ライフサイエンスコーパス: testes

1 an immunologically privileged tissues (i.e., testes).

2 germ cells and occur most frequently in the testes.

3 to mice, where expression is limited to the testes.

4 productive processes, expressed primarily in testes.

5 ough the latter occurred rarely in the human testes.

6 e seminiferous epithelium of adult mammalian testes.

7 h, including the development of eggs in male testes.

8 o-siRNA class with predominant expression in testes.

9 nfluenced the homing of these cells in mouse testes.

10 e primary self-renewal pathway in Drosophila testes.

11 nd and elongated spermatids, in normal human testes.

12 pupal development, opposes EGF signaling in testes.

13 was also evident in ALC stem cells in fetal testes.

14 dative stress and cell junction signaling in testes.

15 d uniquely in a rare subset of SSCs in mouse testes.

16 leen, liver, brain, lung, heart, kidney, and testes.

17 to HSP70 stabilization in tissues other than testes.

18 ntains germline identity in Drosophila adult testes.

19 ifference depends on the ovaries but not the testes.

20 at the Stra8 promoter in beta-TrCP-deficient testes.

21 glycans were significantly reduced in Bsg KO testes.

22 ferous tubules in the Arid4a(-/-)Arid4b(+/-) testes.

23 anscript of Gudu is highly enriched in adult testes.

24 recapitulating those observed with TRF2(-/-) testes.

25 adult ALC numbers were comparable to control testes.

26 ilence regulators of pluripotency than in B6 testes.

27 stis barrier (BTB) was compromised in Bsg KO testes.

28 ly to maintaining the free ubiquitin pool in testes.

29 that regulates sex steroid synthesis in the testes.

30 ajor suppression of steroidogenesis in fetal testes.

31 of germ cells undergoing apoptosis in Bsg KO testes.

32 milar pattern of results was obtained in the testes.

33 to neuronal tissues (brain, spinal cord) and testes.

34 e hematopoietic system, small intestine, and testes.

35 e of Taf4b-regulated germ stem cell genes in testes.

36 gust 2010 to assess tissue elasticity of the testes.

37 genes were differentially expressed in GCKO testes.

38 in spermatogenic disruptions than Dicer cKO testes.

39 expressed during embryogenesis and in adult testes.

40 tly hypoechoic, round-to-oval masses in both testes.

41 ified TRIM28 as a new SOX9 partner in foetal testes.

42 s of the basement membrane (BM) in adult rat testes.

43 1 that associate with chromatin in embryonic testes.

44 dymis-specific genes were upregulated in the testes.

45 d reduce malignancy in boys with undescended testes.

46 rectly and significantly to RA production in testes.

47 ptosis markers annexin V and p53 in knockout testes.

48 relatively higher expression of PRL2 in the testes.

49 tly within the seminiferous tubules of human testes.

50 ght loss and ZIKV infection in the brain and testes.

51 or supernumerary testis means more than two testes.

52 hybrid males using mRNA-sequencing of whole testes.

53 ith this defect, we have identified in mouse testes 1,551 differentially expressed genes that cover b

54 %, followed by neck mass (4.2%), undescended testes (1.9%), breast mass (1.2%), club foot (1%), hypos

55 10-12 GW, or in second trimester xenografted testes (14-17 GW).

56 Human fetal testes (15-19 weeks' gestation, n = 6) were xenografted

57 and penile size, which contrasted with small testes (4.5 mL).

58 rmatogonia were present at normal density in testes 5 d after birth, but they lacked the capacity for

59 s, whereas germ cells were found in 13 of 26 testes (50%).

60 well-defined Sertoli cell adenomas (26 of 46 testes, 56%).

61 lar parenchyma was heterogeneous in 30 of 46 testes (65%).

62 To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using

63 imple-looking paratesticular cysts (34 of 46 testes, 74%) and low-signal-intensity, well-defined Sert

64 lyses at P18 showed that in comparison to WT testes, 75% of miRNA genes and 37% of protein coding gen

65 absence of Sertoli cell adenomas in 19 of 23 testes (83%).

66 ar cysts were correctly detected in 22 of 23 testes (96%).

