ライフサイエンスコーパス: testicular

1 noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and co

2 fathead minnow had returned to baseline, and testicular abnormalities were absent.

3 ences, laterality of tumors and incidence of testicular abnormalities, are useful for identification

4 tified loci that promote bilateral tumors or testicular abnormalities.

5 In this study, we identified ACPT (testicular acid phosphatase) biallelic mutations causing

6 ct is highly suggestive for the diagnosis of testicular adrenal rest tissues on ultrasonography.

7 magnetic resonance (MR) imaging features of testicular adrenal rest tumors (TART) in patients with c

8 bilateral testicular masses, a diagnosis of testicular adrenal rest tumour was made; biopsy was defe

9 Testicular adrenal rest tumours (TARTs) are benign testi

10 Prompt diagnosis of testicular adrenal rest tumours is essential, as it only

11 l adrenal hyperplasia, common issues include testicular adrenal rest tumours.

12 patient was discovered to harbour bilateral testicular adrenal rests as well.

13 niche) to direct non-mammary cells including testicular and embryonic stem cells (ESCs) to adopt a ma

14 and principal piece of the flagellum between testicular and epididymal spermatozoa.

15 ns that significantly increase risk for both testicular and intestinal cancer.

16 nscriptome sequencing of precursor, primary (testicular and mediastinal) and chemoresistant metastati

17 testis descent, INSL3 has been implicated in testicular and sperm function in adult males via interac

18 (breast, prostate, ovarian, endometrial, and testicular) and to investigate whether dietary fiber int

19 he study data set except kidney, pancreatic, testicular, and liver cancers, which have been associate

20 sue and several cancers, including prostate, testicular, and ovarian.

21 It causes liver, testicular, and pancreatic tumors in rats.

22 iation in rodents results from the perinatal testicular androgen surge.

23 mbryonic Sertoli cells (SCs) leads to severe testicular atrophy and male sterility owing to rapid dep

24 However, PRL1(-/-)/PRL2(+/-) male mice show testicular atrophy phenotype similar to PRL2(-/-) mice.

25 At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and l

26 ands attributed to androgen effects, such as testicular atrophy, seminiferous tubule diameter reducti

27 fluence this phenotype, the role of PPARD in testicular biology was examined.

28 For prepubertal boys, testicular biopsy cryopreservation is offered in some ce

29 Testicular, bone marrow, and left ventricular uptake inc

30 s; the most frequently reported cancers were testicular, breast, and lymphoma.

31 5-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk,

32 slightly higher lifetime mortality risk from testicular cancer (598 per 100 000; 95% uncertainty inte

33 owever, life expectancy loss attributable to testicular cancer (83 days; 95% UI: 42, 124) was more th

34 mors after older radiotherapy strategies for testicular cancer (TC) are well established.

35 ardiovascular disease (CVD) in patients with testicular cancer (TC) given chemotherapy in European st

36 wo), nasopharyngeal (one), thyroid (one) and testicular cancer (two).

37 s were positively associated with kidney and testicular cancer [hazard ratio (HR) = 1.10; 95% CI: 0.9

38 The international Testicular Cancer Consortium (TECAC) combined five publi

39 of 5190 men with GCC who entered the Danish Testicular Cancer database between January 1, 1984, and

40 From the Danish Testicular Cancer database, we identified all patients w

41 we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region

42 PFOA exposure was associated with kidney and testicular cancer in this population.

43 must be maintained, as defects can result in testicular cancer or infertility.

44 cisplatin-induced ototoxic effects in adult testicular cancer patients.

