ライフサイエンスコーパス: testis

1 ported to other tissues (e.g. vitellaria and testis).

2 ction of mature piwi-interacting RNAs in the testis.

3 es with previously known activities in adult testis.

4 the adult Drosophila ovary as well as in the testis.

5 es, whereas MTP-C was prominent in brain and testis.

6 OX9/8 maintain Dmrt1 expression in the adult testis.

7 germline stem cells (GSCs) in the Drosophila testis.

8 OBP2, besides male tarsi, is also present in testis.

9 ouse tissues but was highly expressed in the testis.

10 upon removal of let-7 in the adult ovary or testis.

11 d become adult Leydig cells in post-pubertal testis.

12 such as the central nervous system (CNS) and testis.

13 omatic cell lineage progression in the mouse testis.

14 r testicular volume (TV) >/= 20 mL in either testis.

15 in a 50% increase of AR-negative LC in adult testis.

16 PIWI-interacting RNAs (piRNAs) in mammalian testis.

17 e induces germ cell effects in the fetal rat testis.

18 RPE but highly abundant expression in mouse testis.

19 document the expression of p53R172H in mouse testis.

20 as Sertoli-cell only (SCO) pathology of the testis.

21 ion of stem cell daughters in the Drosophila testis.

22 r approximately 20% of the vig2-like mRNA in testis.

23 kes place in the seminiferous tubules of the testis.

24 germ cell or PTMC support in the prepubertal testis.

25 ne spermatocytes and round spermatids in the testis.

26 other tissues besides the nervous system and testis.

27 ecies which can also be found in adult human testis.

28 pes that support ZIKV infection in the human testis.

29 the principal immune cells of the mammalian testis.

30 ion in the ovary, and wild-type dmrt1 in the testis.

31 tion along the length of Sertoli cell in the testis.

32 ic cyst stem cells (CySCs) in the Drosophila testis.

33 ng a long-term effect on Leydig cells of the testis.

34 two species yet is similarly abundant in the testis.

35 lood-tissue barriers in the eyes, brain, and testis.

36 6), which exhibits expression exclusively in testis and a broad range of human cancers.

37 inary tract anomalies, bilateral undescended testis and absence of anterior abdominal wall muscles.

38 ct endocrine disturbances in the human fetal testis and alteration of the germ cell biology.

39 In testis and brain, Stra6 expression was regulated by vita

40 ion factor that is normally expressed in the testis and causes apoptosis and FSHD when misexpressed i

41 mester human embryonic and fetal ovaries and testis and confirmed by qPCR and immunohistochemistry (I

42 closely related dengue virus (DENV), in the testis and epididymis of male mice, and this was associa

43 aled bilaterally enlarged echogenic kidneys, testis and epididymis with echogenic peritoneal fluid tr

44 inal wall deficiency, unilateral undescended testis and female neonates with abdominal wall laxity ar

45 in adult tissues revealed expression in the testis and intestine but little or none in the brain and

46 plex detection of miRNAs from brain, kidney, testis and liver.

47 However, cellular targets of ZIKV in human testis and mechanisms by which the virus enters seminife

48 cells for ALCs must be present in the fetal testis and might be susceptible to programming by fetal

49 ttern and is localized almost exclusively in testis and more specifically in postmeiotic spermatids a

50 orrelated with the PTEN protein level in the testis and PRL1(+/-)/PRL2(-/-) mice have the highest lev

51 e viable isoforms, being highly expressed in testis and retina.

52 sly identified ubiquitin ligase Huwe1 in the testis and showed that it can ubiquitinate histones.

53 ings will affect target antigen selection in testis and sperm autoimmunity and the immune responses t

54 y underwent an ultrasound examination of the testis and spermatic cord that showed a left scrotal hem

55 nesis and oogenesis, which take place in the testis and the ovary, respectively.

56 aintaining the homeostasis of BTB in the rat testis and the phenotypes of Sertoli cell-conditional Cx

57 a single systemic tamoxifen injection on the testis and the wider endocrine system.

