ライフサイエンスコーパス: tertiary amine

1 ups (i.e., phenylureas, tertiary amides, and tertiary amines).

2 for a sacrificial electron donor, usually a tertiary amine.

3 noline and aporphine substrates possessing a tertiary amine.

4 d formation was driven by the oxidation of a tertiary amine.

5 elective palladium-catalyzed alkenylation of tertiary amines.

6 d the formation of NDMA by chloramination of tertiary amines.

7 e design of a series of substituted N-phenyl tertiary amines.

8 e synthesis of enantioenriched secondary and tertiary amines.

9 complete reduction to give the corresponding tertiary amines.

10 y binding hot spot, preferably binding small tertiary amines.

11 tion of a variety of primary, secondary, and tertiary amines.

12 thoxycarbonyl)isocyanate upon treatment with tertiary amines.

13 ation reactions during chloramination of the tertiary amines.

14 the slow nitrosation rates hypothesized for tertiary amines.

15 on does not exhibit the ordinary basicity of tertiary amines; 3 can be extracted from acidic media wi

16 difications to the head group containing the tertiary amine, a tail group that extends away from this

17 With tertiary amines, a >2-order of magnitude decrease in k(H

18 With Lewis basic C-H donors such as THF and tertiary amines, a decrease in k(H) with increasing Lewi

19 In contrast, tertiary amine adds reversibly to S1, because nitrogen c

20 ocycle, and a late-stage installation of the tertiary amine-aldehyde proximity interaction.

21 , sugar, hydroxyl, thiophene, sulfur, azide, tertiary amines, alkyne, vinyl, or phosphonate groups we

22 P attachment, and simultaneously incorporate tertiary amines along with carboxyl and/or hydroxyl grou

23 The ligands contain a tertiary amine, an amino acid side chain, and a carbamat

24 A series of tertiary amine analogs of 3 were synthesized and assayed

25 lic substitution reaction between the parent tertiary amine and a novel derivatizing reagent, di-tert

26 With a balanced composition of tertiary amine and carboxylic acid groups, these nanopar

27 (ii) downstream protoberberines containing a tertiary amine and forming quaternary intermediates dest

28 A number of tertiary amine and quaternary ammonium cations spanning

29 lines that were not affected by the type of tertiary amine and treatment conditions, suggesting that

30 Nitrosatable drugs, such as secondary or tertiary amines and amides, form N-nitroso compounds in

31 bic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH's in drugs.

32 The reaction is catalyzed by tertiary amines and can occur with diastereoselectivity

33 by primary and secondary amines, but not by tertiary amines and carbonate buffer.

34 ion of wastewaters impacted by anthropogenic tertiary amines and containing bromide ion.

35 compounds, including primary, secondary, and tertiary amines and quaternary ammonium compounds, all s

36 Interestingly, UGT activity toward tertiary amines and some steroid hormones was equal.

37 group, with the highest clearance rates for tertiary amines and sulfates and no clearance of QACs.

38 ters, amides, ethers, acetals, nitriles, and tertiary amines and, therefore, should be applicable to

39 in k(H) was observed going from secondary to tertiary amines and, with tertiary amines, on increasing

40 strongly ionized bases (primary, secondary, tertiary amines), and a pair of quaternary ammonium comp

41 to their functional group (secondary amine, tertiary amine, and amide).

42 commercially available N-methyl substituted tertiary amines, and therefore it represents an attracti

43 e MAO-N-D5 variant, which is able to oxidise tertiary amines, appear to influence the active-site env

44 To elaborate on this promise, tertiary amines are attached nearby.

45 st, a broad range of alkylated secondary and tertiary amines are obtained in good to excellent yields

46 -dimethyl 5-HT, in which the side chain is a tertiary amine, are found in the computational simulatio

47 Interaction of the tertiary amines, arecolone, eserine (physostigmine), (+)

48 The use of a tertiary amine as an allosteric effector also enabled a

49 n the application of primary, secondary, and tertiary amines as efficient organocatalysts for the de

50 es, which is the first example of the use of tertiary amines as intermolecular nucleophiles in metal-

51 ly meta-selective C-H arylation using simple tertiary amines as the directing group.

52 Different tertiary amines as well as aryl iodides have been examin

53 a, select protonated primary, secondary, and tertiary amines as well as tetramethylammonium with 19-2

54 Direct C-H vinylations of N-aryl tertiary amines, as well as decarboxylative vinylations

55 The selective sp(3) C-N bond activation of tertiary amines at the less steric side using O2 as a so

56 We examined primary, secondary, and tertiary amines at various pHs.

57 The addition of tertiary amine base is found to dramatically accelerate

58 Calcium salts and a tertiary amine base promote the reaction with high site-

59 vation through the Lewis acid and a tethered tertiary amine base.