45 rmation on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of

46 s are an important complication that affects testicular cancer survivors as a consequence of treatmen

47 y white men aged 18-55 years into a study of testicular cancer susceptibility conducted in the Philad

48 carcinoma, men undergoing surveillance after testicular cancer treatment, parents of patients treated

49 y losses and lifetime mortality risks due to testicular cancer were compared with life expectancy los

50 veloped to project outcomes in patients with testicular cancer who were undergoing CT surveillance in

51 The largest AOR was for testicular cancer with the very high exposure category [

52 noma, thyroid cancer, pancreatic cancer, and testicular cancer) were identified among ABOi recipients

53 17 years or older, diagnosed with germ cell testicular cancer, and previously treated with cisplatin

54 hat the action of Dnd1Ter was not limited to testicular cancer, but also significantly increased poly

55 nd 1.58 (linear trend test p = 0.18) and for testicular cancer, HRs were 1.0, 1.04, 1.91, 3.17 (linea

56 Children and adolescents with testicular cancer, leukaemia, and Ewing sarcomas are at

57 resence of cardiovascular disease, diabetes, testicular cancer, or prostate cancer.

58 from 1.1% for pancreatic cancer to 98.2% for testicular cancer.

59 ug reaction in adult patients with germ cell testicular cancer.

60 er; 487518 due to liver cancer; 13927 due to testicular cancer; and 829396 due to non-Hodgkin lymphom

61 ection, ranging from <1/tumor in thyroid and testicular cancers to >10/tumor in endometrial and color

62 genetic impairment of NER, such as skin and testicular cancers.

63 t left inguinal orchiectomy, which disclosed testicular carcinoma composed of 90% choriocarcinoma, 9%

64 iparameter sort of MOLT-4-contaminated human testicular cell suspensions was performed to isolate EpC

65 ize cell surface antigen expression on human testicular cells and leukemic cells (MOLT-4 and TF-1a).

66 ies to assess interactions of SCs with other testicular cells and to test the ability of anti-ZIKV dr

67 Testicular cells exhibit similar molecular responses to

68 PFOS induces Sertoli cell injury using testicular cells isolated from rodent testes, but it rem

69 d from omental fat and lung did not redirect testicular cells to a MEC fate, indicating the necessity

70 studies to explore the interactions of other testicular cells with Sertoli cells and to test novel an

71 MR imaging is accurate in the detection of testicular changes, including paratesticular cysts and S

72 rasite burden, horn length, horn growth, and testicular circumference.

73 r that, magnetic resonance imaging (MRI) and testicular color Doppler ultrasound (CDU) were performed

74 Testicular concentrations of DEHP and PCB153 perturbed s

75 ApoA-1 amyloidosis with a Glu34Lys mutation; testicular, conjunctival, and renal involvement; and the

76 yndromes including Crouzon and Pfeiffer, but testicular defects were not reported.

77 ic acid have reduced fertility subsequent to testicular defects.

78 Atrophic testes and testicular degeneration were observed in Ppard(-/-) mice

79 lt mice and rats were sufficient to redirect testicular derived cells to produce normal mammary epith

80 are sufficient to direct differentiation of testicular-derived cells and ESCs to form functional mam

81 udy was to examine the protective effects of testicular-derived sex hormones on the development of jo

82 ing activational roles for ovarian-, but not testicular-, derived hormones in mediating hedonic sensi

83 to heat stress, and therefore, mammals with testicular descent may be at a greater risk in the event

84 involved in gonadogenesis, spermatogenesis, testicular determination, and sex determination are poor

85 involved in gonadogenesis, spermatogenesis, testicular determination, gametogenesis, gonad different

86 This process revealed that testicular development and spermatogenesis, preputial se

87 cific germline ablation but other aspects of testicular development are normal.

88 srupting chemicals during critical phases of testicular development may be related to poorer semen pa

89 Down-regulation of sFRP1 during testicular development was found to coincide with the on

90 s, thyroid hormone signaling and metabolism, testicular development, and spermatogenesis.

91 hways, such as thyroid hormone signaling and testicular development, could be linked with biological

92 is both necessary and sufficient to initiate testicular development, thereby acting as an upstream re

93 d not compensate for low levels during early testicular development.

94 f both SCs and germ cells during prepubertal testicular development.

95 of SRY is necessary for robust initiation of testicular development.

96 and are differentially regulated during the testicular development.

97 However, whether it is sufficient to induce testicular differentiation has remained unresolved.

98 Hypogonadism may arise from testicular disease (primary hypogonadism) or dysfunction

99 100 testes of 50 patients with a unilateral testicular disease.

