ライフサイエンスコーパス: testosterone

1 terone, corticosterone, 11-deoxycortisol and testosterone).

2 Males were protected by the presence of testosterone.

3 l therapies, and a castrate concentration of testosterone.

4 but was positively correlated with the men's testosterone.

5 s of detection were approximately 0.1 pg for testosterone.

6 rols and received placebos for goserelin and testosterone.

7 eroidal 5alpha-reductase substrates, such as testosterone.

8 es of men for whom we also measured salivary testosterone.

9 I: 27.9, 30.3 ng/dL), respectively] and free testosterone [0.178 ng/mL (95% CI: 0.171, 0.185 ng/dL) c

10 ean age, 72.3 years [SD, 5.8]; mean baseline testosterone, 234 ng/dL [SD, 65.1]), 247 were assigned t

11 significantly increased mean (SD) levels of testosterone (24.61 [7.97] vs 20.57 [4.9] nmol/L; P = .0

12 eine tertile was associated with lower total testosterone [27.9 ng/dL (95% CI: 26.7, 29.0 ng/dL) comp

13 ant associations were found between PFOS and testosterone (-6.6%; 95% CI: -10.1, -2.8%) and IGF-1 (-5

14 with the risk of PAH (odds ratio per 1 ln[E2:testosterone], 6.0; 95% confidence interval, 2.2-16.4; P

15 layed 10-word recall score (-0.02 per nmol/L testosterone, 95% confidence interval (CI) -0.06-0.02) o

16 duce the repeated game effect on trust after testosterone administration in subjects with relatively

17 , depending on prenatal sex hormone priming, testosterone administration in women moderates the effec

18 t-ratio (2D:4D ratio), influences effects of testosterone administration on human social behaviour.

19 aimed to establish the effects of long-term testosterone administration on multiple domains of cogni

20 Nonetheless, recent testosterone administration studies in humans repeatedly

21 emale mice, and this effect was abolished by testosterone administration.

22 erone, however, this effect disappears after testosterone administration.

23 Monthly testosterone advertising ratings were linked to DMA-leve

24 Conversely, higher testosterone among the lower-status participants was ass

25 equilibrium is eliminated by the addition of testosterone, an allosteric activator.

26 dL [SD, 65.1]), 247 were assigned to receive testosterone and 246 to receive placebo.

27 with Girard T reagent was used to charge-tag testosterone and 5alpha-dihydrotestosterone allowing dir

28 er cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI)

29 Among older men with low testosterone and age-associated memory impairment, treat

30 onsistent with a simple relationship between testosterone and aggression and provide causal evidence

31 Higher concentrations of testosterone and androstenedione associated with an incr

32 Although s.c. treatment with testosterone and aromatase inhibitor applied beginning o

33 a significant association between exogenous testosterone and cardiovascular events, in men aged 18 y

34 regarding the association between exogenous testosterone and cardiovascular events, we systematicall

35 no significant association between exogenous testosterone and cardiovascular events, with summary est

36 d magnitude of association between exogenous testosterone and cardiovascular events.

37 vidence of the association between exogenous testosterone and cardiovascular events.

38 Testosterone and cortisol have been proposed to influenc

39 revealed that group-level concentrations of testosterone and cortisol interact to predict a group's

40 oncentrations of total testosterone and free testosterone and decreased risk of anovulation were grea

41 ensitivity C-reactive protein and lower free testosterone and dehydroepiandrosterone levels.

42 Testosterone and DHT treatment increased tissue non-spec

43 tly reduced (10-fold, P < 0.01) intratumoral testosterone and dihydrotestosterone concentrations in t

44 TMPRSS2 and KLK3, despite the low levels of testosterone and dihydrotestosterone.

45 t P63 showed significant reductions in serum testosterone and epididymal sperm count.

46 Although implantation of testosterone and estradiol (T+E2) pellets for 2 months i

47 steroids (21 tested), including the hormones testosterone and estradiol as well as steroidal drugs.

48 also suppressed, suggesting effects of both testosterone and estradiol deficiency.