58 demonstrating that the FLC survive in adult testis and their ontogeny is distinct from ALC.

59 Mirroring higher UBE2W expression levels in testis and thymus, Ube2w KO mice showed a disproportiona

60 ion induction, caused adverse effects to the testis and to the reproductive endocrine system that per

61 n, esophagus, trachea, tongue, eye, bladder, testis and uterus.

62 bryonic FLC precursors, but not in postnatal testis, and a dual fluorescent Cre recombinase reporter

63 steroid-sensitive tissues, namely placenta, testis, and adipose tissue.

64 r the efficient regenerative capacity of the testis, and also display facultative stem activity in tr

65 Examination of liver, testis, and cerebellum suggest, however, that the precis

66 lengthening in head and 3' UTR shortening in testis, and characterize new tissue and developmental 3'

67 tected in mouse reproductive tissues (ovary, testis, and prostate) and lung and colon tissues from bo

68 he ZZ dmrt1 mutant fish developed ovary-like testis, and the spermatogenesis was disrupted.

69 city similar to, or slightly lower than, the testis, and the two large lesions had posterior acoustic

70 pressed in male reproductive tissues such as testis, and thus an "out of testis" hypothesis for the e

71 Its product is a cancer testis antigen (CTA), and it is often expressed in tumor

72 sidue at position 124 of the NY-ESO-1 cancer/testis antigen as the acceptor site for the formation of

73 Analysis of cancer/testis antigen expression and CD8 T-cell abundance sugge

74 f MAGEA2, and related members of this cancer-testis antigen family, is upregulated in tamoxifen-resis

75 and two of the AD subtypes expressed cancer testis antigen genes, whereas three AD subtypes expresse

76 We show here that the cancer/testis antigen PASD1 fulfills this role to suppress circ

77 ssed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leu

78 PAGE4) is an intrinsically disordered cancer/testis antigen that is up-regulated in the fetal and dis

79 ses than women, likely due to gonadal cancer-testis-antigen expression.

80 Many MGCA are also expressed as cancer/testis antigens (CTA) in human cancers, but the toleranc

81 Cancer testis antigens (CTAs) represented a poorly characterize

82 to the testis, collectively known as cancer-testis antigens (CTAs).

83 AG5 and TSSK6 as putative immunogenic cancer/testis antigens in multiple cancers.

84 rally processed peptide shared by the cancer-testis antigens NY-ESO-1 and LAGE-1.

85 sed in soma-derived human cancers as "cancer/testis antigens" (CTAs), and piRNA (PIWI-interacting RNA

86 ce include mutant sequences, selected cancer testis antigens, and viral antigens.

87 elper T cells against melanocytic and cancer-testis antigens, has been shown to induce specific Th1-d

88 some cases shared differentiation or cancer-testis antigens.

89 lation of endogenous retroviruses and cancer testis antigens.

90 Here we show that, despite aberrant testis architecture, males of the aneuploid Tc1 mouse st

91 SRY/SOX9 expression initiated in testis around day 40 pc, followed by initiation of AMH a

92 d for alternative splicing regulation in the testis, as in brain.

93 Polymorphisms in the testis-associated gene DMRT1 displayed interactions with

94 PAX7+ cells were present in the testis at birth.

95 ed on the cross-talk that occurs in the bone-testis axis.

96 esearch pertains to the newly described bone-testis axis.

97 t is localized in Sertoli cells at the blood-testis barrier (BTB) and at the apical ectoplasmic speci

98 manent infertility due to irreversible blood-testis barrier (BTB) disruption even though the populati

99 hese changes destabilized Sertoli cell blood-testis barrier (BTB) integrity.

100 of Sertoli cells was observed, but the blood-testis barrier (BTB) was not formed.

101 etween the basement membrane (BM), the blood-testis barrier (BTB), and the apical ectoplasmic special

102 CRB3 also expressed at the blood-testis barrier (BTB), co-localized with F-actin, TJ prot

103 The blood-testis barrier (BTB), formed between adjacent Sertoli ce

104 sing an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli c

105 cell-cell (basal ES) interface at the blood-testis barrier (BTB).