100 osure on neonatal testes and its relation to testicular dysfunction in adult offspring.

101 findings provide the first evidence for how testicular dysgenesis can result after normal testis dif

102 etal endocrine disruption and the associated testicular dysgenesis syndrome (TDS).

103 stosterone, and is used as a model for human testicular dysgenesis syndrome (TDS).

104 found to have a 46,XY karyotype with partial testicular dysgenesis.

105 r Tgr5 are protected against the deleterious testicular effects of BA exposure.

106 t species because it occurs within a complex testicular environment characterized by the intimate ass

107 A testicular examination was normal.

108 Here we used an ex vivo testicular explant model and in vivo exposure to determi

109 ppress testosterone synthesis in human fetal testicular explants to an extent greater than that seen

110 s; and, in a significant proportion of mice, testicular failure and atrophy with tubule lithiasis, po

111 e analyzed a cohort of patients with primary testicular failure and identified 2 individuals harborin

112 ble just two decades ago, azoospermia due to testicular failure, including 47,XXY (Klinefelter syndro

113 Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the

114 e demasculinized in adult males carrying the testicular feminization mutation (Tfm) of the AR gene, w

115 ther sedentary lifestyle was associated with testicular function (semen quality and reproductive horm

116 Testicular function is often impaired even years after t

117 To investigate the involvement of PLAG1 in testicular function, we determined (i) the spatial distr

118 uld be specifically disruptive of ovarian or testicular function, while leaving extragonadal function

119 heir distinct roles in organ homeostasis and testicular function.

120 tion of PFOS on lipid mediators in affecting testicular functions.

121 Hh signaling in Leydig cell development and testicular functions.

122 that PFOS has potential negative impacts on testicular functions.

123 e absence of detectable changes in the intra-testicular GC transcriptome.

124 not find significant changes in the F0 intra-testicular GC transcriptome.

125 om precursor to primary disease, and primary testicular GCTs (TGCTs) are uniformly wild type for TP53

126 NA profiling found that DMRT1 activates many testicular genes and downregulates ovarian genes and sin

127 tance: Patients given systemic treatment for testicular germ cell cancer (GCC) are at increased risk

128 rognosticate survival outcomes in metastatic testicular germ cell tumor (MT-GCT), but how the initial

129 Complex genetic factors underlie testicular germ cell tumor (TGCT) development.

130 Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 sus

131 Testicular germ cell tumor (TGCT) is the most common can

132 Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans an

133 (Dnd1) gene are the most potent modifiers of testicular germ cell tumor (TGCT) susceptibility in mice

134 reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT).

135 ysis to identify new susceptibility loci for testicular germ cell tumor (TGCT).

136 published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970

137 Testicular germ cell tumors (TGCT) are considered a para

138 Testicular germ cell tumors (TGCT) are the most frequent

139 lity is a risk factor for the development of testicular germ cell tumors (TGCT), but the initiating e

140 osis, management, and risk stratification of testicular germ cell tumors (TGCTs) in the past year.

141 discusses several important developments in testicular germ cell tumors (TGCTs) over the past year.

142 Testicular germ cell tumors (TGCTs) share germline ances

143 ansformed understanding of susceptibility to testicular germ cell tumors (TGCTs), but much of the her

144 mutant testes also are misregulated in human testicular germ cell tumors (TGCTs), suggesting similar

145 Testicular germ cell tumors (TGCTs), the most common neo

146 ariants associated with an increased risk of testicular germ cell tumors (TGCTs).

147 ly used anticancer drug for the treatment of testicular germ cell tumors (TGCTs).

148 t in vertebrates that has been implicated in testicular germ cell tumors of mouse and human.

149 Testicular germ cell tumour (TGCT) is the most common ca

150 A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to b

151 GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygeni

152 ng for >15% of the genetic susceptibility to testicular germ cell tumour (TGCT).