60 in the presence of potassium carbonate or a tertiary amine base.

61 A squaramide-containing tertiary amine based bifunctional organocatalyst efficie

62 enewable sources, we synthesized a series of tertiary amine-based ILs from aromatic aldehydes derived

63 We report the synthesis of 46 tertiary amine-bearing N-alkylated benzo[d]imidazol-2(3H

64 on of metal-organic framework materials with tertiary amine-binding sites.

65 step in the intramolecular C-H borylation of tertiary amine boranes activated with catalytic amounts

66 an extended structure containing a terminal tertiary amine, but this had no beneficial effects on bi

67 he iminium ion, which is then reduced to the tertiary amine by Et(2)SiH(2).

68 tudied for releasing primary, secondary, and tertiary amines by direct photochemical breaking of the

69 rimary amines--over branched, secondary, and tertiary amines--by a two-step process involving a proto

70 lutamate using aqueous hydrogen peroxide and tertiary amine catalysis.

71 ong-range electron-transfer oxidation of the tertiary amine center by the HRP oxidants.

72 ntrol (7) revealed that the presence of a N1 tertiary amine center imparted a significant reduction i

73 al complexation process, it is proposed that tertiary amine compounds, having N-substituents which ar

74 -stage lithiation-borylation reaction with a tertiary amine containing carbenoid.

75 Tertiary amine containing poly(propyleneimine) second (G

76 We report the development of a tertiary amine-containing beta-turn peptide that catalyz

77 The library consisted of dialkyl tertiary amine-containing commercially available pharmac

78 a model compound (quinuclidine) and to three tertiary amine-containing drugs (cinnarizine, loxapine,

79 ion while olefins undergo aziridination, and tertiary amine-containing natural products are converted

80 analysis, we describe herein a new series of tertiary amine-containing pyrazolones and their structur

81 Studies with a tertiary-amine-containing antibiotic show that the resul

82 rbamate bond; however, the ability to employ tertiary-amine-containing bioactive molecules has been e

83 ino)ferrocene (DPPF) in combination with the tertiary amine Cy(2)NMe proved effective in the olefinat

84 aternary ammonium compound clofilium and its tertiary amine derivative LY97241 were used to analyze m

85 (N(4)S(thiolate))Fe(II) complex, containing tertiary amine donors, [Fe(II)(Me(4)[15]aneN(4))(SPh)]BP

86 NDMA formation from the most reactive tertiary amines (e.g., dimethylaminomethylfurfuryl alcoh

87 Increased positive charge at the tertiary amine end of tetracaine results in higher poten

88 active group, a quinoline fluorophore, and a tertiary amine for enhancing ESI+ MS ionization.

89 tin, and ferric TRENCAM, which substitutes a tertiary amine for the macrocyclic lactone ring of ferri

90 CI: 1.40, 2.73); odds ratios associated with tertiary amines from the lowest tertile of nitrite intak

91 leton, hexamethylindotricarbocyanine, with a tertiary amine functionality that was electronically cou

92 tones; however, the direct polymerization of tertiary amine functionalized cyclic esters has remained

93 ines to give the corresponding secondary and tertiary amines generally in high yields (up to 96%) and

94 hat in the presence of a proton source and a tertiary amine generates the corresponding alpha-difluor

95 heterocycles like azaacene and secondary and tertiary amines give exclusively the dyes containing a t

96 Using a cationic tertiary amine gradient, anionic molecules were directio

97 g the water solubility of drugs containing a tertiary amine group are reported.

98 metal-organic framework functionalized with tertiary amine groups that exhibits high capacities for

99 n alkylating agent, to convert polymer-bound tertiary amine groups to less chloramine-reactive quater

100 erionic compounds with hydrocarbon ester and tertiary amine groups, the bulk polymer itself is elasto

101 tivity lower than that of the compounds with tertiary amine groups.

102 in the order: secondary amines approximately tertiary amines >> primary amines.

103 o-catecholato) with equimolar AlCl(3) and a tertiary amine has been applied to a wide range of arene

104 o nitrosatable drugs, including secondary or tertiary amines, has been associated with preterm birth.

105 molecular C-H functionalization reactions of tertiary amines have been developed.

106 provides high yields in methanol, release of tertiary amines in MeCN/water can improve yields and red

107 .) are reported for several hydrocarbons and tertiary amines in solution.

