2) residues at the N terminus.

5 precedes the proteasome-activating carboxyl terminus.

6 d when the needle tip is close to the apical terminus.

7 different charge and length at the protein C-terminus.

8 h a novel dynein interacting site near its C terminus.

9 a plastid transit peptide (PTP) at its amino terminus.

10 ires only the two cysteines closest to the C-terminus.

11 s using an amphipathic helix at its unique N-terminus.

12 top codon with 46 additional codons at the C-terminus.

13 transactivation domain (TAD) of the BMAL1 C terminus.

14 drophobic signal sequence near the protein N terminus.

15 of as few as seven amino acids from the K2 C terminus.

16 d fusing an interacting BH3 peptide to the C terminus.

17 t with faster reverse protonation from the C terminus.

18 on on Ser-1700 and Ser-1928 at the channel C terminus.

19 roteins that interact with the CB1R at the C-terminus.

20 o the flagella in the absence of the IFT46 N-terminus.

21 owth factor receptor at tyrosine 88 in its N-terminus.

22 dependent on the effector function of the N-terminus.

23 TF palmitoylation occurs primarily in the N terminus.

24 isomerization of a single proline near the C-terminus.

25 entified an Snx3 sorting motif in the Neo1 N-terminus.

26 tic domain in the C terminus of A3G to its N terminus.

27 hed to cysteine has been introduced at its N-terminus.

28 t with faster forward deprotonation to the C terminus.

29 n anti-autoinhibitor domain at the extreme C-terminus.

30 d between the glutamate-binding domain and C-terminus.

31 ingle leucine-rich repeat (LRR) within its N-terminus.

32 a buttressing force directly on the glacier terminus.

33 that FBXO32 physically interacts with the N-terminus (1-60 aa) of KLF4 via its C-terminus (228-355 a

34 rylation at threonine-468 of a CB1R distal C-terminus 14-mer peptide reduced CB1R-CRIP1a association.

35 h the N-terminus (1-60 aa) of KLF4 via its C-terminus (228-355 aa) and directly targets KLF4 for ubiq

36 her result leads to DNA damage at the primer terminus (3-end) during the succeeding insertion event.

37 Ubiquitination of GABARAP occurs in the N terminus, a domain associated with ATG8-family-specific

38 ified a nuclear export signal (NES) at the N terminus (AAs 176-192) that contributes to CASZ1 nuclear

39 , we define a critical region at the CASZ1 N terminus (AAs 23-40) that mediates the CASZ1b nuclear lo

40 ings are consistent with a model where the N terminus acts as a lever to support amphetamine-induced

41 Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, sugges

42 ingle amino acid in the distal part of the C-terminus affects multiple aspects of NHE3 complex format

43 Our observations show that the N terminus affords the switch between transport modes.

44 ctural alterations that propagate from the N terminus all the way to the C terminus, without destabil

45 The N- to C-terminus amide cyclized peptide with one d-amino acid (k

46 of the ligand's ammonium group toward the N-terminus and (B) to the lack of a helical kink upon liga

47 patients impaired the interaction with the C terminus and also affected protein stability.

48 demonstrate that substitutions at both the N-terminus and C-terminus of Cl-amidine result in >100-fol

49 Mutations near the N-terminus and C-terminus of PZase were associated with Ea

50 single positive charge from the lysine at C-terminus and causes aggregation of citrate anion-stabili

51 This effect requires the N-terminus and coiled-coil domain (C-C) as mutations withi

52 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and constitutively phosphorylates a downstream

53 zed several variants located in the GluN2B C terminus and found that three variants in patients with

54 (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region sugges

55 also permissive communication of the Orai N terminus and loop2 in an isoform-specific manner.

56 Nesprin-2G engaged actin through its N terminus and microtubules through a novel dynein interac

57 M1-specific inhibitors should focus on its N-terminus and predict that other PRMTs may employ similar

58 CXCL11 depends on the ACKR3 N terminus and some extracellular loop (ECL) positions for

59 like CRY circadian regulation on the BMAL1 C terminus and the CLK PAS-B domain and demonstrate the im

60 domain, dynamic flexibility occurs at the N-terminus and the first alpha-helix that connects the Hly

61 e, which leads to the repositioning of the N terminus and transition to an inward-open state.

62 ex with peptides corresponding to the RPN2 C terminus and ubiquitin.