106 l interface, known as basal ES, at the blood-testis barrier (BTB).

107 Regulation of the blood-testis barrier by a local axis in the testis: role of la

108 onnexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogene

109 igen-presenting cells, and sustain the blood-testis barrier formed by their tight junctions.

110 germ cell sloughing and rupture of the blood-testis barrier occur and are correlated with decreased p

111 assessment, and overexpression of BTB (blood-testis barrier) regulatory genes such as FAK and its pho

112 ed site in the testis protected by the blood-testis barrier, also called the Sertoli cell (SC) barrie

113 higher claudin-11 expression along the blood-testis barrier.

114 ordinated across tissues such that autosomal testis-biased miRNAs tend to be somatically male-biased,

115 MRT1 expression was observed not only in the testis but also in lung macrophages.

116 s whose expression is normally restricted to testis but are frequently up-regulated in cancer cells.

117 mouse, the IFT proteins are very abundant in testis, but we here show that mature sperm are completel

118 Active surveillance for CSI testis cancer leads to excellent outcomes.

119 We suggest that changes in testis cell types originate from modified transcriptiona

120 whose expression is otherwise biased to the testis, collectively known as cancer-testis antigens (CT

121 aled a small left-sided palpable mass of the testis, compatible with an inguinal hernia or hydrocele.

122 Furthermore, a testis-conditioned medium induced the migration of REH a

123 e we provide evidence that in the Drosophila testis, connectivity serves as a mechanism that confers

124 xpression and become Sertoli cells that form testis cords, whereas the remaining WT1(+) cells contrib

125 Cancer/testis (CT) antigens are potential immunotherapeutic tar

126 els have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and s

127 Cancer-testis (CT) genes represent the similarity between the p

128 -attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregn

129 vent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman

130 Essential for fetal testis descent, INSL3 has been implicated in testicular

131 asures such as penis and preputial size, and testis descent, were greater in Sgta(-/-).

132 We propose that beyond its roles in testis determination and spermatogenesis, the Y chromoso

133 romosome research over the past six decades: testis determination and spermatogenesis.

134 rs expressed in Sertoli cells at the time of testis determination in mice.

135 A model is provided by testis determination in therian mammals.

136 Human testis determination is initiated by SRY, a Y-encoded ar

137 ls of FGFR2 signaling is important for human testis determination.

138 her correlated with silencing of a serial of testis determining genes, including SOX9, SF1, SOX8, AMH

139 ent; TDSD/OTDSD), due to the presence of the testis-determining gene, SRY Other rare complex syndromi

140 can silence Foxl2 even in the absence of the testis-determining genes Sox8 and Sox9.

141 mutations in pro-ovarian genes that repress testis development (e.g. WNT4); however, the genetic cau

142 termining region Y (SRY) coactivation of the testis development gene SOX9.

143 NR5A1 is associated with variable degree of testis development in 46,XX children and adults from fou

144 veal that SCs remain essential regulators of testis development long after the period of sex determin

145 We show impaired testis development, degenerated seminiferous tubules, re

146 their role during the intervening period of testis development, in particular during adult Leydig ce

147 ows that, in addition to its crucial role in testis development, Sox9, together with Sox8 and coordin

148 g the function of Sertoli cells during early testis development.

149 by adult Leydig cells (ALC) during perinatal testis development.

150 PRL2 is required for spermatogenesis during testis development.

151 are a consequence of aberrant germ cell and testis development.

152 esticular dysgenesis can result after normal testis differentiation/development and may be relevant t

153 ese two subsets were interrogated for cancer-testis, differentiation, and somatic mutational antigens

154 l development and fertility, consistent with testis-directed function of the hpRNA pathway.

155 ponent of the apical and basal ES in the rat testis, displaying spatiotemporal expression during the

156 sion of female sex determinants in the adult testis disrupts tissue morphology.