108 en investigated by chloramination of several tertiary amines in the absence and presence of bromide i

109 Upon protonation of the tertiary amines in the dendritic interior, binding becam

110 trosatable drugs, particularly secondary and tertiary amines, in conjunction with higher levels of di

111 ing a broad range of alkylated secondary and tertiary amines, including fluoroalkyl-substituted anili

112 y gold catalysis without the purification of tertiary amine intermediates.

113 displacement of a methyl group attached to a tertiary amine is a reaction without an obvious preceden

114 , and L-proline), but N,N-dimethylglycine, a tertiary amine, is not a substrate.

115 Nitrosation of MDEA, a tertiary amine, is not catalyzed by the addition of CO2

116 HAS polymers possess primary, secondary, and tertiary amines, leading to multiple chemisorption react

117 ty of 14 and why converting the secondary to tertiary amine leads to enhanced selectivity.

118 quenching of the Ir(3+) excited state by the tertiary amine leads to the ammonium radical cation, wit

119 tions of copper(II) bromide and an aliphatic tertiary amine ligand (Me6-Tren; Tren = tris(2-aminoethy

120 ows the construction of stable secondary and tertiary amine-linked protein conjugates without affecti

121 itine binding is inhibited by bupivacaine, a tertiary amine local anesthetic.

122 The use of the tertiary amine matrix solution permits the simultaneous

123 nol (AMP) and monoethanolamine (MEA) and the tertiary amine methyldiethanolamine (MDEA).

124 argensis was able to biotransform two of the tertiary amines, mianserin (MIA) and ranitidine (RAN), e

125 odifiers without amine groups nor those with tertiary amine moieties are capable of adsorbing on the

126 structurally diverse primary, secondary, and tertiary amine moieties.

127 , the 9-aza-APs carrying a distal lipophilic tertiary amine moiety in both chains were capable of ove

128 could be explained by the speciation of the tertiary amine moiety of TRA, with apparent second-order

129 ) cage contains 12 amide NH groups plus four tertiary amine N groups, the latter of which are positio

130 approach to the characterization of dialkyl tertiary amine-N-oxides is presented.

131 form through diagnostic losses from dialkyl tertiary amine-N-oxides.

132 s location in the membrane placed the drug's tertiary amine near the phosphate of the headgroup, its

133 t method for accessing N-aryl alpha-branched tertiary amines, new catalysts have been designed to sup

134 Interestingly, the tertiary amine nicotine dramatically enhances uracil chl

135 f a "crypt" that contains eight nonreducible tertiary amine nitrogens.

136 Here we report that tertiary amine nucleophiles show excellent C-2 selectivi

137 likely than were control women to have taken tertiary amines (odds ratio = 1.60, 95% confidence inter

138 es that MeTr decreases the acidity of the N5 tertiary amine of CH3-H4folate by 1 pK unit in both wate

139 mechanism in which both the thiourea and the tertiary amine of the catalyst are involved productively

140 ate first, by the action of the quinuclidine tertiary amine of the cinchona catalyst on MK.

141 tituted benzene rings linked directly to the tertiary amine of the saturated heterocycle.

142 of the terminal primary amines and interior tertiary amines of the dendrimer structures.

143 the terminal primary amines and the interior tertiary amines of the dendrimers to the observed EMF re

144 The dimers, in which the tertiary amines of the lidocaine moieties are linked by

145 sitive to negative greatly shifts the pKa of tertiary amines of the PAMAM dendrimer interior.

146 are selective blockers of 5HT reuptake, and tertiary amines of the trans compounds are less potent t

147 The (13)C chemical shifts of six tertiary amines of unambiguous conformational structure

148 ted and experimental (13)C shifts of the six tertiary amines of unambiguous structure are found.

149 from secondary to tertiary amines and, with tertiary amines, on increasing steric hindrance at nitro

150 l exposure to NSDs containing a secondary or tertiary amine or amide.

151 ators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional grou

152 ive aldol reactions realized by using either tertiary amines or a dizinc aldol catalyst constitute tw

153 It has been shown for selected tertiary amine pharmaceuticals that they react with ozon

154 Mechanistic investigation revealed that tertiary amines predominately operate as Bronsted rather

155 Certain tertiary amine products generated through this method ar

156 dendrimers have a significant percentage of tertiary amines protonated, approximately 30%.

157 These results indicate that tertiary amine pyrazolones comprise a valuable class of

158 Tertiary amines react rapidly and reversibly with arylke

159 e DCA-loaded compound 10, characterized by a tertiary amine scaffold, because it exhibited enhanced (

160 cated that 4-substituted amino groups with a tertiary amine side chain, such as chloroquine, were ass

161 and the length of the tether connecting the tertiary amine site used for ionization via protonation

162 he combustion products in a 5% water-soluble tertiary amine solution.

