ライフサイエンスコーパス: tertiary

1 ormation of the docking transition state and tertiary A-minor hydrogen bond interactions form after t

2 Patients from all 3 tertiary academic centers (Rochester, Phoenix, and Jacks

3 Retrospective cohort study at 2 tertiary academic centers including cases diagnosed 1995

4 examined 38 patients after AIS admitted to a tertiary academic medical center between 2012 and 2014 w

5 The neurocritical care unit at a tertiary academic medical center.

6 These samples were analyzed at a tertiary academic ocular oncology referral center using

7 15, at the specialist Photobiology Unit of a tertiary academic referral center.

8 Cohort 2: single tertiary, academic medical center.

9 Single, tertiary, academic medical center.

10 The open Cu(II) sites are the secondary/tertiary adsorption sites in these structures.

11 atin derived difluoronitromethyl substituted tertiary alcohol benzoates and naphthoates were prepared

12 ic synthesis of 3-methyleneindanes bearing a tertiary alcohol center.

13 C in the presence of primary, secondary and tertiary alcohols affords the corresponding glycosides i

14 guous, fully substituted carbon atoms (i.e., tertiary alcohols and quaternary centers) are often not

15 g ready access to a range of enantioenriched tertiary alcohols and thiols.

16 sis of fluoroalkyl-substituted Z-homoallylic tertiary alcohols has been developed.

17 The desired tertiary alcohols were isolated in up to 97 % yield and

18 ] rings is reported where Cat=a secondary or tertiary alkyl ammonium ion, x=7, 8 or 9, and M=Fe(III)

19 e stereoselective synthesis of secondary and tertiary alkyl boronic esters have spanned over five dec

20 he transformation of primary, secondary, and tertiary alkyl carboxylic acids as well as a diverse ran

21 he cross-coupling of primary, secondary, and tertiary alkyl carboxylic acids with both aryl and heter

22 y hindered substrates, such as those bearing tertiary alkyl groups, were additions slower.

23 2-lithio furan and non-racemic secondary and tertiary alkyl or aryl boronic esters undergo deborylati

24 pling of unactivated primary, secondary, and tertiary alkylcarbastannatrane nucleophiles with acyl el

25 applied in the synthesis of nonracemic alpha-tertiary allylamines via stereocontrolled cyanate-to-iso

26 oton source, both enantiomers of a series of tertiary alpha-aryl-1-indanones are readily accessed fro

27 interesting direct arylation of an aliphatic tertiary amide by using density functional theory.

28 The Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope,

29 lines that were not affected by the type of tertiary amine and treatment conditions, suggesting that

30 metal-organic framework functionalized with tertiary amine groups that exhibits high capacities for

31 erionic compounds with hydrocarbon ester and tertiary amine groups, the bulk polymer itself is elasto

32 odifiers without amine groups nor those with tertiary amine moieties are capable of adsorbing on the

33 It has been shown for selected tertiary amine pharmaceuticals that they react with ozon

34 on of metal-organic framework materials with tertiary amine-binding sites.

35 ows the construction of stable secondary and tertiary amine-linked protein conjugates without affecti

36 To elaborate on this promise, tertiary amines are attached nearby.

37 loying a series of sterically differentiated tertiary amines suggest that the steric nature of the am

38 romotes the alpha-cyanation of secondary and tertiary amines using magnetic nano-ferrites.

39 tems for the chloramination of secondary and tertiary amines, we investigated the kinetics of precurs

40 monium salts, derived from alkyl halides and tertiary amines, were the intermediates to yield thioest

41 Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope, is demonstrated fo

42 ation reactions during chloramination of the tertiary amines.

43 elective palladium-catalyzed alkenylation of tertiary amines.

44 Primary and tertiary amino ozonides with cycloalkyl and heterocycle

45 For tertiary amino ozonides, addition of polar functional gr

46 onides had higher metabolic stabilities than tertiary amino ozonides, consistent with their higher pK

47 The tertiary analysis (all studies; n=2332 patients) precise

48 strates, similar trends in reactivity toward tertiary and benzylic C-H bonds are observed.