67 cells and found that mutant mice had smaller testes, a delay in differentiation of pre-meiotic germ c

68 y lineage-tracing experiments in E(z) mutant testes, a portion of excessive early-stage somatic gonad

69 Thus, in both cultured cell lines and the testes, absence of Klp10A leads to longer centrioles tha

70 Moreover, we find Orco localization in testes across distinct insect taxa and posit that OR-med

71 number of genes misregulated in 129Sv mutant testes also are misregulated in human testicular germ ce

72 Finally, H3f3b null testes also exhibited abnormal germ cell chromatin reorg

73 d the relative male investment in hyoids and testes among howler monkey species in relation to the le

74 ears; age range, 18-39 years) retained their testes and 13 (mean age, 22 years; age range, 17-37 year

75 A recrudescence of testes and body mass occurred from mid-February, but Dio

76 ne-sheltered spaces, including the placenta, testes and brain.

77 tic variant, FerT, are coexpressed in normal testes and cancerous tumors, but whether they exert rela

78 nol 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations report

79 derepresses its target ATP synthase-beta in testes and compromises spermatogenesis and male fertilit

80 ed with apoptotic corpse accumulation in the testes and degeneration of photoreceptors in the eye.

81 ornaments and armaments) and postcopulatory (testes and ejaculates) sexual traits due to the costs as

82 sociated with chromatin domain boundaries in testes and embryonic stem cells.

83 genetic studies of Rdh10 in postnatal mouse testes and found that an RDH10 deficiency in Sertoli cel

84 omeric double-ring TRiC purified from bovine testes and HeLa cells.

85 examine Sertoli and germ cell markers on rat testes and human fetal testis xenografts after exposure

86 ction, likely causing premature aging of the testes and impaired liver metabolic capacity.

87 d to histological alterations of ovaries and testes and increased gonadosomatic index.

88 icantly reduced Sox9 transcripts in cultured testes and increased Sox9 levels in ovaries.

89 ffects of in utero PFOS exposure on neonatal testes and its relation to testicular dysfunction in adu

90 e in the maintenance and regeneration of the testes and male accessory reproductive organs.

91 Upon nhr-1 knockdown, germ cells in the testes and ovaries fail to mature, and remain as undiffe

92 y tissue, PRAME expression is limited to the testes and ovaries, making it a highly attractive cancer

93 d in spermatids and granulosa cells of adult testes and ovaries, respectively.

94 e Kdr promoter in the chromatin of embryonic testes and ovaries.

95 KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries.

96 s mice against ZIKV-associated damage to the testes and sperm and prevents viral persistence in the t

97 Atrophic testes and testicular degeneration were observed in Ppar

98 astrocytes was compromised in the absence of testes and testosterone signaling via AR.

99 g duplicate genes are expressed primarily in testes and that their expression breadth increases over

100 sistent DNA double-strand breaks in p53R172H testes and the formation of giant spermatogonia (GSG) fo

101 Doppler ultrasonographic (US) images of the testes and the inguinoscrotal region were obtained.

102 strate that basal body formation in the male testes and the production of functional sperm does not r

103 hosphamide therapy had significantly smaller testes and total sperm counts (median: 12.5 mL and 16.3

104 >7,000 transcripts found in the gonads, 243 (testes) and 3,600 (ovaries) occurred pairing-dependently

105 s-1 are improperly localized in Akap9 mutant testes, and Cx43 fails to compartmentalize germ cells ne

106 tein expression level was low in the newborn testes, and gradually increased from 1- to 3-week-old te

107 permatozoa generation, lower actin levels in testes, and impaired motility and ultrastructural disorg

108 that GAR22beta is highly expressed in mouse testes, and its absence resulted in reduced spermatozoa

109 manifestations, persistent infection in the testes, and neurologic sequelae.

110 lethality, reduced ZIKV levels in brains and testes, and preserved sperm counts.

111 ion limited to the lumen of small intestine, testes, and prostate, is co-expressed with CEACAM1 in ad

112 0.0006, and 0.0074 rad/mCi) for the ovaries, testes, and red marrow, respectively.