63 at Tyr(334) (in the newly exposed deltaKD N terminus), and this (or an S359A substitution) rescues d

64 tion of helices I-V from ChR1, without its C-terminus, and helices VI-VII from ChR2, is used as a tem

65 modulates the palmitoylation of TF at the N terminus, and palmitoylated TF is preferentially traffic

66 lpha-helix in its aggregation-accelerating N terminus, and semi-rigid polyproline II helices in the p

67 ansport complex A binding to the TULP3/TUB N terminus, and subsequent release into PI(4,5)P2-deficien

68 Expression of the K2 C terminus as an extension of membrane-anchored P-selectin

69 d, truncated leucine zipper motif near the N terminus as well as a strictly conserved arginine residu

70 ccupied N-linked glycosylation site at the N terminus at position 1 (equivalent to Asp-221 in the Fc

71 nteractions with the CaV2.1 alpha1 subunit C-terminus at the active zone, the role of these interacti

72 ion) "undocks" and repositions the cofilin N terminus away from the filament axis, which compromises

73 Finally, we demonstrated that UL46 via its N terminus binds to STING and, via its C terminus, to TBK1

74 The helix at the C-terminus binds to the well-known p53-binding pocket in m

75 -CoV S protein fused to the RABV G protein C terminus (BNSP333-S1).

76 r phosphorylation, primarily in the carboxyl terminus but also in the cytoplasmic loops, and subseque

77 However, the humoral response to the PfCSP C terminus (C-PfCSP) is less well characterized.

78 imal syntaxin 1A-binding sequence of Kv2.1 C terminus (C1aB) was first identified via a far-Western p

79 The IFT46 C-terminus can assemble into and stabilize IFT-B but does

80 in CAR-DCN was engineered with an extended C-terminus comprised of CAR homing peptide that recognizes

81 duplex nucleic acids in which the 3-OH nick terminus consists of two or more ribonucleotides.

82 n of two acidic sequences within the MRE11 C terminus containing serines 558/561 and 688/689.

83 Peptides mimicking the CB1R C-terminus could bind to both CRIP1a in cell extracts as w

84 The proximal Kv7.1 C terminus (CT) binds calmodulin (CaM) and phosphatidylino

85 hanous-autoregulatory domain (DAD) and the C terminus (CT) of formins have also been shown to regulat

86 t cognate metal binding to RcnR orders its N terminus, decreases helix 1 flexibility, and induces con

87 These mutations, as well as C terminus deletion (Cox1DeltaC15), reduced binding of Mss

88 Deletion of the distal N-terminus (Delta2-135) accelerated off-gating current, bu

89 of the last 10 amino acids from the pUL33 C terminus did not affect viral replication or the interac

90 ta20 IFITM2) lacking 20 amino acids at the N terminus differentially restricts X4 and R5 HIV-1.

91 splicing variant missing 90 amino acids at C-terminus does not promote LD fusion or TAG accumulation,

92 action between the channel's intracellular C-terminus domain and the SNARE (soluble N-ethylmaleimide-

93 change of the GluN1 subunit intracellular C-terminus domain.

94 s) and human BCL9 and B9L to show that the C-terminus downstream of their adaptor elements is crucial

95 and hydrophobic spacer peptide (SP) at its C-terminus early in the maturation process, which is progr

96 evels of EIN2 protein and demonstrate EIN2 C terminus (EIN2-C) is sufficient to rescue the levels of

97 oil to disperse the droplets at the circuit terminus for analysis.

98 configuration, the last 36 residues at the C-terminus form a bundle of five alpha-helices co-linear w

99 by the ubiquitin-proteasome system and an N-terminus fragment remains in the cytoplasm where it asso

100 esult is consistent with the view that the C-terminus functions as a molecular sieve and stabilizer o

101 In particular, the C terminus functions as a toggle switch, which affects acc

102 ereby restricting it to homologous to E6AP C-terminus (HECT) and RING-in-between-RING (RBR) E3s.

103 In contrast, CIA2A bound to viperin's N terminus in a CIA1-, CIA2B-, and MMS19-independent fashi

104 We present crystal structures of the eVP30 C-terminus in complex with this eNP peptide.

105 ull-length approximately 7-kDa cytoplasmic C terminus in cultured cells and purified from Escherichia

106 en AR retains LBD suggesting a role for AR C-terminus in E2/E3 substrate recognition.