157 MN was expressed at high levels in adult C/C testis due to an adult-specific splicing switch, but cou

158 across seminiferous epithelium in mammalian testis during spermatogenesis, are tightly coordinated b

159 The more severe testis dysgenesis in DBP-MPW animals may result from the

160 o disrupt androgen production in human fetal testis explants and to evaluate the importance of mixtur

161 stimulated testosterone secretion from adult testis explants.

162 articular, we discover that Foetal and Adult Testis Expressed 1 (FATE1) is a key survival factor in m

163 by means of direct Sanger sequencing of the testis-expressed 11 gene (TEX11) open reading frame in b

164 ed with loss of diversity is the location of testis-expressed ampliconic genes, which also have reduc

165 We identified 142 segregating and 106 fixed testis-expressed de novo genes in a population sample of

166 other of regulator of imprinted sites), is a testis-expressed gene whose function is largely unknown.

167 the transcription start sites of hundreds of testis-expressed genes; evolutionarily conserved across

168 ssociated factor (TBP)] and third-trimester [Testis-expressed sequence 15 protein (TEX15)] protein bi

169 ed convergent gene functions associated with testis expression.

170 phenotypes in humans ranging from a lack of testis formation to male infertility.

171 ds, we resolved the copy number for a cancer-testis gene family (CT47) within an unresolved region of

172 Derepression of testis genes, and inappropriate Phf7 expression, is also

173 Sxl protein exhibit a global derepression of testis genes, including Phf7, a male germline sexual ide

174 ulted in transcriptional derepression of the testis genes, indicating that they may be affected by en

175 , focusing on regulators of adult Drosophila testis germline stem cells (GSCs).

176 internal self-fertilization in a mixed ovary/testis gonad.

177 ls (GSCs) but was considered dispensable for testis GSC maintenance.

178 Primary LC cultures from adult testis had either recombinant (20%) or nonrecombinant (8

179 mbinant, whereas the majority of LC in adult testis had the nonrecombinant reporter.

180 All FLC in newborn testis had the recombinant, whereas the majority of LC i

181 In summary, the mouse testis has adopted a regenerative strategy to expand ste

182 male fertility, but their role in the adult testis has not been investigated.

183 n regulators of spermatogenesis in the adult testis; however, their role during the intervening perio

184 tissues such as testis, and thus an "out of testis" hypothesis for the emergence of new genes has be

185 l lines, but not in normal parenchyma of the testis, implying tumor-specific expression.

186 ot possible to explain the sterol profile of testis in cAMP responsive element modulator tau (Crem ta

187 ctor can switch organ fate from the ovary to testis in mammals and represents the first missense muta

188 isruption, making the barrier leaky), in the testis in vivo We report our findings that NC1 domain de

189 ed by studies in vivo by plastin 3 KD in the testis in which mis-localization of N-cadherin and beta-

190 300 mostly spermatid-specific transcripts in testis, including nearly complete elimination of those e

191 enged with Zika virus were protected against testis infection, injury, and oligospermia.

192 Also, Sox9/8 warrant testis integrity by controlling the expression of struct

193 cells contribute to progenitor cells in the testis interstitium.

194 n together with embryonal carcinoma and rete testis invasion in the testicular primary identified a g

195 ic cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as Cy

196 Organogenesis of the testis is initiated when expression of Sry in pre-Sertol

197 ental models have shown that the human fetal testis is insensitive to the steroidogenic effects of ph

198 and ectopic expression of let-7 in the adult testis is sufficient to recapitulate the chinmo loss-of-

199 ilarly result in an increase of FLC in adult testis, leading to abnormal LC differentiation.

200 novel class of functionally important cancer/testis lncRNAs whose structure and function have undergo

201 postnatal testes, but the mechanism of adult testis maintenance remains mostly unknown.

202 coordinately with Dmrt1, also controls adult testis maintenance.