153 Testicular germ cell tumours (TGCTs) are the most common

154 also summarise the consensus on how to treat testicular germ cell tumours and focus on a few controve

155 Testicular germ cell tumours are at the crossroads of de

156 Testicular germ cell tumours are highly sensitive to rad

157 f the epidemiology, genetics, and biology of testicular germ cell tumours.

158 liconic genes are expressed predominantly in testicular germ cells, and many were independently acqui

159 y model, we analyzed population-wide data on testicular germ-cell tumor (TGCT) status in 1,135,320 tw

160 confirmed the sonographic diagnosis of left testicular hematoma and of the right cryptorchidism.

161 These alterations of testicular histology and gene expression patterns were s

162 sequences of PLAG1 deficiency by determining testicular histology, daily sperm production and sperm m

163 ssing cells results in a transient impact on testicular homeostasis, with this population behaving st

164 determined if PR exists and is regulated by testicular hormones in forebrain sites traditionally inf

165 This phenotype appears to be suppressed by testicular hormones in male Prkca(-/-) mice.

166 gene editing to knockout the HMGB4 gene in a testicular human embryonic carcinoma and examined cellul

167 ive oligosaccharides were obtained by bovine testicular hyaluronidase digestion.

168 in cell culture conditions, using zebrafish testicular hyperplasia cells that accumulate early stage

169 report a strong positive association between testicular hypofunction and subsequent MS (rate ratio =

170 investigated a potential association between testicular hypofunction, as a proxy for low testosterone

171 PRL2-deficient male mice exhibit testicular hypotrophy and impaired spermatogenesis, lead

172 rm trial, patients with IR MGCT (stage II-IV testicular, II-III ovarian, I-II extragonadal, or stage

173 s (TM) play an important role in maintaining testicular immune privilege and display reduced proinfla

174 Our results suggest that TM maintain testicular immune privilege by inhibiting NF-kappaB sign

175 dentify SCs as a therapeutic target to clear testicular infections.

176 e equivalent dose of 20 g/m(2) or greater or testicular irradiation with 20 Gy or greater.

177 her PFOA serum levels may be associated with testicular, kidney, prostate, and ovarian cancers and no

178 reast; cervical; uterine; ovarian; prostate; testicular; kidney; bladder; brain and nervous system; t

179 normal testicular tissues as well as benign testicular lesions (P=0.000).

180 t difference between ADC values of malignant testicular lesions and normal testicular tissues as well

181 From January 2012 to December 2015, 55 focal testicular lesions that were indeterminate on gray-scale

182 rs; age range, 14-61 years) with nonpalpable testicular lesions were consecutively enrolled between 2

183 Results Of 55 testicular lesions, 43 (78.2%) were benign and 12 (21.8%

184 .3% of sand flies feeding on ear, mouth, and testicular lesions, respectively, were parasite-positive

185 n differentiating benign and malignant focal testicular lesions.

186 nosis and individualized management of small testicular lesions.

187 axin/insulin superfamily and is expressed in testicular Leydig cells.

188 us system (CNS) lymphoma (PCNSL) and primary testicular lymphoma (PTL) are rare extranodal large B-ce

189 Primary testicular lymphoma (PTL) is a rare, clinically aggressi

190 ervous system lymphomas (PCNSLs) and primary testicular lymphomas (PTLs) are extranodal large B-cell

191 Testicular macrophages (TM) play an important role in ma

192 Testicular macrophages (tMphi) are the principal immune

193 ctions between viable Leydig cells (LCs) and testicular macrophages that may lead to male infertility

194 ed a high accuracy in the diagnosis of small testicular malignancies (area under the ROC receiver ope

195 produce susceptibility to the development of testicular malignancies, and expression of certain prote

196 on of gonads, significant down-regulation of testicular markers Amh and Sox9, and remarkable up-regul

197 previously healthy man presented with a left testicular mass, confirmed on ultrasound.