49 Tertiary and benzylic C-H hydroxylation is strongly favo

50 Nine tertiary and community hospitals over 1.5 years.

51 Cohort 3: five tertiary and four community hospitals.

52 Sterically hindered tertiary and neopentyl substrates are reduced efficientl

53 n play a crucial role in modulating both the tertiary and quaternary structure of Hsp27, which is piv

54 d can be applied to functionalize secondary, tertiary, and benzylic C-H bonds with good yields and fu

55 fusion state, showing large-scale secondary, tertiary, and quaternary rearrangements compared with th

56 The secondary, tertiary, and quaternary structures of squid hemocyanin

57 osition of alpha-HCH from the Quaternary and Tertiary aquifers were analyzed.

58 Surgical procedures were performed at 4 tertiary Aravind eye hospitals in Tamil Nadu, India, fro

59 and provide a wide array of beta-stereogenic tertiary aryl glycolate derivatives with high levels of

60 ble with carbocyclic amides containing alpha-tertiary as well as alpha-quaternary carbon centers.

61 ization by Sharpless dihydroxylation affords tertiary azides in excellent enantioselectivity (up to 9

62 rees C for 24 h to afford ortho-benzoxylated tertiary benzamides is described.

63 A highly regioselective C-H benzoxylation of tertiary benzamides with aromatic acids by weak O-amide

64 ion and a stereospecific hydrogenolysis of a tertiary benzylic center using Pd/C or Ni/Raney catalyst

65 ational barrier study was performed on eight tertiary biaryl 2-amides using variable-temperature (VT)

66 f ortho- and para-phenols with secondary and tertiary boronic esters has been explored.

67 t4M refolding of stem secondary structure or tertiary bridging interactions between loop and stem.

68 cise site-selectivity at the most accessible tertiary C-H bonds.

69 e 3 trial, we recruited patients at a single tertiary cancer centre in the USA.

70 d alkynes to generate vicinal quaternary and tertiary carbon stereocenters.

71 nin I concentrations (>/=0.05 microg/L) at a tertiary cardiac center.

72 Tertiary care academic center.

73 All are major international tertiary care and training centers in ophthalmology.

74 by the clinical genetics service at a single tertiary care cancer center from 1998 through 2015.

75 ischemic core greater than 50 mL on CTP at a tertiary care center from May 1, 2011, through October 3

76 A medical ICU in a tertiary care center.

77 MCC Program at the University of Michigan, a tertiary care center.

78 Multispecialty tertiary care center.

79 ce, composed of pediatric practitioners from tertiary care centers experienced in caring for children

80 1, through June 24, 2013, at 9 secondary and tertiary care centers throughout the Netherlands.

81 clude quality of life assessments outside of tertiary care centers, impacts on partners and families

82 This paper from a single tertiary care centre discusses ten real-life patients wi

83 0 centres (academic, primary, secondary, and tertiary care centres) in 22 countries.

84 work database) and a prospectively collected tertiary care cohort (all patients whose data were prosp

85 , snap-on type 1 Boston KPros performed at a tertiary care facility between January 1, 2007, and Dece

86 Respiratory ICU of a tertiary care hospital in North India.

87 Tertiary care hospital in the United States.

88 ing with an attending surgeon at an academic tertiary care hospital.

89 sic outbreak of Mycobacterium abscessus at a tertiary care hospital.

90 . pneumoniae infections were identified at a tertiary care hospital.

91 Five ICUs within a tertiary care hospital.

92 Large tertiary care hospitals (TCHs) are thought to have highe

93 t-in-man study, we collected data from seven tertiary care hospitals in five countries that had a com

94 of consecutive adults in the mixed ICUs of 2 tertiary care hospitals in the Netherlands.

