ライフサイエンスコーパス: tertiary structure

1 g its environmental change from secondary to tertiary structure.

2 s proteins unfold with loss of secondary and tertiary structure.

3 theoretic approach when considering protein tertiary structure.

4 utational clusters while considering protein tertiary structure.

5 rpoS leader, folding the RNA into a compact tertiary structure.

6 ond-to-microsecond movement of secondary and tertiary structure.

7 y applied to the characterization of protein tertiary structure.

8 ate NMR, which is important to study protein tertiary structure.

9 elices, it is not known how they disrupt RNA tertiary structure.

10 step towards accurate prediction of the full tertiary structure.

11 support formation of predicted secondary and tertiary structure.

12 ting the coupling of transient secondary and tertiary structure.

13 base both in DNA secondary structure and RNA tertiary structure.

14 lpha-helical but to adopt only heterogeneous tertiary structure.

15 ying a simplified link between secondary and tertiary structure.

16 nterest in developing tools for modeling RNA tertiary structure.

17 that contained well-ordered and homogeneous tertiary structure.

18 unfolding to changes in protein primary and tertiary structure.

19 ective encapsulation afforded by a protein's tertiary structure.

20 sible folding pathways leading to its native tertiary structure.

21 le and maintains a near-native secondary and tertiary structure.

22 of cation-pi interactions that stabilize the tertiary structure.

23 2 with the large-scale transformation of its tertiary structure.

24 mation in primary sequence and secondary and tertiary structure.

25 asmid, BTA121 can serve as a model for their tertiary structures.

26 omated tool for analyzing and annotating RNA tertiary structures.

27 e, proteins showed strong evidence of stable tertiary structures.

28 polymers that can self-assemble into complex tertiary structures.

29 the same thermal stability and very similar tertiary structures.

30 s are prevalent in DNA and RNA secondary and tertiary structures.

31 ated only minor alterations in secondary and tertiary structures.

32 reports on the quality of predicted protein tertiary structures.

33 ns have very similar primary, secondary, and tertiary structures.

34 ing of RNA by destabilizing RNA secondary or tertiary structures.

35 e proteins differ in primary, secondary, and tertiary structures.

36 l mechanisms of RNAs are determined by their tertiary structures.

37 have essentially identical active sites and tertiary structures.

38 re of a protein, separate from secondary and tertiary structures.

39 le stranded regions to discrete secondary or tertiary structures.

40 goal of extending the alpha/beta approach to tertiary structures.

41 ital for folding mt-tRNAs into their correct tertiary structures.

42 tool for the analysis and annotation of RNA tertiary structures.

43 t the self-assembly of discrete thermostable tertiary structures.

44 , and rate of formation of the secondary and tertiary structures.

45 the highest rates and largest secondary and tertiary structures.

46 rface ((568)NGR) and the other buried in the tertiary structure ((962)NGR).

47 detergent prevents the loss of secondary and tertiary structures after thermal unfolding at 90 degree

48 for which locations of the secondary and the tertiary structure agreed well with the predictions from

49 Secondary and tertiary structure analyses as well as biological assays

50 In silico pre-mRNA secondary and tertiary structure analysis revealed that this substitut

51 e secondary structure, (ii) assume canonical tertiary structure and (iii) form native complexes with

52 rcaptoethanol caused significant loss in the tertiary structure and a drop in caspase 3 and 9 activat

53 activity and binding assays to dissect this tertiary structure and assess its functional role.

54 via a multistep unfolding process, with the tertiary structure and C(H)2 domain unfolding first, fol

55 , which seem to be important to maintain its tertiary structure and compact fold.

56 terized by their lack of stable secondary or tertiary structure and comprise a large part of the euka

57 lations predicted a more relaxed NC1 hexamer tertiary structure and diminished assembly competence in

58 dentical in human Hsp90 but which differs by tertiary structure and dynamics.

59 sitively charged residues concentrate in the tertiary structure and form a clear binding surface.

60 requiring an interacting partner to acquire tertiary structure and function.