163 c and experimental data strongly suggest the tertiary amine-stabilized dichlorosilylene to be the mos

164 amino acids), but not from secondary amines, tertiary amines, sterically hindered primary amines, or

165 eaction conditions, with good generality for tertiary amine structure and moderate to excellent yield

166 In several cases of tertiary amines subject to rapid exchange, where experim

167 e H(8)BINOL-AM compounds containing 3,3'-bis-tertiary amine substituents are synthesized by using a o

168 ine-amide-dithiol (AADT) chelates containing tertiary amine substituents as small-molecule probes for

169 ine-amide-dithiol (AADT) chelates containing tertiary amine substituents were synthesized and shown t

170 cidic complex, 1H-1,2,3-benzotriazole, and a tertiary amine such as DBU.

171 loying a series of sterically differentiated tertiary amines suggest that the steric nature of the am

172 Three classes of Lewis bases-tertiary amines, sulfides, and selenophosphoramides-were

173 for a switchable cationic surfactant, e.g., tertiary amine surfactant (Ethomeen C12), is 2.22% in DI

174 affold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the other, a spirocy

175 Sibutramine is a tertiary amine that has been shown to induce dose-depend

176 ral helical (thio)urea oligomer and a simple tertiary amine that is able to promote the Michael react

177 catalyst is a simple tetrapeptide bearing a tertiary amine that may function as a Bronsted base.

178 explains the capsule's high affinity toward tertiary amines that are protonated and therefore encoun

179 (CSIA) of NDMA during chloramination of four tertiary amines that produce NDMA at high yields, namely

180 For gel-entrapped Ru(bpy)3 2-/tertiary amines, the shape and intensity of the ECL-pote

181 ctional chiral phosphines or multifunctional tertiary amine-thioureas as the catalyst, respectively.

182 ion of the catalyst, which is reduced by the tertiary amine to produce the single-electron reducing a

183 d by photoinduced electron transfer from the tertiary amine to the Bodipy excited state.

184 t are trapped in the presence of co-oxidized tertiary amines to form alpha-amino nitriles.

185 lex natural products containing nucleophilic tertiary amines to generate a C-C bond.

186 The photocycloaddition of tertiary amines to inverted question mark60fullerene (C(

187 queous mixtures of commonly used primary and tertiary amines to study the influence of the different

188 ts oxidative N-dealkylation/carbonylation of tertiary amines to tertiary amides by using molecular ox

189 strated (conversion to quaternary centers, C-tertiary amines) together with application of the method

190 For secondary and tertiary amines, total N-nitrosamine formation under the

191 s, are rapidly and quantitatively reduced to tertiary amines under mild conditions with low catalyst

192 osition of alpha-diazo carbonyls tethered to tertiary amines underwent a benzylic Stevens [1,2]-rearr

193 The adjusted hazard ratios for tertiary amine use in the third trimester by increasing

194 s were converted into tertiary alcohols or C-tertiary amines using chloramine.

195 oped for the synthesis of a diverse range of tertiary amines using inexpensive polymethylhydrosiloxan

196 romotes the alpha-cyanation of secondary and tertiary amines using magnetic nano-ferrites.

197 eneral method for the difluoromethylation of tertiary amines, using diethyl bromodifluoromethylphosph

198 en-deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen methodo

199 substituents, the alkyl chain length and the tertiary amine was conducted.

200 ylation of primary and secondary amines into tertiary amines was confirmed by FTIR and NMR analysis.

201 tems for the chloramination of secondary and tertiary amines, we investigated the kinetics of precurs

202 Chloropicrin yields from tertiary amines were low.

203 aryl sulfonamides, while bulky secondary and tertiary amines were preferred at the benzylic amine pos

204 monium salts, derived from alkyl halides and tertiary amines, were the intermediates to yield thioest

205 ive deracemisation of primary, secondary and tertiary amines when used as part of a chemoenzymatic ox

206 nt yield from the reaction of a secondary or tertiary amine with o-iodoxybenzoic acid (IBX) or o-iodo

207 the catalytic asymmetric alpha-acylation of tertiary amines with aldehydes facilitated by the combin

208 ation of various aliphatic as well as cyclic tertiary amines with alkynes has been described.

209 The mechanism directly couples tertiary amines with cyanoaromatics by using mild and op

210 In general, secondary amines or tertiary amines with nonsterically demanding substituent

211 Blends of tertiary amines with piperazine (PZ) showed n-nitrosopip

212 ing substituents on nitrogen are superior to tertiary amines with sterically demanding substituents o

213 Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope, is demonstrated fo