49 regulate bone homeostasis in adult men, and testosterone and estradiol levels must decline substanti

50 Additionally, the threshold levels of testosterone and estradiol that initiate bone loss are u

51 gh reductions in the concentrations of total testosterone and free testosterone and decreased risk of

52 However, physiological concentrations of testosterone and hydrocortisone inhibited CatSper activa

53 ased monotonically across quartiles for both testosterone and IGF-1 in relation to PFOS, and for IGF-

54 erage source, may be associated with reduced testosterone and improved menstrual cycle function in he

55 entally, males are exposed to high levels of testosterone and its byproduct, estradiol.

56 Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during cultur

57 ctive hormonal profile characterized by high testosterone and low cortisol exhibited the highest perf

58 increased risk in subgroup analyses of oral testosterone and men aged 65 years or older during their

59 Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sp

60 raph recall score among men with AAMI in the testosterone and placebo groups (adjusted estimated diff

61 the absence of interferences from estradiol, testosterone and progesterone.

62 ollicle-stimulating hormone and decreases in testosterone and the testosterone/luteinizing hormone ra

63 between treatment groups receiving exogenous testosterone and their controls (with a two-sided p valu

64 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism wh

65 re, we report a key role for the male gonad, testosterone, and androgen receptor (AR) in CNS remyelin

66 Joint effects of mixtures with fenarimol, testosterone, and ecdysone were antagonistic, mixtures o

67 between levels of PFAS and estradiol, total testosterone, and IGF-1 in 2,292 children (6-9 years of

68 Pupil dilation was not affected by testosterone, and increased relatively more in response

69 esulting from suppression of intratesticular testosterone, and is used as a model for human testicula

70 and corticosteroids, decreased formation of testosterone, and reduced strength alongside growth arre

71 is circulating androgens [testosterone, free testosterone, androstenedione, dehydroepiandrosterone su

72 When XY females were exposed to testosterone, aneurysm rupture rates were striking.

73 Additionally, testosterone antagonized the effect of pregnenolone sulf

74 but not in Asgr2(-/-) mice; however, LH and testosterone are elevated in all three knockouts.

75 dehydroepiandrosterone-sulfate [DHEA-S], and testosterone) are associated with PAH in men.

76 On the basis of these results, we recommend testosterone as a sensitive biomarker of POP exposure an

77 male mice were administered a single dose of testosterone as neonates or as adults before angiotensin

78 nse to the faces of men with high versus low testosterone, as well as in response to non-facial image

79 Strikingly, salivary testosterone at scan-time was negatively related to both

80 e cancer by inhibiting CYP17A, an enzyme for testosterone auto-production.

81 ween total testosterone (TT) or bioavailable testosterone (BT) with T2D.

82 in the absence of provocation indicates that testosterone can also cause prosocial behaviors that are

83 ceived BAT, which consisted of intramuscular testosterone cipionate 400 mg every 28 days until progre

84 90 men 65 years of age or older with a serum testosterone concentration of less than 275 ng per decil

85 60 years and older with low or low-to-normal testosterone concentrations (3.47-13.9 nmol/L, or free t

86 ly, rapid cycling between high and low serum testosterone concentrations (bipolar androgen therapy [B

87 :5n-3) was not significantly associated with testosterone concentrations (P-trend = 0.86 in energy su

88 was associated with increased total and free testosterone concentrations (total: percentage change of

89 Serum testosterone concentrations and urinary bisphenol A, ben

90 Serum testosterone concentrations decrease as men age, but ben

91 exposed group had 45-64% significantly lower testosterone concentrations during their peak mating sea

92 omatic men 65 years of age or older, raising testosterone concentrations for 1 year from moderately l

93 , is associated with very small increases in testosterone concentrations in healthy women and that in

94 osterone therapy is usually to achieve serum testosterone concentrations in the male reference range.

95 mol/L (SD 2.2) to 19.7 nmol/L (9.2) and free testosterone concentrations increased from 222 pmol/L (6

96 ably independent from changes in circulating testosterone concentrations since levels of the steroid

97 11.1 nmol/L (3.2) post-intervention and free testosterone concentrations were 210 pmol/L (61) and 172

98 had similar sex organ weights and low serum testosterone concentrations.