113 varied from 8% in preputial gland to 97% in testes, and the tissue-specificity observed in vivo was

114 nd gradually increased from 1- to 3-week-old testes, and then remained constant after three weeks of

115 , injuries or wounds, neck mass, undescended testes, and vaginal fistula) was created.

116 viremia, and viral loads in spinal cord and testes-and increased mortality.

117 .7 mGy, liver; 2.1 mGy, red marrow; 1.7 mGy, testes; and 1.9 mGy, ovaries.

118 ciated with strong gene expression levels in testes; and overrepresented on the X chromosome.

119 Here we identify the cancer/testes antigen melanoma antigen-A4 (MAGE-A4) as a tumour

120 al use encoding a TCR recognizing the cancer/testes antigen NY-ESO-1, coexpressing the PET/suicide ge

121 tivity was detected at the highest levels in testes, aorta and perirenal fat.

122 n Drosha and Dicer cKO males, but Drosha cKO testes appeared to be more severe in spermatogenic disru

123 out-of-testes" hypothesis, which posits that testes are a catalyst for the emergence of new genes tha

124 suggesting that SF1(+) progenitors in fetal testes are a potential source of both FLCs and ALCs.

125 Drosophila testes are among the most thoroughly characterized syste

126 s from systemic circulation in the brain and testes are limited due to high levels of P-glycoprotein

127 About half of the fish showed immature testes around eleven weeks after fertilization.

128 tion of virions with developing sperm within testes as well as with mature sperm within epididymis.

129 roduce divergent gene expression profiles in testes, as measured with RNA sequencing.

130 In fetal testes at embryonic day 17.5, endogenous DNMT3L also enh

131 ctivity in the blood-brain barrier and blood-testes barrier.

132 this organ, given the existence of the blood-testes barrier.

133 spermatogonia remains similar to normal rat testes, because spermatogonia fail to differentiate into

134 males despite the levels of WT STAMP mRNA in testes being 20-fold higher than in any other organ exam

135 patients with CAIS who chose to retain their testes beyond age 16 years and who were imaged between J

136 ituitary and in Leydig and germ cells in the testes, but at very low levels in Sertoli cells.

137 using testicular cells isolated from rodent testes, but it remains unknown if PFOS has similar effec

138 Dmrt1 plays a similar role in postnatal testes, but the mechanism of adult testis maintenance re

139 an elevated level in larval males and adult testes, but they are not accessory gland proteins and th

140 e show that CnnT is expressed exclusively in testes by alternative splicing and localizes to giant mi

141 were confirmed in germ cell knock-out (GCKO) testes by postnatal day 18 (P18).

142 (P-gp) in the luminal membranes of brain and testes capillary endothelial cells.

143 ical analysis of seminiferous tubules in the testes, caput and corpus epididymis do not reveal obviou

144 Here we show that alphaT (testes)-catenin, a protein unique to amniotes that is ex

145 In particular, loss of Dmrt1 in 129Sv testes caused a more severe failure to silence regulator

146 mic homeostasis in SC-specific Upf2 knockout testes, characterized by an accumulation of PTC-containi

147 al form (CnnC) and a non-centrosomal form in testes (CnnT).

148 a higher level in lung tumor tissue and the testes compared with other nontumor tissues and identifi

149 der Se-compromised conditions, the brain and testes compete for Se utilization, with concomitant effe

150 Testes contain two distinct Leydig cell populations duri

151 Gene expression profiling of neonatal testes containing Sin3a-deleted gonocytes identified upr

152 Interestingly, Nr4a1 levels were elevated in testes containing Stra8-expressing, Sin3a-deleted sperma

153 The testes contribute sperm in addition to a diverse array o

154 We found that both male accessory glands and testes contribute to its formation.

155 In both rat and human fetal testes, DBP exposure induced similar germ cell effects,

156 in immune response, muscle differentiation, testes development and DNA damage, although little is kn

157 iency for CRB3 KD in the testis, the CRB3 KD testes displayed defects in spermatid and phagosome tran

158 redominantly by testosterone secreted by the testes during the perinatal period.

159 In Drosophila testes, each Germline Stem Cell (GSC) contacts apical hu

160 mice to ZIKV results in severe damage to the testes, epididymis and sperm.