107 Ordering of the ArfA N-terminus in the second state rearranges RF2 into an exte

108 ombinant domain 1, 1+2 (N terminus), or 4 (C terminus) independently activated myofibroblast differen

109 hold of positive charge in the mutant CALR C terminus influences both binding of mutant CALR to MPL a

110 Phosphor-residues at the amino-terminus instigate an intra-molecular interaction that e

111 Specifically, the TFG C terminus interacts with Sec23 through a shared interface

112 ons, L290S and A296V, converting the FHR-1 C terminus into that of factor H (FH).

113 n could sterically hinder insertion of the N terminus into the HABP2 protease domain, helping to expl

114 idic residues Asp and Glu near the peptide N-terminus is by far the most prominent among them.

115 that tyrosine (Y382-384) within the P2X7R C-terminus is differentially modulated by repeated morphin

116 The ARTEMIS C terminus is dispensable for cellular V(D)J recombination

117 clusion, the conserved portion of the Orai N terminus is essential for STIM1, as it fine-tunes the op

118 Our results reveal that POT1 C terminus is essential to prevent initiation of genome in

119 ed C terminus, whereas the surface-exposed N terminus is highly variable, a feature used for identifi

120 the main coupling site for STIM1, the Orai N terminus is indispensable for Orai channel gating.

121 ty of SWR, whereas an acidic region at the N-terminus is required for optimal SWR function.

122 data suggest that polymorphism in the CagA C-terminus is responsible for differential alterations in

123 id residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular

124 ia their amino terminus, whereas the carboxy terminus is unstructured and therefore may better tolera

125 3 has a 20 kDa internally translated small C terminus isoform, GJA1-20k (Gap Junction Protein Alpha 1

126 nded polyglutamine (polyQ) sequence at the N terminus leads to neuronal degeneration both in a cell-a

127 ased to bind to the carrier domain via its C-terminus, locking the carrier in an inhibited state.

128 We conclude that the IFT46 N-terminus, ODA16, and outer arm dynein interact for IFT o

129 enzyme first removes 10 residues from the N-terminus of a 35-residue substrate.

130 tached the complementary DNA strand to the N-terminus of a protein.

131 d group is attached to a cysteine near the C terminus of a substrate protein by protein farnesyltrans

132 extending from the catalytic domain in the C terminus of A3G to its N terminus.

133 find that location of cysteine at the amino terminus of an alpha-helix, associated with activity in

134 activity produces Cys-sulfinic acid at the N terminus of an ERF-VII peptide, which then undergoes eff

135 interaction assay reveals that the carboxyl terminus of APC interacts with the matrix region of Gag.

136 H3 nucleosome binding CENPC-k motif at the C terminus of Arabidopsis thaliana KNL2, which is conserve

137 peptides and proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cyste

138 We propose a model in which the C-terminus of ATP8A2 consists of an autoinhibitor domain u

139 We investigated the role of the C-terminus of ATP8A2 in its expression, subcellular locali

140 s of immunization with NtCFlg fused to the C-terminus of Bet v 1 inhibited binding of patients' IgE a

141 NtCFlg) was genetically fused to the N- or C-terminus of Bet v 1.

142 ed RII subunits directing the myristylated N terminus of catalytic subunits toward the membrane for r

143 Fusing GFP onto the C-terminus of CbiK(P) confirmed that the protein is transp

144 When we replace the C terminus of CCR5 with the C terminus of CXCR4, R5 viruse

145 sitive cysteine and lysine residues within N-terminus of channel protein.

146 ted in the membrane-proximal region of the N terminus of chECL1, suggesting that the binding site of

147 r the addition of IDL (Ile-Asp-Leu) to the C terminus of CHR peptide WQ or MT-WQ, the conjugated pept

148 t substitutions at both the N-terminus and C-terminus of Cl-amidine result in >100-fold increases in

149 Rare codons at the 5' terminus of coding sequences have been shown to increase

150 we replace the C terminus of CCR5 with the C terminus of CXCR4, R5 viruses become more susceptible to

151 the C-terminus of aspartic acid and at the N-terminus of cysteine.

152 conserved FLV motif was identified in the C-terminus of DLP1, mutation of which significantly reduce

153 Thus, the N-terminus of DPPA3 has a significant role in cytoplasmic

154 (KIM) located within the non-catalytic amino terminus of DUSP2.