99 ction in older men with low or low-to-normal testosterone concentrations.

100 Here, we explored the joint impact of testosterone, cortisol, and brain reactivity to anger ex

101 gical propensity toward status pursuit (high testosterone) coupled with reduced stress-axis activity

102 To evaluate safety of intravaginal testosterone cream (IVT) or an estradiol-releasing vagin

103 e organs can cause impaired spermatogenesis, testosterone deficiency, and physical sexual dysfunction

104 ested for levels of total testosterone, free testosterone, dehydroepiandrosterone (DHEAS), androstene

105 The testosterone dependency of CNS oligodendrocyte remyelina

106 As testosterone dosage decreased, the percent change in C-t

107 The testosterone dose was adjusted to achieve concentrations

108 pressed, and this decline was independent of testosterone dose.

109 QCT spine BMD fell substantially in all testosterone-dose groups in which aromatization was also

110 Monthly Nielsen ratings for testosterone DTCA in the 75 largest DMAs.

111 potheses in healthy young males by injecting testosterone enanthate or a placebo in a double-blind, b

112 k in endometrioid and mucinous tumors [e.g., testosterone, endometrioid tumors, ORlog2 = 1.40 (1.03-1

113 However, recent research suggests that testosterone enhances strategic social behaviour rather

114 systematically investigated the influence of testosterone, estradiol and progesterone on initiation a

115 The results show that testosterone, estrogen, and hydrocortisone did not alter

116 Specifically, hardly any prior testosterone experiments in humans scrutinized the inter

117 on in subjects with relatively high prenatal testosterone exposure and propose a neurobiological expl

118 Last, testosterone exposure applied chronically, or as a singl

119 Whereas testosterone failed to alter male treatment response, co

120 Thus, testosterone favors astrocyte recruitment and spontaneou

121 associated memory impairment, treatment with testosterone for 1 year compared with placebo was not as

122 between pre-diagnosis circulating androgens [testosterone, free testosterone, androstenedione, dehydr

123 All patients were tested for levels of total testosterone, free testosterone, dehydroepiandrosterone

124 m linearly responded to the concentration of testosterone from 0muM to 280muM and the limit of detect

125 Testosterone gel (adjusted to maintain the testosterone

126 eatment with 0, 1.25, 2.5, 5, or 10 grams of testosterone gel daily for 16 weeks.

127 ith symptomatic hypogonadism, treatment with testosterone gel for 1 year compared with placebo was as

128 randomisation, to receive either 7.5 g of 1% testosterone gel or placebo gel daily for 3 years.

129 suggesting hypoandrogenism to receive either testosterone gel or placebo gel for 1 year.

130 Testosterone gel, with the dose adjusted to maintain the

131 .0 at 6 months, and 16.2 at 12 months in the testosterone group and 14.4 at baseline, 16.0 at 6 month

132 Of these groups, 247 men in the testosterone group and 245 men in the placebo completed

133 low-up time was 29.0 months (SD 11.5) in the testosterone group and 31.1 months (9.5) in the placebo

134 hanged from 255 to 244 Agatston units in the testosterone group vs 494 to 503 Agatston units in the p

135 to 12 months from 272 mm3 to 318 mm3 in the testosterone group vs from 499 mm3 to 541 mm3 in the pla

136 In the testosterone group, mean concentrations of serum total t

137 Testosterone had no significant benefit with respect to

138 Testosterone has several desired effects as well as unde

139 cells, dehydroepiandrosterone sulfate, free testosterone, homeostatic model assessment of insulin re

140 jects prenatally relatively highly primed by testosterone, however, this effect disappears after test

141 ration of testosterone in water and identify testosterone in cell by fluorescence imaging as a visibl

142 causal evidence for a more complex role for testosterone in driving status-enhancing behaviors in ma

143 reliable, rapid and easy method to determine testosterone in environmental water.

144 be system also performed well at determining testosterone in groundwater with average recoveries of t

145 ualize the selection process, and the use of testosterone in men with hypogonadism and obesity.