61 ot can be applied to any protein for which a tertiary structure and homologous sequences are availabl

62 al levels of collagen assembly including its tertiary structure and interfibrillar alignment, thus su

63 by NMR and CD spectroscopy that LcrG lacks a tertiary structure and it consists of three partially fo

64 elength of r-betaLg suggested changes in its tertiary structure and more solvent-exposed tryptophan r

65 nd the biological implications of native RNA tertiary structure and nucleoside modifications on PKR a

66 is predominantly alpha-helical with extended tertiary structure and oligomerizes in solution.

67 However, when the effects of tertiary structure and protein interactions were removed

68 4-ORF3 protein revealed an ordered secondary/tertiary structure and the ability to form heterogeneous

69 ovide new insight into the interplay between tertiary structure and the inhibitory activity of a mult

70 d by a strong coupling between the subunits' tertiary structure and the integrity of the dimer interf

71 The unique tertiary structures and ease of synthesis of CovCore pro

72 pieces of preexisting proteins to create new tertiary structures and functions.

73 rough-space interaction networks that define tertiary structures and govern sampling of multiple conf

74 portant information to undefirstafinding the tertiary structures and thus the functions of ncRNAs.

75 cy depends on accurate formation of the HHRz tertiary structure, and cross-links are not observed for

76 c fluorescence of OCP reveals changes in its tertiary structure, and the fluorescence properties of N

77 ies, including the quaternary structure, the tertiary structure, and the ligand-binding site.

78 copy that the monomeric form of PrgJ lacks a tertiary structure, and the only well-structured part of

79 econdary structure, the HP model for protein tertiary structure, and the Polyomino model for protein

80 However, introducing specific sequences, tertiary structures, and chemical modifications into lam

81 actions and the resulting flexibility of the tertiary structure are essential for tRNA(Sec) function.

82 inhibitor induced changes within the kinase tertiary structure are significant, few technologies are

83 that electrostatics, excluded volume, and NA tertiary structure are sufficient to predict assembly th

84 nd functions of coronavirus S1 domains whose tertiary structures are currently unknown.

85 ns caused significant destabilization of the tertiary structure as measured by variable-temperature c

86 d protein MxiI indicate this protein lacks a tertiary structure as well.

87 to extraordinarily complicated secondary and tertiary structures as a result of intramolecular base p

88 ondary structure and three have well ordered tertiary structure, as demonstrated by circular dichrois

89 ra-C2 domain interactions forming a "closed" tertiary structure at low calcium that "opens" as calciu

90 edicted RNAs secondary structure, only a few tertiary structure base pairs have been identified.

91 econdary structural features, nor have their tertiary structures been characterized because solved st

92 Key differences in secondary and tertiary structure between myoc-OLF(D380A) and wild-type

93 functional paradox because they lack stable tertiary structure, but nonetheless play a central role

94 the "disulfide-locked" Rgg2Sd secondary and tertiary structures, but another displayed more extensiv

95 Stabilization of protein tertiary structure by disulfides can interfere with glyc

96 y now have we been able to quantify one such tertiary structure by making use of pseudorotaxanes desi

97 creasing monovalent concentration stabilizes tertiary structure by reducing the entropic penalty for

98 However, the nucleic acid secondary and tertiary structure can also act as a recognition site fo

99 ditions, aspects of the native secondary and tertiary structure can be conserved.

100 orts the conclusion that the oligonucleotide tertiary structure can significantly alter the chemical

101 ansition involving cooperative secondary and tertiary structure changes and a partially folded interm

102 early indicate that the bovine serum albumin tertiary structure changes as protein concentration and

103 ure preformed in the unbound state with only tertiary structure changes occurring during target bindi

104 erogeneous-backbone foldamer design to a new tertiary structure class and show that judiciously appli

105 and are in regions predicted to have altered tertiary structure compared with the receiver domains of

106 Chemokines are defined by a conserved tertiary structure composed of a three-stranded beta-she

107 arious chemokines adopt remarkable conserved tertiary structure comprising an anti-parallel beta-shee