95 The ICUs of two tertiary care hospitals in the Netherlands.

96 s of 133 clinical isolates recovered from 24 tertiary care hospitals located in 10 cities throughout

97 Three large tertiary care ICUs in the Netherlands.

98 d, placebo-controlled trial conducted at two tertiary care institutes in India, 370 patients with cir

99 This is a case report from an academic tertiary care institution of a 3-year-old boy with homoz

100 Overall, in two tertiary care institutions in Boston, MA, a decline in S

101 nensis isolates recovered from patients at a tertiary care medical center from 2008 to 2015 were revi

102 ICUs at a tertiary care medical center.

103 h symptoms of rhinitis were recruited from a tertiary care outpatient clinic of the Otorhinolaryngolo

104 the Rome III criteria for IBS at a secondary/tertiary care outpatient clinics in Sweden, as well as f

105 7 secondary and tertiary care pain management centers in the United King

106 Tertiary care PICU.

107 This case-control study was conducted at a tertiary care psychiatric hospital from May 1, 2010, to

108 breast cancer treated at a federally funded tertiary care referral cancer center in Trujillo, Peru,

109 nd retrospective cohort study performed at a tertiary care referral center, 50 African American patie

110 Nine tertiary care university hospitals.

111 ith Coats' disease who sought treatment at a tertiary care university-based practice.

112 Tertiary care university-based research institute.

113 Experiments were performed in a tertiary care University-based research institute.

114 ean processes over 3 fiscal years (FYs) at a tertiary care Veterans Affairs medical center.

115 view board-approved study was performed at a tertiary care, academic medical center ED with approxima

116 among people with diabetes presenting to the tertiary-care academic diabetes outpatient clinics in Ir

117 the University of Virginia Health System, a tertiary-care academic medical center.

118 essor-blinded case-control study in 6 French tertiary-care hospitals.

119 Cross-sectional study from a tertiary-care retinal referral practice.

120 ged 18-75 years who underwent first OLT in a tertiary-care teaching hospital (2002-2011).

121 of transcription factors transcribed during tertiary cell wall formation were revealed.

122 12% complex) prospectively followed up in a tertiary center for 37 607 person-years.

123 CRS) for peritoneal carcinomatosis (PC) in a tertiary center.

124 t among gastrointestinal pathologists from 5 tertiary centers in the United States and Europe.

125 Hydroxylation of chiral tertiary centers is enantiospecific in spite of the ioni

126 ave access to adult congenital heart disease tertiary centers with experienced reproductive programs.

127 lar preexcitation in the ECG originates from tertiary centers.

128 A single, university-based, tertiary children's hospital.

129 asons, we identified 54 cases of IAND at two tertiary children's hospitals from Australia that accoun

130 seasons, we identified 54 cases of IAND at 2 tertiary children's hospitals from Australia that accoun

131 PICUs in tertiary children's hospitals in United States and abroa

132 H1)-dependent stabilization of higher order 'tertiary' chromatin structures but do not alter the intr

133 llance and shows subtle but clear changes in tertiary conformation.

134 energetic perturbation from a mutation in a tertiary contact (DeltaDeltaGtert).

135 y scattering data, and any readily available tertiary contact information to determine the topologica

136 ization of metastable states on the basis of tertiary contact maps and per-residue accessible surface

137 of DeltaGalign, the probability of aligning tertiary contact partners, and DeltaGtert, the favorable

138 s potential sites for secondary structure or tertiary contact.

139 coherence spectra reveals disruption of the tertiary contacts among the regions close to the active

140 ons, indicating that secondary structure and tertiary contacts are influenced by pH and to a lesser e

141 is predicts that changes in the alignment of tertiary contacts from different connecting helices and

142 energetic contribution from the formation of tertiary contacts in an aligned state.

143 ted by the EphB2/ephrinB1 system that govern tertiary dentin formation in vitro and in vivo.

144 on of Wnt/beta-catenin signaling can enhance tertiary dentine formation.

145 ur data infer a modular architecture of four tertiary domains: 1) C2A, which is readily removed as a

146 oningen LOngitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherla

147 tained (primary school, secondary school, or tertiary education) and the allocation of their children

148 orbidity in patients with DR at a peripheral tertiary eye care center of Nepal.

149 During the study period 1996 to 2007 at a tertiary eye care institute, 481 eyes of 295 children ag

150 013, at the Singapore National Eye Centre, a tertiary eye care institute.