146 ng-term administration of both estradiol and testosterone in mice can result in prostatic enlargement

147 ll fluorescence imaging to monitor levels of testosterone in the cytoplasm of cells with a promising

148 developed to determine the concentration of testosterone in water and identify testosterone in cell

149 ne group, mean concentrations of serum total testosterone increased from 10.6 nmol/L (SD 2.2) to 19.7

150 sers who made unfair offers, indicating that testosterone indeed potentiates aggressive responses to

151 Testosterone-induced calcification was blunted in VSMC-s

152 new serum testosterone testing; (2) rates of testosterone initiation (in-office injection, surgical i

153 Testosterone initiation increased substantially in the U

154 ed and for specific brands; and (3) rates of testosterone initiation without recent serum testosteron

155 Testosterone is the primary and most well-recognised and

156 ween pre-existing social status and salivary testosterone level among members of a rugby team at a Ja

157 gel, with the dose adjusted to maintain the testosterone level in the normal range for young men, or

158 men who were 65 years or older with a serum testosterone level less than 275 ng/mL and impaired sexu

159 Plasma testosterone level was consistent with Tanner 4 (255 ng/

160 Testosterone gel (adjusted to maintain the testosterone level within the normal range for young men

161 on tomography-computed tomography, and serum testosterone levels > 50 ng/mL.

162 who met the PCOS criteria had elevated total testosterone levels (40.7% [105 of 258] vs 4.3% [2 of 47

163 Estradiol levels above 10 pg/ml and testosterone levels above 200 ng/dl were generally suffi

164 ignificant negative association between free testosterone levels and both anxiety and depression seve

165 ssociated with higher rates of elevated free testosterone levels as well as several metabolic abnorma

166 ive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a l

167 decrease as men age, but benefits of raising testosterone levels in older men have not been establish

168 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigne

169 osterone levels, which suggests that urinary testosterone levels may not accurately reflect blood lev

170 ivary testosterone levels, and neither basal testosterone levels nor testosterone reactivity induced

171 the stress task and had higher cortisol and testosterone levels than women after stress.

172 Testosterone treatment increased serum testosterone levels to the mid-normal range for men 19 t

173 The increase in testosterone levels was associated with significantly in

174 Higher E2 and E2/testosterone levels were associated with the risk of PAH

175 ikely to punish the proposer and that higher testosterone levels were specifically associated with in

176 ological profiles (LH, FSH, SHBG, DHEAS, and testosterone levels) of men with early AGA and to compar

177 timulating hormone, luteinizing hormone, and testosterone levels).

178 s had no discernible influence upon salivary testosterone levels, and neither basal testosterone leve

179 Pubertal maturation, indexed by testosterone levels, shifted neural regulation of emotio

180 the boys nor a gender-specific difference in testosterone levels, which suggests that urinary testost

181 testosterone treatment in older men with low testosterone levels.

182 radiol levels and negatively associated with testosterone levels.

183 The men, with a total testosterone <12 nmol/L, were treated with 15 g soy prot

184 ne concentrations (3.47-13.9 nmol/L, or free testosterone <173 pmol/L) were randomly assigned (1:1),

185 Estradiol, estrone, testosterone, luteinizing hormone (LH), follicle-stimula

186 ormone and decreases in testosterone and the testosterone/luteinizing hormone ratio were detected in

187 However, to what extent testosterone may also contribute, and whether duration o

188 Our results suggest that testosterone may enhance socially dominant behaviour amo

189 and 5alpha-androstane-3alpha,17beta-diol, a testosterone metabolite also known as 3alpha-androstaned

190 assigned 308 participants to receive either testosterone (n=156) or placebo (n=152).

191 Enrichment analysis showed effects of testosterone on BCAA degradation pathway and mitochondri

192 t corroborate observed protective effects of testosterone on cognitive function among older men.

193 The effects of testosterone on cognitive function in older men are inco

194 hich the cardiovascular effects of exogenous testosterone on men aged 18 years or older were examined

195 r of rat models of PCOS phenotype induced by testosterone or estradiol.

196 ed significantly to changes in total or free testosterone, or oestradiol concentrations.