108 Addition of NaCl led to an increase in the tertiary structure conformation of vicilin as determined

109 ties such as binding affinity, secondary and tertiary structure, conformational dynamics, and thermal

110 etic resonance of Skint-1 DV revealed a core tertiary structure conserved across the Skint family, bu

111 hose members share a unique disulfide-bonded tertiary structure, conserved catalytic motifs, and the

112 cal significance of membrane proteins, their tertiary structures constitute less than 3% of known str

113 The stability of RNA tertiary structures depends heavily on Mg(2+).

114 oteins (i.e. ~75,000 or < 0.07%) have solved tertiary structures determined by experimental technique

115 ary structure, but the completely folded RNA tertiary structure develops small pockets of very negati

116 tional clustering by considering the protein tertiary structure directly in 3D space.

117 A oligonucleotide and 8.15 for cytidine in a tertiary structure element from beet western yellows vir

118 at is characterized by increased mobility of tertiary structure elements and solvent accessibility.

119 the importance of considering secondary and tertiary structure elements and their role in RNA-protei

120 te tetratricopeptide repeats, their distinct tertiary structures enable them to bind different partne

121 ods have generally failed to determine ncRNA tertiary structures, even at the 1-nm resolution that en

122 er design can be extended to reliably create tertiary structure features that mimic more complex biom

123 g dynamics of 10 ms or faster, likely due to tertiary structure fluctuations, and slow dynamics on th

124 nal folding revealed different secondary and tertiary structure folding pathways for GlpG and DsbB th

125 Exploring the tertiary structure folding processes of RNA enables us t

126 rough target mass loading coupled to aptamer tertiary structure folding.

127 ous modeling approaches to propose candidate tertiary structures for the apical region of domain 3, t

128 Our findings pinpoint the earliest steps of tertiary structure formation and open up possibilities t

129 escence resonance energy transfer to monitor tertiary structure formation of the hairpin ribozyme as

130 scence experiments revealed that kinetics of tertiary structure formation upon addition of MgCl2 are

131 dy the influence of Mg(2+) and Ca(2+) on RNA tertiary structure formation.

132 Prediction of RNA tertiary structure from sequence is an important problem

133 by the removal of semi-stable secondary and tertiary structures from single polymer strands leading

134 lie in close proximity to each other in the tertiary structure, from the pre-M1 linker and Cys-loop.

135 by utilizing graph theory to account for the tertiary structure, GraphPAC discovers clusters in DPP4,

136 folding pathway from secondary structure to tertiary structure has not been previously observed, but

137 amide bond to the formation of protein-like tertiary structure, has and will continue to enable the

138 secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitou

139 ow that the DEAD-box protein CYT-19 disrupts tertiary structure in a group I intron using a helix cap

140 ubdomain folds to local native secondary and tertiary structure in a linked transition and assembles

141 in hydrophobicity indicated unfolding of the tertiary structure in all samples.

142 Secondary or tertiary structure in an mRNA, such as a pseudoknot, can

143 urrent methodology that incorporates protein tertiary structure in order to increase our power when i

144 t a number of proteins do not adopt a unique tertiary structure in solution and that some degree of d

145 contribute specific interactions to the GAC tertiary structure in the cocrystals.

146 the coupling between transient secondary and tertiary structure in the protein activator for thyroid

147 fic transient opening rates of secondary and tertiary structure in the protein provides a structural

148 contain regions which do not adopt a stable tertiary structure in their native state.

149 dingly, the full secondary structure and the tertiary structure in TM1-TM2 of the Y4 receptor is like

150 Similar to the space of protein tertiary structures in which discrete patterns are clear

151 This demonstrates that tertiary structure intactness of Cyt c was essential for

152 lysis indicates a decomposition of the RNase tertiary structure into spatially distributed yet physic

153 been subdivided-based on their secondary and tertiary structures-into two major groups (A and B), eac

154 the existence of a pH- and Mg(2+)-dependent tertiary structure involving pseudoknot formation within

155 ant dependency of the ligand dynamics on the tertiary structure is also observed.