151 vision impairment in children attending the tertiary eye hospital in Eritrea.

152 ndependent of stacking, significantly affect tertiary folding and appear to largely explain previousl

153 This reconstitution hypothesis considers RNA tertiary folding in terms of DeltaGalign, the probabilit

154 ces that bear on correct membrane insertion, tertiary folding, oligomerization, and biochemical modif

155 ble junctions between helices help guide RNA tertiary folding, the mechanisms through which junctions

156 lting from the ability of RNA to form stable tertiary folds aided by long-range intermolecular intera

157 >20% modified backbones can form native-like tertiary folds with metal-binding environments identical

158 The posterior thalamic nucleus, tertiary gustatory nucleus proper, and nucleus of the la

159 wo patients with CP presented for TPIAT at a tertiary hospital from January 1, 2013, through December

160 Twenty-six-bed tertiary hospital ICU.

161 preterm and term infants born vaginally at a tertiary hospital in Kathmandu, Nepal, from October 2 to

162 ective longitudinal cohort study at a single tertiary hospital.

163 observational cohort study in the ICU of two tertiary hospitals between January 2011 and January 2014

164 SETTINGS: Eight tertiary hospitals in Australia.

165 t-effectiveness analysis was performed in 12 tertiary hospitals in Spain.

166 from the INCREMENT cohort, recruited from 26 tertiary hospitals in ten countries.

167 ort study includes all ICU admissions from 2 tertiary hospitals in the Netherlands.

168 diagnosed before age 21 years from pediatric tertiary hospitals in the United States and Canada betwe

169 crossover trial was done in two Ghanaian non-tertiary hospitals where invasive mechanical ventilation

170 ICUs at three university tertiary hospitals.

171 g 212 consecutively-selected nurses from two tertiary hospitals.

172 gh-risk patients receiving HPS followed in a tertiary HPS unit were randomly assigned in a double-bli

173 nt hydratase yielding an intermediate with a tertiary hydroxyl-group.

174 ed hypertrophic cardiomyopathy probands at 5 tertiary hypertrophic cardiomyopathy centers.

175 g 1,782 patients with sepsis admitted to two tertiary intensive care units in the Netherlands between

176 bstrate remodeling, and implicates roles for tertiary interactions in catalytic activation of the cle

177 simulations are qualitatively similar, their tertiary interactions show little consistency.

178 cted Pb(2+)-accelerated catalysis, intrinsic tertiary interactions, and molecular kink at the active

179 secondary structure, backbone fluctuations, tertiary interactions, and radius of gyration.

180 in ribosomal RNAs and that are stabilized by tertiary interactions.

181 zed approach and should be positioned at the tertiary level of care, given the efforts needed for its

182 ty (mean 455 508 inhabitants) or admitted to tertiary level, district general, or geriatric hospitals

183 tute at Providence St Johns Health Center, a tertiary-level melanoma referral center, included 1623 p

184 study included adult patients who visited a tertiary Lyme center between January 2008 and December 2

185 ptoms in subgroups of patients referred to a tertiary Lyme center, to investigate whether depressive

186 s cannot be used to discriminate for LB in a tertiary Lyme center.

187 , in some cases with features of B cell-rich tertiary lymph follicles, along the cortical meningeal s

188 tory disease of the intestinal tract, report tertiary lymphoid organs present within the mucosal wall

189 ell infiltration with increased formation of tertiary lymphoid organs.

190 resence of lymph node-like structures called tertiary lymphoid structures (TLS) is associated with im

191 n in the kidneys, and the formation of renal tertiary lymphoid structures (TLSs).

192 herapy negatively affects the development of tertiary lymphoid structures and abrogates their prognos

193 ng and its potential role for the Cretaceous-Tertiary mass extinction.

194 Surgical and critically ill patients at a tertiary medical center between 2011 and 2015.

195 ients who underwent surgical correction at a tertiary medical center for congenital ptosis.

196 ividuals with type 2 diabetes and NAFLD at a tertiary medical center in Germany from June 2013 throug

197 tem) from October 2011 through May 2016 at a tertiary medical center.