197 In contrast, vasopressin, serotonin, and testosterone play only limited roles.

198 at 7 mo or 1 y of age without or with adult testosterone plus estradiol (T+E) to promote carcinogene

199 anner that is not statistically regulated by testosterone, possibly through increased feeling of enti

200 We investigated testosterone production and semen parameters in farmed A

201 h and differentiation parameters, as well as testosterone production, and observed that many spermato

202 The ManR clears LH thus regulating testosterone production, whereas the ASGR appears to med

203 cal implant, or pharmacy dispensing) for all testosterone products combined and for specific brands;

204 dione, androsterone, trans-androsterone, and testosterone), progestins and metabolites (progesterone,

205 Endogenous testosterone promotes behaviours intended to enhance soc

206 emale rats received sc injections of 1.25 mg testosterone propionate (Testos; n = 10), 0.5 mg estradi

207 sses of steroid agonists applied (androgen - Testosterone propionate (TP), estrogen - Diethystilbeste

208 Treatment with testosterone-propionate (TP) reveals sex-specific gene e

209 Testosterone protected both CYP3A4 and CYP3A5 from inact

210 was observed across endocrine (cortisol and testosterone), psychological (feeling in control), and b

211 ne in groundwater with average recoveries of testosterone ranging from 96% to 107% at spiking levels

212 ty, plasma leptin and luteinising hormone to testosterone ratio.

213 s, and neither basal testosterone levels nor testosterone reactivity induced by competition predicted

214 ced interview performance, whereas increased testosterone reactivity predicted worse performance.

215 and its association with competition-induced testosterone reactivity.

216 nce was explained by feelings of control and testosterone reactivity.

217 hinese men from Hong Kong, based on selected testosterone-related single nucleotide polymorphisms (rs

218 ), and men demonstrated higher prevalence of testosterone replacement (P < .001) after cyclophosphami

219 Testosterone replacement for older men is increasingly c

220 ls are needed to investigate the efficacy of testosterone replacement in patients with impaired cogni

221 Purpose The association between exposure to testosterone replacement therapy (TRT) and prostate canc

222 While testosterone replacement therapy has been shown to impro

223 re needed to clarify the association between testosterone-replacement therapy and major adverse cardi

224 Therapy-Fatigue scale, but men who received testosterone reported slightly better mood and lower sev

225 ge lipid accumulation, whereas fenarimol and testosterone (reported inhibitors of ecdysteroid synthes

226 associated with cotton wool spots, and serum testosterone response during flight was associated with

227 However, we found neither a neonatal testosterone rise in the boys nor a gender-specific diff

228 Although popular discussion of testosterone's influence on males often centers on aggre

229 An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the d

230 ty in vitro but did not affect LH stimulated testosterone secretion from adult testis explants.

231 untested predictions of this theory are that testosterone selectively increases status-relevant aggre

232 ling, we demonstrated that the pressure- and testosterone-sensitive transition is also revealed by pr

233 The serum concentrations of total testosterone, sex hormone-binding globulin (SHBG), dehyd

234 was compromised in the absence of testes and testosterone signaling via AR.

235 However, testosterone significantly attenuated the association be

236 testosterone treatment of older men with low testosterone slows progression of noncalcified coronary

237 Most of the effects of testosterone start to develop within several months of s

238 after castration but restored with exogenous testosterone, suggesting that male susceptibility to UTI

239 Mixtures of antiandrogens can suppress testosterone synthesis in human fetal testicular explant

240 17-dione and 5alpha-androstane-3,17-dione to testosterone (T) and 5alpha-dihydrotestosterone, respect

241 Here, we show that administration of testosterone (T) increases foot flagging behavior under

242 We found that testosterone (T) induces GDNF expression in mouse PM cel

243 onal wisdom suggests that baseline levels of testosterone (T) promote aggressive behavior, decades of

244 n the most masculinised of females have less testosterone (T) than do conspecific males.

245 ated with a monthly increase in rates of new testosterone testing (rate ratio [RR], 1.006; 95% CI, 1.

246 gate associations between televised DTCA and testosterone testing and initiation in the United States

247 Associations between DTCA and testosterone testing, initiation, and initiation without

248 umer advertising was associated with greater testosterone testing, new initiation, and initiation wit

249 testosterone initiation without recent serum testosterone testing.