155 Here we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed vir

156 ial proteasomal ATPases, buries the carboxyl terminus of each protomer in the central channel of the

157 we examined the structural dynamics of the C-terminus of EcMscL using site-directed spin labelling el

158 Further, the Endocarpon-specific C-terminus of EpMBF1 was found to participate in stress to

159 The N terminus of Ets-1 interacts with a part of the ERK2 D-re

160 eity of signal peptide cleavage at the amino terminus of FGF2, whereas IGF1 displayed homogeneous ami

161 ic spine morphology and interacts with the C terminus of GABAB receptors (GABABRs) to control their c

162 ) DCs, the mutant virus that lacks the amino terminus of gamma134.5 undergoes temporal replication wi

163 ngle chain variable fragment (scFv) at the N-terminus of gD failed to mediate entry, even though the

164 dies reacted with linear epitopes near the N terminus of gH, exhibited strain specificity, and neutra

165 The extracellular amino terminus of gK has been shown to be important to the abi

166 for the structure and function of the amino terminus of gK.IMPORTANCE We have previously identified

167 some degradation, and fusion of GFP to the C-terminus of hClC-Kb improves protein expression.

168 nce of various modes of interaction of the N-terminus of hDAT in controlling the pathways of release.

169 icity of the PHD domain for the unmodified N terminus of histone H3 and of the BRD domain for H3 acet

170 in, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ub

171 ry and neurotropic determinants in the amino terminus of HSV-1 glycoprotein K (gK).

172 3-3 protein binding of the cytoplasmic amino-terminus of iRhom2 alter its interaction with mature TAC

173 Our findings indicate that the extreme C terminus of K2 is essential for integrin co-activation a

174 PA specifically and directly binds to the C terminus of KIF5B.

175 ctrophoretic mobility shift assay that the C terminus of KNL2 binds DNA sequence-independently and in

176 es indicate that the 22 amino acids at the C terminus of Loqs-PD, including an FDF-like motif, direct

177 ests that the key binding partners are the C-terminus of LtnA1 and pyrophosphate of lipid II.

178 of alpha1(I) collagen (Trimer-Tag) to the C-terminus of mature human TRAIL leads to a disulfide bond

179 The N-terminus of MerA is able to extract the bound Pb(VI) but

180 The N-terminus of MLL and MLL-fusions form a complex with lens

181 pan-opioid sequence Tyr-Gly-Gly-Phe at the N terminus of most endogenous opioid peptides (EOPs).

182 a a recently identified LEWD domain in the C-terminus of nesprin-1.

183 gnalling by identifying a C2 domain at the N-terminus of Notch ligands, which has both lipid- and rec

184 complementation analyses revealed that the C terminus of OeGLU is essential for the proper assembly o

185 nt virus containing stop codons at the amino terminus of ORF2 does not reactivate from latency in cal

186 ctly conserved arginine residue toward the C terminus of ORF52 play critical roles in its ability to

187 The carboxyl terminus of p17 is necessary for interaction with CDK2 a

188 cid mutations and a modified HA tag at the C terminus of PB1, which is sufficient to attenuate the IB

189 In the final transmembrane state, the C terminus of pHLIP gets exposed to the cytoplasm of the t

190 ate that the membrane translocation of the C terminus of pHLIP, the folding step more directly releva

191 es the attachment of the GPI anchor to the C terminus of precursor proteins in the endoplasmic reticu

192 ovalent attachment of myristic acid to the N terminus of proteins in eukaryotic cells.

193 Additionally, our results identify the C terminus of PrP(C) as a new and potentially more druggab

194 Mutations near the N-terminus and C-terminus of PZase were associated with East-Asian and Eu

195 we report that 3E10 directly binds to the N-terminus of RAD51, sequesters RAD51 in the cytoplasm, an

196 identify a polybasic motif in the proximal C terminus of retigabine-sensitive KCNQ channels that cont

197 estin complex, in which the phosphorylated C terminus of rhodopsin forms an extended intermolecular b

198 The zf-MYND-like domain at the N terminus of rice CCR4 and the PXLXP motif of rice CAF1 p

199 revealed that the Mynd-like domain at the N-terminus of rice CCR4 proteins and the PXLXP motif at th

200 lycine and an added GGGGSLPETGG peptide at C-terminus of SCRII, SCRII subunits were conjugated by sor

201 Adding a transmembrane anchor to the N-terminus of Sec17 bypasses this requirement for apolarit

202 ox active cysteine pair C52 and C57 in the N terminus of Sil1 results in the Doa10-dependent ERAD of

203 Fluorescent protein fusions to the amino terminus of small capsid protein VP26 are the most widel

204 The data suggest that the C terminus of SPI-1 acts as a competitive inhibitor of tar

205 last four amino acids at the newly formed C terminus of SPI-1 matched both the cleavage specificity