198 both retinal and strabismus specialists in a tertiary medical center.

199 Urban tertiary medical center.

200 ossover trial among 974 adults admitted to a tertiary medical intensive care unit from February 3, 20

201 racellular events amplified by secondary and tertiary messenger molecules.

202 Two tertiary mixed ICUs in The Netherlands.

203 ous and biologically important metal-binding tertiary motif, and do so with a folded stability that i

204 Here we use Rosetta and Tertiary Motifs (TERMs) to design small proteins that fo

205 sis, 60.18 [13.60] years) were observed in a tertiary multidisciplinary center, and the analysis was

206 of patients with ALS observed by an Italian tertiary multidisciplinary center.

207 ar behavior of RNA elements and suggest that tertiary mutations may be used to identify rate-limiting

208 namically significant PDA was conducted at 3 tertiary neonatal intensive care units and affiliated fo

209 Retrospective cohort study at tertiary neonatal intensive care units.

210 inically established diagnosis of FMS from a tertiary neurology clinic in London, UK.

211 m October 1, 2012, to October 31, 2015, at a tertiary ophthalmic center.

212 compatible with substrates containing alpha-tertiary or alpha-quaternary carbon centers.

213 zed by apparently strict restraints on their tertiary or quaternary amine and their distance to an es

214 Exemplar compounds feature a tertiary or quaternary ammonium group.

215 n amino acid sequences but not on secondary, tertiary or quaternary protein structure.

216 ns-acting factors is required to remodel the tertiary organization and unmask cryptic primary microRN

217 catalytic strategy for the cross-coupling of tertiary organoboron reagents with aryl halides is repor

218 Nonstabilized alpha-O-substituted tertiary organolithium species are difficult to generate

219 1664), although maximal cIMT (a prespecified tertiary outcome) was significantly reduced (-0.013 mm p

220 The review of new literature highlights two tertiary pediatric centers that implemented quality impr

221 1, 2011, through March 13, 2015, in a large tertiary pediatric hospital in Ohio.

222 ization led to the enantiomerically enriched tertiary phosphine sulfide, possessing a cyclohexyl frag

223 To obtain the secondary and tertiary plant genus of pollen, the results present a lo

224 ory identified that WES performed at initial tertiary presentation resulted in an incremental cost sa

225 ls of stereoselectivity, affording versatile tertiary propargylic alcohols containing two stereocente

226 o new azetidine scaffolds containing vicinal tertiary-quaternary and even quaternary-quaternary stere

227 se dynamic disulfide bonds to impart defined tertiary/quaternary structures for the formation of bind

228 Nonstabilized primary, secondary, and tertiary radicals can be used to install functional grou

229 s favor C-2 addition (2->10:1), while softer tertiary radicals favor bond formation to C-4 (4.7->29:1

230 lectivities in the addition of secondary and tertiary radicals to pyidinium salts are documented: har

231 ciated frequency and variety of secondary or tertiary Ras pathway activating mutations, though not hi

232 fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determ

233 ren (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and J

234 ith CIS between March 2002 and May 2015 in a tertiary referral center for multiple sclerosis, in coll

235 ing pancreatic surgery at a university-based tertiary referral center from July 1, 2013, through June

236 gle-center trial was conducted in a neonatal tertiary referral center in Germany.

237 s and test results from patients attending a tertiary referral center in the UK.

238 Italian tertiary referral center medical-surgical ICU.

239 Massachusetts General Hospital (tertiary referral center) and two affiliated community h

240 terdam Dementia Cohort (longitudinal cohort, tertiary referral center) were studied.

241 These data, from an ocular tertiary referral center, suggest that conjunctival tumo

242 y a board-certified dermatologist at a large tertiary referral center, where ENFD testing became a ro

243 ndergoing cranial and spinal operations in a tertiary referral center.

244 pective case series at a single institution, tertiary referral center.

245 The study was performed in a tertiary referral center.

246 a cross-sectional study at a single academic tertiary referral center.

247 opathologic phenotypes at a university-based tertiary referral center.