198 ular adrenal rest tumours (TARTs) are benign testicular masses that are found in inadequately treated

199 typical sonographic appearance of bilateral testicular masses, a diagnosis of testicular adrenal res

200 that the impacts of persistent pollutants on testicular maturation and function require further inves

201 lusion There is a strong association between testicular microlithiasis and primary testicular neoplas

202 y define the strength of association between testicular microlithiasis and testicular neoplasia in a

203 Testicular microlithiasis was present in 4 of 9 patients

204 Testicular microvessels and blood flow are known to cont

205 Hence HTPCs via control of testicular microvessels may contribute to the regulation

206 Cul4bled to male infertility, despite normal testicular morphology and comparable numbers of spermato

207 nt system seems to be dispensable for normal testicular morphology and spermatogenesis.

208 Testicular morphology and the position of the nucleus in

209 This was a retrospective review of the testicular MR images and histologic reports from 25 pati

210 iation between testicular microlithiasis and testicular neoplasia in a large geographically diverse p

211 etween testicular microlithiasis and primary testicular neoplasia in this pediatric population.

212 ive and developmental stages to populate the testicular niche prior to productive spermatogenesis.

213 he site-specific risk of solid cancers among testicular nonseminoma patients treated in the modern er

214 rs) were calculated for 15,006 patients with testicular nonseminoma reported to the population-based

215 ors were calculated for 12,691 patients with testicular nonseminoma reported to the population-based

216 d risks of solid cancers among patients with testicular nonseminoma treated in the modern era of cisp

217 We found the expression of testicular nuclear receptor 4 (TR4) is significantly hig

218 46,XX karyotype develop testes or ovotestes (testicular or ovotesticular disorder of sex development;

219 Here, we show that testicular orphan nuclear receptor 4 (TR4, nuclear recep

220 hat loxp/cre-mediated CNS deletion of TR4, a testicular orphan nuclear receptor, results in loss of m

221 used in a number of malignancies, including testicular, ovarian, cervical, bladder, lung, head, and

222 tation causing isolated, non-syndromic 46,XX testicular/ovotesticular DSD in humans.

223 Review of the MR images showed that testicular parenchyma was heterogeneous in 30 of 46 test

224 ascularity was observed in the heterogeneous testicular parenchyma.

225 and emphasize TGR5 as a critical element in testicular pathophysiology.

226 Our proteomic study using cultured human testicular peritubular cells (HTPCs) i.e. the cells, whi

227 Thus testicular peritubular cells, via PEDF, may prevent vasc

228 ence of modifier genes which exacerbated the testicular phenotype.

229 We examined testicular phenotypes of sks/sks mice to investigate the

230 1d20-null mutation and exhibit cataracts and testicular phenotypes similar to those observed in WARBM

231 TBC1D20 as a RABGAP and the bs cataract and testicular phenotypes, we hypothesized that mutations in

232 rences in temperature-sensitive expressions, testicular physiology, spermatogenesis, as well as its r

233 al carcinoma and rete testis invasion in the testicular primary identified a group with a relapse ris

234 rises from a complete deficiency in juvenile testicular RA synthesis and can be rescued by retinoid a

235 ermatogonia that are essential for efficient testicular regeneration after injury.

236 We find that DMRT1 blocks testicular retinoic acid (RA) signaling from activating

237 Knowledge of the regulation of testicular retinoic acid synthesis is crucial for unders

238 ey were older than 16 years, had evidence of testicular, retroperitoneal, or mediastinal non-seminoma

239 a complex delayed diagnosed example case of testicular rupture clinically mimicing epididymo-orchiti

240 Early diagnosis of testicular rupture may lead to the salvaging of the test

241 Testicular rupture may occur even after moderate sportiv

242 blunt trauma may result in injuries, such as testicular rupture, dislocation, torsion, hematoma, sper

243 inal stromal tumors, acute myeloid leukemia, testicular seminomas and mastocytosis.

244 g effort and parenting effort, as indexed by testicular size and nurturing-related brain function, re

245 nnual cycle of body weight, temperature, and testicular size.

246 cases when combining surgical harvesting of testicular sperm and ICSI.