156 rect folding of the active site and ribozyme tertiary structure is also regulated by metal ions in a

157 This complex tertiary structure is established during the regenerativ

158 The analysis of RNA tertiary structure is hindered by the fact that not too

159 ed RNAs have led to the perspective that RNA tertiary structure is modular, made of locally stable do

160 understanding of RNA primary, secondary, and tertiary structure is necessary.

161 The tertiary structure is stabilized by a charge-transfer in

162 Given that Concanavalin A's tertiary structure is thought to be relatively robust, t

163 Comparing protein tertiary structures is a fundamental procedure in struct

164 nts in a biomolecule, transition dynamics of tertiary structures is often too complex to profile usin

165 l radical cleavage is widely used to map RNA tertiary structure, lack of mechanistic understanding of

166 ant in the micromolar range and modifies its tertiary structure leading to a decrease of its thermost

167 ch can interact with a target mRNA to form a tertiary structure like a pre-tRNA and recruit intracell

168 ues, which are common stabilizers of protein tertiary structure, might serve as rotameric molecular s

169 tions, because often, specific cases require tertiary structure mimetics.

170 te a platform for the discovery of potential tertiary structure mimetics.

171 to play a larger and larger role in protein tertiary structure modeling and evaluation.

172 te combination and alignment, template-based tertiary structure modeling, protein model quality asses

173 local quality assessment method for protein tertiary structure models.

174 ds to changes in the aptamer's secondary and tertiary structure; monitoring such changes has led to t

175 de binding and hydrolysis motifs in the ParF tertiary structure nor at interfaces implicated in ParF

176 While MIBS adopts the tertiary structure of a class I terpenoid cyclase, its d

177 l changes in the nature of the secondary and tertiary structure of a larger assembly.

178 Finally, this server predicts tertiary structure of a sequence by feeding its predicte

179 ted efforts to investigate the secondary and tertiary structure of Abeta monomers, whose conformation

180 alpha-helical fraction and marked change in tertiary structure of actomyosin.

181 560 nm, referring to the conservation of the tertiary structure of bR in nanodiscs of different lipid

182 ondary structure and irreversible changes in tertiary structure of capsid proteins.

183 Thus, it is the particular tertiary structure of epitope II, which is presented in

184 These RNA-coat interactions stabilize the tertiary structure of gRNA within the virion, which coul

185 imary structure of single nucleosomes or the tertiary structure of long-range looping interactions.

186 led the structure of MxB using the published tertiary structure of MxA.

187 ondary structure and lack the tightly packed tertiary structure of natively folded globular proteins.

188 E-Symm, to detect pseudo-symmetry within the tertiary structure of protein chains.

189 We found a dramatic change of the overall tertiary structure of protein G'e when the pH was change

190 py was used to investigate the secondary and tertiary structure of proteins carefully transferred fro

191 cess to folded structures reminiscent of the tertiary structure of proteins.

192 In the same way DNA was modeled, the tertiary structure of RNA is constrained using an elasti

193 rstanding protein-RNA binding and predicting tertiary structure of RNA.

194 oldRNA server that permits the prediction of tertiary structure of RNAs as long as a few hundred nucl

195 s between Rpg1b and Rpg1r onto the predicted tertiary structure of Rpg1b, which revealed highly polym

196 wered, such as a detailed description of the tertiary structure of SpA domains in complex with Fc and

197 difficult to characterize the secondary and tertiary structure of the Abeta monomer, the starting po

198 mental data, suggest a plausible theoretical tertiary structure of the apical region in FMDV IRES dom

199 Based on the tertiary structure of the APP CuBD, we examined the hist

200 h synthetic epitope targeting to exploit the tertiary structure of the BoNT protein as a landscape fo

201 First, calcium ions change the tertiary structure of the bound Abeta monomer by destabi

202 Here, we have determined the tertiary structure of the CUB module from human TSG-6, i

203 The tertiary structure of the folded domains is well underst

204 The tertiary structure of the GTPase center (GAC) of 23S rib

205 a noncanonical residue can closely mimic the tertiary structure of the native sequence.