248 17 patients 6 years and older at baseline at tertiary referral centers in Europe, the United States,

249 retrospective cohort study was conducted at tertiary referral centers in the United States and Europ

250 This study involved 5 tertiary referral centers with a specialized adult conge

251 h embolic stroke at an academic hospital and tertiary referral centre between March 2010 and March 20

252 obtained information for 2566 patients at 21 tertiary referral centres (two in Egypt, nine in Nigeria

253 2 children with perforated appendicitis at a tertiary referral children's hospital were treated using

254 ine work-up at the Imperial Memory Centre, a tertiary referral clinic in the UK National Health Servi

255 e archiving and communication systems of two tertiary referral hospitals were searched to identify pa

256 ials]) in 35 centres (a mix of secondary and tertiary referral hospitals) in the UK.

257 ctional comparative study was conducted at a tertiary referral university hospital between May 27, 20

258 safe and improves respiratory rate in a non-tertiary setting in a lower-middle-income country.

259 y defined populations in predominantly urban tertiary settings.

260 nm) tubes, and cannot maintain secondary and tertiary structural and functional domains present in ce

261 iption of RNA folding from its secondary and tertiary structural elements.

262 and Tyr125 with Trp159 are indispensable for tertiary structural intactness through optimal positioni

263 properties of a set of variants of a common tertiary structural motif, the tetraloop/tetraloop-recep

264 , which seem to be important to maintain its tertiary structure and compact fold.

265 terized by their lack of stable secondary or tertiary structure and comprise a large part of the euka

266 erogeneous-backbone foldamer design to a new tertiary structure class and show that judiciously appli

267 Exploring the tertiary structure folding processes of RNA enables us t

268 Prediction of RNA tertiary structure from sequence is an important problem

269 The analysis of RNA tertiary structure is hindered by the fact that not too

270 local quality assessment method for protein tertiary structure models.

271 In the same way DNA was modeled, the tertiary structure of RNA is constrained using an elasti

272 disordered PPIs, it is crucial to obtain the tertiary structure of the PPIs.

273 The secondary and tertiary structure of this protein was determined, which

274 boosting our group's performance in the main tertiary structure prediction category.

275 Protein tertiary structure prediction methods have matured in re

276 Predictions of RNA tertiary structure tend to be least accurate in loop reg

277 ed proteins (IDPs) lack stable secondary and tertiary structure under physiological conditions in the

278 X maintained its secondary structure but the tertiary structure was substantially affected and enzyme

279 ties such as binding affinity, secondary and tertiary structure, conformational dynamics, and thermal

280 s proteins unfold with loss of secondary and tertiary structure.

281 unfolding to changes in protein primary and tertiary structure.

282 step towards accurate prediction of the full tertiary structure.

283 The unique tertiary structures and ease of synthesis of CovCore pro

284 The secondary and tertiary structures of 3A5 and 3A4 are similar, but the

285 ges were analyzed based on the secondary and tertiary structures of a previously crystallized protein

286 (2+) or Mg(2+), stabilized the secondary and tertiary structures of CML36, guiding a large structural

287 sequences called DNAzymes that can fold into tertiary structures that display catalytic activity.

288 Both secondary and tertiary structures were affected severely by higher pre

289 However, introducing specific sequences, tertiary structures, and chemical modifications into lam

290 the "disulfide-locked" Rgg2Sd secondary and tertiary structures, but another displayed more extensiv

291 polymers that can self-assemble into complex tertiary structures.

292 have essentially identical active sites and tertiary structures.

293 le stranded regions to discrete secondary or tertiary structures.

294 asmid, BTA121 can serve as a model for their tertiary structures.

295 tool for the analysis and annotation of RNA tertiary structures.

296 The reactivity of cyclic tertiary sulfamidates derived from alpha-methylisoserine

297 r (OM) in soils and sediments; however, this tertiary system has rarely been studied.

298 study of patients admitted to five ICUs at a tertiary university medical center (Beth Israel Deacones

299 ious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics.

300 Follow-up was conducted in tertiary uveitis subspecialty practices in the United St