247 Post-testicular sperm maturation, in which sperm centrioles f

248 In testicular sperm, tRNA fragments are scarce but increase

249 g CatSper currents from human epididymal and testicular spermatozoa, we show that CatSper sensitivity

250 iarrheic pig from Ohio was isolated in swine testicular (ST) and LLC porcine kidney (LLC-PK) cell cul

251 is failure was probably explained by reduced testicular steroidogenic acute regulatory protein expres

252 suppress gonadotropins, thereby blocking the testicular T production needed for spermatogenesis, whil

253 Testicular teratocarcinoma cells rarely contain mutation

254 t new therapeutic possibilities of targeting testicular teratocarcinoma.

255 v strain mice results in a >90% incidence of testicular teratomas, tumors consisting cells of multipl

256 In contrast intra-testicular testosterone levels were reduced by 89%, in f

257 orage aimed at subsequent transplantation of testicular tissue and associated stem cells.

258 All lesions appeared hypointense compared to testicular tissue on T1W and T2W magnetic resonance imag

259 their female equivalents-granulosa cells-and testicular tissue reorganizes to a more ovarian morpholo

260 Only 12% of the genetic males showed testicular tissue six months after fertilization.

261 ion of apoptosis-related genes (P < 0.05) in testicular tissue.

262 s of malignant testicular lesions and normal testicular tissues as well as benign testicular lesions

263 Extravaginal testicular torsion (ETT), also called prenatal or perina

264 Although testicular torsion is the most frequent cause of acute s

265 Testicular torsion may concern boys even in the perinata

266 Testicular torsion must be taken into consideration in d

267 A testicular torsion was suspected, so the baby underwent

268 ticle affected and 2 patients with bilateral testicular torsion.

269 chitis and radiologically mimicing traumatic testicular torsion.

270 ency surgical treatment, required in case of testicular torsion.

271 auxiliary method in the diagnosis of partial testicular torsion.

272 ul tool in the early diagnosis of incomplete testicular torsion.

273 ficient (ADC) in the diagnosis of incomplete testicular torsion.

274 ates include hydrocoele, inguinal hernia and testicular torsion; less common is epididymo-orchitis.

275 ical emergencies in children often caused by testicular torsion; the diagnosis is mostly clinical but

276 Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in hu

277 wn mitochondrial dysfunction in DEHP-induced testicular toxicity and highlight the importance of SIRT

278 investigate the molecular mechanisms of its testicular toxicity which are largely unknown.

279 Testicular tumor was significantly more likely in boys w

280 GSG does not translate to higher efficacy of testicular tumorigenesis arising from mutant p53 cells,

281 reprogramming in both normal development and testicular tumorigenesis.

282 ata bases were searched for pathology-proven testicular tumors (benign or malignant germ cell or stro

283 test was used to analyze the association of testicular tumors and TM.

284 Benign testicular tumors are frequent incidental findings.

285 ions or microlithiasis and all patients with testicular tumors from pathology database were identifie

286 Four patients with TM had malignant testicular tumors, all diagnosed after the age of 16 yea

287 Testicular tumors, the most common cancer in young men,

288 There is a significant association of TM and testicular tumors.

289 p53 is a common finding in most cancers but testicular tumours accumulate wild-type p53 (wtp53).

290 accompanied by increased G-CSF signaling and testicular vacuolation associated with decreased fertili

291 Normal testicular vessels coursing through the lesions undistur

292 Doppler ultrasound showed normal testicular vessels passing through the mass which were u

293 th, Tanner stage 5 for pubic hair growth, or testicular volume (TV) >/= 20 mL in either testis.

294 al staging [genitalia (G), pubarche (P), and testicular volume (TV)].

295 Pubertal onset was based on testicular volume and on genitalia staging.

296 d to assess reproductive endocrine function, testicular volume, semen quality, and fertility in adult

297 efined by genitalia staging, although not by testicular volume.

298 The testicular volumes and total sperm counts of the RTx pat

299 activation in SF1(+) progenitors had reduced testicular weight, oligospermia, and decreased sperm mob

300 ls and to test novel antivirals for clearing testicular ZIKV infection.