161 Analysis of Mov10l1(-/-) testes established that de novo methylation of the L1 tr

162 t rats from e13.5-e20.5 and effects on fetal testes evaluated at e21.5.

163 Brain regions and testes exhibited significant downregulation of Neanderth

164 an organotypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA) with tis

165 ctuary sites for viral replication including testes, eyes, and brain.

166 sperm and prevents viral persistence in the testes following challenge with a contemporary strain of

167 evealing a competition between the brain and testes for selenium utilization.

168 ex determining SRY, which activates Sox9 for testes formation.

169 ial distribution of the c.922A>G mutation in testes from 15 unaffected men and found that the mutatio

170 EGF signaling in the GSCs, and reproduced in testes from animals with soma-depleted EGF-Receptor (EGF

171 Testosterone was not suppressed in testes from fetuses younger than 8 GW, older than 10-12

172 rison to adjacent AR-retaining Leydig cells, testes from littermate controls, and to human testes, in

173 In 14 testes from men aged 39-90 y, we identified 11 distinct

174 at increased levels of IFNbeta were found in testes from mice deficient in MOV10L1, a germ cell-speci

175 In testes from Mtdh exon 3-deficient mice, Rad18 foci were

176 protein Mili was expressed at high levels in testes from Mtdh knock-out mice.

177 ni in-depth we isolated complete ovaries and testes from paired and unpaired schistosomes for compara

178 In NSun2-depleted testes, genes encoding Ddx4, Miwi, and Tudor domain-cont

179 zation is unique to the ovary because in the testes, gonadotropin receptors are expressed in separate

180 ncy in male mice was accompanied by impaired testes growth, a characteristic feature of KS.

181 While spermatogenesis is completed in the testes, here we demonstrate sperm centriole reduction oc

182 s, neck mass, obstetric fistula, undescended testes, hypospadias, hydrocephalus, cleft lip or palate,

183 neck masses, obstetric fistulas, undescended testes, hypospadias, hydrocephalus, cleft lip/palate, an

184 This finding supports the "out-of-testes" hypothesis, which posits that testes are a catal

185 known to adversely affect the development of testes in African clawed frogs (Xenopus laevis), but lit

186 rugs or preconception radiation doses to the testes in male and ovaries in female cancer survivors.

187 On the pathological examination, all left testes in the torsion group were recoverable after four

188 direct detection of these steroids in mouse testes, in both basal and maximally stimulated states, a

189 h is expressed mainly in neurons, heart, and testes, in contrast to ubiquitous JNK1 and JNK2.

190 ers reproductive function in oocytes and the testes, in part caused by defects in central neuro-endoc

191 estes from littermate controls, and to human testes, including from patients with complete androgen i

192 ral signaling pathways in Dmrt1 mutant fetal testes, including Nodal, Notch, and GDNF.

193 sely packed seminiferous tubules in the left testes, indicating reversible damage in the torsion grou

194 ale-specific gene expression in Smad2-mutant testes, indicating that SMAD2 signaling promotes male di

195 mary, but not exclusive, source of RA in the testes is Sertoli cells.

196 observations indicate that, similar to adult testes, Jak-STAT signaling from the hub acts on both GSC

197 es with sequencing of RNA samples from mouse testes lacking Sox9.

198 ry circuit, which can be detected in rooster testes, likely predates the divergence of birds and mamm

199 Diets that optimized testes mass and epididymal sperm counts (indicators of g

200 ve A. insignis invests in relatively greater testes mass and less in pronotal weapon length.

201 d evidence for a trade-off when investing in testes mass vs. horn length between the species.

202 ater investment in weapons at the expense of testes mass while the smaller, less-aggressive A. insign

203 -resolution X-ray CT scanning data, relative testes mass, and male-male agonistic behaviour between t

204 e heavily in weapon length at the expense of testes mass.

205 ctory receptor function and are expressed in testes more often than expected, consistent with reduced

206 e infertility, as well as abnormal sperm and testes morphology.