203 hesis in fetal life has been associated with testis maldescent, malformations of the genitalia at bir

204 Polyorchidism or supernumerary testis means more than two testes.

205 tricts activation by Aly, a component of the testis-meiotic arrest complex, to transcripts for male g

206 Adjacent to TGCTs, benign testis methylation profiles are determined by spermatoge

207 iously unappreciated role for macrophages in testis morphogenesis and suggest that macrophages are an

208 Testis morphogenesis is a highly orchestrated process in

209 blishment of somatic cell populations during testis morphogenesis.

210 ermination of Sertoli cells that orchestrate testis morphogenesis.

211 In the adult Drosophila testis niche, local Jak-STAT signaling promotes somatic

212 igens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy.

213 CR) in HTPCs, however PEDF expression in the testis of a non-human primate occurs before puberty.

214 ably, we obtained an intersex ZW fish with a testis on one side and an ovary on the other side.

215 tually antagonistic organogenetic fates, the testis or the ovary.

216 several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta.

217 gest that Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as

218 t human tissues, we detect ERbeta protein in testis, ovary, lymphoid cells, granulosa cell tumours, a

219 the scrotal mass is similar with the normal testis parenchyma, multitestis should be considered.

220 rspectives on the potential effect of BAs on testis physiology during liver dysfunction.

221 in nature to piRNAs [P-element-induced wimpy testis (Piwi)-interacting small RNAs], we investigated w

222 In mouse testis, Pontin is essential for the stabilization of axo

223 a history of a mixed germ cell tumor of the testis presented with acute-onset, right-sided weakness

224 FA revealed that KDR signaling represses the testis-promoting gene Sox9 in embryonic XX gonads.

225 us tubules, an immune-privileged site in the testis protected by the blood-testis barrier, also calle

226 In testis, RA acts directly in Sertoli, Leydig and pre-meio

227 absence from normal human tissues except the testis, RBMY represents a feasible therapeutic target fo

228 The process of testis regression culminates in complete degeneration of

229 Here, we show that Drosophila testis responds to protein starvation by eliminating tra

230 imary spermatocytes and Sertoli cells in the testis, resulting in cell death and destruction of the s

231 blood-testis barrier by a local axis in the testis: role of laminin alpha2 in the basement membrane.

232 atogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollage

233 specific germ cell subtypes from fixed human testis samples.

234 e analysis of RNAseq data from the liver and testis showed a difference in their PAS number and usage

235 ed requirement for SMN expression, wild type testis showed extremely high levels of SMN protein compa

236 alysis of a vulnerable organ, presymptomatic testis, showed a preferential accumulation of disordered

237 ame infertile with age, with all LC in older testis showing signs of incomplete differentiation, such

238 We describe new differences in behavior, testis size and steroid metabolism among morphs and iden

239 j knockout mice had: significantly increased testis sizes; increased expression of niche factors, suc

240 ion pathway to maintain the male identity of testis somatic cells.

241 Conversely, the feminization of the testis somatic stem cell lineage caused by loss of chinm

242 TAT target chinmo prevents transformation of testis somatic stem cells into their ovarian counterpart

243 more recently evolved and are predominately testis specific.

244 roteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic "readers" a

245 MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose exp

246 s, whereas FDY remained functional, acquired testis-specific expression, and now accounts for approxi

247 , a murine autosomal retrogene of Rpl10 with testis-specific expression, disturbs ribosome biogenesis

248 2 paralogs have independently specialized to testis-specific expression.

249 h biological processes that are upregulated (testis-specific gene expression) or downregulated (metab

250 ort that Spata6, an evolutionarily conserved testis-specific gene, encodes a protein required for for

251 ed a large number of cilia-related genes and testis-specific genes that were regulated by RFX2.