206 In vitro studies showed the acidic N-terminus of Swc5 preferentially binds to the H2A-H2B dim

207 how that a unique, conserved domain at the C-terminus of Swc5, called Bucentaur (BCNT), is essential

208 believed to be mediated by both the N- and C-terminus of TDP-43; however, the mechanistic basis of th

209 We propose a model where the C terminus of TF modulates the palmitoylation of TF at the

210 s in the intermembrane space are high, the N-terminus of the amphipathic alpha-helix is bound to a cl

211 on function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive

212 L36 interacts directly with the regulative N terminus of the Arabidopsis plasma membrane Ca(2+)-ATPas

213 rgies, arising from addition to the nitrogen terminus of the C horizontal lineN bond.

214 Conserved basic residues at the N terminus of the channel are important for activation by

215 of green fluorescent protein (GFP) to the C-terminus of the channel may ameliorate proteasome degrad

216 -bisphosphate (PtdIns(3,5)P2) binds to the N terminus of the channel-distal from the pore-and the hel

217 ry similar to that of the tetramer but the C terminus of the dimer is more flexible.

218 of interaction of both Cy3 and Cy5 with the terminus of the dsRNA is significantly different from th

219 A disordered region at the N-terminus of the glucocorticoid receptor can fine tune ho

220 gold finger peptides were derived from the C-terminus of the HIV nucleocapsid p7 protein (NCp7-F2) an

221 prior to secretion by the pathogen and the N terminus of the mature effector was found likely to be a

222 tes and occurs co-translationally when the N-terminus of the nascent polypeptide is still attached to

223 ositioning the aromatic units close to the N-terminus of the peptide backbone near the hydrophobic co

224 mon posttranslational modifications at the C terminus of the peptide in vivo to create the pathogenic

225 durans membrane fraction suggests that the N-terminus of the protein interacts with the membrane.

226 e cohesion is mediated by sequences in the N terminus of the protein.

227 t the Salmonella adaptor ClpS binds to the N terminus of the regulatory protein PhoP, resulting in Ph

228 n-I inhibits release by inserting into the C-terminus of the SNARE complex.

229 eoxyribose sugar remnant (3'ddR5p) at the 3'-terminus of the strand break.

230 d to a truncated SNARE complex lacking the C-terminus of the synaptobrevin SNARE motif (SNAREDelta60)

231 ariants (R8272Q, S8381C and N8406K) in the C-terminus of the SYNE1 gene (nesprin-1) were identified i

232 inactive dSpCas9 protein fused to the amino-terminus of the transposase enzyme designed to target th

233 These data demonstrate that the N terminus of the VACV E3 protein prevents DAI-mediated in

234 dynamic dissociation of NHERF1/2 from the C terminus of TRPC5 as a prerequisite for DAG sensitivity.

235 ghts into the impact of damage at the primer terminus on genomic stability and DNA synthesis.

236 When 8-oxoG is at the primer terminus opposite cytosine, DNA centric changes lead to

237 Treatment with recombinant domain 1, 1+2 (N terminus), or 4 (C terminus) independently activated myo

238 our additional Cys residues in TF's unique C terminus, or all nine Cys residues in TF.

239 t alpha-helix (within the purified soluble C terminus) partitioned into membranes only when its acidi

240 In addition, mice expressing the C terminus phosphonull in ipRGCs reentrain faster to a del

241 king all C-terminal phosphorylation sites (C terminus phosphonull) leads to a prolonged intrinsic lig

242 ate that both the charge and length of the C-terminus play an important role at the stage of initial

243 teins and the PXLXP motif at the rice CAF1 N-terminus play critical roles in OsCCR4-OsCAF1 interactio

244 e the evidence that the negatively charged C-terminus plays a critical role in the regulation of alph

245 We conclude that the C-terminus plays an important role in the efficient foldin

246 These peptides were extended at the C terminus (POmega) and contained charged amino acids not

247 Regardless of terminus position, the (125)I-HPEM label provided more t

248 The POT1 C-terminus (POT1C) forms a bilobal structure consisting of

249 strates, ADP-ribosylation of the Ub carboxyl terminus precludes ubiquitylation.