207 in the seminiferous epithelium of adult rat testes, most notably at the apical ES at the Sertoli-spe

208 chemical manipulations of RA levels in mouse testes now reveal that RA also regulates the two postmei

209 pression in wild type and Dmrt1 mutant fetal testes of 129Sv and B6 mice at embryonic day 15.5 (E15.5

210 MATERIAL/METHODS: The study included 100 testes of 50 patients with a unilateral testicular disea

211 lly, PAX7+ spermatogonia were present in the testes of a diverse set of mammals.

212 activities are significantly reduced in the testes of ACBP(-/-) mice, concomitant with a significant

213 ression vector pCI-neo was used to transfect testes of adjudin-treated ratsversusempty vector.

214 ansion, which is likely to take place in the testes of all men, leads to the relative enrichment of m

215 lower expression of BRD7 was detected in the testes of azoospermia patients exhibiting spermatogenesi

216 while expression was greatly reduced in the testes of Bsg KO mice.

217 ith T-treated PM cells were able to colonize testes of germ cell-depleted mice after transplantation.

218 The testes of Ifnar1(-/-) mice had the highest viral loads,

219 ng the observation of low CHD5 expression in testes of infertile men.

220 in spermatogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which enco

221 ues clearance of apoptotic germ cells in the testes of Mertk (-/-) mice it fails to enhance RPE phago

222 ased drug accumulation within the brains and testes of mice due to inhibition of P-gp activity.

223 nstrated altered expression of piRNAs in the testes of Mtdh knock-out mice as compared with wild type

224 and karr are also expressed strongly in the testes of other Drosophila species and have similar gene

225 In contrast, testes of patients who had azoospermia with TEX11 mutati

226 more, evaluation of molecular markers in the testes of patients with nonobstructive azoospermia (NOA)

227 s of meiosis to generate round spermatids in testes of rats treated with an acute dose of adjudin tha

228 read overexpression of X-linked genes in the testes of sterile but not fertile F1 males.

229 em cells (SSCs) a selective advantage in the testes of the father, but have a deleterious effect in o

230 brain is less pronounced than in either mgr testes or in cultured cells.

231 onset of morphological differentiation into testes or ovaries and usually maintain this fate in the

232 gonadotropic and sex steroid hormones, small testes or ovaries, impaired spermatogenesis, and lack of

233 e individuals with a 46,XX karyotype develop testes or ovotestes (testicular or ovotesticular disorde

234 adillo-repeat-containing protein enriched in testes, our results suggest that Gudu and ARMC4 are a su

235 Neonatal testes (P1) were collected for the detection of PFOS, an

236 In developing and adult testes, p53R172H was expressed in gonocytes, type A, Int

237 ssues that exhibit neuronal-like exocytosis (testes, pituitary, and adrenal gland).

238 P-element-induced wimpy testes (Piwi) proteins are known for suppressing retrotr

239 ity to control ZIKV infection in the brains, testes, placentas, and fetuses of mice.

240 Mael129-null mutant testes possess low levels of piRNAs derived from MAEL-as

241 levels, resembling conserved piRNAs in mouse testes [primarily LINE1 (long interspersed nuclear eleme

242 pe in an individual with an XY karyotype and testes producing age-appropriate normal concentrations o

243 pithelium of the seminiferous tubules of the testes, producing millions of spermatozoa per day in an

244 pression of X-linked genes in the Drosophila testes reflects a balance between chromosome-wide epigen

245 ction have shorter mating seasons and larger testes relative to body size.

246 1(-/-) and noncleavable TFIIAalpha-betanc/nc testes release immature germ cells with impaired transcr

247 opulations are splicing-derived mirtrons and testes-restricted, recently evolved, clustered (TRC) can

248 and expression analysis in the Yhtdc2 mutant testes reveal an upregulation of m(6)A-enriched transcri

249 alysis of wild-type (WT) and Taf7l(-/Y) (KO) testes revealed that Taf7l ablation impairs the expressi

250 Importantly, histological analysis of testes revealed that Taf7l(-/Y) mice develop postmeiotic

251 ibition of p38 signaling in the Smad2-mutant testes severely impeded XY PGC differentiation and induc

252 Moreover, wild type testes showed strong expression of N-cadherin (CDH2) whi

253 eg length, parasite burden, horn length, and testes size, but not for horn growth or our measure of a