206 In addition, the tertiary structure of the peptide is efficiently maintai

207 The disulfide bridges stabilize the tertiary structure of the peptides and often make them s

208 disordered PPIs, it is crucial to obtain the tertiary structure of the PPIs.

209 nteractions that stabilize the secondary and tertiary structure of the protein.

210 n sequence to interpreting the secondary and tertiary structure of their models, their domain composi

211 Despite the conserved tertiary structure of these regulators, structural analy

212 The secondary and tertiary structure of this protein was determined, which

213 The secondary and tertiary structures of 3A5 and 3A4 are similar, but the

214 ges were analyzed based on the secondary and tertiary structures of a previously crystallized protein

215 DB is becoming a fundamental resource of the tertiary structures of biological macromolecules.

216 ing a resolution sufficient to determine the tertiary structures of both gp7 and gp10 protein subunit

217 ein threading predictor (RAPTOR) to generate tertiary structures of closely related monomeric chemoki

218 (2+) or Mg(2+), stabilized the secondary and tertiary structures of CML36, guiding a large structural

219 The tertiary structures of functional RNA molecules remain d

220 approaches for determining the secondary and tertiary structures of proteins.

221 r more helices come together in space in the tertiary structures of RNA molecules.

222 The primary, secondary, and tertiary structures of spectrin are reasonably well defi

223 The code is realized by distinct dynamic tertiary structures of the anchor on the plasma membrane

224 Overall, the unique secondary and tertiary structures of the N-terminal domains of apoB su

225 The tertiary structures of theromacin and neuromacin confirm

226 In this study, by comparing the primary and tertiary structures of two GH1 beta-glucosidases with di

227 Many of solved tertiary structures of unknown functions do not have glo

228 ein crystallography to determine the folded (tertiary) structure of biologically active Ts3 toxin by

229 mera explored the effects of tail length and tertiary structure on sodium channel activity.

230 e studies give us a view of the formation of tertiary structure on the folding pathway, which complem

231 in interaction (PPI), gene ontology, protein tertiary structures, orthologous sequences, kinase/phosp

232 Further, by utilizing the tertiary structure, our algorithm also identifies cluste

233 rdance with their conformational dependence, tertiary structure perturbations compromised recognition

234 high glycosylation levels caused some minor tertiary structure perturbations.

235 boosting our group's performance in the main tertiary structure prediction category.

236 ls compared with the previous version of our tertiary structure prediction method, IntFOLD-TS.

237 models for the improvement of our IntFOLD-TS tertiary structure prediction method.

238 Protein tertiary structure prediction methods have matured in re

239 Finally, tertiary structure prediction of E4 34K and its comparis

240 rises an integrated pipeline of methods for: tertiary structure prediction, global and local 3D model

241 d as one of the major challenges for protein tertiary structure prediction.

242 ones of similar category in both contact and tertiary structure prediction.

243 sis offers an efficient way for accurate RNA tertiary structure predictions.

244 on, Qprob makes contributions to our protein tertiary structure predictor MULTICOM, which is official

245 ues leads to progressive disruption of HSP90 tertiary structure, promoting exposure of R502/R510 to P

246 Overall, the predicted tertiary structure provides a platform for the biochemic

247 Hb subunits can adopt high- and low-affinity tertiary structures, r and t, within each quaternary sta

248 ount of beta-sheets) were observed while the tertiary structure remained unchanged.

249 system which sustains delicate secondary and tertiary structures, reminiscent of those present in nuc

250 correspond to the formation of secondary and tertiary structures, respectively.

251 Homology modeling of the protein F tertiary structure revealed a strong resemblance to the

252 nimal but fully active construct lacking the tertiary structure reveals a crucial role in PKR binding

253 ecognition of an RNA hairpin loop and an RNA tertiary structure, reveals the capacity of minimalist l

254 In the absence of base-pairing and tertiary structure, ribonucleic acid (RNA) assumes a ran

255 the other hand, a limitation in longer-range tertiary structure sensitivity was revealed.