252 dhesion molecule (IgCAM) BT-IgSF (brain- and testis-specific Ig superfamily protein) plays a major ro

253 prises four members-BRD2, BRD3, BRD4 and the testis-specific isoform BRDT-that largely function as tr

254 two distinct isoforms in mammals: a longer, testis-specific isoform that was used for the previous s

255 hat most endogenous X-linked genes, not just testis-specific ones, are transcriptionally suppressed s

256 pulation genetic analyses, we show that most testis-specific paralogs have significantly lower geneti

257 ically, RHAMM expression is regulated by the testis-specific polyadenylation protein CFIm25, which is

258 elanogaster used a reporter gene driven by a testis-specific promoter to show that expression was gre

259 that expression of reporter genes driven by testis-specific promoters is considerably lower-approxim

260 The gonadoblastoma gene, testis-specific protein Y-encoded (TSPY), on the Y chrom

261 We explore their relationship with testis-specific regulatory elements.

262 and BORIS-only sites are occupied by several testis-specific transcriptional regulators (TSTRs) and a

263 of the nucleosomal histones are replaced by testis-specific transition proteins, TP1, TP2, and TP4.

264 cal ectoplasmic specialization (apical ES; a testis-specific, actin-rich adherens junction at the Ser

265 disrupting ectoplasmic specialization (ES; a testis-specific, actin-rich anchoring junction) function

266 We speculate that the repeated evolution of testis specificity in obscura group Ago2 genes, combined

267 re is a crucial role for this pathway in the testis stem cell niche, a true physiological function of

268 A(single) spermatogonia functions as robust testis stem cells that maintain fertility in normal sper

269 is, whereas GLI1 was significantly higher in testis than ovaries.

270 elium, and thus Slc15a1 is a novel target in testis that could be genetically modified to improve the

271 ctivation of EcR increases cell death in the testis that is rescued by expression of EcR-B2 in the Cy

272 dium with high efficiency for CRB3 KD in the testis, the CRB3 KD testes displayed defects in spermati

273 In the Drosophila testis, the JAK-STAT signaling pathway regulates germlin

274 In the adult Drosophila testis, the putative transcription factor Chronologicall

275 al competition in the cyst stem cells of the testis, there are important tissue-specific differences.

276 aftment of B-ALL cells in the bone marrow or testis, through RAC1 activation.

277 s of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential

278 We explanted testis tissue at postnatal day (P)5.5 and cultured it un

279 toli cells of adult, fertile Sox8(-/-) mice, testis-to-ovary genetic reprogramming occurs and Sertoli

280 This phenotype was mostly replaced by the "testis-to-ovary" or "ovaries" phenotypes during developm

281 t and exacerbation of the C (+/+)/Tia1 (-/-) testis transcriptome.

282 In the adult testis, two different macrophage populations have been i

283 (i) the spatial distribution of PLAG1 in the testis using X-gal staining; (ii) transcriptomic consequ

284 On ultrasound, the left testis was located in the inguinal canal, the right kidn

285 -state protein level of Slc15a1 in adult rat testis was not affected by F5-peptide treatment.

286 ated kinase (ERK) activation by PPARD in the testis was observed in Ppard(+/+) mice and was associate

287 Knockdown of Slc15a1 by in vivo RNAi in rat testis was shown to prevent F5-peptide induced disruptiv

288 us adult males exhibit cryptorchidism, lower testis weight, lower sperm count, and subfertility.

289 The binding partners of CRB3 in the testis were the branched actin polymerization protein Ar

290 nding protein 5) and NUT (nuclear protein in testis) were also demonstrated to be methylated by HEMK2

291 In mice, Rfx1-4 are highly expressed in the testis where flagellated sperm are produced, but the fun

292 and ETV5, were significantly higher than in testis, whereas GLI1 was significantly higher in testis

293 ned vitamin A levels of the eyes, brain, and testis, which highly express Stra6, as well as of tissue

294 In summary, overexpression of Cx43 in the testis with aspermatogenesis reboots meiosis and reseals

295 ed hypoechoic lesions around the mediastinum testis with hypervascularity dispersing in ten patients

296 most frequent interstitial neoplasms of the testis with increased incidence in recent years.

297 hoic lesions depicted around the mediastinum testis with no mass effect is highly suggestive for the

298 els of L-2-HG were observed in the brain and testis, with a corresponding increase in histone methyla

299 m cell markers on rat testes and human fetal testis xenografts after exposure to vehicle or di(n-buty

300 r, differentiation, and aggregation in human testis xenografts and in vivo in rats.