254 In foetal testes, SOX9 modulates both transcription and directly o

255 The binding of enantiomers with salmon testes (st)-DNA and synthetic polynucleotides are studie

256 HSPBP1 deficiency in testes strongly reduces the expression of the inducible,

257 ngle-male groups have large hyoids and small testes, suggesting high levels of vocally mediated compe

258 Genes that are more highly expressed in testes than in any other tissue are especially reduced i

259 Higher Spiroplasma density in testes than in ovaries was also detected by fluorescent

260 me X and near genes more highly expressed in testes than other tissues (p = 1.2 x 10(-7) to 3.2 x 10(

261 d insects, Spiroplasma density was higher in testes than ovaries, and was significantly higher densit

262 ancy induces focal dysgenetic areas in fetal testes that appear between e19.5-e21.5, manifesting as f

263 BD18 is a pachytene nuclear protein in mouse testes that occupies a subset of pachytene piRNA-produci

264 ough both receptors are expressed within the testes, the potential effect of BAs on testis physiology

265 the presence of SOX9 on chromatin in foetal testes, therefore equating this signature to a genomic b

266 brain, and similar to the role of piRNAs in testes, they may be involved in the silencing of retrotr

267 In wild-type testes, this sex chromosome-wide transcriptional suppres

268 EBOV dissemination into the eyes, brain and testes through vascular structures, similar to observati

269 gement of ectoplasmic specialization (ES) in testes, thus impairing spermiogenesis and spermiation.

270 in the cyst stem cells (CySCs) of Drosophila testes to control the interaction of CySCs with the hub.

271 we hypothesised that exposure of human fetal testes to DES would result in a reduction in testosteron

272 we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and ChIP-seq for H3K27ac.

273 mRNA profiling of Dmrt6 mutant testes together with DMRT6 chromatin immunoprecipitation

274 tion of a BTB-impermeable component into the testes under in vivo conditions.

275 MGB4), a protein preferentially expressed in testes, uniquely blocks excision repair of cisplatin-DNA

276 male and female reproductive organs (penis, testes, uterus, ovaries).

277 as the number of males per group increases, testes volume also increases, indicating higher levels o

278 Both plasma testosterone levels and testes volume were independently inversely correlated wi

279 (ulna length, asymmetry, weight-at-weaning, testes volume, reproductive success and survival).

280 nal caregiving and was negatively related to testes volume.

281 Drosophila ovaries and early embryos than in testes, we herein sought to determine whether ASUN plays

282 malian sperm development and is expressed in testes, we posed the hypothesis that NlSPATA5 occurs in

283 ced apoptosis in seminiferous tubules of C/C testes, we recorded a drastic increase in cells with DNA

284 ion to finding AgOr transcript expression in testes, we show that the OR coreceptor, AgOrco, is local

285 Microscopic examination showed that the testes were composed of atrophic seminiferous tubules, w

286 MECP2 mutations in various tissues including testes were miscarried during midgestation, consistent w

287 TE) and 15-HETE from arachidonic acid in the testes were significantly elevated and a linear increasi

288 renic acid and docosahexaenoic acid (DHA) in testes were significantly reduced in the PFOS treatment

289 After CDU, testes were surgically removed and a pathological examin

290 Fifty normal contralateral testes were used as a control group.

291 Primary cultures, initiated from testes, were treated with G418 to eliminate the somatic

292 ostenone is a boar pheromone produced in the testes, whereas skatole and indole originate from the mi

293 d4b are expressed mainly in Sertoli cells of testes, which implies that their roles in Sertoli cell f

294 y-stage somatic gonadal cells in E(z) mutant testes, which originate from both overproliferative cyst

295 hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the s

296 Wnt4 and Fgfr2/Wnt4 double mutants developed testes with male somatic and germ cells present, suggest

297 omatin regions from murine and bovine foetal testes with sequencing of RNA samples from mouse testes

298 ines) resulted in male infertility, atrophic testes with vacuolation, azoospermia, and spermatogenesi

299 ancers of the bladder, kidney, prostate, and testes, with common molecular features spanning differen

300 nal modifications and gene expression in the testes, with the most prominent changes occurring at gen