250 (1) Rates of new serum testosterone testing; (2) rates of testosterone initiati

251 an age, 49.6 [SD, 11.5] years) had new serum testosterone tests and 283317 (mean age, 51.8 [SD, 11.3]

252 An additional benefit of testosterone therapy (with or without mastectomy) is a r

253 A major limitation in the study of testosterone therapy for transgender men is a paucity of

254 Testosterone therapy is a cornerstone of medical treatme

255 The goal of testosterone therapy is usually to achieve serum testost

256 P450 aromatase (AROM), the enzyme converting testosterone to 17beta-estradiol (E2), contributes to th

257 atase inhibition decreases the conversion of testosterone to 17beta-estradiol (E2), thereby reducing

258 e considerably greater when aromatization of testosterone to estradiol was also suppressed, suggestin

259 the enzyme that catalyzes the conversion of testosterone to estradiol.

260 and finasteride) to block the conversion of testosterone to the more potent androgen receptor ligand

261 4-mediated conversion of the model compound, testosterone, to its major metabolite, 6beta-hydroxy tes

262 show that a proxy for individuals' prenatal testosterone-to-estradiol ratio, second-to-fourth digit-

263 associated with increases in total and free testosterone (total: percentage change of 3.7%; 95% CI:

264 es in female rat liver that mimic NAFLD with testosterone-treated rats showing impaired BCAA metaboli

265 ical function, or vitality were allocated to testosterone treatment (n = 394) or placebo (n = 394).

266 170 men who were enrolled, 138 (73 receiving testosterone treatment and 65 receiving placebo) complet

267 To determine if testosterone treatment compared with placebo is associat

268 For the primary outcome, testosterone treatment compared with placebo was associa

269 als) were 7 trials to assess the efficacy of testosterone treatment in older men with low testosteron

270 Testosterone treatment increased serum testosterone leve

271 ve yielded conflicting results as to whether testosterone treatment increases cardiovascular risk.

272 Prior studies suggest that testosterone treatment may improve these functions.

273 In vitro, testosterone treatment not only decreased Th1 and Th17 d

274 To test the hypothesis that testosterone treatment of older men with low testosteron

275 These findings indicate that neonatal testosterone treatment, but not estradiol, produces hist

276 (mean age, 51.8 [SD, 11.3] years) initiated testosterone treatment.

277 o few to draw conclusions about the risks of testosterone treatment.

278 The Testosterone Trials (TTrials) were 7 trials to assess th

279 ive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2

280 iclosan (TCS), and parabens with serum total testosterone (TT) levels in child and adolescent partici

281 No association was observed between total testosterone (TT) or bioavailable testosterone (BT) with

282 At baseline, total estradiol (TE) and total testosterone (TT) were measured.

283 s validated for phylloquinone, cyclosporine, testosterone undecanoate, cabazitaxel and seven other bi

284 advertising ratings were linked to DMA-level testosterone use data from 2009-2013 derived from commer

285 , among the most senior participants, higher testosterone was associated with lower acquiescence.

286 A genetic score predicting testosterone was developed in 289 young Chinese men from

287 case status (C statistic for both, 0.82) but testosterone was not (C statistic, 0.53).

288 Predicted testosterone was not associated with delayed 10-word rec

289 Testosterone was not suppressed in testes from fetuses y

290 rone, to its major metabolite, 6beta-hydroxy testosterone was noted.

291 Testosterone was positively associated with EOC risk (al

292 aised total sex steroid concentrations, free testosterone was unaffected while sex steroid bioactivit

293 bo group, mean concentrations of serum total testosterone were 10.7 nmol/L (SD 2.3) at baseline and 1

294 We found that participants treated with testosterone were more likely to punish the proposer and

295 infectious disease burden in males is due to testosterone, which drives the development of secondary

296 the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly

297 We examined the association of endogenous testosterone with cognitive function among older men in

298 The association of genetically predicted testosterone with delayed 10-word recall score and Mini-

299 in humans scrutinized the interdependency of testosterone with the social environment.

300 2 fold change) and anabolic hormone milieu (testosterone, Y: 367 +/- 19; O: 274 +/- 19 ng dl(-1) (al