250 rees for JM22 and by a focus by F50 on the C terminus rather than the center of the MHC alpha1 helix

251 mechanism by which phosphorylation at the C terminus regulates calcium signaling by tuning the conte

252 , mostly based on their long intracellular C terminus regulating trafficking to the cell membrane, pr

253 Moreover, dissection of the C terminus revealed that palmitoylation was not sufficient

254 sphorylation at four sites within the AQP2 C terminus (Ser(256), Ser(261), Ser(264), and Thr(269)), o

255 y conserved serine residue near the carboxyl terminus (Ser-883 in Xenopus).

256 rnative 3'-end processing, whose divergent C terminus shares the CBD common to all isoforms, but lack

257 we found that the 2nd position towards the N-terminus side of the HA PCS (P2 position) avoided hydrop

258 Meanwhile, charge variation of the C-terminus significantly changed the rate of alpha-synucle

259 At its N terminus, SLP-76 has three key tyrosines (Tyr-113, Tyr-1

260 Glacier, Nepal, to aid assessment of future terminus stability.

261 excited state ensemble was an unstructured N-terminus stabilized by non-native contacts in a conforma

262 observed that the last 18 residues of the C terminus ("tail" region) of IN (residues 1-286) determin

263 efers a longer NS domain at the non-reducing terminus than FGF22-FGFR1c2 In addition, FGF22-FGFR1c2 c

264 cine motif housed in the cytoplasmic Slack C terminus that binds AP-2.

265 d nuclear localization signal (NLS) at its C-terminus that binds to importin-beta and is required for

266 ing domain) and a region closer to the amino-terminus that collectively could completely determine th

267 ccumulation of NOTCH2 carrying a truncated C terminus that escapes FBW7-mediated ubiquitination and d

268 One isoform, Orb2A, has a unique N-terminus that has been shown to be important for the for

269 We identify a conserved region in the Ulp2 C terminus that mediates its specificity for rDNA-associat

270 d bulky hydrophobic nature to the AbetapE3 N terminus that might explain the enhanced aggregation pro

271 Key molecular determinants within the Orai N terminus that together with STIM1 maintained the typical

272 rries a polyglutamine stretch close to the C-terminus that triggers a neurodegenerative disease in hu

273 In addition to the Orai C terminus, the main coupling site for STIM1, the Orai N t

274 metal binding altered flexibility from the N terminus through helix 1 and modulated the RcnR-DNA inte

275 in through a 37-residue domain and the HCN C terminus through the TPR domains.

276 recruits KPAP1 poly(A) polymerase to the 3' terminus, thus leading to pre-mRNA stabilization, or dec

277 its N terminus binds to STING and, via its C terminus, to TBK1.

278 ocated to the plasma membrane, whereas the C-terminus truncated (DeltaC) form localized in the cytopl

279 selective expression of dominant-negative C-terminus-truncated human DISC1 (mutant DISC1) in astrocy

280 This dependence on the C terminus was also observed in activation of endogenous a

281 pecific dsDNA binding protein Sso7d in the N-terminus was designed.

282 ng membranes: in the absence of Na(+), the N terminus was rapidly digested.

283 Residues 582 to 596 in the DAT carboxy terminus were identified as the primary binding site of

284 APT6, having the (HE)3DANS sequence at the N terminus were produced and site-specifically labeled usi

285 sid proteins bind to capsids via their amino terminus, whereas the carboxy terminus is unstructured a

286 ved sortase A-dependent cell wall-anchored C terminus, whereas the surface-exposed N terminus is high

287 ant far more rapidly when pulling from the N terminus, whereas translocation speed is reduced only mo

288 conserved threonine in the cytosolic AMT1 C terminus, which allosterically inactivates AMT1 trimers.

289 a unique 29-amino acid insertion near the C terminus, which folds as a separate domain in the struct

290 hes to lipid cargoes via a PX motif at its C-terminus, which has nanomolar affinity for bilayers cont

291 face of the beta1AR, but the extracellular N-terminus, which is a target for post-translational modif

292 with drastically different conformation of N-terminus, which is also a key difference between Dark an

293 ssion with a chromosomal bias from origin to terminus, which is associated with a similar general bia

294 epends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly con

295 This efflux was proposed to rely on the N terminus, which was suggested to adopt different conform

296 lusion of exon 3 generates a unique carboxyl terminus with specific anti-apoptotic functions.

297 T inhibitors, whereas substituting the DAT C terminus with that of SERT affected neither substrate no

298 Replacing the DAT N terminus with that of SERT had no effect on DA transport

299 ate from the N terminus all the way to the C terminus, without destabilizing the dimeric state.

300 Placement of a label at the C terminus yields the best biodistribution features for bo