256 striking changes in topology, RsmF adopts a tertiary structure similar to other CsrA family members

257 y unannotated prophage-encoded proteins with tertiary structures similar to gpFI, although they lack

258 silon that both share sequence and predicted tertiary structure similarity with a family of phospho-h

259 rs and coaxial stacking interactions for the tertiary structure stabilization.

260 and final morphologies of the secondary and tertiary structures strongly depend on the cation employ

261 l regions, which are widely separated in the tertiary structure, suggest a higher order architecture

262 Mapping on the DinB tertiary structure suggests these are noncatalytic, and

263 Comparisons of primary and tertiary structures supported that ePKs and ChKs evolved

264 NA interactions, it is important to know the tertiary structures surrounding the splice sites.

265 Predictions of RNA tertiary structure tend to be least accurate in loop reg

266 of VA RNAI is proposed to contain a complex tertiary structure that contributes to its optimal inhib

267 ipts contain nucleoside modifications and/or tertiary structure that could affect PKR activation.

268 sequences called DNAzymes that can fold into tertiary structures that display catalytic activity.

269 ne can then determine both its secondary and tertiary structures through structure prediction, which

270 KIIRDYGK(273)) that come together in the CTD tertiary structure to form an exposed antiparallel beta-

271 btuB riboswitch modulates the formation of a tertiary structure to perform metabolite sensing and reg

272 A secondary structures translated from known tertiary structures to suggest which hypothetical large

273 ed proteins (IDPs) lack stable secondary and tertiary structure under physiological conditions in the

274 dered regions of proteins, which lack unique tertiary structure under physiological conditions, are e

275 DPs) are proteins that lack secondary and/or tertiary structure under physiological conditions.

276 iants investigated herein exhibit non-native tertiary structures under physiological conditions, lead

277 It folds into an intricate tertiary structure upon addition of Mg(2+) ions, which i

278 conformational changes in both secondary and tertiary structure upon Ca(2+) binding.

279 milestone to the accurate prediction of RNA tertiary structure using unbiased all-atom molecular dyn

280 onal clusters by taking into account protein tertiary structure via a graph theoretical approach.

281 f had similar secondary structures while the tertiary structure was different for holo-Lf.

282 The resulting tertiary structure was investigated using intermolecular

283 X maintained its secondary structure but the tertiary structure was substantially affected and enzyme

284 In addition to secondary and tertiary structure, we consider generic structural prope

285 Both secondary and tertiary structures were affected severely by higher pre

286 The secondary and tertiary structures were indistinguishable from pd-A1PI.

287 phorylation and acetyl-Lys sites mapped onto tertiary structures were proximal in >50% of proteins in

288 celles (3HM), based on a coiled-coil protein tertiary structure, were evaluated as an alternative to

289 IDPs can acquire tertiary structure when bound to their partners; therefo

290 ng sampling of a wide range of noncanonical, tertiary structures when it is in the O3' orientation.

291 New displays of tertiary structures, which can be rotated or have the su

292 Our results demonstrate that complex RNA tertiary structures, which may be difficult to predict c

293 Protein domains can fold into stable tertiary structures while they are synthesized on the ri

294 destabilize the native TTR quaternary and/or tertiary structure, wild-type TTR amyloidogenesis also l

295 ity with known PagP enzymes, the beta-barrel tertiary structure with an interior hydrocarbon ruler ap

296 Pseudoknots are a fundamental RNA tertiary structure with important roles in regulation of

297 family, which is predicted to share similar tertiary structure with visual-/beta-arrestins and also

298 shows that TNA has the ability to fold into tertiary structures with sophisticated chemical function

299 t depending on the amino acid properties and tertiary structure within the MBD.

300 onstrained peptides with precisely specified tertiary structures would enable the design of shape-com